{"id":"https://openalex.org/W101997918","doi":"https://doi.org/10.2165/0044011-200929010-00006","title":"Ciprofloxacin Strongly Inhibits Clozapine Metabolism","display_name":"Ciprofloxacin Strongly Inhibits Clozapine Metabolism","publication_year":2008,"publication_date":"2008-12-10","ids":{"openalex":"https://openalex.org/W101997918","doi":"https://doi.org/10.2165/0044011-200929010-00006","mag":"101997918","pmid":"https://pubmed.ncbi.nlm.nih.gov/19067475"},"language":"en","primary_location":{"id":"doi:10.2165/0044011-200929010-00006","doi":"https://doi.org/10.2165/0044011-200929010-00006","is_oa":false,"landing_page_url":"https://doi.org/10.2165/0044011-200929010-00006","pdf_url":null,"source":{"id":"https://openalex.org/S138241747","display_name":"Clinical Drug Investigation","issn_l":"0114-2402","issn":["0114-2402","1173-2563","1179-1918","2196-4920"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Drug Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5019749356","display_name":"Elke E. M. Brouwers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"E E M Brouwers","raw_affiliation_strings":["Department of Pharmacy and Pharmacology, Slotervaart Hospital, the Netherlands Cancer Institute, Amsterdam, the Netherlands. Elke.Brouwers@slz.nl","Slotervaart Hospital/The Netherlands Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmacology, Slotervaart Hospital, the Netherlands Cancer Institute, Amsterdam, the Netherlands. Elke.Brouwers@slz.nl","institution_ids":["https://openalex.org/I2802065108","https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Slotervaart Hospital/The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2802065108","https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107856778","display_name":"Maaike S\u00f6hne","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"M S\u00f6hne","raw_affiliation_strings":["Department of Internal Medicine, Slotervaart Hospital/the Netherlands Cancer Institute, Amsterdam, the Netherlands","Slotervaart Hospital/The Netherlands Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Slotervaart Hospital/the Netherlands Cancer Institute, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802065108","https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Slotervaart Hospital/The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2802065108","https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059657091","display_name":"Saskia Kuipers","orcid":"https://orcid.org/0000-0002-1869-2493","observed_orcids":["https://orcid.org/0000-0002-1869-2493"]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"S Kuipers","raw_affiliation_strings":["Department of Internal Medicine, Slotervaart Hospital/the Netherlands Cancer Institute, Amsterdam, the Netherlands","Slotervaart Hospital/The Netherlands Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Slotervaart Hospital/the Netherlands Cancer Institute, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802065108","https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Slotervaart Hospital/The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2802065108","https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113456514","display_name":"E.C.M. van Gorp","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"E C M van Gorp","raw_affiliation_strings":["Department of Internal Medicine, Slotervaart Hospital/the Netherlands Cancer Institute, Amsterdam, the Netherlands","Slotervaart Hospital/The Netherlands Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Slotervaart Hospital/the Netherlands Cancer Institute, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802065108","https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Slotervaart Hospital/The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2802065108","https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000418012","display_name":"Jan H.M. Schellens","orcid":"https://orcid.org/0000-0001-6832-1976","observed_orcids":["https://orcid.org/0000-0001-6832-1976"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J H M Schellens","raw_affiliation_strings":["Department of Biomedical Analysis, Faculty of Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands","Department of Medical Oncology, Antoni van Leeuwenhoek Hospital/the Netherlands Cancer Institute, Amsterdam, the Netherlands","Antoni van Leeuwenhoek Hospital/The Netherlands Cancer Institute","Utrecht University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Analysis, Faculty of Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Department of Medical Oncology, Antoni van Leeuwenhoek Hospital/the Netherlands Cancer Institute, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Antoni van Leeuwenhoek Hospital/The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Utrecht University","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113785658","display_name":"Cornelis H.W. Koks","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"C H W Koks","raw_affiliation_strings":["Department of Pharmacy and Pharmacology, Slotervaart Hospital/the Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, the Netherlands","Slotervaart Hospital/The Netherlands Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmacology, Slotervaart Hospital/the Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802065108","https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Slotervaart Hospital/The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2802065108","https://openalex.org/I2898336195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062227574","display_name":"Jos H. Beijnen","orcid":"https://orcid.org/0000-0003-0118-561X","observed_orcids":["https://orcid.org/0000-0003-0118-561X"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"J H Beijnen","raw_affiliation_strings":["Department of Biomedical Analysis, Faculty of Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands","Department of Pharmacy and Pharmacology, Slotervaart Hospital/the Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, the Netherlands","Slotervaart Hospital\u2014The Netherlands Cancer Institute","Utrecht University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Analysis, Faculty of Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Department of Pharmacy and Pharmacology, Slotervaart Hospital/the Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802065108","https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Slotervaart Hospital\u2014The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2802065108","https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Utrecht University","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010531755","display_name":"Alwin D. R. Huitema","orcid":"https://orcid.org/0000-0003-1939-4639","observed_orcids":["https://orcid.org/0000-0003-1939-4639"]},"institutions":[{"id":"https://openalex.org/I2802065108","display_name":"Slotervaartziekenhuis","ror":"https://ror.org/01w502745","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802065108"]},{"id":"https://openalex.org/I2898336195","display_name":"The Netherlands Cancer Institute","ror":"https://ror.org/03xqtf034","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2898336195"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A D R Huitema","raw_affiliation_strings":["Department of Pharmacy and Pharmacology, Slotervaart Hospital/the Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, the Netherlands","Slotervaart Hospital/The Netherlands Cancer Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy and Pharmacology, Slotervaart Hospital/the Netherlands Cancer Institute, Louwesweg 6, 1066 EC, Amsterdam, the Netherlands","institution_ids":["https://openalex.org/I2802065108","https://openalex.org/I2898336195"]},{"raw_affiliation_string":"Slotervaart Hospital/The Netherlands Cancer Institute","institution_ids":["https://openalex.org/I2802065108","https://openalex.org/I2898336195"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5019749356"],"corresponding_institution_ids":["https://openalex.org/I2802065108","https://openalex.org/I2898336195"],"apc_list":{"value":4190,"currency":"USD","value_usd":4190},"apc_paid":null,"fwci":1.8738,"has_fulltext":false,"cited_by_count":47,"citation_normalized_percentile":{"value":0.82104584,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"29","issue":"1","first_page":"59","last_page":"63"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ciprofloxacin","display_name":"ciprofloxacin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/clozapine","display_name":"clozapine","score":1.0},{"id":"https://openalex.org/keywords/drug-drug-interactions","display_name":"drug-drug interactions","score":0.949999988079071},{"id":"https://openalex.org/keywords/rhabdomyolysis","display_name":"rhabdomyolysis","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cytochrome-p450-inhibition","display_name":"cytochrome P450 inhibition","score":0.8370000123977661},{"id":"https://openalex.org/keywords/cyp1a2","display_name":"CYP1A2","score":0.9779999852180481},{"id":"https://openalex.org/keywords/cyp3a4","display_name":"CYP3A4","score":1.0},{"id":"https://openalex.org/keywords/fluoroquinolones","display_name":"fluoroquinolones","score":0.8479999899864197},{"id":"https://openalex.org/keywords/antipsychotic-drugs","display_name":"antipsychotic drugs","score":0.871999979019165},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.628000020980835},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.453000009059906}],"concepts":[{"id":"https://openalex.org/C2780864610","wikidata":"https://www.wikidata.org/wiki/Q221361","display_name":"Clozapine","level":3,"score":0.9576913714408875},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8327469229698181},{"id":"https://openalex.org/C2778512257","wikidata":"https://www.wikidata.org/wiki/Q256602","display_name":"Ciprofloxacin","level":3,"score":0.8150027990341187},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5080893039703369},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45597800612449646},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.45007163286209106},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.34813162684440613},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.3128739595413208},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0835612416267395},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000892","descriptor_name":"Anti-Infective Agents, Urinary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000892","descriptor_name":"Anti-Infective Agents, Urinary","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002939","descriptor_name":"Ciprofloxacin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002939","descriptor_name":"Ciprofloxacin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003024","descriptor_name":"Clozapine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003024","descriptor_name":"Clozapine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D012559","descriptor_name":"Schizophrenia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014150","descriptor_name":"Antipsychotic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019388","descriptor_name":"Cytochrome P-450 CYP1A2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051544","descriptor_name":"Cytochrome P-450 CYP3A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.2165/0044011-200929010-00006","doi":"https://doi.org/10.2165/0044011-200929010-00006","is_oa":false,"landing_page_url":"https://doi.org/10.2165/0044011-200929010-00006","pdf_url":null,"source":{"id":"https://openalex.org/S138241747","display_name":"Clinical Drug Investigation","issn_l":"0114-2402","issn":["0114-2402","1173-2563","1179-1918","2196-4920"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Drug Investigation","raw_type":"journal-article"},{"id":"pmid:19067475","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19067475","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical drug investigation","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W42353108","https://openalex.org/W1652672991","https://openalex.org/W1967263873","https://openalex.org/W1979610724","https://openalex.org/W1992790914","https://openalex.org/W1997815372","https://openalex.org/W2013970121","https://openalex.org/W2040242297","https://openalex.org/W2048282464","https://openalex.org/W2092754854","https://openalex.org/W2103986732","https://openalex.org/W2117086645","https://openalex.org/W2120217336","https://openalex.org/W2144816995","https://openalex.org/W2152558468","https://openalex.org/W2414090488","https://openalex.org/W4229754189"],"related_works":["https://openalex.org/W2546266058","https://openalex.org/W2048282464","https://openalex.org/W4410967385","https://openalex.org/W6925323734","https://openalex.org/W2030403705","https://openalex.org/W2103986732","https://openalex.org/W1976262478","https://openalex.org/W2055934609","https://openalex.org/W1889866680","https://openalex.org/W1970017068"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}