{"id":"https://openalex.org/W101811734","doi":null,"title":"A phase-II study of liposomal doxorubicin and docetaxel in patients with advanced pancreatic cancer.","display_name":"A phase-II study of liposomal doxorubicin and docetaxel in patients with advanced pancreatic cancer.","publication_year":2002,"publication_date":"2002-11-01","ids":{"openalex":"https://openalex.org/W101811734","mag":"101811734","pmid":"https://pubmed.ncbi.nlm.nih.gov/12552960"},"language":"en","primary_location":{"id":"pmid:12552960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12552960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Clinical Trial"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049509860","display_name":"Konstantinos N. Syrigos","orcid":"https://orcid.org/0000-0002-3474-1363","observed_orcids":["https://orcid.org/0000-0002-3474-1363"]},"institutions":[{"id":"https://openalex.org/I4210166756","display_name":"Sotiria General Hospital","ror":"https://ror.org/05gbdc474","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I4210166756"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"K N Syrigos","raw_affiliation_strings":["Oncology Unit, 3rd Department of Medicine, Athens Medical School, Building Z, Sotiria General Hospital, Mesogion 152, 115 26 Athens, Greece. knsyrigos@usa.net"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oncology Unit, 3rd Department of Medicine, Athens Medical School, Building Z, Sotiria General Hospital, Mesogion 152, 115 26 Athens, Greece. knsyrigos@usa.net","institution_ids":["https://openalex.org/I4210166756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081243593","display_name":"B Michalaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B Michalaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035673405","display_name":"Fotini Alevyzaki","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F Alevyzaki","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"A Machairas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A Machairas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026893744","display_name":"D. Mandrekas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Mandrekas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036191431","display_name":"K Kindilidis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Kindilidis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5113762166","display_name":"Gabriel Karatzas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Karatzas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.184,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.77219299,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"22","issue":"6B","first_page":"3583","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/liposomal-doxorubicin","display_name":"liposomal doxorubicin","score":0.9810000061988831},{"id":"https://openalex.org/keywords/docetaxel","display_name":"docetaxel","score":0.9980000257492065},{"id":"https://openalex.org/keywords/advanced-pancreatic-cancer","display_name":"advanced pancreatic cancer","score":0.9589999914169312},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.9369999766349792},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.6520000100135803},{"id":"https://openalex.org/keywords/chemotherapy-toxicity","display_name":"chemotherapy toxicity","score":0.8799999952316284},{"id":"https://openalex.org/keywords/neutropenia","display_name":"neutropenia","score":0.9710000157356262},{"id":"https://openalex.org/keywords/thrombocytopenia","display_name":"thrombocytopenia","score":0.9599999785423279},{"id":"https://openalex.org/keywords/diarrhea","display_name":"diarrhea","score":0.5899999737739563},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.8080000281333923},{"id":"https://openalex.org/keywords/hand-foot-syndrome","display_name":"hand-foot syndrome","score":0.9580000042915344},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5860000252723694},{"id":"https://openalex.org/keywords/treatment-response","display_name":"treatment response","score":0.3319999873638153}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8849837779998779},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.7749665975570679},{"id":"https://openalex.org/C2781190966","wikidata":"https://www.wikidata.org/wiki/Q420436","display_name":"Docetaxel","level":3,"score":0.7536648511886597},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6568769216537476},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6118488311767578},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.556263267993927},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.5549074411392212},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.5289716124534607},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.5249367356300354},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.45076900720596313},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.41410592198371887}],"mesh":[{"descriptor_ui":"D000077143","descriptor_name":"Docetaxel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010190","descriptor_name":"Pancreatic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015996","descriptor_name":"Survival Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D043823","descriptor_name":"Taxoids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:12552960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12552960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anticancer research","raw_type":"Clinical Trial"},{"id":"mag:101811734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12552960","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2028352641","https://openalex.org/W2424910480","https://openalex.org/W2596442104","https://openalex.org/W2003082720","https://openalex.org/W2330406879","https://openalex.org/W2181725274","https://openalex.org/W2021315454","https://openalex.org/W2242194182","https://openalex.org/W1967370107","https://openalex.org/W2234542209"],"abstract_inverted_index":{"BACKGROUND:":[0],"Both":[1],"liposomal":[2],"doxorubicin":[3,261],"(LD)":[4],"and":[5,51,82,106,115,146,182,200,220,253,262],"docetaxel":[6,263],"(D)":[7],"have":[8,40,275],"a":[9,42,167,276],"broad":[10],"range":[11],"of":[12,36,53,137,152,170,172,191],"activity":[13,278],"against":[14],"solid":[15],"tumors,":[16],"including":[17],"advanced":[18],"pancreatic":[19,74,280],"cancer":[20,75],"(APC),":[21],"as":[22,56],"single":[23],"agents,":[24],"while":[25],"their":[26,54],"combination":[27,55,264],"has":[28],"produced":[29],"encouraging":[30],"response":[31,160,171],"rates":[32],"in":[33,45,59,163,179,185,216,224,232,279],"the":[34,49,135,201],"treatment":[35,58],"several":[37],"malignancies.":[38],"We":[39],"conducted":[41],"Phase-II":[43],"study":[44],"order":[46],"to":[47,131,210],"evaluate":[48],"tolerance":[50],"efficacy":[52],"front-line":[57],"patients":[60,68,141,181,219,283],"with":[61,69,85,166,288],"APC.":[62],"PATIENTS":[63],"AND":[64],"METHODS:":[65],"Twenty-one":[66],"chemotherapy-na\u00efve":[67],"unresectable,":[70],"locally-advanced":[71],"or":[72],"metastatic":[73],"were":[76,119,142,155],"enrolled.":[77],"These":[78],"included":[79,140],"16":[80],"males":[81],"5":[83],"females":[84],"median":[86,168,189],"age":[87],"66":[88],"years":[89],"(range":[90],"57-80).":[91],"Performance":[92],"status":[93],"(PS)":[94],"was":[95,129,161,177,193,206,230,265],"0":[96],"(n":[97,102,108],"=":[98,103,109],"10":[99,194],"pts),":[100],"1":[101],"7":[104,180],"pts)":[105],"2":[107,248],"4":[110,225],"pts).":[111],"D":[112],"(80":[113],"mg/m2),":[114],"LD":[116],"(30":[117],"mg/m2)":[118],"administered":[120,156],"on":[121],"day":[122],"1,":[123],"every":[124],"3":[125,173],"weeks.":[126],"RhG-CSF":[127],"s.c.":[128],"given":[130],"all":[132,139],"patients.":[133,187,227,271],"At":[134],"time":[136],"analysis,":[138],"evaluated":[143],"for":[144,147],"toxicity":[145,229],"response.":[148],"RESULTS:":[149],"A":[150],"total":[151],"92":[153],"cycles":[154],"(4.38":[157],"cycles/patient).":[158],"Partial":[159],"achieved":[162],"6":[164],"patients,":[165],"duration":[169,190],"months.":[174],"Stable":[175],"disease":[176,184],"observed":[178],"progressive":[183],"8":[186,217],"The":[188,260],"survival":[192,204],"months":[195],"(95%":[196],"CI,":[197],"6-14":[198],"months)":[199],"actuarial":[202],"1-year":[203],"rate":[205],"33.33%.":[207],"With":[208],"regard":[209],"toxicity,":[211],"grades":[212,221,236],"3,4":[213,222,237],"neutropenia":[214],"occurred":[215],"(38%)":[218],"thrombocytopenia":[223],"(19%)":[226],"Non-hematological":[228],"recorded":[231],"15":[233],"(71%)":[234],"patients:":[235],"diarrhea":[238],"(3":[239,244],"pts,":[240,251,257],"14%),":[241,246],"hypersensitivity":[242],"reactions":[243],"pt,":[245],"grade":[247],"neurotoxicity":[249],"(6":[250],"29%)":[252],"palmar-plantar":[254],"erythrodysesthesia":[255],"(9":[256],"43%).":[258],"CONCLUSION:":[259],"well-tolerated":[266],"by":[267],"these":[268],"poor":[269],"prognosis":[270],"Although":[272],"both":[273],"drugs":[274],"marginal":[277],"cancer,":[281],"most":[282],"experienced":[284],"significant":[285],"clinical":[286],"improvement,":[287],"acceptable":[289],"toxicity.":[290]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
