{"id":"https://openalex.org/W102413465","doi":null,"title":"The role of purinergic signaling in depressive disorders.","display_name":"The role of purinergic signaling in depressive disorders.","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W102413465","mag":"102413465","pmid":"https://pubmed.ncbi.nlm.nih.gov/23269209"},"language":"en","primary_location":{"id":"pmid:23269209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23269209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006946764","display_name":"Be\u00e1ta Sperl\u00e1gh","orcid":"https://orcid.org/0000-0003-0099-591X","observed_orcids":["https://orcid.org/0000-0003-0099-591X"]},"institutions":[{"id":"https://openalex.org/I4210106880","display_name":"HUN-REN Institute of Experimental Medicine","ror":"https://ror.org/01jsgmp44","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210106880","https://openalex.org/I4387152226"]},{"id":"https://openalex.org/I7597260","display_name":"Hungarian Academy of Sciences","ror":"https://ror.org/02ks8qq67","country_code":"HU","type":"government","lineage":["https://openalex.org/I7597260"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Beata Sperlagh","raw_affiliation_strings":["Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences IEM HAS, H-1083 Budapest, Hungary. sperlagh@koki.hu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Pharmacology, Institute of Experimental Medicine, Hungarian Academy of Sciences IEM HAS, H-1083 Budapest, Hungary. sperlagh@koki.hu","institution_ids":["https://openalex.org/I4210106880","https://openalex.org/I7597260"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053945770","display_name":"Cec\u00edlia Cs\u00f6lle","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Cecilia Csolle","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110064421","display_name":"R\u00f3me\u00f3 D. And\u00f3","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Romeo D Ando","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075575084","display_name":"Fl\u00f3ra G\u00f6l\u00f6ncs\u00e9r","orcid":"https://orcid.org/0009-0008-2965-3044","observed_orcids":["https://orcid.org/0009-0008-2965-3044"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Flora Goloncser","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068836281","display_name":"\u00c1gnes Kittel","orcid":"https://orcid.org/0000-0002-6888-7731","observed_orcids":["https://orcid.org/0000-0002-6888-7731"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Agnes Kittel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5013083618","display_name":"M\u00e1ria Baranyi","orcid":"https://orcid.org/0000-0001-6305-8857","observed_orcids":["https://orcid.org/0000-0001-6305-8857"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Baranyi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.8766,"has_fulltext":false,"cited_by_count":55,"citation_normalized_percentile":{"value":0.94089647,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"14","issue":"4","first_page":"231","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/purinergic-signaling","display_name":"purinergic signaling","score":1.0},{"id":"https://openalex.org/keywords/p2x7-receptor","display_name":"P2X7 receptor","score":0.7960000038146973},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.9190000295639038},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":1.0},{"id":"https://openalex.org/keywords/mood-disorders","display_name":"mood disorders","score":0.7630000114440918},{"id":"https://openalex.org/keywords/adenosine","display_name":"adenosine","score":0.5950000286102295},{"id":"https://openalex.org/keywords/atp","display_name":"ATP","score":0.7049999833106995},{"id":"https://openalex.org/keywords/p2y-receptors","display_name":"P2Y receptors","score":0.7580000162124634},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.9440000057220459},{"id":"https://openalex.org/keywords/glutamate-release","display_name":"glutamate release","score":0.7689999938011169},{"id":"https://openalex.org/keywords/extrasynaptic-nmda-receptors","display_name":"extrasynaptic NMDA receptors","score":0.9739999771118164},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.9890000224113464},{"id":"https://openalex.org/keywords/monoaminergic-transmission","display_name":"monoaminergic transmission","score":0.8320000171661377},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.9599999785423279},{"id":"https://openalex.org/keywords/antidepressant-like-effects","display_name":"antidepressant-like effects","score":0.7509999871253967},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C57306754","wikidata":"https://www.wikidata.org/wiki/Q1010629","display_name":"Purinergic receptor","level":3,"score":0.9086567163467407},{"id":"https://openalex.org/C115955781","wikidata":"https://www.wikidata.org/wiki/Q6063798","display_name":"Ionotropic effect","level":4,"score":0.7376187443733215},{"id":"https://openalex.org/C172590197","wikidata":"https://www.wikidata.org/wiki/Q17165723","display_name":"Purinergic signalling","level":5,"score":0.6654065251350403},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.5513184666633606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5267788171768188},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5224869847297668},{"id":"https://openalex.org/C67907053","wikidata":"https://www.wikidata.org/wiki/Q356147","display_name":"Adenosine receptor","level":4,"score":0.4632388949394226},{"id":"https://openalex.org/C160225129","wikidata":"https://www.wikidata.org/wiki/Q6591687","display_name":"P2Y receptor","level":4,"score":0.4375340938568115},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4068014621734619},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.3666391372680664},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.34781959652900696},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3435991406440735},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.257124662399292},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.12898778915405273},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12596344947814941}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001714","descriptor_name":"Bipolar Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003865","descriptor_name":"Major Depressive Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003866","descriptor_name":"Depressive Disorder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011983","descriptor_name":"Receptors, Purinergic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019964","descriptor_name":"Mood Disorders","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043682","descriptor_name":"Receptor, Adenosine A1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043705","descriptor_name":"Receptor, Adenosine A2A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058486","descriptor_name":"Receptors, Purinergic P2X7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058916","descriptor_name":"Adenosine A1 Receptor Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D058917","descriptor_name":"Adenosine A2 Receptor Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:23269209","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23269209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology","raw_type":"Journal Article"},{"id":"mag:102413465","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23269209","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1921156264","https://openalex.org/W1974201237","https://openalex.org/W1992995820","https://openalex.org/W2018231959","https://openalex.org/W2044259424","https://openalex.org/W2052422061","https://openalex.org/W2074907255","https://openalex.org/W2084383502","https://openalex.org/W2095056441","https://openalex.org/W2102096852","https://openalex.org/W2123882810","https://openalex.org/W2137756761","https://openalex.org/W2147386725","https://openalex.org/W2172099127"],"related_works":["https://openalex.org/W4384461406","https://openalex.org/W3010734963","https://openalex.org/W4389285448","https://openalex.org/W4415000167","https://openalex.org/W7154372422","https://openalex.org/W3131345369","https://openalex.org/W3003384561","https://openalex.org/W2333930244","https://openalex.org/W2909299853","https://openalex.org/W2948329699"],"abstract_inverted_index":{"The":[0,29],"purinergic":[1,244],"signaling":[2,54,245],"system":[3,63,246],"consists":[4],"of":[5,19,31,45,92,170,182,195,215,242],"transporters,":[6],"enzymes":[7],"and":[8,16,23,37,65,70,87,100,140,162,186,198,218],"receptors":[9,185,220],"responsible":[10],"for":[11],"the":[12,43,60,76,128,147,206,213,239,243],"synthesis,":[13],"release,":[14,180],"action":[15],"extracellular":[17,25],"inactivation":[18],"adenosine":[20,46,51,216],"5'-triphosphate":[21],"(ATP)":[22],"its":[24,68,93,101],"breakdown":[26],"product":[27],"adenosine.":[28],"actions":[30,44],"ATP":[32],"are":[33,47,56],"mediated":[34,48],"ionotropic":[35],"P2X":[36,74],"metabotropic":[38],"P2Y":[39],"receptor":[40,78],"subfamilies,":[41],"whilst":[42],"by":[49],"P1":[50],"receptors.":[52],"Purinergic":[53],"pathways":[55],"widely":[57],"expressed":[58],"in":[59,67,84,96,108,127,160,164,190,209,225,247],"central":[61],"nervous":[62],"(CNS)":[64],"participate":[66],"normal":[69],"pathological":[71],"functions.":[72],"Among":[73],"receptors,":[75],"P2X7":[77,130],"(P2rx7)":[79],"has":[80],"received":[81],"considerable":[82],"interest":[83],"both":[85],"basic":[86],"clinical":[88],"neuropsychiatric":[89],"research":[90],"because":[91],"profound":[94],"effects":[95,224],"animal":[97,226],"CNS":[98],"pathology":[99],"potential":[102,168,241],"involvement":[103],"as":[104],"a":[105],"susceptibility":[106],"gene":[107,131],"mood":[109,174,248],"disorders.":[110,249],"Although":[111],"genetic":[112,148],"findings":[113,236],"were":[114],"not":[115],"always":[116],"consistently":[117],"replicated,":[118],"several":[119],"studies":[120,144],"demonstrated":[121],"that":[122,146],"single":[123],"nucleotide":[124],"polymorphisms":[125],"(SNPs)":[126],"human":[129],"(P2RX7)":[132],"show":[133],"significant":[134],"association":[135],"with":[136],"major":[137],"depressive":[138],"disorder":[139],"bipolar":[141],"disorder.":[142],"Animal":[143],"revealed":[145],"knock-down":[149],"or":[150],"pharmacological":[151],"antagonism":[152],"leads":[153],"to":[154,205,238],"reduced":[155],"depressive-like":[156],"behavior,":[157],"attenuated":[158],"response":[159],"mania-model":[161],"alterations":[163],"stress":[165],"reactivity.":[166],"A":[167],"mechanism":[169],"P2rx7":[171],"activation":[172,181],"on":[173],"related":[175],"behavior":[176],"is":[177],"increased":[178],"glutamate":[179],"extrasynaptic":[183],"NMDA":[184],"subsequent":[187],"enduring":[188],"changes":[189,208],"neuroplasticity.":[191],"In":[192,228],"addition,":[193],"dysregulation":[194],"monoaminergic":[196],"transmission":[197],"HPA":[199],"axis":[200],"reactivity":[201],"could":[202],"also":[203,221],"contribute":[204],"observed":[207],"behavior.":[210],"Besides":[211],"P2rx7,":[212],"inhibition":[214],"A1":[217],"A2A":[219],"mediate":[222],"antidepressant-like":[223],"experiments.":[227],"conclusion,":[229],"despite":[230],"contradictions":[231],"between":[232],"existing":[233],"data,":[234],"these":[235],"point":[237],"therapeutic":[240]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}