{"id":"https://openalex.org/W101366706","doi":"https://doi.org/10.1007/978-1-4614-4118-2_8","title":"The Effects of Selective Complement and CD14 Inhibition on the E. coli-Induced Tissue Factor mRNA Upregulation, Monocyte Tissue Factor Expression, and Tissue Factor Functional Activity in Human Whole Blood","display_name":"The Effects of Selective Complement and CD14 Inhibition on the E. coli-Induced Tissue Factor mRNA Upregulation, Monocyte Tissue Factor Expression, and Tissue Factor Functional Activity in Human Whole Blood","publication_year":2012,"publication_date":"2012-08-10","ids":{"openalex":"https://openalex.org/W101366706","doi":"https://doi.org/10.1007/978-1-4614-4118-2_8","mag":"101366706","pmid":"https://pubmed.ncbi.nlm.nih.gov/23402023"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4614-4118-2_8","doi":"https://doi.org/10.1007/978-1-4614-4118-2_8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4614-4118-2_8","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4237240638","display_name":"Complement Therapeutics"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038155398","display_name":"Ole\u2010Lars Brekke","orcid":"https://orcid.org/0000-0002-2323-0154","observed_orcids":["https://orcid.org/0000-0002-2323-0154"]},"institutions":[{"id":"https://openalex.org/I2801800136","display_name":"Nordland Hospital Trust","ror":"https://ror.org/04wjd1a07","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2801800136","https://openalex.org/I63903255"]},{"id":"https://openalex.org/I4210109413","display_name":"Nordland Hospital","ror":"https://ror.org/01pj4nt72","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210109413"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"O.-L. Brekke","raw_affiliation_strings":["Department of Laboratory Medicine, Nordland Hospital, Bod\u00f8, N-8092, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Nordland Hospital, Bod\u00f8, N-8092, Norway","institution_ids":["https://openalex.org/I2801800136","https://openalex.org/I4210109413"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074539478","display_name":"Christian Waage","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801800136","display_name":"Nordland Hospital Trust","ror":"https://ror.org/04wjd1a07","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2801800136","https://openalex.org/I63903255"]},{"id":"https://openalex.org/I4210109413","display_name":"Nordland Hospital","ror":"https://ror.org/01pj4nt72","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210109413"]},{"id":"https://openalex.org/I78037679","display_name":"UiT The Arctic University of Norway","ror":"https://ror.org/00wge5k78","country_code":"NO","type":"education","lineage":["https://openalex.org/I78037679"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"C. Waage","raw_affiliation_strings":["Department of Laboratory Medicine, Nordland Hospital, Bod\u00f8, N-8092, Norway","Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Nordland Hospital, Bod\u00f8, N-8092, Norway","institution_ids":["https://openalex.org/I2801800136","https://openalex.org/I4210109413"]},{"raw_affiliation_string":"Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway","institution_ids":["https://openalex.org/I78037679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009489606","display_name":"Dorte Christiansen","orcid":"https://orcid.org/0000-0002-7420-3762","observed_orcids":["https://orcid.org/0000-0002-7420-3762"]},"institutions":[{"id":"https://openalex.org/I2801800136","display_name":"Nordland Hospital Trust","ror":"https://ror.org/04wjd1a07","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2801800136","https://openalex.org/I63903255"]},{"id":"https://openalex.org/I4210109413","display_name":"Nordland Hospital","ror":"https://ror.org/01pj4nt72","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210109413"]},{"id":"https://openalex.org/I78037679","display_name":"UiT The Arctic University of Norway","ror":"https://ror.org/00wge5k78","country_code":"NO","type":"education","lineage":["https://openalex.org/I78037679"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"D. Christiansen","raw_affiliation_strings":["Department of Laboratory Medicine, Nordland Hospital, Bod\u00f8, N-8092, Norway","Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Nordland Hospital, Bod\u00f8, N-8092, Norway","institution_ids":["https://openalex.org/I2801800136","https://openalex.org/I4210109413"]},{"raw_affiliation_string":"Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway","institution_ids":["https://openalex.org/I78037679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070394757","display_name":"Hilde Fure","orcid":"https://orcid.org/0000-0002-3634-0969","observed_orcids":["https://orcid.org/0000-0002-3634-0969"]},"institutions":[{"id":"https://openalex.org/I2801800136","display_name":"Nordland Hospital Trust","ror":"https://ror.org/04wjd1a07","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2801800136","https://openalex.org/I63903255"]},{"id":"https://openalex.org/I4210109413","display_name":"Nordland Hospital","ror":"https://ror.org/01pj4nt72","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210109413"]},{"id":"https://openalex.org/I78037679","display_name":"UiT The Arctic University of Norway","ror":"https://ror.org/00wge5k78","country_code":"NO","type":"education","lineage":["https://openalex.org/I78037679"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"H. Fure","raw_affiliation_strings":["Department of Laboratory Medicine, Nordland Hospital, Bod\u00f8, N-8092, Norway","Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Nordland Hospital, Bod\u00f8, N-8092, Norway","institution_ids":["https://openalex.org/I2801800136","https://openalex.org/I4210109413"]},{"raw_affiliation_string":"Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway","institution_ids":["https://openalex.org/I78037679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079894417","display_name":"Hongchang Qu","orcid":"https://orcid.org/0000-0002-9835-3503","observed_orcids":["https://orcid.org/0000-0002-9835-3503"]},"institutions":[{"id":"https://openalex.org/I2801800136","display_name":"Nordland Hospital Trust","ror":"https://ror.org/04wjd1a07","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2801800136","https://openalex.org/I63903255"]},{"id":"https://openalex.org/I4210109413","display_name":"Nordland Hospital","ror":"https://ror.org/01pj4nt72","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210109413"]},{"id":"https://openalex.org/I78037679","display_name":"UiT The Arctic University of Norway","ror":"https://ror.org/00wge5k78","country_code":"NO","type":"education","lineage":["https://openalex.org/I78037679"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"H. Qu","raw_affiliation_strings":["Department of Laboratory Medicine, Nordland Hospital, Bod\u00f8, N-8092, Norway","Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Nordland Hospital, Bod\u00f8, N-8092, Norway","institution_ids":["https://openalex.org/I2801800136","https://openalex.org/I4210109413"]},{"raw_affiliation_string":"Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway","institution_ids":["https://openalex.org/I78037679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074301183","display_name":"John D. Lambris","orcid":"https://orcid.org/0000-0002-9370-5776","observed_orcids":["https://orcid.org/0000-0002-9370-5776"]},"institutions":[{"id":"https://openalex.org/I2801800136","display_name":"Nordland Hospital Trust","ror":"https://ror.org/04wjd1a07","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2801800136","https://openalex.org/I63903255"]},{"id":"https://openalex.org/I4210109413","display_name":"Nordland Hospital","ror":"https://ror.org/01pj4nt72","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210109413"]},{"id":"https://openalex.org/I78037679","display_name":"UiT The Arctic University of Norway","ror":"https://ror.org/00wge5k78","country_code":"NO","type":"education","lineage":["https://openalex.org/I78037679"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"John D. Lambris","raw_affiliation_strings":["Department of Laboratory Medicine, Nordland Hospital, Bod\u00f8, N-8092, Norway","Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Nordland Hospital, Bod\u00f8, N-8092, Norway","institution_ids":["https://openalex.org/I2801800136","https://openalex.org/I4210109413"]},{"raw_affiliation_string":"Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway","institution_ids":["https://openalex.org/I78037679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072812338","display_name":"Bjarne \u00d8sterud","orcid":"https://orcid.org/0000-0002-9321-2971","observed_orcids":["https://orcid.org/0000-0002-9321-2971"]},"institutions":[{"id":"https://openalex.org/I2801800136","display_name":"Nordland Hospital Trust","ror":"https://ror.org/04wjd1a07","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2801800136","https://openalex.org/I63903255"]},{"id":"https://openalex.org/I4210109413","display_name":"Nordland Hospital","ror":"https://ror.org/01pj4nt72","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210109413"]},{"id":"https://openalex.org/I78037679","display_name":"UiT The Arctic University of Norway","ror":"https://ror.org/00wge5k78","country_code":"NO","type":"education","lineage":["https://openalex.org/I78037679"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"B. \u00d8sterud","raw_affiliation_strings":["Department of Laboratory Medicine, Nordland Hospital, Bod\u00f8, N-8092, Norway","Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Nordland Hospital, Bod\u00f8, N-8092, Norway","institution_ids":["https://openalex.org/I2801800136","https://openalex.org/I4210109413"]},{"raw_affiliation_string":"Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway","institution_ids":["https://openalex.org/I78037679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082985622","display_name":"Erik Waage Nielsen","orcid":"https://orcid.org/0000-0002-8358-3226","observed_orcids":["https://orcid.org/0000-0002-8358-3226"]},"institutions":[{"id":"https://openalex.org/I2801800136","display_name":"Nordland Hospital Trust","ror":"https://ror.org/04wjd1a07","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2801800136","https://openalex.org/I63903255"]},{"id":"https://openalex.org/I4210109413","display_name":"Nordland Hospital","ror":"https://ror.org/01pj4nt72","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210109413"]},{"id":"https://openalex.org/I78037679","display_name":"UiT The Arctic University of Norway","ror":"https://ror.org/00wge5k78","country_code":"NO","type":"education","lineage":["https://openalex.org/I78037679"]}],"countries":["NO"],"is_corresponding":false,"raw_author_name":"E. W. Nielsen","raw_affiliation_strings":["Department of Laboratory Medicine, Nordland Hospital, Bod\u00f8, N-8092, Norway","Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Nordland Hospital, Bod\u00f8, N-8092, Norway","institution_ids":["https://openalex.org/I2801800136","https://openalex.org/I4210109413"]},{"raw_affiliation_string":"Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway","institution_ids":["https://openalex.org/I78037679"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034439136","display_name":"Tom Eirik Mollnes","orcid":"https://orcid.org/0000-0002-5785-802X","observed_orcids":["https://orcid.org/0000-0002-5785-802X"]},"institutions":[{"id":"https://openalex.org/I2801800136","display_name":"Nordland Hospital Trust","ror":"https://ror.org/04wjd1a07","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I2801800136","https://openalex.org/I63903255"]},{"id":"https://openalex.org/I4210109413","display_name":"Nordland Hospital","ror":"https://ror.org/01pj4nt72","country_code":"NO","type":"healthcare","lineage":["https://openalex.org/I4210109413"]},{"id":"https://openalex.org/I78037679","display_name":"UiT The Arctic University of Norway","ror":"https://ror.org/00wge5k78","country_code":"NO","type":"education","lineage":["https://openalex.org/I78037679"]}],"countries":["NO"],"is_corresponding":true,"raw_author_name":"T. E. Mollnes","raw_affiliation_strings":["Department of Laboratory Medicine, Nordland Hospital, Bod\u00f8, N-8092, Norway","Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Nordland Hospital, Bod\u00f8, N-8092, Norway","institution_ids":["https://openalex.org/I2801800136","https://openalex.org/I4210109413"]},{"raw_affiliation_string":"Institute of Medical Biology, University of Troms\u00f8, Troms\u00f8, Norway","institution_ids":["https://openalex.org/I78037679"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5034439136"],"corresponding_institution_ids":["https://openalex.org/I2801800136","https://openalex.org/I4210109413","https://openalex.org/I78037679"],"apc_list":null,"apc_paid":null,"fwci":5.092,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.94706262,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"735","issue":null,"first_page":"123","last_page":"136"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.9550999999046326,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.033799998462200165,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11917","display_name":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tissue-factor","display_name":"tissue factor","score":0.9739999771118164},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.7400000095367432},{"id":"https://openalex.org/keywords/cd14","display_name":"CD14","score":0.9950000047683716},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9480000138282776},{"id":"https://openalex.org/keywords/monocytes","display_name":"monocytes","score":0.8230000138282776},{"id":"https://openalex.org/keywords/compstatin","display_name":"compstatin","score":0.9549999833106995},{"id":"https://openalex.org/keywords/c5a-receptor-antagonist","display_name":"C5a receptor antagonist","score":0.9739999771118164},{"id":"https://openalex.org/keywords/c3-convertase-inhibition","display_name":"C3 convertase inhibition","score":0.800000011920929},{"id":"https://openalex.org/keywords/plasma-microparticles","display_name":"plasma microparticles","score":0.6629999876022339},{"id":"https://openalex.org/keywords/cytokine-expression","display_name":"cytokine expression","score":0.6489999890327454},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.4659999907016754},{"id":"https://openalex.org/keywords/whole-blood","display_name":"whole blood","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C186738567","wikidata":"https://www.wikidata.org/wiki/Q412841","display_name":"Tissue factor","level":3,"score":0.8744663000106812},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.7344096302986145},{"id":"https://openalex.org/C2778513237","wikidata":"https://www.wikidata.org/wiki/Q419553","display_name":"CD14","level":3,"score":0.7312936186790466},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.691999614238739},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.6044750809669495},{"id":"https://openalex.org/C179369057","wikidata":"https://www.wikidata.org/wiki/Q20970075","display_name":"Complement factor I","level":4,"score":0.5981673002243042},{"id":"https://openalex.org/C144594695","wikidata":"https://www.wikidata.org/wiki/Q6153218","display_name":"Thromboplastin","level":3,"score":0.46180054545402527},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.45894208550453186},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4444769322872162},{"id":"https://openalex.org/C14356644","wikidata":"https://www.wikidata.org/wiki/Q14911975","display_name":"Factor H","level":4,"score":0.41074037551879883},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4024893641471863},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.37670665979385376},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.22840014100074768},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2260735034942627},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17411646246910095},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15486526489257812},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.12361666560173035},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.10118880867958069},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0930030345916748}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005434","descriptor_name":"Flow Cytometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006629","descriptor_name":"Hirudins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009000","descriptor_name":"Monocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013925","descriptor_name":"Thromboplastin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D018950","descriptor_name":"Lipopolysaccharide Receptors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051056","descriptor_name":"Complement Inactivating Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-4614-4118-2_8","doi":"https://doi.org/10.1007/978-1-4614-4118-2_8","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4614-4118-2_8","pdf_url":null,"source":{"id":"https://openalex.org/S43790123","display_name":"Advances in experimental medicine and biology","issn_l":"0065-2598","issn":["0065-2598","2214-8019"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","ki-jl-1","medline","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"book series"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in Experimental Medicine and Biology","raw_type":"book-chapter"},{"id":"pmid:23402023","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23402023","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advances in experimental medicine and biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5471682281","display_name":"Complement in inflammatory diseases: mechanisms & therapeutic modulation","funder_award_id":"P01AI068730","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8049625842","display_name":"Design of Novel Complement Inhibitors","funder_award_id":"R01GM062134","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W1214608791","https://openalex.org/W1487188207","https://openalex.org/W1489377217","https://openalex.org/W1811402656","https://openalex.org/W1904977791","https://openalex.org/W1971115464","https://openalex.org/W1975979865","https://openalex.org/W1984264727","https://openalex.org/W1986843662","https://openalex.org/W1988926553","https://openalex.org/W1995261375","https://openalex.org/W1995911132","https://openalex.org/W2009399552","https://openalex.org/W2018000814","https://openalex.org/W2018550668","https://openalex.org/W2024242455","https://openalex.org/W2030144700","https://openalex.org/W2035315634","https://openalex.org/W2041896408","https://openalex.org/W2061813367","https://openalex.org/W2064626913","https://openalex.org/W2064653038","https://openalex.org/W2075296811","https://openalex.org/W2085229085","https://openalex.org/W2085783349","https://openalex.org/W2092141484","https://openalex.org/W2094837152","https://openalex.org/W2097802875","https://openalex.org/W2102809922","https://openalex.org/W2106089614","https://openalex.org/W2107269020","https://openalex.org/W2113542718","https://openalex.org/W2114602085","https://openalex.org/W2132616983","https://openalex.org/W2137469895","https://openalex.org/W2139367421","https://openalex.org/W2139789471","https://openalex.org/W2148613841","https://openalex.org/W2148904550","https://openalex.org/W2152936026","https://openalex.org/W2157217694","https://openalex.org/W2166870291","https://openalex.org/W2167870644","https://openalex.org/W2170157402","https://openalex.org/W2170921103","https://openalex.org/W2280035016","https://openalex.org/W4323873775"],"related_works":["https://openalex.org/W2150360809","https://openalex.org/W2060894546","https://openalex.org/W2119599585","https://openalex.org/W7095797598","https://openalex.org/W2092523881","https://openalex.org/W2069689815","https://openalex.org/W2080865322","https://openalex.org/W2901272827","https://openalex.org/W7098780263","https://openalex.org/W1973779939"],"abstract_inverted_index":null,"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}