{"id":"https://openalex.org/W1024636072","doi":"https://doi.org/10.1097/01.hjh.0000467477.44202.16","title":"4A.03: CATHETER-BASED RENAL DENERVATION FOR RESISTANT HYPERTENSION 24 MONTH RESULTS OF THE ENLIGHTN I STUDY USING A MULTIELECTRODE ABLATION SYSTEM","display_name":"4A.03: CATHETER-BASED RENAL DENERVATION FOR RESISTANT HYPERTENSION 24 MONTH RESULTS OF THE ENLIGHTN I STUDY USING A MULTIELECTRODE ABLATION SYSTEM","publication_year":2015,"publication_date":"2015-06-01","ids":{"openalex":"https://openalex.org/W1024636072","doi":"https://doi.org/10.1097/01.hjh.0000467477.44202.16","mag":"1024636072"},"language":"fr","primary_location":{"id":"doi:10.1097/01.hjh.0000467477.44202.16","doi":"https://doi.org/10.1097/01.hjh.0000467477.44202.16","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.hjh.0000467477.44202.16","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108805684","display_name":"Costas Tsioufis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"C. Tsioufis","raw_affiliation_strings":["First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, GREECE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, GREECE","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210165841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043591193","display_name":"Vasilios Papademetriou","orcid":"https://orcid.org/0000-0002-2882-2757","observed_orcids":["https://orcid.org/0000-0002-2882-2757"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V. Papademetriou","raw_affiliation_strings":["Veterans Affairs and Georgetown University Medical Centers, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Affairs and Georgetown University Medical Centers, Washington, DC, USA","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091336195","display_name":"Konstantinos Dimitriadis","orcid":"https://orcid.org/0000-0002-1912-0294","observed_orcids":["https://orcid.org/0000-0002-1912-0294"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"K. Dimitriadis","raw_affiliation_strings":["First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, GREECE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, GREECE","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210165841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058399015","display_name":"Alexandros Kasiakogias","orcid":"https://orcid.org/0000-0002-1090-4965","observed_orcids":["https://orcid.org/0000-0002-1090-4965"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"A. Kasiakogias","raw_affiliation_strings":["First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, GREECE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, GREECE","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210165841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080650197","display_name":"Athanasios Kordalis","orcid":"https://orcid.org/0000-0003-4093-4601","observed_orcids":["https://orcid.org/0000-0003-4093-4601"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"A. Kordalis","raw_affiliation_strings":["First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, GREECE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, GREECE","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210165841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065539150","display_name":"Costas Thomopoulos","orcid":"https://orcid.org/0000-0002-8491-6029","observed_orcids":["https://orcid.org/0000-0002-8491-6029"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"C. Thomopoulos","raw_affiliation_strings":["First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, GREECE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, GREECE","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210165841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035609575","display_name":"Dimitris Tsiachris","orcid":"https://orcid.org/0000-0003-4531-9712","observed_orcids":["https://orcid.org/0000-0003-4531-9712"]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"D. Tsiachris","raw_affiliation_strings":["First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, GREECE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, GREECE","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210165841"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109388677","display_name":"D Tousoulis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210165841","display_name":"Hippocration General Hospital","ror":"https://ror.org/05v5wwy67","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210165841"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"D. Tousoulis","raw_affiliation_strings":["First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, GREECE"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Cardiology Clinic, University of Athens, Hippokration Hospital, Athens, GREECE","institution_ids":["https://openalex.org/I200777214","https://openalex.org/I4210165841"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105990171","display_name":"Stephen Grant Worthley","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320133117","display_name":"Royal Adelaide Hospital","ror":"https://ror.org/00carf720","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I1320133117","https://openalex.org/I4392738059"]},{"id":"https://openalex.org/I5681781","display_name":"The University of Adelaide","ror":"https://ror.org/00892tw58","country_code":"AU","type":"education","lineage":["https://openalex.org/I4405259444","https://openalex.org/I5681781"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"S. Worthley","raw_affiliation_strings":["Cardiology Department, Royal Adelaide Hospital, University of Adelaide, Adelaide, AUSTRALIA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiology Department, Royal Adelaide Hospital, University of Adelaide, Adelaide, AUSTRALIA","institution_ids":["https://openalex.org/I1320133117","https://openalex.org/I5681781"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2091,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.55449882,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"33","issue":"Supplement 1","first_page":"e49","last_page":"e50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11839","display_name":"Hormonal Regulation and Hypertension","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12067","display_name":"Renal and Vascular Pathologies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-denervation","display_name":"renal denervation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/resistant-hypertension","display_name":"resistant hypertension","score":0.9169999957084656},{"id":"https://openalex.org/keywords/ambulatory-blood-pressure","display_name":"ambulatory blood pressure","score":0.9599999785423279},{"id":"https://openalex.org/keywords/home-blood-pressure-monitoring","display_name":"home blood pressure monitoring","score":0.8859999775886536},{"id":"https://openalex.org/keywords/renal-function-decline","display_name":"renal function decline","score":0.8309999704360962},{"id":"https://openalex.org/keywords/procedural-safety","display_name":"procedural safety","score":0.6240000128746033},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.41499999165534973},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.8029999732971191},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.6449999809265137},{"id":"https://openalex.org/keywords/heart-rate","display_name":"heart rate","score":0.47200000286102295},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.656000018119812},{"id":"https://openalex.org/keywords/renal-sympathetic-nerves","display_name":"renal sympathetic nerves","score":0.3889999985694885},{"id":"https://openalex.org/keywords/percutaneous-femoral-access","display_name":"percutaneous femoral access","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9792237281799316},{"id":"https://openalex.org/C35785553","wikidata":"https://www.wikidata.org/wiki/Q756720","display_name":"Ambulatory","level":2,"score":0.740479588508606},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.6971435546875},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.6135717034339905},{"id":"https://openalex.org/C2780192228","wikidata":"https://www.wikidata.org/wiki/Q575890","display_name":"Antihypertensive drug","level":3,"score":0.5681696534156799},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5555306077003479},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5385850667953491},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5282379984855652},{"id":"https://openalex.org/C149323552","wikidata":"https://www.wikidata.org/wiki/Q3090739","display_name":"Ambulatory blood pressure","level":3,"score":0.4917161762714386},{"id":"https://openalex.org/C2777953023","wikidata":"https://www.wikidata.org/wiki/Q1073121","display_name":"Heart rate","level":3,"score":0.4436270296573639},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.1006571352481842}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/01.hjh.0000467477.44202.16","doi":"https://doi.org/10.1097/01.hjh.0000467477.44202.16","is_oa":false,"landing_page_url":"https://doi.org/10.1097/01.hjh.0000467477.44202.16","pdf_url":null,"source":{"id":"https://openalex.org/S115964404","display_name":"Journal of Hypertension","issn_l":"0263-6352","issn":["0263-6352","1473-5598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Hypertension","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1860528211","https://openalex.org/W2746814882","https://openalex.org/W2740058200","https://openalex.org/W2197629768","https://openalex.org/W2219435981","https://openalex.org/W2318277966","https://openalex.org/W4238950897","https://openalex.org/W2611801906","https://openalex.org/W2334138116","https://openalex.org/W3080079626"],"abstract_inverted_index":{"Objective:":[0],"The":[1,32,287],"EnligHTN":[2,288],"I,":[3],"the":[4,40,102,163,284,294,325],"first-in-human":[5],"study":[6,36,290],"using":[7,137],"a":[8,92,267,299,312],"multielectrode":[9,295],"ablation":[10,296],"system":[11,297],"for":[12,98,186,260,269],"renal":[13,270],"denervation":[14],"(RDN)":[15],"in":[16,146,165,170,209,223,237,304],"patients":[17,68,224,305],"with":[18,84,283,306],"drug":[19,221],"resistant":[20],"hypertension":[21],"(dRHT)":[22],"demonstrated":[23],"efficacy":[24],"and":[25,29,50,63,109,125,141,151,159,169,179,218,308,318],"safety":[26],"at":[27,149,173,229,321,335],"6":[28],"12":[30,130],"months.":[31],"aim":[33],"of":[34,43,254,302,315,330],"this":[35],"was":[37,135],"to":[38,241],"report":[39],"complete":[41],"set":[42],"24":[44,152,174,230,263,322],"month":[45],"data":[46],"on":[47,86],"office,":[48,316],"ambulatory":[49,107,167,317],"home":[51,110,171,319],"blood":[52],"pressure":[53],"(BP)":[54],"changes":[55],"as":[56,58,233],"well":[57],"long":[59,336],"term":[60,337],"safety.":[61],"Design":[62],"method:":[64],"We":[65],"studied":[66],"46":[67],"(age:":[69],"60\u00b110":[70],"years,":[71],"4.7":[72,196],"\u00b1":[73,81,114,116,120,122,127,129,195,199],"1.0":[74],"antihypertensive":[75,88,220],"drugs,":[76],"body":[77,191],"mass":[78,192],"index:":[79],"32":[80],"5":[82],"kg/m2)":[83],"dRHT":[85,307],">or=3":[87],"medications":[89],"who":[90],"had":[91],"systolic":[93],"BP>or=160":[94],"mmHg":[95,97,124,131,158,178,181,235],"(>or=150":[96],"diabetics).":[99],"At":[100,262],"baseline,":[101],"average":[103],"office":[104,147,212,238],"BP,":[105,213],"24-hour":[106,166],"BP":[108,111,148,168,172,239,320],"were":[112,156,176,206,226,274,333],"176":[113],"16/96":[115],"14":[117],"mmHg,":[118,161],"150":[119],"14/83":[121],"13":[123],"158":[126],"16/90":[128],"respectively.":[132],"Bilateral":[133],"RDN":[134,227,255,303,331],"performed":[136],"percutaneous":[138],"femoral":[139],"approach":[140],"standardized":[142],"techniques.":[143],"Results:":[144],"Reduction":[145],"18":[150],"months":[153,175,231,264,323],"from":[154,189,266],"baseline":[155,211,219,242],"-24/-10":[157],"-29/-13":[160],"while":[162],"reduction":[164,314],"-13/-7":[177],"-11/-6":[180],"respectively":[182],"(p":[183,257],"<":[184,203],"0.05":[185],"all).":[187,261],"Apart":[188],"higher":[190],"index":[193],"(33.3":[194],"vs":[197],"29.5":[198],"6.2":[200],"kg/m2,":[201],"p":[202],"0.05),":[204],"there":[205,273],"no":[207,252,275,328],"differences":[208],"age,":[210],"heart":[214],"rate,":[215],"diabetes":[216],"mellitus":[217],"therapy":[222],"that":[225,293],"responders":[228],"[defined":[232],"10":[234],"decline":[236],"compared":[240],"(74%,":[243],"n":[244],"=":[245,258],"34)].":[246],"Stepwise":[247],"logistic":[248],"regression":[249],"analysis":[250],"revealed":[251],"prognosticators":[253],"response":[256,332],"NS":[259],"apart":[265],"trend":[268],"function":[271],"decrease,":[272],"new":[276],"serious":[277],"or":[278],"life-threatening":[279],"adverse":[280],"events":[281],"related":[282],"procedure.":[285,326],"Conclusions:":[286],"I":[289],"provides":[291],"evidence":[292],"constitutes":[298],"safe":[300],"method":[301],"is":[309],"accompanied":[310],"by":[311],"sustained":[313],"after":[324],"However,":[327],"predictors":[329],"identified":[334],"follow-up.":[338]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2016-06-24T00:00:00"}
