{"id":"https://openalex.org/W1024112113","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.752.13","title":"Cancer Preventive Mechanisms by Exercise: Activation of p53 and p53\u2010related IGF\u20101 Pathway Regulators","display_name":"Cancer Preventive Mechanisms by Exercise: Activation of p53 and p53\u2010related IGF\u20101 Pathway Regulators","publication_year":2015,"publication_date":"2015-04-01","ids":{"openalex":"https://openalex.org/W1024112113","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.752.13","mag":"1024112113"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.29.1_supplement.752.13","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.752.13","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.752.13","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://krex.k-state.edu/bitstreams/76628366-895d-4e1a-b90f-cd4abd83f3cc/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110437155","display_name":"Miao Yu","orcid":"https://orcid.org/0009-0007-9455-6550","observed_orcids":["https://orcid.org/0009-0007-9455-6550"]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miao Yu","raw_affiliation_strings":["Human NutritionKansas State UniversityManhattanKansasUnited States","1Human Nutrition Kansas State University Manhattan Kansas United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human NutritionKansas State UniversityManhattanKansasUnited States","institution_ids":["https://openalex.org/I189590672"]},{"raw_affiliation_string":"1Human Nutrition Kansas State University Manhattan Kansas United States","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057654089","display_name":"Brenee S. King","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brenee King","raw_affiliation_strings":["Human NutritionKansas State UniversityManhattanKansasUnited States","1Human Nutrition Kansas State University Manhattan Kansas United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human NutritionKansas State UniversityManhattanKansasUnited States","institution_ids":["https://openalex.org/I189590672"]},{"raw_affiliation_string":"1Human Nutrition Kansas State University Manhattan Kansas United States","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005112534","display_name":"Emily Ewert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Ewert","raw_affiliation_strings":["Human NutritionKansas State UniversityManhattanKansasUnited States","1Human Nutrition Kansas State University Manhattan Kansas United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human NutritionKansas State UniversityManhattanKansasUnited States","institution_ids":["https://openalex.org/I189590672"]},{"raw_affiliation_string":"1Human Nutrition Kansas State University Manhattan Kansas United States","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066710639","display_name":"Xiaoyu Su","orcid":"https://orcid.org/0000-0002-2472-3591","observed_orcids":["https://orcid.org/0000-0002-2472-3591"]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoyu Su","raw_affiliation_strings":["Human NutritionKansas State UniversityManhattanKansasUnited States","1Human Nutrition Kansas State University Manhattan Kansas United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human NutritionKansas State UniversityManhattanKansasUnited States","institution_ids":["https://openalex.org/I189590672"]},{"raw_affiliation_string":"1Human Nutrition Kansas State University Manhattan Kansas United States","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022524199","display_name":"Nur Mardiyati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nur Mardiyati","raw_affiliation_strings":["Human NutritionKansas State UniversityManhattanKansasUnited States","1Human Nutrition Kansas State University Manhattan Kansas United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human NutritionKansas State UniversityManhattanKansasUnited States","institution_ids":["https://openalex.org/I189590672"]},{"raw_affiliation_string":"1Human Nutrition Kansas State University Manhattan Kansas United States","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042257192","display_name":"Soyoung Lim","orcid":"https://orcid.org/0000-0002-3012-9193","observed_orcids":["https://orcid.org/0000-0002-3012-9193"]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Soyoung Lim","raw_affiliation_strings":["Human NutritionKansas State UniversityManhattanKansasUnited States","1Human Nutrition Kansas State University Manhattan Kansas United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human NutritionKansas State UniversityManhattanKansasUnited States","institution_ids":["https://openalex.org/I189590672"]},{"raw_affiliation_string":"1Human Nutrition Kansas State University Manhattan Kansas United States","institution_ids":["https://openalex.org/I189590672"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100665274","display_name":"Weiqun Wang","orcid":"https://orcid.org/0000-0002-1295-8246","observed_orcids":["https://orcid.org/0000-0002-1295-8246"]},"institutions":[{"id":"https://openalex.org/I189590672","display_name":"Kansas State University","ror":"https://ror.org/05p1j8758","country_code":"US","type":"education","lineage":["https://openalex.org/I189590672"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weiqun Wang","raw_affiliation_strings":["Human NutritionKansas State UniversityManhattanKansasUnited States","1Human Nutrition Kansas State University Manhattan Kansas United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human NutritionKansas State UniversityManhattanKansasUnited States","institution_ids":["https://openalex.org/I189590672"]},{"raw_affiliation_string":"1Human Nutrition Kansas State University Manhattan Kansas United States","institution_ids":["https://openalex.org/I189590672"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I189590672"],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.1457,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.54620315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"29","issue":"S1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.6830999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.6830999851226807,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.18860000371932983,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.06440000236034393,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.9559999704360962},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.9210000038146973},{"id":"https://openalex.org/keywords/igfbp-3","display_name":"IGFBP-3","score":0.8740000128746033},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.9459999799728394},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9990000128746033},{"id":"https://openalex.org/keywords/skin-cancer","display_name":"skin cancer","score":0.7310000061988831},{"id":"https://openalex.org/keywords/epidermis","display_name":"epidermis","score":0.7639999985694885},{"id":"https://openalex.org/keywords/sencar-mice","display_name":"SENCAR mice","score":0.8569999933242798},{"id":"https://openalex.org/keywords/treadmill-exercise","display_name":"treadmill exercise","score":0.5270000100135803},{"id":"https://openalex.org/keywords/phorbol-myristate-acetate","display_name":"phorbol myristate acetate","score":0.8640000224113464},{"id":"https://openalex.org/keywords/tumor-suppressor-signaling","display_name":"tumor suppressor signaling","score":0.5550000071525574}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.8435449004173279},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.7292710542678833},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.595686674118042},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4667615592479706},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4439365863800049},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4388178288936615},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4253098666667938},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.4200124144554138},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.407241553068161},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40513429045677185},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.2157508134841919},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08700913190841675}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1096/fasebj.29.1_supplement.752.13","doi":"https://doi.org/10.1096/fasebj.29.1_supplement.752.13","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.29.1_supplement.752.13","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmh:oai:krex.k-state.edu:2097/32219","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2097/32219","pdf_url":"https://krex.k-state.edu/bitstreams/76628366-895d-4e1a-b90f-cd4abd83f3cc/download","source":{"id":"https://openalex.org/S4306402339","display_name":"K-State Research Exchange (Kansas State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189590672","host_organization_name":"Kansas State University","host_organization_lineage":["https://openalex.org/I189590672"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"}],"best_oa_location":{"id":"pmh:oai:krex.k-state.edu:2097/32219","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2097/32219","pdf_url":"https://krex.k-state.edu/bitstreams/76628366-895d-4e1a-b90f-cd4abd83f3cc/download","source":{"id":"https://openalex.org/S4306402339","display_name":"K-State Research Exchange (Kansas State University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189590672","host_organization_name":"Kansas State University","host_organization_lineage":["https://openalex.org/I189590672"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5626836194","display_name":"Mechanism of Cancer Prevention by Weight Control","funder_award_id":"1r15ca167678-01a1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1024112113.pdf","grobid_xml":"https://content.openalex.org/works/W1024112113.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2504852182","https://openalex.org/W2155361231","https://openalex.org/W1989853294","https://openalex.org/W7097900169","https://openalex.org/W2561510530","https://openalex.org/W2021097736","https://openalex.org/W2140570350","https://openalex.org/W1626837","https://openalex.org/W2793332614","https://openalex.org/W2206480826"],"abstract_inverted_index":{"Exercise":[0],"has":[1],"been":[2],"previously":[3],"reported":[4],"to":[5,25,138,144,187],"lower":[6],"cancer":[7,20,190,198],"risk":[8],"through":[9,178],"reducing":[10,148],"circulating":[11],"IGF-1":[12,38,168,176],"and":[13,33,75,132,158,162,169,181],"IGF-1-dependent":[14,170],"signaling":[15],"in":[16,37,41,79,116,136,152,194],"a":[17],"mouse":[18,196],"skin":[19,42,197],"model.":[21],"This":[22],"study":[23],"is":[24],"investigate":[26],"the":[27,76,80,85,188],"effects":[28],"of":[29,108,112,155,175],"exercise":[30,57,142,193],"on":[31],"p53":[32,109,146,179],"p53-related":[34,125,182],"proteins":[35,78,87,127],"engaged":[36],"pathway":[39,177],"regulation":[40,174],"epidermis.":[43],"Female":[44],"SENCAR":[45],"mice":[46],"were":[47,66,82],"fed":[48],"an":[49],"iso-caloric":[50],"diet":[51],"with":[52,68,121],"or":[53],"without":[54],"10-week":[55],"treadmill":[56],"at":[58],"20":[59],"m/min":[60],"for":[61,89],"60":[62],"min":[63],"daily.":[64],"Animals":[65],"treated":[67],"TPA":[69,93],"topically":[70],"2":[71],"hours":[72],"before":[73],"sacrifice":[74],"target":[77,86],"epidermis":[81],"assessed.":[83],"All":[84],"except":[88],"MDM2":[90,113,149],"decreased":[91],"under":[92],"treatment":[94],"versus":[95],"vehicle":[96],"acetone":[97],"as":[98,129],"measured":[99],"by":[100,147,192,201],"immunohistochemistry":[101],"and/or":[102],"Western":[103],"blot.":[104],"A":[105,172],"significant":[106],"increase":[107],"but":[110],"decrease":[111],"was":[114],"observed":[115,189],"exercised":[117],"group":[118],"when":[119],"compared":[120],"sedentary":[122],"control.":[123],"Additionally,":[124],"downstream":[126],"such":[128],"p21,":[130,157],"IGF-BP3,":[131,156],"PTEN":[133,163],"increased":[134],"significantly":[135],"response":[137],"exercise.":[139],"Taken":[140],"together,":[141],"appears":[143],"activate":[145],"suppression,":[150],"resulting":[151],"enhanced":[153],"expression":[154],"PTEN.":[159],"Both":[160],"IGF-BP3":[161],"may":[164,184],"further":[165],"reduce":[166],"bioavailable":[167],"signaling.":[171],"negative":[173],"activation":[180],"regulators":[183],"thus":[185],"contribute":[186],"prevention":[191],"this":[195],"model":[199],"(supported":[200],"NIH":[202],"CA167678).":[203]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2016-06-24T00:00:00"}
