{"id":"https://openalex.org/W1014831390","doi":null,"title":"Quantitative studies on the numerical frequency of myonuclei in the muscles of exercised rats: evidence against the occurrence of fibre-splitting.","display_name":"Quantitative studies on the numerical frequency of myonuclei in the muscles of exercised rats: evidence against the occurrence of fibre-splitting.","publication_year":1981,"publication_date":"1981-12-01","ids":{"openalex":"https://openalex.org/W1014831390","mag":"1014831390","pmid":"https://pubmed.ncbi.nlm.nih.gov/7326216","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2041721"},"language":"en","primary_location":{"id":"pmid:7326216","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7326216","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of experimental pathology","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2041721/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108880623","display_name":"N.T. James","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N T James","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5058842022","display_name":"M. \u010cabri\u0107","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M Cabric","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"62","issue":"6","first_page":"600","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9887999892234802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11209","display_name":"Cardiovascular and exercise physiology","score":0.004000000189989805,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11585","display_name":"Exercise and Physiological Responses","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/myonuclei","display_name":"myonuclei","score":0.6869999766349792},{"id":"https://openalex.org/keywords/fiber-splitting","display_name":"fiber splitting","score":0.9210000038146973},{"id":"https://openalex.org/keywords/satellite-cells","display_name":"satellite cells","score":0.8019999861717224},{"id":"https://openalex.org/keywords/exercise-induced-hypertrophy","display_name":"exercise-induced hypertrophy","score":0.8109999895095825},{"id":"https://openalex.org/keywords/extensor-digitorum-longus","display_name":"extensor digitorum longus","score":0.8270000219345093},{"id":"https://openalex.org/keywords/swimming-training","display_name":"swimming training","score":0.824999988079071},{"id":"https://openalex.org/keywords/capillary-density","display_name":"capillary density","score":0.8220000267028809},{"id":"https://openalex.org/keywords/nuclear-volume","display_name":"nuclear volume","score":0.9350000023841858},{"id":"https://openalex.org/keywords/muscle-fiber-cross-sectional-area","display_name":"muscle fiber cross-sectional area","score":0.7870000004768372},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.656000018119812}],"concepts":[{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.6026878952980042},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.5863484144210815},{"id":"https://openalex.org/C3017897630","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Muscle fibre","level":3,"score":0.56081223487854},{"id":"https://openalex.org/C20556612","wikidata":"https://www.wikidata.org/wiki/Q4469374","display_name":"Volume (thermodynamics)","level":2,"score":0.4508490562438965},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4234640896320343},{"id":"https://openalex.org/C3017597547","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell size","level":2,"score":0.4111970067024231},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3538912236690521},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32089218497276306},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30597370862960815},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.211482971906662},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17146643996238708},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.08005231618881226},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.05795595049858093},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002196","descriptor_name":"Capillaries","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005082","descriptor_name":"Physical Exertion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006984","descriptor_name":"Hypertrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009132","descriptor_name":"Muscles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D013550","descriptor_name":"Swimming","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:7326216","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7326216","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of experimental pathology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2041721","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2041721/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Exp Pathol","raw_type":"Text"},{"id":"mag:1014831390","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7326216","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2041721","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2041721/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Exp Pathol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6553999781608582,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W119210054","https://openalex.org/W268994810","https://openalex.org/W269719549","https://openalex.org/W1804495246","https://openalex.org/W1968744214","https://openalex.org/W1973193068","https://openalex.org/W1985050677","https://openalex.org/W1996684720","https://openalex.org/W2005210803","https://openalex.org/W2006047089","https://openalex.org/W2046468365","https://openalex.org/W2047458364","https://openalex.org/W2059828371","https://openalex.org/W2064499617","https://openalex.org/W2071778059","https://openalex.org/W2087803244","https://openalex.org/W2088871098","https://openalex.org/W2089889195","https://openalex.org/W2100413744","https://openalex.org/W2288824416","https://openalex.org/W2399703408","https://openalex.org/W2436352411","https://openalex.org/W2883288666"],"related_works":["https://openalex.org/W2022338902","https://openalex.org/W3038003578","https://openalex.org/W1969955679","https://openalex.org/W4301442481","https://openalex.org/W3026925098","https://openalex.org/W1973193068","https://openalex.org/W2124519680","https://openalex.org/W7096135828","https://openalex.org/W2009641135","https://openalex.org/W2088871098"],"abstract_inverted_index":{"The":[0,71],"histological":[1],"changes":[2,108],"associated":[3],"with":[4],"exercise-induced":[5],"muscular":[6],"hypertrophy":[7],"have":[8,47,147],"variously":[9],"been":[10],"interpreted":[11],"as":[12],"due":[13,20],"to":[14,21,63,123,131,146,165],"fibre-splitting":[15,134],"or":[16],"satellite-cell":[17,161],"activity.":[18],"If":[19],"fibre-splitting,":[22],"than":[23],"a":[24],"marked":[25],"fall":[26],"in":[27,56,149],"the":[28,44,119,136,142,167],"number":[29,97],"of":[30,35,51,75,85,90,98,103,158],"nuclei":[31,99],"per":[32,87,100],"unit":[33,88,101],"volume":[34,89,102,113],"muscle":[36,76,91,104],"must":[37],"occur.":[38],"To":[39],"see":[40],"if":[41,133],"this":[42,140],"is":[43],"case,":[45],"we":[46],"examined":[48],"post-mortem":[49],"specimens":[50],"extensor":[52],"digitorum":[53],"longus":[54],"muscles":[55,120],"rats":[57],"exercised":[58],"by":[59,80,94,105,115],"swimming":[60],"for":[61,68],"up":[62],"30":[64],"min":[65],"twice":[66],"daily":[67],"35":[69],"days.":[70],"mean":[72,83],"cross-sectional":[73],"area":[74],"fibres":[77,143],"was":[78,92],"unaltered":[79],"exercise":[81,124],"but":[82],"length":[84],"capillary":[86],"increased":[93,114,148],"55%":[95],"and":[96,125,151],"30%,":[106],"both":[107],"being":[109],"significant.":[110],"Mean":[111],"nuclear":[112],"approximately":[116],"75%.":[117],"Thus":[118],"did":[121],"adapt":[122],"new":[126],"myonuclei":[127],"were":[128,135],"formed,":[129],"contrary":[130],"expectations":[132],"essential":[137],"change.":[138],"In":[139],"study":[141],"seemed":[144],"not":[145],"size":[150],"further":[152],"studies,":[153],"perhaps":[154],"using":[155],"autoradiographic":[156],"analysis":[157],"tritiated":[159],"thymidine-labelled":[160],"nuclei,":[162],"are":[163],"needed":[164],"clarify":[166],"precise":[168],"mechanisms":[169],"involved.":[170]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}