{"id":"https://openalex.org/W102454576","doi":null,"title":"Physical and molecular processes controlling the formation, structure and breakdown of the salivary pellicle","display_name":"Physical and molecular processes controlling the formation, structure and breakdown of the salivary pellicle","publication_year":2014,"publication_date":"2014-03-01","ids":{"openalex":"https://openalex.org/W102454576","mag":"102454576"},"language":"en","primary_location":{"id":"pmh:oai:ueaeprints.uea.ac.uk:48387","doi":null,"is_oa":true,"landing_page_url":"https://ueaeprints.uea.ac.uk/48387/1/Final_Corrected_Thesis_.pdf","pdf_url":"https://ueaeprints.uea.ac.uk/48387/1/Final_Corrected_Thesis_.pdf","source":{"id":"https://openalex.org/S4306400384","display_name":"UEA Digital Repository (University of East Anglia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1118541","host_organization_name":"University of East Anglia","host_organization_lineage":["https://openalex.org/I1118541"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ueaeprints.uea.ac.uk/48387/1/Final_Corrected_Thesis_.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108586797","display_name":"Anthony Ash","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Anthony Ash","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5108586797"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.3285999894142151,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11521","display_name":"Salivary Gland Disorders and Functions","score":0.3285999894142151,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.12700000405311584,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11958","display_name":"Dental Erosion and Treatment","score":0.11840000003576279,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/salivary-pellicle","display_name":"salivary pellicle","score":0.9990000128746033},{"id":"https://openalex.org/keywords/pellicle-formation","display_name":"pellicle formation","score":0.75},{"id":"https://openalex.org/keywords/mucin","display_name":"mucin","score":0.9649999737739563},{"id":"https://openalex.org/keywords/parotid-saliva","display_name":"parotid saliva","score":0.8399999737739563},{"id":"https://openalex.org/keywords/calcium-concentration","display_name":"calcium concentration","score":0.7049999833106995},{"id":"https://openalex.org/keywords/ph-effect","display_name":"pH effect","score":0.5929999947547913},{"id":"https://openalex.org/keywords/low-ph","display_name":"low pH","score":0.5740000009536743},{"id":"https://openalex.org/keywords/sodium-thiosulfate","display_name":"sodium thiosulfate","score":0.5580000281333923},{"id":"https://openalex.org/keywords/hydroxyapatite","display_name":"hydroxyapatite","score":0.781000018119812},{"id":"https://openalex.org/keywords/qcm-d","display_name":"QCM-D","score":0.7099999785423279}],"concepts":[{"id":"https://openalex.org/C504460877","wikidata":"https://www.wikidata.org/wiki/Q155925","display_name":"Saliva","level":2,"score":0.9135168194770813},{"id":"https://openalex.org/C179264091","wikidata":"https://www.wikidata.org/wiki/Q410862","display_name":"Mucin","level":2,"score":0.7204999923706055},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.619776725769043},{"id":"https://openalex.org/C9996572","wikidata":"https://www.wikidata.org/wiki/Q629569","display_name":"Quartz crystal microbalance","level":3,"score":0.4800068736076355},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4545036256313324},{"id":"https://openalex.org/C96294017","wikidata":"https://www.wikidata.org/wiki/Q308708","display_name":"Isoelectric point","level":3,"score":0.43333524465560913},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.309906542301178},{"id":"https://openalex.org/C150394285","wikidata":"https://www.wikidata.org/wiki/Q180254","display_name":"Adsorption","level":2,"score":0.167995423078537},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16078174114227295},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.08341380953788757},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ueaeprints.uea.ac.uk:48387","doi":null,"is_oa":true,"landing_page_url":"https://ueaeprints.uea.ac.uk/48387/1/Final_Corrected_Thesis_.pdf","pdf_url":"https://ueaeprints.uea.ac.uk/48387/1/Final_Corrected_Thesis_.pdf","source":{"id":"https://openalex.org/S4306400384","display_name":"UEA Digital Repository (University of East Anglia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1118541","host_organization_name":"University of East Anglia","host_organization_lineage":["https://openalex.org/I1118541"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:102454576","doi":null,"is_oa":false,"landing_page_url":"https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.601090","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:ueaeprints.uea.ac.uk:48387","doi":null,"is_oa":true,"landing_page_url":"https://ueaeprints.uea.ac.uk/48387/1/Final_Corrected_Thesis_.pdf","pdf_url":"https://ueaeprints.uea.ac.uk/48387/1/Final_Corrected_Thesis_.pdf","source":{"id":"https://openalex.org/S4306400384","display_name":"UEA Digital Repository (University of East Anglia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1118541","host_organization_name":"University of East Anglia","host_organization_lineage":["https://openalex.org/I1118541"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W102454576.pdf","grobid_xml":"https://content.openalex.org/works/W102454576.grobid-xml"},"referenced_works_count":217,"referenced_works":["https://openalex.org/W17203398","https://openalex.org/W88039580","https://openalex.org/W101532009","https://openalex.org/W130339680","https://openalex.org/W141881479","https://openalex.org/W178207067","https://openalex.org/W208006937","https://openalex.org/W260994251","https://openalex.org/W1487606280","https://openalex.org/W1536993479","https://openalex.org/W1546439439","https://openalex.org/W1593700484","https://openalex.org/W1596668175","https://openalex.org/W1600986677","https://openalex.org/W1620746264","https://openalex.org/W1734166369","https://openalex.org/W1816059433","https://openalex.org/W1890552350","https://openalex.org/W1924852874","https://openalex.org/W1963728608","https://openalex.org/W1963748070","https://openalex.org/W1965672452","https://openalex.org/W1966099845","https://openalex.org/W1966599324","https://openalex.org/W1967203110","https://openalex.org/W1970173206","https://openalex.org/W1970531656","https://openalex.org/W1970823577","https://openalex.org/W1971678867","https://openalex.org/W1972711662","https://openalex.org/W1972829767","https://openalex.org/W1973273827","https://openalex.org/W1973304902","https://openalex.org/W1973649095","https://openalex.org/W1973684998","https://openalex.org/W1973704437","https://openalex.org/W1975187960","https://openalex.org/W1976720082","https://openalex.org/W1977452467","https://openalex.org/W1978380437","https://openalex.org/W1979133296","https://openalex.org/W1979515901","https://openalex.org/W1980650460","https://openalex.org/W1981593008","https://openalex.org/W1981989283","https://openalex.org/W1985676128","https://openalex.org/W1986893074","https://openalex.org/W1989065796","https://openalex.org/W1992006214","https://openalex.org/W1992084055","https://openalex.org/W1994810661","https://openalex.org/W1995436480","https://openalex.org/W1996006776","https://openalex.org/W1996680998","https://openalex.org/W1997162828","https://openalex.org/W1997391685","https://openalex.org/W2000230300","https://openalex.org/W2004923291","https://openalex.org/W2005394596","https://openalex.org/W2005480901","https://openalex.org/W2006258603","https://openalex.org/W2006444125","https://openalex.org/W2011882903","https://openalex.org/W2012030587","https://openalex.org/W2012085532","https://openalex.org/W2012651880","https://openalex.org/W2012717554","https://openalex.org/W2013010814","https://openalex.org/W2013677467","https://openalex.org/W2014226845","https://openalex.org/W2014536520","https://openalex.org/W2015632907","https://openalex.org/W2015736470","https://openalex.org/W2016234249","https://openalex.org/W2016393626","https://openalex.org/W2016716820","https://openalex.org/W2016853320","https://openalex.org/W2020606719","https://openalex.org/W2020712586","https://openalex.org/W2021072563","https://openalex.org/W2021294822","https://openalex.org/W2022132405","https://openalex.org/W2022396506","https://openalex.org/W2023804098","https://openalex.org/W2025046185","https://openalex.org/W2025960727","https://openalex.org/W2026775020","https://openalex.org/W2027872382","https://openalex.org/W2027890150","https://openalex.org/W2031929695","https://openalex.org/W2034421973","https://openalex.org/W2034513377","https://openalex.org/W2034612884","https://openalex.org/W2035260910","https://openalex.org/W2036003934","https://openalex.org/W2036163274","https://openalex.org/W2037811659","https://openalex.org/W2037943737","https://openalex.org/W2038102074","https://openalex.org/W2038138644","https://openalex.org/W2038544285","https://openalex.org/W2039875326","https://openalex.org/W2040001373","https://openalex.org/W2040486347","https://openalex.org/W2041229550","https://openalex.org/W2041747849","https://openalex.org/W2042042803","https://openalex.org/W2043312528","https://openalex.org/W2044375463","https://openalex.org/W2044932535","https://openalex.org/W2046726022","https://openalex.org/W2047243092","https://openalex.org/W2047561198","https://openalex.org/W2049031266","https://openalex.org/W2049436397","https://openalex.org/W2050372127","https://openalex.org/W2051809212","https://openalex.org/W2055218251","https://openalex.org/W2057045350","https://openalex.org/W2058292118","https://openalex.org/W2058749085","https://openalex.org/W2059214699","https://openalex.org/W2059532608","https://openalex.org/W2060570910","https://openalex.org/W2062338879","https://openalex.org/W2062568462","https://openalex.org/W2063233815","https://openalex.org/W2063968553","https://openalex.org/W2064240198","https://openalex.org/W2064564846","https://openalex.org/W2067170583","https://openalex.org/W2067208285","https://openalex.org/W2067475942","https://openalex.org/W2069283011","https://openalex.org/W2072089627","https://openalex.org/W2073016966","https://openalex.org/W2073077653","https://openalex.org/W2075211753","https://openalex.org/W2075631409","https://openalex.org/W2076241019","https://openalex.org/W2076419915","https://openalex.org/W2076484460","https://openalex.org/W2077694312","https://openalex.org/W2077820995","https://openalex.org/W2077862200","https://openalex.org/W2077978477","https://openalex.org/W2078958726","https://openalex.org/W2079762153","https://openalex.org/W2079765666","https://openalex.org/W2081259055","https://openalex.org/W2081875004","https://openalex.org/W2081889435","https://openalex.org/W2082928650","https://openalex.org/W2083214965","https://openalex.org/W2084512200","https://openalex.org/W2084962819","https://openalex.org/W2085317185","https://openalex.org/W2085938580","https://openalex.org/W2086218786","https://openalex.org/W2087498729","https://openalex.org/W2090457399","https://openalex.org/W2090596375","https://openalex.org/W2092734238","https://openalex.org/W2094170571","https://openalex.org/W2094201777","https://openalex.org/W2095574609","https://openalex.org/W2098561534","https://openalex.org/W2099245827","https://openalex.org/W2104294391","https://openalex.org/W2106002788","https://openalex.org/W2106788781","https://openalex.org/W2106944893","https://openalex.org/W2107997423","https://openalex.org/W2108374371","https://openalex.org/W2115387219","https://openalex.org/W2117771841","https://openalex.org/W2117910342","https://openalex.org/W2119485878","https://openalex.org/W2119727448","https://openalex.org/W2121107089","https://openalex.org/W2121415771","https://openalex.org/W2122858288","https://openalex.org/W2123137119","https://openalex.org/W2123998092","https://openalex.org/W2128353927","https://openalex.org/W2131720570","https://openalex.org/W2132418255","https://openalex.org/W2133370146","https://openalex.org/W2133441143","https://openalex.org/W2134082800","https://openalex.org/W2134865618","https://openalex.org/W2141194339","https://openalex.org/W2142958919","https://openalex.org/W2143246536","https://openalex.org/W2143829072","https://openalex.org/W2144353549","https://openalex.org/W2155963087","https://openalex.org/W2157567143","https://openalex.org/W2159748646","https://openalex.org/W2162478389","https://openalex.org/W2162962060","https://openalex.org/W2163088193","https://openalex.org/W2164337426","https://openalex.org/W2167212038","https://openalex.org/W2170324613","https://openalex.org/W2171755866","https://openalex.org/W2172055710","https://openalex.org/W2186018600","https://openalex.org/W2295402325","https://openalex.org/W2336253926","https://openalex.org/W2401210627","https://openalex.org/W2409558188","https://openalex.org/W2409945823","https://openalex.org/W2418389207","https://openalex.org/W2419085426","https://openalex.org/W2591581239","https://openalex.org/W4295880516"],"related_works":["https://openalex.org/W2038102074","https://openalex.org/W2333986251","https://openalex.org/W4255119624","https://openalex.org/W4415323290","https://openalex.org/W2022396506","https://openalex.org/W3142909074","https://openalex.org/W2149818714","https://openalex.org/W2012742767","https://openalex.org/W2332734514","https://openalex.org/W2901507263"],"abstract_inverted_index":{"Objectives:":[0],"\\nDespite":[1],"the":[2,5,16,23,35,43,47,59,67,75,93,138,154,190,217,237,241,245,248,270,279,283,288,294,305,309,315,319,340,343,348],"importance":[3],"of":[4,15,28,69,103,240,272,282,297,308,331,347],"pellicle":[6,48,65,155,177,181,191,218,262,320],"in":[7,64,159,165,216,244],"oral":[8,133,332],"physiological":[9],"and":[10,19,26,54,98,107,119,132,145,147,202,226,286,326,345],"pathological":[11],"processes,":[12],"an":[13,275],"understanding":[14],"fundamental":[17],"physical":[18,139,280,306],"molecular":[20],"mechanisms":[21,341],"underlying":[22,342],"structural":[24,44,76,316],"formation":[25,344],"breakdown":[27,346],"this":[29,160],"protein":[30,150],"film":[31],"remains":[32],"unresolved.":[33],"Therefore":[34],"work":[36],"carried":[37],"out":[38],"herein":[39],"attempts":[40],"to":[41,52,129,136,171,179,206,224,236,254,291,329,337],"elucidate":[42],"changes":[45,77,215,231,317],"that":[46,61,78,153,232,269,302,318],"undergoes":[49,156,321],"upon":[50,80,222,327],"exposure":[51,223,328],"intrinsic":[53],"extrinsic":[55],"factors.":[56],"Such":[57],"as;":[58],"role":[60],"mucins":[62],"play":[63],"formation,":[66],"effect":[68,277],"a":[70,112,120,174,180,300],"changing":[71],"acidic":[72,324],"environment":[73],"or":[74],"occur":[79],"contact":[81],"with":[82,116],"dentifrice":[83],"components.":[84],"\\nMethods:":[85],"\\nin":[86],"vitro":[87],"adsorbed":[88,284],"pellicles":[89,125,207],"were":[90,126,169,335],"formed":[91,182,192,208,311],"from":[92,183,193,209],"saliva":[94,97,168,186,194,210,273,298],"(stimulated":[95],"parotid":[96],"stimulated":[99],"whole":[100,166],"mouth":[101,167],"saliva)":[102],"14":[104],"healthy":[105],"volunteers,":[106],"studied":[108],"using":[109],"techniques":[110],"including":[111],"quartz":[113],"crystal":[114],"microbalance":[115],"dissipation":[117],"monitoring":[118],"dual":[121],"polarisation":[122],"interferometer.":[123],"The":[124],"then":[127],"exposed":[128],"certain":[130],"food":[131],"hygiene":[134,333],"ingredients":[135],"observe":[137],"(e.g.":[140,149],"surface":[141],"mass,":[142],"density,":[143],"thickness":[144],"viscoelasticity)":[146],"chemical":[148],"composition)":[151],"modifications":[152],"when":[157],"challenged":[158],"way.":[161],"\\nResults:":[162],"\\nMucins":[163],"present":[164,243],"shown":[170,253],"help":[172,338],"form":[173,263],"more":[175,200,256],"viscous":[176],"compared":[178,205],"mucin":[184],"free":[185],"(parotid":[187],"saliva).":[188],"Whereas,":[189],"containing":[195,211],"10":[196],"mM":[197],"CaCl2":[198],"was":[199,252],"diffuse":[201],"less":[203],"stable":[204],"1mM":[212],"CaCl2.":[213],"Structural":[214],"also":[219],"took":[220],"place":[221],"pH4":[225],"pH3":[227],"\\n3":[228],"\\ncitrate":[229],"buffers,":[230],"may":[233],"be":[234,255],"related":[235],"isoelectric":[238],"points":[239],"proteins":[242],"pellicle.":[246,312,350],"Finally,":[247],"polyanionic":[249],"STP":[250],"molecule":[251],"effective":[257],"than":[258],"SDS":[259],"at":[260],"displacing":[261],"hydroxyapatite.":[264],"\\nConclusion:":[265],"\\nThis":[266],"research":[267],"demonstrated":[268],"composition":[271],"has":[274],"important":[276],"on":[278],"properties":[281,307],"pellicle;":[285],"lays":[287],"foundations":[289],"as":[290],"how":[292],"regulating":[293],"calcium":[295],"concentration":[296],"provides":[299],"mechanism":[301],"can":[303],"control":[304],"in-vitro":[310],"In":[313],"addition,":[314],"under":[322],"differing":[323],"environments,":[325],"components":[330],"products,":[334],"observed":[336],"understand":[339],"salivary":[349]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}