{"id":"https://openalex.org/W102196233","doi":"https://doi.org/10.1007/0-387-32824-6_11","title":"Prolyl Endopeptidase Cleaves the Apoptosis Rescue Peptide Humanin and Exhibits an Unknown Post-Cysteine Cleavage Specificity","display_name":"Prolyl Endopeptidase Cleaves the Apoptosis Rescue Peptide Humanin and Exhibits an Unknown Post-Cysteine Cleavage Specificity","publication_year":2006,"publication_date":"2006-12-09","ids":{"openalex":"https://openalex.org/W102196233","doi":"https://doi.org/10.1007/0-387-32824-6_11","mag":"102196233","pmid":"https://pubmed.ncbi.nlm.nih.gov/16700513"},"language":"en","primary_location":{"id":"doi:10.1007/0-387-32824-6_11","doi":"https://doi.org/10.1007/0-387-32824-6_11","is_oa":false,"landing_page_url":"https://doi.org/10.1007/0-387-32824-6_11","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4233084563","display_name":"Dipeptidyl Aminopeptidases"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109218988","display_name":"Joachim Wolfgang B\u00e4r","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Joachim Wolfgang B\u00e4r","raw_affiliation_strings":["Departments of Molecular Biology & Enzymology, Probiodrug AG, Weinbergweg 22, 06120, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Biology & Enzymology, Probiodrug AG, Weinbergweg 22, 06120, Halle (Saale), Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078054782","display_name":"Jens\u2010Ulrich Rahfeld","orcid":"https://orcid.org/0000-0002-8979-581X","observed_orcids":["https://orcid.org/0000-0002-8979-581X"]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jens-Ulrich Rahfeld","raw_affiliation_strings":["Departments of Molecular Biology & Enzymology, Probiodrug AG, Weinbergweg 22, 06120, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Biology & Enzymology, Probiodrug AG, Weinbergweg 22, 06120, Halle (Saale), Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019265052","display_name":"Ingo Schulz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ingo Schulz","raw_affiliation_strings":["Departments of Molecular Biology & Enzymology, Probiodrug AG, Weinbergweg 22, 06120, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Biology & Enzymology, Probiodrug AG, Weinbergweg 22, 06120, Halle (Saale), Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109925046","display_name":"Kathrin Gans","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kathrin Gans","raw_affiliation_strings":["Departments of Molecular Biology & Enzymology, Probiodrug AG, Weinbergweg 22, 06120, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Biology & Enzymology, Probiodrug AG, Weinbergweg 22, 06120, Halle (Saale), Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083211939","display_name":"David Ruiz Carrillo","orcid":"https://orcid.org/0000-0001-8273-9615","observed_orcids":["https://orcid.org/0000-0001-8273-9615"]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"David Ruiz-Carrillo","raw_affiliation_strings":["Departments of Molecular Biology & Enzymology, Probiodrug AG, Weinbergweg 22, 06120, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Biology & Enzymology, Probiodrug AG, Weinbergweg 22, 06120, Halle (Saale), Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040786000","display_name":"Susanne Manhart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Susanne Manhart","raw_affiliation_strings":["Departments of Molecular Biology & Enzymology, Probiodrug AG, Weinbergweg 22, 06120, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Biology & Enzymology, Probiodrug AG, Weinbergweg 22, 06120, Halle (Saale), Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058391718","display_name":"Fred Rosche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fred Rosche","raw_affiliation_strings":["Departments of Molecular Biology & Enzymology, Probiodrug AG, Weinbergweg 22, 06120, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Biology & Enzymology, Probiodrug AG, Weinbergweg 22, 06120, Halle (Saale), Germany","institution_ids":["https://openalex.org/I4210144058"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102711941","display_name":"Hans\u2010Ulrich Demuth","orcid":"https://orcid.org/0000-0003-3505-6795","observed_orcids":["https://orcid.org/0000-0003-3505-6795"]},"institutions":[{"id":"https://openalex.org/I4210144058","display_name":"Probiodrug (Germany)","ror":"https://ror.org/03p4y9t51","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210144058"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hans-Ulrich Demuth","raw_affiliation_strings":["Departments of Molecular Biology & Enzymology, Probiodrug AG, Weinbergweg 22, 06120, Halle (Saale), Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular Biology & Enzymology, Probiodrug AG, Weinbergweg 22, 06120, Halle (Saale), Germany","institution_ids":["https://openalex.org/I4210144058"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210144058"],"apc_list":null,"apc_paid":null,"fwci":3.3093,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.92181818,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"575","issue":null,"first_page":"103","last_page":"108"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.8192999958992004,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.8192999958992004,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.062300000339746475,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.061000000685453415,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prolyl-endopeptidase","display_name":"prolyl endopeptidase","score":0.9959999918937683},{"id":"https://openalex.org/keywords/humanin","display_name":"humanin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/proteolytic-specificity","display_name":"proteolytic specificity","score":0.777999997138977},{"id":"https://openalex.org/keywords/exopeptidases","display_name":"exopeptidases","score":0.7080000042915344},{"id":"https://openalex.org/keywords/dp4","display_name":"DP4","score":0.9929999709129333},{"id":"https://openalex.org/keywords/neuronal-survival","display_name":"neuronal survival","score":0.6759999990463257},{"id":"https://openalex.org/keywords/apoptosis-inhibition","display_name":"apoptosis inhibition","score":0.8370000123977661},{"id":"https://openalex.org/keywords/protein-turnover","display_name":"protein turnover","score":0.34599998593330383}],"concepts":[{"id":"https://openalex.org/C2777774944","wikidata":"https://www.wikidata.org/wiki/Q417262","display_name":"Endopeptidase","level":3,"score":0.838166356086731},{"id":"https://openalex.org/C2781307694","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Proteolysis","level":3,"score":0.8162851333618164},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6329526305198669},{"id":"https://openalex.org/C175156509","wikidata":"https://www.wikidata.org/wiki/Q1990218","display_name":"Cleavage (geology)","level":3,"score":0.6288537979125977},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5998143553733826},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5339122414588928},{"id":"https://openalex.org/C54374919","wikidata":"https://www.wikidata.org/wiki/Q421015","display_name":"Exopeptidase","level":3,"score":0.5161162614822388},{"id":"https://openalex.org/C2779201268","wikidata":"https://www.wikidata.org/wiki/Q186474","display_name":"Cysteine","level":3,"score":0.5100020170211792},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5099321603775024},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5027740001678467},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.4544321894645691},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.41955599188804626},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3918269872665405},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3372945785522461},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C43369102","wikidata":"https://www.wikidata.org/wiki/Q2307625","display_name":"Fracture (geology)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000085822","descriptor_name":"Prolyl Oligopeptidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003545","descriptor_name":"Cysteine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012697","descriptor_name":"Serine Endopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018819","descriptor_name":"Dipeptidyl Peptidase 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018819","descriptor_name":"Dipeptidyl Peptidase 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1007/0-387-32824-6_11","doi":"https://doi.org/10.1007/0-387-32824-6_11","is_oa":false,"landing_page_url":"https://doi.org/10.1007/0-387-32824-6_11","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},{"id":"pmid:16700513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16700513","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in experimental medicine and biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1261481828","https://openalex.org/W1497358941","https://openalex.org/W1536031381","https://openalex.org/W1971481135","https://openalex.org/W1974207881","https://openalex.org/W1999043545","https://openalex.org/W1999107098","https://openalex.org/W2003693754","https://openalex.org/W2017671645","https://openalex.org/W2026178423","https://openalex.org/W2045001408","https://openalex.org/W2104592988","https://openalex.org/W2140547760","https://openalex.org/W2159027901"],"related_works":["https://openalex.org/W2037393544","https://openalex.org/W1974350099","https://openalex.org/W3096164106","https://openalex.org/W2159740399","https://openalex.org/W78396749","https://openalex.org/W2921856198","https://openalex.org/W2028028433","https://openalex.org/W7223318842","https://openalex.org/W4404528449","https://openalex.org/W2082374716"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
