{"id":"https://openalex.org/W1020529447","doi":"https://doi.org/10.2143/acb.66.2.2062536","title":"Late vitamin K deficiency bleeding leading to a diagnosis of cystic fibrosis: a case report.","display_name":"Late vitamin K deficiency bleeding leading to a diagnosis of cystic fibrosis: a case report.","publication_year":2011,"publication_date":"2011-03-01","ids":{"openalex":"https://openalex.org/W1020529447","doi":"https://doi.org/10.2143/acb.66.2.2062536","mag":"1020529447","pmid":"https://pubmed.ncbi.nlm.nih.gov/21630615"},"language":"en","primary_location":{"id":"pmid:21630615","doi":"https://doi.org/10.2143/acb.66.2.2062536","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21630615","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta clinica Belgica","raw_type":"Case Reports"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"B Ngo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148648","display_name":"Ziekenhuis Oost-Limburg","ror":"https://ror.org/04fg7az81","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210148648"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"B Ngo","raw_affiliation_strings":["Laboratory of Clinical Biology, Ziekenhuis Oost-Limburg, Campus St.-Jan, Genk, Belgium. bram_ngo@hotmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Biology, Ziekenhuis Oost-Limburg, Campus St.-Jan, Genk, Belgium. bram_ngo@hotmail.com","institution_ids":["https://openalex.org/I4210148648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071805364","display_name":"Kristien Van Pelt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Van Pelt","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056676933","display_name":"Veerle Labarque","orcid":"https://orcid.org/0000-0002-5052-9274","observed_orcids":["https://orcid.org/0000-0002-5052-9274"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"V Labarque","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026833569","display_name":"W. Van de Casseye","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"W Van De Casseye","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5050653749","display_name":"Joris Penders","orcid":"https://orcid.org/0000-0003-1877-6125","observed_orcids":["https://orcid.org/0000-0003-1877-6125"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J Penders","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1825,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.77459261,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"66","issue":"2","first_page":"142","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13004","display_name":"Vitamin K Research Studies","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13004","display_name":"Vitamin K Research Studies","score":0.9702000021934509,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.0142000000923872,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12460","display_name":"Pediatric Hepatobiliary Diseases and Treatments","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitamin-k-deficiency-bleeding","display_name":"vitamin K deficiency bleeding","score":0.9169999957084656},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.8769999742507935},{"id":"https://openalex.org/keywords/intracranial-hemorrhage","display_name":"intracranial hemorrhage","score":0.8610000014305115},{"id":"https://openalex.org/keywords/vitamin-k-prophylaxis","display_name":"vitamin K prophylaxis","score":0.7889999747276306},{"id":"https://openalex.org/keywords/fat-soluble-vitamin-malabsorption","display_name":"fat-soluble vitamin malabsorption","score":0.8820000290870667},{"id":"https://openalex.org/keywords/preterm-infants","display_name":"preterm infants","score":0.7170000076293945},{"id":"https://openalex.org/keywords/breastfeeding","display_name":"breastfeeding","score":0.777999997138977},{"id":"https://openalex.org/keywords/cholestasis","display_name":"cholestasis","score":0.8659999966621399},{"id":"https://openalex.org/keywords/prothrombin-time","display_name":"prothrombin time","score":0.7620000243186951},{"id":"https://openalex.org/keywords/activated-partial-thromboplastin-time","display_name":"activated partial thromboplastin time","score":0.9649999737739563},{"id":"https://openalex.org/keywords/vitamin-k-therapy","display_name":"vitamin K therapy","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9559371471405029},{"id":"https://openalex.org/C2780439177","wikidata":"https://www.wikidata.org/wiki/Q1442923","display_name":"Malabsorption","level":2,"score":0.7705052495002747},{"id":"https://openalex.org/C2779520540","wikidata":"https://www.wikidata.org/wiki/Q4138767","display_name":"Vitamin K deficiency","level":3,"score":0.7455514669418335},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.7294772863388062},{"id":"https://openalex.org/C2778593092","wikidata":"https://www.wikidata.org/wiki/Q1075923","display_name":"Cholestasis","level":2,"score":0.5336867570877075},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.46916231513023376},{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.43268924951553345},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4171704053878784},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3607724905014038},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.35928797721862793},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3352571129798889}],"mesh":[{"descriptor_ui":"D001779","descriptor_name":"Blood Coagulation Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001942","descriptor_name":"Breast Feeding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003550","descriptor_name":"Cystic Fibrosis","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004333","descriptor_name":"Drug Administration Routes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005183","descriptor_name":"Failure to Thrive","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D005183","descriptor_name":"Failure to Thrive","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005183","descriptor_name":"Failure to Thrive","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006475","descriptor_name":"Vitamin K Deficiency Bleeding","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006475","descriptor_name":"Vitamin K Deficiency Bleeding","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006475","descriptor_name":"Vitamin K Deficiency Bleeding","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006475","descriptor_name":"Vitamin K Deficiency Bleeding","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D006475","descriptor_name":"Vitamin K Deficiency Bleeding","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008286","descriptor_name":"Malabsorption Syndromes","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008286","descriptor_name":"Malabsorption Syndromes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008286","descriptor_name":"Malabsorption Syndromes","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008286","descriptor_name":"Malabsorption Syndromes","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010188","descriptor_name":"Exocrine Pancreatic Insufficiency","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D010188","descriptor_name":"Exocrine Pancreatic Insufficiency","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010188","descriptor_name":"Exocrine Pancreatic Insufficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010188","descriptor_name":"Exocrine Pancreatic Insufficiency","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014812","descriptor_name":"Vitamin K","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D014812","descriptor_name":"Vitamin K","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014815","descriptor_name":"Vitamins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D014815","descriptor_name":"Vitamins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056947","descriptor_name":"Enzyme Replacement Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:21630615","doi":"https://doi.org/10.2143/acb.66.2.2062536","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21630615","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta clinica Belgica","raw_type":"Case Reports"},{"id":"pmh:oai:documentserver.uhasselt.be:1942/12013","doi":"https://doi.org/10.2143/acb.66.2.2062536","is_oa":false,"landing_page_url":"http://hdl.handle.net/1942/12013","pdf_url":null,"source":{"id":"https://openalex.org/S4306401926","display_name":"Document Server@UHasselt (UHasselt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I878454856","host_organization_name":"Hasselt University","host_organization_lineage":["https://openalex.org/I878454856"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W2007497876","https://openalex.org/W2064863324","https://openalex.org/W2415631549"],"related_works":["https://openalex.org/W1493890349","https://openalex.org/W1996583856","https://openalex.org/W1831430847","https://openalex.org/W2075548255","https://openalex.org/W2148573378","https://openalex.org/W2166821314","https://openalex.org/W2103760209","https://openalex.org/W1971198541","https://openalex.org/W2040106931","https://openalex.org/W2004403401"],"abstract_inverted_index":{"Vitamin":[0],"K":[1,37],"deficiency":[2,38],"bleeding":[3],"(VKDB)":[4],"in":[5,34],"infants":[6,46],"still":[7,81],"occurs":[8],"despite":[9],"worldwide":[10],"use":[11],"of":[12,22,32,66,75,87,91,103],"prophylaxis.":[13],"Clinical":[14],"manifestations":[15],"can":[16,60,80],"be":[17,43,61,82],"dramatic":[18],"with":[19,25,47],"over":[20],"50%":[21],"patients":[23],"presenting":[24],"intracranial":[26],"haemorrhage":[27],"and":[28],"a":[29,48],"mortality":[30],"rate":[31],"20%":[33],"late":[35],"vitamin":[36,76],"bleeding.":[39],"Special":[40],"attention":[41],"should":[42],"given":[44],"to":[45,100],"high":[49],"risk":[50],"profile":[51],"(preterm,":[52],"breast":[53],"feeding,":[54],"cholestasis,":[55],"malabsorption).":[56],"A":[57],"tentative":[58],"diagnosis":[59,102],"made":[62],"observing":[63],"quick":[64],"normalisation":[65],"some":[67],"easy-to-perform":[68],"haemostatic":[69],"parameters":[70],"(PT,":[71],"aPTT)":[72],"after":[73],"administration":[74],"K.":[77],"Nowadays,":[78],"VKDB":[79,98],"the":[83,101,106],"first":[84],"clinical":[85],"sign":[86],"diseases":[88],"causing":[89],"malabsorption":[90],"fat-soluble":[92],"vitamins.":[93],"In":[94],"this":[95],"case":[96],"report,":[97],"led":[99],"cystic":[104],"fibrosis,":[105],"most":[107],"common":[108],"fatal":[109],"autosomal":[110],"recessive":[111],"disease":[112],"among":[113],"Caucasian":[114],"people.":[115]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}