{"id":"https://openalex.org/W101951938","doi":"https://doi.org/10.1007/s13631-013-0032-0","title":"Autoanticorpi nel diabete mellito","display_name":"Autoanticorpi nel diabete mellito","publication_year":2013,"publication_date":"2013-11-13","ids":{"openalex":"https://openalex.org/W101951938","doi":"https://doi.org/10.1007/s13631-013-0032-0","mag":"101951938"},"language":"it","primary_location":{"id":"doi:10.1007/s13631-013-0032-0","doi":"https://doi.org/10.1007/s13631-013-0032-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13631-013-0032-0","pdf_url":null,"source":{"id":"https://openalex.org/S4210223908","display_name":"La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine","issn_l":"1825-859X","issn":["1825-859X","2039-6821"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074269585","display_name":"Alberto Falorni","orcid":"https://orcid.org/0000-0003-4532-3519","observed_orcids":["https://orcid.org/0000-0003-4532-3519"]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Alberto Falorni","raw_affiliation_strings":["Dipartimento di Medicina Interna, Sezione di Medicina Interna e Scienze Endocrine e Metaboliche, Universit\u00e0 degli Studi di Perugia, Via E. Dal Pozzo, 06126, Perugia, Italia","Universita Degli Studi Di Perugia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Interna, Sezione di Medicina Interna e Scienze Endocrine e Metaboliche, Universit\u00e0 degli Studi di Perugia, Via E. Dal Pozzo, 06126, Perugia, Italia","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"Universita Degli Studi Di Perugia","institution_ids":["https://openalex.org/I27483092"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056827589","display_name":"Viviana Minarelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27483092","display_name":"University of Perugia","ror":"https://ror.org/00x27da85","country_code":"IT","type":"education","lineage":["https://openalex.org/I27483092"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Viviana Minarelli","raw_affiliation_strings":["Dipartimento di Medicina Interna, Sezione di Medicina Interna e Scienze Endocrine e Metaboliche, Universit\u00e0 degli Studi di Perugia, Via E. Dal Pozzo, 06126, Perugia, Italia","Universita Degli Studi Di Perugia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Medicina Interna, Sezione di Medicina Interna e Scienze Endocrine e Metaboliche, Universit\u00e0 degli Studi di Perugia, Via E. Dal Pozzo, 06126, Perugia, Italia","institution_ids":["https://openalex.org/I27483092"]},{"raw_affiliation_string":"Universita Degli Studi Di Perugia","institution_ids":["https://openalex.org/I27483092"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5074269585"],"corresponding_institution_ids":["https://openalex.org/I27483092"],"apc_list":{"value":3140,"currency":"USD","value_usd":3140},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00800733,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"4","first_page":"209","last_page":"217"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10560","display_name":"Diabetes Management and Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/autoantibodies","display_name":"autoantibodies","score":0.9100000262260437},{"id":"https://openalex.org/keywords/type-1-diabetes","display_name":"type 1 diabetes","score":0.9490000009536743},{"id":"https://openalex.org/keywords/insulin-autoantibodies","display_name":"insulin autoantibodies","score":0.8320000171661377},{"id":"https://openalex.org/keywords/gad65-autoantibodies","display_name":"GAD65 antibodies","score":0.8149999976158142},{"id":"https://openalex.org/keywords/ia-2-antibodies","display_name":"IA-2 autoantibodies","score":0.9470000267028809},{"id":"https://openalex.org/keywords/znt8-autoantibodies","display_name":"ZnT8 autoantibodies","score":0.9580000042915344},{"id":"https://openalex.org/keywords/autoimmunity","display_name":"autoimmunity","score":0.6610000133514404},{"id":"https://openalex.org/keywords/insulitis","display_name":"insulitis","score":0.7649999856948853},{"id":"https://openalex.org/keywords/latent-autoimmune-diabetes-in-adults","display_name":"latent autoimmune diabetes in adults","score":0.7799999713897705},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.5220000147819519}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5836045742034912},{"id":"https://openalex.org/C2908810637","wikidata":"https://www.wikidata.org/wiki/Q1797833","display_name":"Autoimmune diabetes","level":4,"score":0.5667878985404968},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.4641280174255371},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.24906787276268005},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2171536087989807},{"id":"https://openalex.org/C2781232474","wikidata":"https://www.wikidata.org/wiki/Q124407","display_name":"Type 1 diabetes","level":3,"score":0.20394554734230042}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s13631-013-0032-0","doi":"https://doi.org/10.1007/s13631-013-0032-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s13631-013-0032-0","pdf_url":null,"source":{"id":"https://openalex.org/S4210223908","display_name":"La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine","issn_l":"1825-859X","issn":["1825-859X","2039-6821"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"La Rivista Italiana della Medicina di Laboratorio - Italian Journal of Laboratory Medicine","raw_type":"journal-article"},{"id":"mag:2947164839","doi":null,"is_oa":false,"landing_page_url":"https://link.springer.com/content/pdf/10.1007/s13631-013-0032-0.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W1485442318","https://openalex.org/W1501985293","https://openalex.org/W1956674508","https://openalex.org/W1971239948","https://openalex.org/W1972182005","https://openalex.org/W1977100137","https://openalex.org/W1977962868","https://openalex.org/W1978885851","https://openalex.org/W1980705644","https://openalex.org/W1981009470","https://openalex.org/W1981490811","https://openalex.org/W1982544710","https://openalex.org/W1983864650","https://openalex.org/W1985881712","https://openalex.org/W1986358695","https://openalex.org/W1986378193","https://openalex.org/W1987913280","https://openalex.org/W1993249613","https://openalex.org/W1993312496","https://openalex.org/W1997601800","https://openalex.org/W1999913155","https://openalex.org/W2001072123","https://openalex.org/W2002305096","https://openalex.org/W2002668738","https://openalex.org/W2008443993","https://openalex.org/W2012293963","https://openalex.org/W2013359164","https://openalex.org/W2017971549","https://openalex.org/W2019972832","https://openalex.org/W2023181635","https://openalex.org/W2024199579","https://openalex.org/W2026889435","https://openalex.org/W2028981905","https://openalex.org/W2033258102","https://openalex.org/W2038816020","https://openalex.org/W2039743782","https://openalex.org/W2040999790","https://openalex.org/W2050152799","https://openalex.org/W2050664844","https://openalex.org/W2052669556","https://openalex.org/W2055463878","https://openalex.org/W2059144476","https://openalex.org/W2060158312","https://openalex.org/W2061658273","https://openalex.org/W2063798262","https://openalex.org/W2065460816","https://openalex.org/W2066394315","https://openalex.org/W2068144490","https://openalex.org/W2070972996","https://openalex.org/W2071472322","https://openalex.org/W2072081606","https://openalex.org/W2072652145","https://openalex.org/W2073392026","https://openalex.org/W2073625243","https://openalex.org/W2075413718","https://openalex.org/W2075448983","https://openalex.org/W2083754730","https://openalex.org/W2084215480","https://openalex.org/W2090432138","https://openalex.org/W2092847594","https://openalex.org/W2098739800","https://openalex.org/W2098742390","https://openalex.org/W2099852272","https://openalex.org/W2104258246","https://openalex.org/W2109997219","https://openalex.org/W2111625815","https://openalex.org/W2117282940","https://openalex.org/W2121166788","https://openalex.org/W2129551653","https://openalex.org/W2129963016","https://openalex.org/W2133850878","https://openalex.org/W2135525868","https://openalex.org/W2137638424","https://openalex.org/W2140740027","https://openalex.org/W2144297952","https://openalex.org/W2145991477","https://openalex.org/W2150378753","https://openalex.org/W2151688741","https://openalex.org/W2152161585","https://openalex.org/W2152914276","https://openalex.org/W2154652130","https://openalex.org/W2161122681","https://openalex.org/W2254283806","https://openalex.org/W2267284381","https://openalex.org/W2419185757","https://openalex.org/W2608577463"],"related_works":["https://openalex.org/W2947164839","https://openalex.org/W25276299","https://openalex.org/W7119419337","https://openalex.org/W1967405478","https://openalex.org/W2918982350","https://openalex.org/W1663246815","https://openalex.org/W2025380784","https://openalex.org/W7199037132","https://openalex.org/W7058191993","https://openalex.org/W2131903342"],"abstract_inverted_index":{"Il":[0],"diabete":[1,161],"mellito":[2],"di":[3,25,65,77,139,145,171,185,198,203,208,210],"tipo":[4],"1":[5],"(DMT1)":[6],"\u00e8":[7,166],"una":[8],"malattia":[9,142],"autoimmune":[10,43,113,130,162],"cronica":[11],"causata":[12],"dalla":[13,169,191],"selettiva":[14],"distruzione":[15],"delle":[16,51],"cellule":[17,45],"beta":[18],"pancreatiche":[19],"che":[20,53,109,179],"producono":[21,54],"insulina":[22],"da":[23,30],"parte":[24],"un":[26,38,182],"processo":[27,42,112,129],"infiammatorio":[28],"mediato":[29],"linfociti":[31,35],"T":[32],"autoreattivi.":[33],"I":[34],"B":[36],"giocano":[37],"ruolo":[39],"importante":[40],"nel":[41,63,137],"come":[44,49,119],"presentanti":[46],"l\u2019antigene":[47],"e":[48,101,114],"precursori":[50],"plasmacellule":[52],"autoanticorpi":[55,59,199],"anti-insula":[56,200],"pancreatica.":[57],"Gli":[58],"anti-insula,":[60],"inizialmente":[61],"identificati":[62],"siero":[64,138],"pazienti":[66,140],"con":[67,141],"DMT1":[68,211],"utilizzando":[69],"la":[70,91,96,194],"tecnica":[71],"dell\u2019immunofluorescenza":[72],"indiretta":[73],"su":[74],"sezioni":[75],"criostatiche":[76],"pancreas":[78],"umano,":[79],"sono":[80,90,122,125],"diretti":[81],"contro":[82],"vari":[83],"autoantigeni,":[84],"fra":[85],"cui":[86],"i":[87],"pi\u00f9":[88],"importanti":[89],"decarbossilasi":[92],"dell\u2019acido":[93],"glutammico":[94],"(GAD65),":[95],"proteina":[97],"tirosin-fosfatasi":[98],"IA-2,":[99],"l\u2019insulina":[100],"il":[102,111,160,205],"trasportatore":[103],"dello":[104],"zinco":[105],"ZnT8.":[106],"Questi":[107],"autoanticorpi,":[108],"accompagnano":[110],"l\u2019infiammazione":[115],"intra-insulare":[116],"pancreatica":[117,201],"nota":[118],"insulite,":[120],"non":[121,152,177],"patogenetici,":[123],"ma":[124],"fondamentali":[126],"marcatori":[127],"del":[128],"utili":[131],"a":[132],"fini":[133],"clinici.":[134],"Quando":[135],"dimostrabili":[136],"diabetica":[143],"permettono":[144],"discriminare":[146],"le":[147],"forme":[148,151],"autoimmuni":[149,153],"dalle":[150],"della":[154],"malattia.":[155],"Cos\u00ec,":[156],"in":[157,175,196,212],"modo":[158],"particolare,":[159],"latente":[163],"dell\u2019adulto":[164],"(LADA)":[165],"identificato":[167],"proprio":[168],"presenza":[170,195],"anticorpi":[172],"anti-GAD65":[173],"(GADA)":[174],"soggetti":[176,213],"insulino-dipendenti":[178],"per\u00f2":[180],"presentano":[181],"alto":[183],"rischio":[184,206],"sviluppare":[186],"insulino-dipendenza":[187],"entro":[188],"pochi":[189],"anni":[190],"diagnosi.":[192],"Inoltre,":[193],"circolo":[197],"permette":[202],"stimare":[204],"futuro":[207],"sviluppo":[209],"normoglicemici.":[214]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
