{"id":"https://openalex.org/W102127639","doi":null,"title":"Lupus anticoagulant and thrombosis: role of von Willebrand factor multimeric forms.","display_name":"Lupus anticoagulant and thrombosis: role of von Willebrand factor multimeric forms.","publication_year":1997,"publication_date":"1997-01-01","ids":{"openalex":"https://openalex.org/W102127639","mag":"102127639","pmid":"https://pubmed.ncbi.nlm.nih.gov/9093766"},"language":"en","primary_location":{"id":"pmid:9093766","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9093766","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013522339","display_name":"Piercarla Schinco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55143463","display_name":"University of Turin","ror":"https://ror.org/048tbm396","country_code":"IT","type":"education","lineage":["https://openalex.org/I55143463"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"P Schinco","raw_affiliation_strings":["Department of Medicine and Experimental Oncology, University of Turin, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Experimental Oncology, University of Turin, Italy","institution_ids":["https://openalex.org/I55143463"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080599868","display_name":"Alessandra Borchiellini","orcid":"https://orcid.org/0000-0002-8618-145X","observed_orcids":["https://orcid.org/0000-0002-8618-145X","https://orcid.org/0000-0003-3943-1628"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Borchiellini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111992887","display_name":"Giacomo Tamponi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Tamponi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080007446","display_name":"Barbara Montaruli","orcid":"https://orcid.org/0000-0002-5713-2069","observed_orcids":["https://orcid.org/0000-0002-5713-2069"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Montaruli","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056531625","display_name":"G. Garis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Garis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055853592","display_name":"M. Bazzan","orcid":"https://orcid.org/0000-0002-1451-1368","observed_orcids":["https://orcid.org/0000-0002-1451-1368"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Bazzan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000594229","display_name":"Antonella Pannocchia","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Pannocchia","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023437750","display_name":"Vittorio Modena","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Modena","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5020164754","display_name":"Alessandro Pileri","orcid":"https://orcid.org/0000-0002-1025-7171","observed_orcids":["https://orcid.org/0000-0002-1025-7171"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Pileri","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2645,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.51557898,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"1","first_page":"5","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.4997999966144562,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.4997999966144562,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.4772999882698059,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.016100000590085983,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lupus-anticoagulant","display_name":"lupus anticoagulant","score":1.0},{"id":"https://openalex.org/keywords/von-willebrand-factor","display_name":"von Willebrand factor","score":0.8920000195503235},{"id":"https://openalex.org/keywords/vwf-multimers","display_name":"VWF multimers","score":0.9200000166893005},{"id":"https://openalex.org/keywords/thrombosis","display_name":"thrombosis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/arterial-thrombosis","display_name":"arterial thrombosis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/deep-vein-thrombosis","display_name":"deep vein thrombosis","score":0.878000020980835},{"id":"https://openalex.org/keywords/ischemic-stroke","display_name":"ischemic stroke","score":0.9290000200271606},{"id":"https://openalex.org/keywords/recurrent-pregnancy-loss","display_name":"recurrent pregnancy loss","score":0.878000020980835},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.7329999804496765},{"id":"https://openalex.org/keywords/shear-stress","display_name":"shear stress","score":0.8399999737739563},{"id":"https://openalex.org/keywords/thrombosis-risk-factors","display_name":"thrombosis risk factors","score":0.8519999980926514}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8875423073768616},{"id":"https://openalex.org/C2779394231","wikidata":"https://www.wikidata.org/wiki/Q412310","display_name":"Von Willebrand factor","level":3,"score":0.874992847442627},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.6924078464508057},{"id":"https://openalex.org/C2780022809","wikidata":"https://www.wikidata.org/wiki/Q5786759","display_name":"Lupus anticoagulant","level":3,"score":0.6243953108787537},{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.5902107357978821},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5666525363922119},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5071389675140381},{"id":"https://openalex.org/C2780921031","wikidata":"https://www.wikidata.org/wiki/Q14873945","display_name":"ADAMTS13","level":4,"score":0.505596399307251},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.4902661144733429},{"id":"https://openalex.org/C2780011451","wikidata":"https://www.wikidata.org/wiki/Q2751330","display_name":"Venous thrombosis","level":3,"score":0.48490577936172485},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.4513383209705353},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.4173758625984192},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3608890771865845},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000026","descriptor_name":"Abortion, Habitual","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001158","descriptor_name":"Arteries","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002561","descriptor_name":"Cerebrovascular Disorders","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002627","descriptor_name":"Chemistry, Physical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008970","descriptor_name":"Molecular Weight","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D014841","descriptor_name":"von Willebrand Factor","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015151","descriptor_name":"Immunoblotting","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016682","descriptor_name":"Lupus Coagulation Inhibitor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D055598","descriptor_name":"Chemical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:9093766","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9093766","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and experimental rheumatology","raw_type":"Journal Article"},{"id":"mag:102127639","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9093766","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4205103388","https://openalex.org/W2038352004","https://openalex.org/W7057808299","https://openalex.org/W1964348621","https://openalex.org/W2063529127","https://openalex.org/W2625426580","https://openalex.org/W2136054381","https://openalex.org/W2418773538","https://openalex.org/W52671841","https://openalex.org/W2006125994"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Patients":[1],"with":[2,47,121,132,145,154,161],"lupus":[3],"anticoagulant":[4],"(LA)":[5],"have":[6],"an":[7,181],"increased":[8],"incidence":[9],"of":[10,60,77,94,127,135,152,159,167],"venous":[11],"and":[12,39,67,163],"arterial":[13,188],"thrombosis":[14,89],"whose":[15],"pathogenesis":[16],"is":[17,173],"still":[18],"unclear.":[19],"High":[20],"molecular":[21],"weight":[22],"von":[23],"Willebrand":[24],"Factor":[25],"(vWF)":[26],"multimers":[27,53],"seem":[28],"to":[29,185],"play":[30],"a":[31,92],"causal":[32],"role":[33],"in":[34,45,50,69,113,143,150,157,165],"shear":[35],"stress-induced":[36],"platelet":[37],"aggregation":[38],"thrombus":[40],"formation.":[41],"We":[42],"studied":[43],"whether":[44],"patients":[46,79,115,153],"LA,":[48],"alterations":[49],"the":[51,78,96,122,125,133,136],"vWF":[52,62,129],"might":[54],"coexist.":[55],"METHODS:":[56],"The":[57,171],"multimeric":[58,109],"composition":[59],"plasma":[61],"was":[63,111,119,140,148],"analysed":[64],"by":[65],"SDS-electrophoresis":[66],"immunoblotting":[68],"43":[70],"subjects":[71,98,144],"positive":[72],"for":[73,187],"LA.":[74],"About":[75],"2/3":[76],"had":[80,81,99,101],"either":[82],"ischemic":[83],"stroke,":[84],"recurrent":[85],"abortions,":[86,156],"deep":[87],"vein":[88],"(DVT)":[90],"or":[91],"combination":[93],"these;":[95],"remaining":[97],"never":[100,141],"any":[102],"thrombotic":[103],"events.":[104],"RESULTS:":[105],"An":[106],"abnormal":[107,128,177],"vWf":[108],"pattern":[110],"found":[112,120,149],"16":[114],"(37.2%);":[116],"no":[117],"correlation":[118],"diagnosis,":[123],"but":[124,147],"presence":[126],"significantly":[130],"correlated":[131],"site":[134],"thrombosis:":[137],"indeed,":[138],"it":[139],"detected":[142],"DVT,":[146],"71.4%":[151],"multiple":[155],"50%":[158],"those":[160],"stroke":[162],"even":[164],"25%":[166],"non-thrombotic":[168],"patients.":[169],"CONCLUSION:":[170],"hypothesis":[172],"put":[174],"forward":[175],"that":[176],"VWF":[178],"may":[179],"represent":[180],"additional":[182],"risk":[183],"factor":[184],"LA":[186],"thrombosis.":[189]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}