{"id":"https://openalex.org/W101527","doi":null,"title":"Proconvulsant effect of ketotifen, a histamine H1 antagonist, confirmed by the use of d-chlorpheniramine with monitoring electroencephalography.","display_name":"Proconvulsant effect of ketotifen, a histamine H1 antagonist, confirmed by the use of d-chlorpheniramine with monitoring electroencephalography.","publication_year":1993,"publication_date":"1993-04-01","ids":{"openalex":"https://openalex.org/W101527","mag":"101527","pmid":"https://pubmed.ncbi.nlm.nih.gov/8101246"},"language":"en","primary_location":{"id":"pmid:8101246","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8101246","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods and findings in experimental and clinical pharmacology","raw_type":"Case Reports"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"H Yokoyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H Yokoyama","raw_affiliation_strings":["Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Tohoku University School of Medicine, Sendai, Japan","institution_ids":["https://openalex.org/I201537933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113822991","display_name":"Kazuie Iinuma","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Iinuma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"K Yanai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Yanai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113527764","display_name":"T. Watanabe","orcid":"https://orcid.org/0000-0002-1351-8162","observed_orcids":["https://orcid.org/0000-0002-1351-8162"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Watanabe","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039321131","display_name":"Eiichi Sakurai","orcid":"https://orcid.org/0000-0002-4210-9915","observed_orcids":["https://orcid.org/0000-0002-4210-9915"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"E Sakurai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111771647","display_name":"K Onodera","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K Onodera","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4987,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.80688913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"15","issue":"3","first_page":"183","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10094","display_name":"Epilepsy research and treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ketotifen","display_name":"ketotifen","score":1.0},{"id":"https://openalex.org/keywords/proconvulsant-effects","display_name":"proconvulsant effects","score":0.8799999952316284},{"id":"https://openalex.org/keywords/histamine-h1-receptor-antagonists","display_name":"histamine H1 receptor antagonists","score":0.953000009059906},{"id":"https://openalex.org/keywords/secondary-generalized-epilepsy","display_name":"secondary generalized epilepsy","score":0.8889999985694885},{"id":"https://openalex.org/keywords/seizures","display_name":"seizures","score":0.5410000085830688},{"id":"https://openalex.org/keywords/epileptic-discharges","display_name":"epileptic discharges","score":0.8399999737739563},{"id":"https://openalex.org/keywords/electroencephalography","display_name":"EEG","score":0.7889999747276306},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":0.6819999814033508},{"id":"https://openalex.org/keywords/allergic-rhinitis","display_name":"allergic rhinitis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/plasma-norepinephrine","display_name":"plasma norepinephrine","score":0.8270000219345093},{"id":"https://openalex.org/keywords/plasma-dopamine","display_name":"plasma dopamine","score":0.9440000057220459},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.4959999918937683}],"concepts":[{"id":"https://openalex.org/C2780571441","wikidata":"https://www.wikidata.org/wiki/Q2458673","display_name":"Ketotifen","level":3,"score":0.9255556464195251},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.8614001274108887},{"id":"https://openalex.org/C10335311","wikidata":"https://www.wikidata.org/wiki/Q309513","display_name":"Histamine H1 receptor","level":4,"score":0.6904991865158081},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.5364831686019897},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.46703195571899414},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.46216297149658203},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43444278836250305},{"id":"https://openalex.org/C2776880894","wikidata":"https://www.wikidata.org/wiki/Q324089","display_name":"Antihistamine","level":2,"score":0.42948171496391296},{"id":"https://openalex.org/C2909530563","wikidata":"https://www.wikidata.org/wiki/Q1328275","display_name":"Histamine H1 Antagonists","level":3,"score":0.4107241928577423},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.27116745710372925},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22059011459350586},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002744","descriptor_name":"Chlorpheniramine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D002744","descriptor_name":"Chlorpheniramine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004569","descriptor_name":"Electroencephalography","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004828","descriptor_name":"Epilepsies, Partial","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D004828","descriptor_name":"Epilepsies, Partial","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004837","descriptor_name":"Epinephrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006255","descriptor_name":"Rhinitis, Allergic, Seasonal","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006634","descriptor_name":"Histamine H1 Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007665","descriptor_name":"Ketotifen","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D007665","descriptor_name":"Ketotifen","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8101246","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8101246","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods and findings in experimental and clinical pharmacology","raw_type":"Case Reports"},{"id":"mag:101527","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8101246","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W4301197248"],"related_works":["https://openalex.org/W2060370653","https://openalex.org/W1219185136","https://openalex.org/W1972473041","https://openalex.org/W1990407420","https://openalex.org/W2098877728","https://openalex.org/W2172161883","https://openalex.org/W2048102171","https://openalex.org/W2053641545","https://openalex.org/W2089340689","https://openalex.org/W2358631735"],"abstract_inverted_index":{"Ketotifen":[0],"produced":[1,72],"seizures":[2,19],"in":[3,44,112,128,132],"a":[4],"5-year-old":[5],"boy":[6],"with":[7,30,48,62],"secondary":[8],"generalized":[9],"epilepsy":[10],"(SGE)":[11],"and":[12,54,74,100],"allergic":[13],"rhinitis.":[14],"To":[15],"confirm":[16],"that":[17,67,86,104,120],"the":[18,39,45,113],"were":[20,57],"due":[21],"to":[22],"histamine":[23,68,87,95,105,122],"H1":[24,69,96,106,123],"receptors":[25,70],"blockade,":[26],"d-chlorpheniramine":[27,36],"was":[28],"administered":[29],"monitoring":[31],"electroencephalography":[32],"(EEG).":[33],"Administration":[34],"of":[35,41,134],"significantly":[37],"increased":[38,75],"number":[40],"epileptic":[42,76,129],"discharges":[43,77],"patient,":[46],"compared":[47],"those":[49],"before":[50],"administration.":[51],"Plasma":[52],"noradrenaline":[53],"dopamine":[55],"levels":[56],"not":[58],"affected":[59],"by":[60],"treatment":[61],"d-chlorpheniramine.":[63],"These":[64],"findings":[65,99],"indicate":[66],"blockade":[71],"convulsions":[73,93],"on":[78,92],"EEG.":[79],"Recently,":[80],"several":[81],"experimental":[82],"reports":[83],"have":[84,108],"shown":[85],"has":[88],"an":[89],"inhibitory":[90],"role":[91],"through":[94],"receptors.":[97],"Experimental":[98],"present":[101],"results":[102],"show":[103],"antagonists":[107,124],"proconvulsant":[109],"effects,":[110],"especially":[111,131],"developmental":[114],"period.":[115],"Thus,":[116],"it":[117],"is":[118],"recommended":[119],"centrally-acting":[121],"should":[125],"be":[126],"avoided":[127],"patients,":[130],"children":[133],"pre-school":[135],"age.":[136]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
