{"id":"https://openalex.org/W1017327681","doi":null,"title":"K6W Mutant Ubiquitin Activates Calpain in Lens","display_name":"K6W Mutant Ubiquitin Activates Calpain in Lens","publication_year":2012,"publication_date":"2012-03-26","ids":{"openalex":"https://openalex.org/W1017327681","mag":"1017327681"},"language":"en","primary_location":{"id":"mag:1017327681","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2359292","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100349852","display_name":"Ke Liu","orcid":"https://orcid.org/0000-0002-4683-9325","observed_orcids":["https://orcid.org/0000-0002-4683-9325"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ke Liu","raw_affiliation_strings":["Human Nutrition Rsrch Ctr on Aging, Tufts University, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Nutrition Rsrch Ctr on Aging, Tufts University, Boston, Massachusetts","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110153127","display_name":"Andrea Caceres","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Caceres","raw_affiliation_strings":["Human Nutrition Rsrch Ctr on Aging, Tufts University, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Nutrition Rsrch Ctr on Aging, Tufts University, Boston, Massachusetts","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005061089","display_name":"Junmin Peng","orcid":"https://orcid.org/0000-0003-0472-7648","observed_orcids":["https://orcid.org/0000-0003-0472-7648","https://orcid.org/0000-0002-4043-8475"]},"institutions":[{"id":"https://openalex.org/I1313298211","display_name":"St. Jude Children's Research Hospital","ror":"https://ror.org/02r3e0967","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1313298211","https://openalex.org/I2802152183"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junmin Peng","raw_affiliation_strings":["Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee"],"raw_orcid":"https://orcid.org/0000-0003-0472-7648","affiliations":[{"raw_affiliation_string":"Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee","institution_ids":["https://openalex.org/I1313298211"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108368141","display_name":"Fu Shang","orcid":"https://orcid.org/0000-0003-0674-6367","observed_orcids":["https://orcid.org/0000-0003-0674-6367"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fu Shang","raw_affiliation_strings":["Human Nutrition Rsrch Ctr on Aging, Tufts University, Boston, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0003-0674-6367","affiliations":[{"raw_affiliation_string":"Human Nutrition Rsrch Ctr on Aging, Tufts University, Boston, Massachusetts","institution_ids":["https://openalex.org/I121934306"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024843689","display_name":"Junyuan Gao","orcid":"https://orcid.org/0000-0002-6108-336X","observed_orcids":["https://orcid.org/0000-0002-6108-336X"]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Junyuan Gao","raw_affiliation_strings":["Physiology & Biophysics, State Univ of NY-Stony Brook, Stony Brook, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology & Biophysics, State Univ of NY-Stony Brook, Stony Brook, New York","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101107016","display_name":"Xiurong Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiurong Sun","raw_affiliation_strings":["Physiology & Biophysics, State Univ of NY-Stony Brook, Stony Brook, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology & Biophysics, State Univ of NY-Stony Brook, Stony Brook, New York","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031408337","display_name":"Richard T. Mathias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59553526","display_name":"Stony Brook University","ror":"https://ror.org/05qghxh33","country_code":"US","type":"education","lineage":["https://openalex.org/I59553526"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard T. Mathias","raw_affiliation_strings":["Physiology & Biophysics, State Univ of NY-Stony Brook, Stony Brook, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Physiology & Biophysics, State Univ of NY-Stony Brook, Stony Brook, New York","institution_ids":["https://openalex.org/I59553526"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068775517","display_name":"Allen Taylor","orcid":"https://orcid.org/0000-0002-2581-1825","observed_orcids":["https://orcid.org/0000-0002-2581-1825"]},"institutions":[{"id":"https://openalex.org/I121934306","display_name":"Tufts University","ror":"https://ror.org/05wvpxv85","country_code":"US","type":"education","lineage":["https://openalex.org/I121934306"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Allen Taylor","raw_affiliation_strings":["Human Nutrition Rsrch Ctr on Aging, Tufts University, Boston, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Nutrition Rsrch Ctr on Aging, Tufts University, Boston, Massachusetts","institution_ids":["https://openalex.org/I121934306"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0547554,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"53","issue":"14","first_page":"5593","last_page":"5593"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13637","display_name":"Calpain Protease Function and Regulation","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13637","display_name":"Calpain Protease Function and Regulation","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11041","display_name":"Ubiquitin and proteasome pathways","score":0.00570000009611249,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calpain-activation","display_name":"calpain activation","score":0.9240000247955322},{"id":"https://openalex.org/keywords/lens","display_name":"lens","score":0.6190000176429749},{"id":"https://openalex.org/keywords/ubiquitin","display_name":"ubiquitin","score":0.46700000762939453},{"id":"https://openalex.org/keywords/proteasome","display_name":"proteasome","score":0.5669999718666077},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"protein degradation","score":0.3370000123977661}],"concepts":[{"id":"https://openalex.org/C56928146","wikidata":"https://www.wikidata.org/wiki/Q2934402","display_name":"Calpain","level":3,"score":0.8275929689407349},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6663587689399719},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.6611810922622681},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5905073285102844},{"id":"https://openalex.org/C15336307","wikidata":"https://www.wikidata.org/wiki/Q1766051","display_name":"Lens (geology)","level":2,"score":0.5108792185783386},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45465943217277527},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20967096090316772},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1367989182472229},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.027958065271377563},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1017327681","doi":null,"is_oa":false,"landing_page_url":"https://iovs.arvojournals.org/article.aspx?articleid=2359292","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Investigative Ophthalmology & Visual Science","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1133374310","https://openalex.org/W3170843170","https://openalex.org/W2078520364","https://openalex.org/W2992317082","https://openalex.org/W1413355711","https://openalex.org/W1198720930","https://openalex.org/W944118998","https://openalex.org/W2316134709","https://openalex.org/W977122704","https://openalex.org/W1149035070"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}