{"id":"https://openalex.org/W102120446","doi":null,"title":"Oligondendrocyte progenitors and their role in adult neural cell genesis","display_name":"Oligondendrocyte progenitors and their role in adult neural cell genesis","publication_year":2009,"publication_date":"2009-06-01","ids":{"openalex":"https://openalex.org/W102120446","mag":"102120446"},"language":"en","primary_location":{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:16312","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/16312/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113222397","display_name":"London Rivers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"L Rivers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5113222397"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oligodendrocyte-progenitors","display_name":"oligodendrocyte progenitors","score":0.996999979019165},{"id":"https://openalex.org/keywords/oligodendrocyte-differentiation","display_name":"oligodendrocyte differentiation","score":0.8259999752044678},{"id":"https://openalex.org/keywords/myelination","display_name":"myelination","score":0.7929999828338623},{"id":"https://openalex.org/keywords/sox10","display_name":"SOX10","score":0.8629999756813049},{"id":"https://openalex.org/keywords/pdgfra","display_name":"PDGFRA","score":0.6190000176429749},{"id":"https://openalex.org/keywords/fate-mapping","display_name":"fate mapping","score":0.8119999766349792},{"id":"https://openalex.org/keywords/corpus-callosum","display_name":"corpus callosum","score":0.7929999828338623},{"id":"https://openalex.org/keywords/piriform-cortex","display_name":"piriform cortex","score":0.8849999904632568},{"id":"https://openalex.org/keywords/cortical-projection-neurons","display_name":"cortical projection neurons","score":0.7879999876022339},{"id":"https://openalex.org/keywords/remyelination","display_name":"remyelination","score":0.7549999952316284},{"id":"https://openalex.org/keywords/schwann-cells","display_name":"Schwann cells","score":0.8190000057220459},{"id":"https://openalex.org/keywords/astrocytes","display_name":"astrocytes","score":0.9259999990463257},{"id":"https://openalex.org/keywords/multipotency","display_name":"multipotency","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C2776985911","wikidata":"https://www.wikidata.org/wiki/Q916698","display_name":"Oligodendrocyte","level":4,"score":0.6409177184104919},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6408707499504089},{"id":"https://openalex.org/C2779055221","wikidata":"https://www.wikidata.org/wiki/Q18035130","display_name":"OLIG2","level":5,"score":0.5929232835769653},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5468562841415405},{"id":"https://openalex.org/C63101894","wikidata":"https://www.wikidata.org/wiki/Q604095","display_name":"Fate mapping","level":4,"score":0.480701744556427},{"id":"https://openalex.org/C200707615","wikidata":"https://www.wikidata.org/wiki/Q13652744","display_name":"Neuroepithelial cell","level":4,"score":0.4730378985404968},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3984091877937317},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.3969554305076599},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37779754400253296},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.35011059045791626},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.3450104594230652},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.28390952944755554}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:16312","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/16312/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":"Thesis"},{"id":"mag:102120446","doi":null,"is_oa":false,"landing_page_url":"http://discovery.ucl.ac.uk/id/eprint/16312/","pdf_url":null,"source":{"id":"https://openalex.org/S4306508231","display_name":"Doctoral thesis, UCL (University College London).","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Doctoral thesis, UCL (University College London).","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8371999859809875,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7004862994","https://openalex.org/W1966395272","https://openalex.org/W2024825981","https://openalex.org/W2058915525","https://openalex.org/W2036605323","https://openalex.org/W1963915146","https://openalex.org/W2233403338","https://openalex.org/W2586559282","https://openalex.org/W4379508673","https://openalex.org/W2035820932"],"abstract_inverted_index":{"Oligodendrocyte":[0],"progenitors":[1],"(OLPs)":[2],"are":[3,16],"widely":[4],"distributed":[5],"throughout":[6],"the":[7,17,20,26,31,52,76,93,99,114,121,127,131,133,153,166,178,193,248],"embryonic":[8],"and":[9,29,71,84,173,200,231,238],"adult":[10],"central":[11],"nervous":[12],"system":[13],"(CNS).":[14],"They":[15],"primary,":[18],"possibly":[19],"only":[21],"source":[22],"of":[23,33,65,87,98,108,113,135,143,176,180,184],"oligodendrocytes":[24,46,199],"in":[25,30,51,68,75,92,152,165,212,247],"developing":[27],"CNS":[28],"repair":[32,183],"\\ndemyelinated":[34],"lesions,":[35,194],"but":[36],"it":[37],"is":[38],"unclear":[39],"whether":[40],"they":[41],"continue":[42],"to":[43,125],"generate":[44],"myelinating":[45,119,223],"or":[47],"any":[48],"other":[49],"cells":[50,89,116,137,142,202,237],"normal":[53],"healthy":[54],"adult.":[55],"\\nA":[56],"transgenic":[57],"mouse":[58,250],"line,":[59],"Pdgfra-CreERT2,":[60],"allowed":[61],"temporally-controlled,":[62],"permanent":[63],"activation":[64],"YFP":[66],"expression":[67],"PDGFRa-expressing":[69],"OLPs":[70,100,181,195,219,241],"their":[72],"differentiated":[73,117,136],"\\nprogeny":[74],"Rosa26-YFP":[77],"reporter":[78],"background.":[79],"In":[80,146,192],"vivo":[81,213],"BrdU":[82],"labelling":[83],"fate":[85],"mapping":[86],"YFP-positive":[88],"revealed":[90],"that,":[91],"corpus":[94],"callosum,":[95],"approximately":[96,109],"half":[97],"were":[101,138,161],"dividing":[102],"with":[103,170],"a":[104,206],"cell":[105],"cycle":[106],"time":[107],"8":[110],"days.":[111],"Half":[112],"daughter":[115],"into":[118,222],"oligodendrocytes,":[120,224],"others":[122],"remained":[123],"undifferentiated":[124],"maintain":[126],"OLP":[128],"population.":[129],"\\nIn":[130,168],"cortex,":[132],"majority":[134],"SOX10+":[139],"non-myelinating":[140,225],"oligodendrocyte-lineage":[141],"unknown":[144],"function.":[145],"addition,":[147],"YFP-labelled":[148],"projection":[149,229],"neurons":[150,230],"accumulated":[151],"piriform":[154],"cortex":[155],"(primary":[156],"olfactory":[157],"cortex).":[158],"\\nYFP-labelled":[159],"astrocytes":[160],"not":[162],"found":[163],"anywhere":[164],"forebrain.":[167],"collaboration":[169],"RMJ":[171],"Franklin":[172],"colleagues":[174],"(University":[175],"Cambridge)":[177],"fates":[179],"during":[182,233],"gliotoxin-induced":[185],"demyelinated":[186],"spinal":[187],"cord":[188],"lesions":[189],"\\nwere":[190],"investigated.":[191],"generated":[196],"mainly":[197],"remyelinating":[198],"Schwann":[201,236],"as":[203,205],"well":[204],"few":[207],"astrocytes.":[208,239],"\\nTaken":[209],"together,":[210],"my":[211],"Cre/lox":[214],"fate-mapping":[215],"studies":[216],"showed":[217],"that":[218],"can":[220],"differentiate":[221],"oligodendrocytelineage":[226],"\\ncells,":[227],"cortical":[228],"-":[232,235],"remyelination":[234],"Thus,":[240],"possess":[242],"multipotential":[243],"stem":[244],"cell-like":[245],"properties":[246],"\\nadult":[249],"CNS.":[251]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
