{"id":"https://openalex.org/W101796757","doi":null,"title":"The changing face of hypophosphatemic disorders in the FGF-23 era.","display_name":"The changing face of hypophosphatemic disorders in the FGF-23 era.","publication_year":2013,"publication_date":"2013-06-01","ids":{"openalex":"https://openalex.org/W101796757","mag":"101796757","pmid":"https://pubmed.ncbi.nlm.nih.gov/23858620","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4170520"},"language":"en","primary_location":{"id":"pmid:23858620","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23858620","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric endocrinology reviews : PER","raw_type":"Case Reports"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4170520","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036032139","display_name":"Janet Y. Lee","orcid":"https://orcid.org/0000-0002-3563-8843","observed_orcids":["https://orcid.org/0000-0002-3563-8843"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet Y Lee","raw_affiliation_strings":["Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009292672","display_name":"Erik Allen Imel","orcid":"https://orcid.org/0000-0002-7284-3467","observed_orcids":["https://orcid.org/0000-0002-7284-3467"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Erik A Imel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.2704,"has_fulltext":true,"cited_by_count":26,"citation_normalized_percentile":{"value":0.86993865,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10 Suppl 2","issue":null,"first_page":"367","last_page":"79"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13453","display_name":"Alkaline Phosphatase Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypophosphatemia","display_name":"hypophosphatemia","score":0.8600000143051147},{"id":"https://openalex.org/keywords/x-linked-hypophosphatemia","display_name":"X-linked hypophosphatemia","score":0.8980000019073486},{"id":"https://openalex.org/keywords/fgf23","display_name":"fibroblast growth factor 23","score":0.972000002861023},{"id":"https://openalex.org/keywords/phosphate-metabolism","display_name":"phosphate metabolism","score":0.8519999980926514},{"id":"https://openalex.org/keywords/renal-phosphate-wasting","display_name":"renal phosphate wasting","score":0.8500000238418579},{"id":"https://openalex.org/keywords/rickets","display_name":"rickets","score":0.777999997138977}],"concepts":[{"id":"https://openalex.org/C2778573388","wikidata":"https://www.wikidata.org/wiki/Q1641384","display_name":"Hypophosphatemia","level":2,"score":0.9514247179031372},{"id":"https://openalex.org/C2911197707","wikidata":"https://www.wikidata.org/wiki/Q1779987","display_name":"Hypophosphatemic Rickets","level":4,"score":0.8291516900062561},{"id":"https://openalex.org/C2779764123","wikidata":"https://www.wikidata.org/wiki/Q7972881","display_name":"Wasting","level":2,"score":0.7623113989830017},{"id":"https://openalex.org/C114276007","wikidata":"https://www.wikidata.org/wiki/Q14897899","display_name":"Fibroblast growth factor 23","level":4,"score":0.6954006552696228},{"id":"https://openalex.org/C2776489590","wikidata":"https://www.wikidata.org/wiki/Q183392","display_name":"Rickets","level":3,"score":0.6141560673713684},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.5069854259490967},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4103360176086426},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30094194412231445},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2513613700866699},{"id":"https://openalex.org/C124490489","wikidata":"https://www.wikidata.org/wiki/Q7936963","display_name":"Vitamin D and neurology","level":2,"score":0.13751232624053955},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.0},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000089703","descriptor_name":"Fibroblast Growth Factor-23","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005346","descriptor_name":"Fibroblast Growth Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007223","descriptor_name":"Infant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010710","descriptor_name":"Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040181","descriptor_name":"Genetic Diseases, X-Linked","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053098","descriptor_name":"Familial Hypophosphatemic Rickets","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053098","descriptor_name":"Familial Hypophosphatemic Rickets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053098","descriptor_name":"Familial Hypophosphatemic Rickets","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false}],"locations_count":6,"locations":[{"id":"pmid:23858620","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23858620","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pediatric endocrinology reviews : PER","raw_type":"Case Reports"},{"id":"pmh:oai:europepmc.org:3139817","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4170520","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4170520","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4170520","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Pediatr Endocrinol Rev","raw_type":"Text"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/47735","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/47735","pdf_url":"https://scholarworks.indianapolis.iu.edu/bitstreams/903c89e3-7018-45f9-b612-5d2123f57a23/download","source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt2vp501h9","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/2vp501h9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pediatric endocrinology reviews : PER, vol 10 Suppl 2, iss 0 2","raw_type":"article"},{"id":"mag:101796757","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23858620","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3139817","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4170520","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.699999988079071}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2847719708","display_name":"FGF23 in Pediatric Phosphate Physiology and X-linked Hypophosphatemic Rickets.","funder_award_id":"K23AR057096","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":110,"referenced_works":["https://openalex.org/W23518110","https://openalex.org/W197840620","https://openalex.org/W1563425273","https://openalex.org/W1965113966","https://openalex.org/W1969508842","https://openalex.org/W1970052428","https://openalex.org/W1974807791","https://openalex.org/W1975164872","https://openalex.org/W1975939208","https://openalex.org/W1978647937","https://openalex.org/W1979425916","https://openalex.org/W1982762889","https://openalex.org/W1984845858","https://openalex.org/W1984898235","https://openalex.org/W1985742682","https://openalex.org/W1991275339","https://openalex.org/W1992140819","https://openalex.org/W1992179815","https://openalex.org/W1993922267","https://openalex.org/W1996442598","https://openalex.org/W1996479063","https://openalex.org/W1996555833","https://openalex.org/W1998100845","https://openalex.org/W2011289811","https://openalex.org/W2011349880","https://openalex.org/W2013026281","https://openalex.org/W2019171239","https://openalex.org/W2019298065","https://openalex.org/W2019620862","https://openalex.org/W2019902366","https://openalex.org/W2020809875","https://openalex.org/W2021006933","https://openalex.org/W2021605540","https://openalex.org/W2021852822","https://openalex.org/W2022604691","https://openalex.org/W2023446262","https://openalex.org/W2025952915","https://openalex.org/W2030221774","https://openalex.org/W2031311109","https://openalex.org/W2034350751","https://openalex.org/W2036143549","https://openalex.org/W2036341320","https://openalex.org/W2039466987","https://openalex.org/W2040738721","https://openalex.org/W2043958868","https://openalex.org/W2045882388","https://openalex.org/W2049193031","https://openalex.org/W2050698413","https://openalex.org/W2051959338","https://openalex.org/W2055073323","https://openalex.org/W2057166126","https://openalex.org/W2059022155","https://openalex.org/W2059512273","https://openalex.org/W2059629870","https://openalex.org/W2059775409","https://openalex.org/W2060745709","https://openalex.org/W2062515748","https://openalex.org/W2065541106","https://openalex.org/W2069528022","https://openalex.org/W2070063902","https://openalex.org/W2070517674","https://openalex.org/W2072767726","https://openalex.org/W2075196606","https://openalex.org/W2076708628","https://openalex.org/W2078117827","https://openalex.org/W2079200056","https://openalex.org/W2083116747","https://openalex.org/W2083190965","https://openalex.org/W2083637886","https://openalex.org/W2086409100","https://openalex.org/W2088108125","https://openalex.org/W2091948921","https://openalex.org/W2094262605","https://openalex.org/W2095938777","https://openalex.org/W2096564814","https://openalex.org/W2097257117","https://openalex.org/W2101491452","https://openalex.org/W2103303116","https://openalex.org/W2103945127","https://openalex.org/W2106107456","https://openalex.org/W2106711282","https://openalex.org/W2109177164","https://openalex.org/W2113340104","https://openalex.org/W2114309748","https://openalex.org/W2114372930","https://openalex.org/W2115522384","https://openalex.org/W2115596685","https://openalex.org/W2122085108","https://openalex.org/W2124542765","https://openalex.org/W2127396817","https://openalex.org/W2128059069","https://openalex.org/W2136996289","https://openalex.org/W2137591192","https://openalex.org/W2139989191","https://openalex.org/W2143098590","https://openalex.org/W2148382170","https://openalex.org/W2148701785","https://openalex.org/W2148823426","https://openalex.org/W2151492782","https://openalex.org/W2154287224","https://openalex.org/W2159323221","https://openalex.org/W2163725334","https://openalex.org/W2164533721","https://openalex.org/W2164952534","https://openalex.org/W2165053324","https://openalex.org/W2167092665","https://openalex.org/W2171100097","https://openalex.org/W2316602758","https://openalex.org/W2339275496","https://openalex.org/W2419553397"],"related_works":["https://openalex.org/W4362685431","https://openalex.org/W4250043560","https://openalex.org/W2793233446","https://openalex.org/W2078187034","https://openalex.org/W2920227719","https://openalex.org/W4409882351","https://openalex.org/W3001412304","https://openalex.org/W4382753331","https://openalex.org/W2909940446","https://openalex.org/W4409504925"],"abstract_inverted_index":{"In":[0],"the":[1,22,37,64],"past":[2],"decade,":[3],"research":[4],"in":[5,49],"genetic":[6],"disorders":[7,54],"of":[8,15,27,36,39,43,67],"hypophosphatemia":[9,19],"has":[10],"significantly":[11],"expanded":[12],"our":[13],"understanding":[14,35],"phosphate":[16,32],"metabolism.":[17],"X-linked":[18],"(XLH)":[20],"is":[21],"most":[23],"common":[24],"inherited":[25],"form":[26],"rickets":[28],"due":[29],"to":[30],"renal":[31],"wasting.":[33],"Recent":[34],"mechanisms":[38],"disease":[40],"and":[41,51],"role":[42],"fibroblast":[44],"growth":[45],"factor":[46],"23":[47],"(FGF-23)":[48],"XLH":[50,70],"other":[52],"hypophosphatemic":[53],"have":[55],"opened":[56],"new":[57],"potential":[58],"therapeutic":[59],"avenues.":[60],"We":[61],"will":[62],"discuss":[63],"current":[65],"standard":[66],"treatment":[68],"for":[69],"as":[71,73],"well":[72],"promising":[74],"future":[75],"directions":[76],"under":[77],"study.":[78]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}