{"id":"https://openalex.org/W1019836896","doi":"https://doi.org/10.1038/srep12291","title":"Hypoxia-induced autophagy mediates cisplatin resistance in lung cancer cells","display_name":"Hypoxia-induced autophagy mediates cisplatin resistance in lung cancer cells","publication_year":2015,"publication_date":"2015-07-23","ids":{"openalex":"https://openalex.org/W1019836896","doi":"https://doi.org/10.1038/srep12291","mag":"1019836896","pmid":"https://pubmed.ncbi.nlm.nih.gov/26201611","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4511870"},"language":"en","primary_location":{"id":"doi:10.1038/srep12291","doi":"https://doi.org/10.1038/srep12291","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep12291","pdf_url":"https://www.nature.com/articles/srep12291.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/srep12291.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075444622","display_name":"Huimei Wu","orcid":"https://orcid.org/0000-0001-8149-6674","observed_orcids":["https://orcid.org/0000-0001-8149-6674"]},"institutions":[{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui-Mei Wu","raw_affiliation_strings":["Department of Pulmonary, Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei 230022, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary, Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei 230022, China","institution_ids":["https://openalex.org/I4210136596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110761750","display_name":"Zi\u2010Feng Jiang","orcid":"https://orcid.org/0009-0000-2946-0711","observed_orcids":["https://orcid.org/0009-0000-2946-0711"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zi-Feng Jiang","raw_affiliation_strings":["Department of Pulmonary, Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei 230022, China","Department of Pulmonary Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University Hefei China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary, Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei 230022, China","institution_ids":["https://openalex.org/I4210136596"]},{"raw_affiliation_string":"Department of Pulmonary Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University Hefei China","institution_ids":["https://openalex.org/I197869895","https://openalex.org/I4210136596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059962695","display_name":"Peishan Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pei-Shan Ding","raw_affiliation_strings":["Department of Pulmonary, Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei 230022, China","Department of Pulmonary Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University Hefei China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary, Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei 230022, China","institution_ids":["https://openalex.org/I4210136596"]},{"raw_affiliation_string":"Department of Pulmonary Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University Hefei China","institution_ids":["https://openalex.org/I197869895","https://openalex.org/I4210136596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060424932","display_name":"Lijie Shao","orcid":"https://orcid.org/0009-0002-8978-5475","observed_orcids":["https://orcid.org/0009-0002-8978-5475"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li-Jie Shao","raw_affiliation_strings":["Department of Pulmonary, Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei 230022, China","Department of Pulmonary Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University Hefei China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary, Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei 230022, China","institution_ids":["https://openalex.org/I4210136596"]},{"raw_affiliation_string":"Department of Pulmonary Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University Hefei China","institution_ids":["https://openalex.org/I197869895","https://openalex.org/I4210136596"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031597080","display_name":"Rong\u2010Yu Liu","orcid":"https://orcid.org/0000-0002-3601-9155","observed_orcids":["https://orcid.org/0000-0002-3601-9155"]},"institutions":[{"id":"https://openalex.org/I197869895","display_name":"Anhui Medical University","ror":"https://ror.org/03xb04968","country_code":"CN","type":"education","lineage":["https://openalex.org/I197869895"]},{"id":"https://openalex.org/I4210136596","display_name":"First Affiliated Hospital of Anhui Medical University","ror":"https://ror.org/03t1yn780","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210136596"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Rong-Yu Liu","raw_affiliation_strings":["Department of Pulmonary, Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei 230022, China","Department of Pulmonary Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University Hefei China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary, Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University, Jixi Road 218, Hefei 230022, China","institution_ids":["https://openalex.org/I4210136596"]},{"raw_affiliation_string":"Department of Pulmonary Anhui Geriatric Institute, the First Affiliated Hospital of Anhui Medical University Hefei China","institution_ids":["https://openalex.org/I197869895","https://openalex.org/I4210136596"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5031597080"],"corresponding_institution_ids":["https://openalex.org/I197869895","https://openalex.org/I4210136596"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":6.8393,"has_fulltext":true,"cited_by_count":186,"citation_normalized_percentile":{"value":0.98366699,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":100},"biblio":{"volume":"5","issue":"1","first_page":"12291","last_page":"12291"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.022600000724196434,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8809999823570251},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":1.0},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9860000014305115},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.9139999747276306},{"id":"https://openalex.org/keywords/hif-2alpha","display_name":"HIF-2\u03b1","score":1.0},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7730000019073486},{"id":"https://openalex.org/keywords/bnip3","display_name":"BNIP3","score":0.9629999995231628},{"id":"https://openalex.org/keywords/atg5","display_name":"ATG5","score":0.9319999814033508},{"id":"https://openalex.org/keywords/3-methyladenine","display_name":"3-methyladenine","score":0.8790000081062317},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":0.8679999709129333},{"id":"https://openalex.org/keywords/spc-a-1-cells","display_name":"SPC-A1 cells","score":0.9929999709129333}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.9572478532791138},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.8759750127792358},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.8018753528594971},{"id":"https://openalex.org/C2781000418","wikidata":"https://www.wikidata.org/wiki/Q18034312","display_name":"ATG5","level":4,"score":0.6933186650276184},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6925384402275085},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.6763909459114075},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.551315188407898},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5111775994300842},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.460782915353775},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.45562103390693665},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.449083536863327},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3677522540092468},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.23677757382392883},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2238858938217163},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.19630810618400574},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1093035638332367},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.10230693221092224},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C540031477","wikidata":"https://www.wikidata.org/wiki/Q629","display_name":"Oxygen","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010100","descriptor_name":"Oxygen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015687","descriptor_name":"Cell Hypoxia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/srep12291","doi":"https://doi.org/10.1038/srep12291","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep12291","pdf_url":"https://www.nature.com/articles/srep12291.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},{"id":"pmid:26201611","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26201611","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific reports","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4511870","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4511870/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sci Rep","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1038/srep12291","doi":"https://doi.org/10.1038/srep12291","is_oa":true,"landing_page_url":"https://doi.org/10.1038/srep12291","pdf_url":"https://www.nature.com/articles/srep12291.pdf","source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1962801911","display_name":null,"funder_award_id":"1206c0805028","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5001399116","display_name":"\u6574\u5408\u7d20\u7ecfMerTK-Src-FAK-Rac1\u4fe1\u53f7\u901a\u8def\u8c03\u63a7\u80ba\u6ce1\u5de8\u566c\u7ec6\u80de\u541e\u566c\u51cb\u4ea1\u55dc\u4e2d\u6027\u7c92\u7ec6\u80de\u7684\u5206\u5b50\u673a\u5236","funder_award_id":"81170030","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6166372980","display_name":"\u9776\u5411\u5e72\u9884TLR2-MyD88-PJNK/P38-PI3K\u4fe1\u53f7\u901a\u8def\u8c03\u63a7\u80ba\u6ce1\u5de8\u566c\u7ec6\u80de\u708e\u75c7\u53cd\u5e94\u53c2\u4e0e\u54ee\u5598\u53d1\u75c5\u7684\u5206\u5b50\u673a\u5236","funder_award_id":"81270082","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8413515967","display_name":null,"funder_award_id":"81300027","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320325599","display_name":"University of Science and Technology of China","ror":"https://ror.org/04c4dkn09"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1019836896.pdf","grobid_xml":"https://content.openalex.org/works/W1019836896.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1523693806","https://openalex.org/W1545664267","https://openalex.org/W1604468403","https://openalex.org/W1637481805","https://openalex.org/W1927873495","https://openalex.org/W1964275068","https://openalex.org/W1965405617","https://openalex.org/W1965549497","https://openalex.org/W1970101770","https://openalex.org/W1972553173","https://openalex.org/W1975403576","https://openalex.org/W1977860891","https://openalex.org/W1980576189","https://openalex.org/W1982883159","https://openalex.org/W1991180348","https://openalex.org/W1996122174","https://openalex.org/W1996526524","https://openalex.org/W1999330214","https://openalex.org/W1999532278","https://openalex.org/W2001562768","https://openalex.org/W2004016119","https://openalex.org/W2005371059","https://openalex.org/W2006879302","https://openalex.org/W2020830322","https://openalex.org/W2021381932","https://openalex.org/W2024549038","https://openalex.org/W2024650854","https://openalex.org/W2035983112","https://openalex.org/W2038535314","https://openalex.org/W2044149912","https://openalex.org/W2054333460","https://openalex.org/W2054650618","https://openalex.org/W2079351077","https://openalex.org/W2085586604","https://openalex.org/W2086632595","https://openalex.org/W2101084498","https://openalex.org/W2101721772","https://openalex.org/W2105035752","https://openalex.org/W2105933029","https://openalex.org/W2106787323","https://openalex.org/W2118901014","https://openalex.org/W2120501245","https://openalex.org/W2122065834","https://openalex.org/W2125257427","https://openalex.org/W2129497554","https://openalex.org/W2132358441","https://openalex.org/W2133000461","https://openalex.org/W2144662794","https://openalex.org/W2148116485","https://openalex.org/W2148419067","https://openalex.org/W2149123160","https://openalex.org/W2149306102","https://openalex.org/W2149823628","https://openalex.org/W2150451425","https://openalex.org/W2150527022","https://openalex.org/W2151713424","https://openalex.org/W2157945371","https://openalex.org/W2158535498","https://openalex.org/W2159033534","https://openalex.org/W2160664949","https://openalex.org/W2164778558","https://openalex.org/W2164901739","https://openalex.org/W2396850422","https://openalex.org/W4238843411"],"related_works":["https://openalex.org/W3133400336","https://openalex.org/W2100110884","https://openalex.org/W4417078595","https://openalex.org/W2980707980","https://openalex.org/W4289938062","https://openalex.org/W2992927788","https://openalex.org/W4205465988","https://openalex.org/W2149823628","https://openalex.org/W3025280047","https://openalex.org/W2971982902"],"abstract_inverted_index":{"Hypoxia":[0],"which":[1,91,117],"commonly":[2],"exists":[3],"in":[4,35,58,161],"solid":[5],"tumors,":[6],"leads":[7],"to":[8,21,120,152,179,194],"cancer":[9,41,191],"cells":[10,53,178,192],"chemoresistance":[11],"via":[12],"provoking":[13],"adaptive":[14],"responses":[15],"including":[16],"autophagy.":[17],"Therefore,":[18],"we":[19,101,129],"sought":[20],"evaluate":[22],"the":[23,32,36,121,154,173,177],"role":[24],"of":[25,39,185],"autophagy":[26,77,93,108,132,148,167,186],"and":[27,51,61,143],"hypoxia":[28,47,71,104,188],"as":[29,31],"well":[30],"underlying":[33],"mechanism":[34,136],"cisplatin":[37,95,138],"resistance":[38],"lung":[40,190],"cells.":[42],"Our":[43],"study":[44],"demonstrated":[45],"that":[46,103,131,171],"significantly":[48],"protected":[49],"A549":[50],"SPC-A1":[52],"from":[54],"cisplatin-induced":[55,68,107,113,174,195],"cell":[56,162],"death":[57,115],"a":[59,134],"Hif-1\u03b1-":[60],"Hif-2\u03b1-dependent":[62],"manner.":[63],"Moreover,":[64],"compared":[65],"with":[66],"normoxia,":[67,147],"apoptosis":[69],"under":[70,97,126,140,146,165],"was":[72,78,88,118,133,169],"markedly":[73],"reduced.":[74],"However,":[75,145],"when":[76],"inhibited":[79],"by":[80,111,157,187],"3-MA":[81],"or":[82],"siRNA":[83],"targeted":[84],"ATG5,":[85],"this":[86],"reduction":[87],"effectively":[89],"attenuated,":[90],"means":[92],"mediates":[94],"resisitance":[96],"hypoxia.":[98,127,144],"In":[99,181],"parallel,":[100],"showed":[102],"robustly":[105],"augmented":[106,170,183],"activation,":[109],"accompanying":[110],"suppressing":[112],"BNIP3":[114],"pathways,":[116],"due":[119],"more":[122],"efficient":[123],"autophagic":[124],"process":[125],"Consequently,":[128],"proposed":[130],"protective":[135],"after":[137],"incubation":[139],"both":[141],"normoxia":[142],"activation":[149],"'was":[150],"unable":[151],"counteract":[153],"stress":[155],"induced":[156],"cisplatin,":[158],"therefore":[159],"resulting":[160],"death,":[163],"whereas":[164],"hypoxia,":[166],"induction":[168,184],"solved":[172],"stress,":[175],"allowing":[176],"survival.":[180],"conclusion,":[182],"decreased":[189],"susceptibility":[193],"apoptosis.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":27},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":29},{"year":2016,"cited_by_count":12},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}