{"id":"https://openalex.org/W1013575510","doi":null,"title":"Targeting insulin-like growth factor - I receptor in breast cancer","display_name":"Targeting insulin-like growth factor - I receptor in breast cancer","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W1013575510","mag":"1013575510"},"language":"en","primary_location":{"id":"pmh:oai:publications.rwth-aachen.de:82608","doi":null,"is_oa":true,"landing_page_url":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-142998%22","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aachen : Publikationsserver der RWTH Aachen University 142 S. : Ill., graph. Darst. (2011). = Aachen, Techn. Hochsch., Diss., 2010","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-142998%22","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077225386","display_name":"Beate C. Litzenburger","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Beate C. Litzenburger","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5041462448","display_name":"Bernhard L\u00fcscher","orcid":"https://orcid.org/0000-0002-9622-8709","observed_orcids":["https://orcid.org/0000-0002-9622-8709"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernhard L\u00fcscher","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9622-8709","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.9359999895095825},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9629999995231628},{"id":"https://openalex.org/keywords/triple-negative-breast-cancer","display_name":"triple-negative breast cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/bms-754807","display_name":"BMS-754807","score":0.9160000085830688},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.8799999952316284},{"id":"https://openalex.org/keywords/erbb2","display_name":"ERBB2","score":0.6880000233650208},{"id":"https://openalex.org/keywords/mammary-carcinogenesis","display_name":"mammary carcinogenesis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/combination-chemotherapy","display_name":"combination chemotherapy","score":0.5040000081062317},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.593999981880188},{"id":"https://openalex.org/keywords/patient-selection","display_name":"patient selection","score":0.3630000054836273},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6173416376113892},{"id":"https://openalex.org/C2780689927","wikidata":"https://www.wikidata.org/wiki/Q24766801","display_name":"Insulin-like growth factor","level":4,"score":0.5436538457870483},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4128195643424988},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.40760281682014465},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4045619070529938},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4013296365737915},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3924707770347595},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3344230353832245},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.29866331815719604}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:publications.rwth-aachen.de:82608","doi":null,"is_oa":true,"landing_page_url":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-142998%22","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aachen : Publikationsserver der RWTH Aachen University 142 S. : Ill., graph. Darst. (2011). = Aachen, Techn. Hochsch., Diss., 2010","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1013575510","doi":null,"is_oa":false,"landing_page_url":"http://publications.rwth-aachen.de/record/82608","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:publications.rwth-aachen.de:82608","doi":null,"is_oa":true,"landing_page_url":"https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-142998%22","pdf_url":null,"source":{"id":"https://openalex.org/S4306401362","display_name":"RWTH Publications (RWTH Aachen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I887968799","host_organization_name":"RWTH Aachen University","host_organization_lineage":["https://openalex.org/I887968799"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aachen : Publikationsserver der RWTH Aachen University 142 S. : Ill., graph. Darst. (2011). = Aachen, Techn. Hochsch., Diss., 2010","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":193,"referenced_works":["https://openalex.org/W62108804","https://openalex.org/W174147162","https://openalex.org/W1490236493","https://openalex.org/W1495654654","https://openalex.org/W1510554288","https://openalex.org/W1511429979","https://openalex.org/W1520332974","https://openalex.org/W1520969765","https://openalex.org/W1522008678","https://openalex.org/W1523335221","https://openalex.org/W1526859945","https://openalex.org/W1546709038","https://openalex.org/W1567404006","https://openalex.org/W1579214734","https://openalex.org/W1607134312","https://openalex.org/W1607267312","https://openalex.org/W1644299043","https://openalex.org/W1708068686","https://openalex.org/W1812227581","https://openalex.org/W1942063438","https://openalex.org/W1964321121","https://openalex.org/W1964652533","https://openalex.org/W1966063402","https://openalex.org/W1968154499","https://openalex.org/W1969920944","https://openalex.org/W1970215626","https://openalex.org/W1971439306","https://openalex.org/W1973713507","https://openalex.org/W1976858193","https://openalex.org/W1979440527","https://openalex.org/W1982093899","https://openalex.org/W1984045427","https://openalex.org/W1985407304","https://openalex.org/W1986018943","https://openalex.org/W1986331836","https://openalex.org/W1987506819","https://openalex.org/W1988737162","https://openalex.org/W1989891233","https://openalex.org/W1991527725","https://openalex.org/W1993199678","https://openalex.org/W1995758629","https://openalex.org/W1997006452","https://openalex.org/W1997367417","https://openalex.org/W1998534698","https://openalex.org/W1998961381","https://openalex.org/W1999030960","https://openalex.org/W2001219721","https://openalex.org/W2001392617","https://openalex.org/W2001447115","https://openalex.org/W2003583183","https://openalex.org/W2009218955","https://openalex.org/W2010867675","https://openalex.org/W2011243429","https://openalex.org/W2011870229","https://openalex.org/W2012211657","https://openalex.org/W2012940389","https://openalex.org/W2020372547","https://openalex.org/W2021942056","https://openalex.org/W2022030433","https://openalex.org/W2023316892","https://openalex.org/W2023427658","https://openalex.org/W2025220707","https://openalex.org/W2027817398","https://openalex.org/W2030183362","https://openalex.org/W2030656376","https://openalex.org/W2033595975","https://openalex.org/W2035317074","https://openalex.org/W2035706870","https://openalex.org/W2038239984","https://openalex.org/W2038437697","https://openalex.org/W2040914220","https://openalex.org/W2041653037","https://openalex.org/W2042854276","https://openalex.org/W2043128103","https://openalex.org/W2043757927","https://openalex.org/W2045066549","https://openalex.org/W2045324973","https://openalex.org/W2049419857","https://openalex.org/W2049533803","https://openalex.org/W2049951346","https://openalex.org/W2050389304","https://openalex.org/W2054140940","https://openalex.org/W2055498399","https://openalex.org/W2057092446","https://openalex.org/W2057418848","https://openalex.org/W2057446208","https://openalex.org/W2059170159","https://openalex.org/W2059815171","https://openalex.org/W2061054148","https://openalex.org/W2065351002","https://openalex.org/W2072772580","https://openalex.org/W2073378157","https://openalex.org/W2077532475","https://openalex.org/W2078071018","https://openalex.org/W2078172132","https://openalex.org/W2079894826","https://openalex.org/W2080503494","https://openalex.org/W2082292567","https://openalex.org/W2082318061","https://openalex.org/W2082562584","https://openalex.org/W2083286739","https://openalex.org/W2086606630","https://openalex.org/W2087729478","https://openalex.org/W2088227103","https://openalex.org/W2089171551","https://openalex.org/W2090908515","https://openalex.org/W2092294060","https://openalex.org/W2092407402","https://openalex.org/W2093221289","https://openalex.org/W2095156669","https://openalex.org/W2098544382","https://openalex.org/W2099063182","https://openalex.org/W2100401891","https://openalex.org/W2100937050","https://openalex.org/W2101995865","https://openalex.org/W2102979193","https://openalex.org/W2103245406","https://openalex.org/W2104248574","https://openalex.org/W2104462810","https://openalex.org/W2105095453","https://openalex.org/W2105253259","https://openalex.org/W2106213925","https://openalex.org/W2106321700","https://openalex.org/W2107277218","https://openalex.org/W2109276980","https://openalex.org/W2110444464","https://openalex.org/W2111909938","https://openalex.org/W2111941775","https://openalex.org/W2112277449","https://openalex.org/W2112474467","https://openalex.org/W2115759102","https://openalex.org/W2116323570","https://openalex.org/W2117237148","https://openalex.org/W2117787937","https://openalex.org/W2118699549","https://openalex.org/W2120512382","https://openalex.org/W2125420434","https://openalex.org/W2125652724","https://openalex.org/W2126041479","https://openalex.org/W2127006469","https://openalex.org/W2127617517","https://openalex.org/W2127930765","https://openalex.org/W2128746359","https://openalex.org/W2131994307","https://openalex.org/W2133215155","https://openalex.org/W2135736714","https://openalex.org/W2136137911","https://openalex.org/W2137340845","https://openalex.org/W2137597433","https://openalex.org/W2137772140","https://openalex.org/W2137915125","https://openalex.org/W2138403978","https://openalex.org/W2141393790","https://openalex.org/W2142739240","https://openalex.org/W2145355816","https://openalex.org/W2147094816","https://openalex.org/W2147357059","https://openalex.org/W2147909933","https://openalex.org/W2148335711","https://openalex.org/W2150671673","https://openalex.org/W2151078130","https://openalex.org/W2151386025","https://openalex.org/W2151444534","https://openalex.org/W2152274262","https://openalex.org/W2152525323","https://openalex.org/W2152578842","https://openalex.org/W2153731513","https://openalex.org/W2154946742","https://openalex.org/W2156394189","https://openalex.org/W2157840751","https://openalex.org/W2159121906","https://openalex.org/W2159459001","https://openalex.org/W2159640574","https://openalex.org/W2159686118","https://openalex.org/W2163563958","https://openalex.org/W2164569674","https://openalex.org/W2166125678","https://openalex.org/W2167156722","https://openalex.org/W2168025217","https://openalex.org/W2170209876","https://openalex.org/W2170245737","https://openalex.org/W2170992136","https://openalex.org/W2171972386","https://openalex.org/W2176931134","https://openalex.org/W2201435537","https://openalex.org/W2310990282","https://openalex.org/W2318605753","https://openalex.org/W2320643989","https://openalex.org/W2329798361","https://openalex.org/W2395886511","https://openalex.org/W2401754340","https://openalex.org/W3140002906","https://openalex.org/W4244421856"],"related_works":["https://openalex.org/W2161415513","https://openalex.org/W2319746454","https://openalex.org/W248893012","https://openalex.org/W1539800777","https://openalex.org/W2321465684","https://openalex.org/W2493347646","https://openalex.org/W2059239345","https://openalex.org/W2084668808","https://openalex.org/W2322774327","https://openalex.org/W2156402569"],"abstract_inverted_index":{"Insulin-like":[0],"growth":[1,291],"factor-I":[2],"receptor":[3,554],"(IGF-IR)":[4],"is":[5,54,106,147,340,463,623,701],"integral":[6,49],"to":[7,17,55,62,175,188,325,512,540,657,692,698],"cancer":[8,111,660,712],"cell":[9,152,170,208,346,518,570],"proliferation,":[10,312],"survival,":[11],"migration,":[12],"and":[13,15,40,140,182,206,229,250,266,269,293,315,354,365,385,393,421,444,458,487,522,589,604,627,677],"invasion,":[14],"resistance":[16],"anti-cancer":[18],"therapies":[19],"in":[20,89,108,134,150,160,234,247,279,294,329,333,342,344,367,370,451,472,481,494,499,507,572,584,625,639,644,661,675],"many":[21,248],"human":[22,136,239],"malignancies":[23],"including":[24],"breast":[25,90,137,164,679,711],"cancer.":[26,91,680],"Within":[27],"the":[28,48,104,129,145,191,203,232,252,258,466,473,500,505,513,552,557,600,620],"last":[29],"few":[30],"years":[31],"several":[32,235],"drugs":[33],"targeting":[34],"IGF-IR":[35,158,177,233,267,338,353,364,471,521,621,631,653],"have":[36,528,617,650],"entered":[37],"clinical":[38,670],"trials":[39],"are":[41,59,597],"showing":[42],"promising":[43],"early":[44],"results.":[45],"One":[46],"of":[47,51,163,190,231,261,376,441,470,476,515,548,559,567,577,586,591,630,672,706],"goals":[50],"my":[52],"thesis":[53],"identify":[56,693],"patients":[57,334,687],"who":[58],"most":[60,204],"likely":[61],"benefit":[63],"from":[64,455,686],"therapy.":[65,699],"The":[66,123],"Lee":[67,124],"Laboratory":[68],"previously":[69],"reported":[70,127],"an":[71,176,273,350],"IGF":[72,98,130,192,263],"gene":[73,193,199],"expression":[74,189,200,268,469],"signature,":[75],"based":[76],"upon":[77],"genes":[78,214],"induced":[79],"or":[80,115,543],"repressed":[81],"by":[82,520],"IGF-I,":[83],"which":[84,215,256],"correlated":[85,187],"with":[86,118,196,284,296,310,331,335,465,641,655,689],"poor":[87],"prognosis":[88],"Confirming":[92],"that":[93,103,128,144,168,183,409,468,504,619,628,652,695,703],"this":[94,161,223,609],"signature":[95,105,131,146,264],"can":[96],"measure":[97],"activity,":[99,270],"I":[100,141,166,243,372,616,649],"report":[101],"here":[102,143],"reversed":[107],"three":[109,119],"different":[110,120,516],"models":[112,375],"(cell":[113],"lines":[114,171,209],"xenografts)":[116],"treated":[117,283,688],"anti-IGF-IR":[121,274,327,673,707],"therapies.":[122],"laboratory":[125],"originally":[126],"was":[132,185,304,308],"present":[133,149],"triple-negative":[135],"cancers":[138],"(TNBC),":[139],"found":[142,167,244,651],"similarly":[148],"TNBC":[151,169,217,240,253,626,676],"lines.":[153],"Supporting":[154],"a":[155,287,321,426,495,530,560,633,667],"role":[156],"for":[157,271,669],"signaling":[159],"subtype":[162],"cancer,":[165],"were":[172,412,417,448],"especially":[173],"sensitive":[174,207],"tyrosine":[178,275,636],"kinase":[179,276,637],"inhibitor":[180,277,638],"(BMS-754807),":[181],"sensitivity":[184],"significantly":[186,398],"signature.":[194],"Consistent":[195],"this,":[197,526],"comparative":[198],"analysis":[201,407],"among":[202],"resistant":[205],"identified":[210,216],"114":[211],"differentially":[212],"expressed":[213],"as":[218,286,358,538],"being":[219],"sensitive.":[220],"To":[221,360,524],"examine":[222,361,684],"association":[224],"further":[225],"we":[226,527],"determined":[227],"levels":[228,260],"activity":[230,246,339],"recently":[236],"developed":[237,395,529],"primary":[238],"tumorgraft":[241],"models.":[242],"high":[245],"models,":[249],"chose":[251],"model":[254,532],"MC1,":[255],"had":[257],"highest":[259],"both":[262,391,429],"score":[265],"testing":[272],"(BMS-754807)":[278],"vivo.":[280,573,662],"MC1":[281],"tumorgrafts":[282],"BMS-754807":[285],"single":[288],"agent":[289],"showed":[290,408,425],"inhibition,":[292],"combination":[295,330,640],"chemotherapy":[297,332,642],"tumor":[298,303,432,508,645],"regression":[299,307],"occurred":[300],"until":[301],"no":[302],"palpable.":[305],"This":[306,461,563],"associated":[309],"reduced":[311],"increased":[313],"apoptosis,":[314],"mitotic":[316],"catastrophe.":[317],"These":[318,663],"data":[319,462],"provide":[320,666],"clear":[322],"biological":[323],"rationale":[324,668],"test":[326],"therapy":[328,674,708],"TNBC.":[336],"While":[337],"elevated":[341],"TNBC,":[343],"vitro":[345],"culture":[347],"evidence":[348],"suggests":[349],"interaction":[351],"between":[352,363,602],"ErbB2":[355,366,394,410,544,656],"(otherwise":[356],"known":[357],"HER2).":[359],"crosstalk":[362],"mammary":[368,378,396,452,474,546,569,593,606,659],"tumorigenesis":[369,607],"vivo,":[371],"used":[373],"two":[374,664],"mouse":[377,531],"tumorigenesis,":[379],"MMTV-CD8-IGF-IR":[380,456],"(a":[381],"constitutively":[382],"active":[383,624],"IGF-IR)":[384],"MMTV-ErbB2.":[386],"Bi-transgenic":[387],"(bigenic)":[388],"mice":[389,401,457,478,550,582],"expressing":[390,402,485,490,551],"CD8-IGF-IR":[392,415,542,603],"tumors":[397,411,416,424,453],"faster":[399],"than":[400],"either":[403],"transgene":[404],"alone.":[405],"Histological":[406],"predominantly":[413],"adenocarcinomas,":[414],"mixed":[418,496],"adenosquamous":[419],"carcinomas,":[420],"interestingly,":[422],"bigenic":[423,459],"phenotype":[427],"resembling":[428],"oncogenes.":[430],"All":[431],"types":[433,519,571],"contained":[434],"CK8-positive":[435],"luminal":[436],"epithelial":[437],"cells.":[438],"Interestingly,":[439],"markers":[440],"myoepithelial":[442,483],"(CK14)":[443],"progenitor":[445,488,517],"(CK6)":[446],"cells":[447,484,489,588],"only":[449],"detected":[450],"arising":[454],"mice.":[460],"consistent":[464],"notion":[467],"gland":[475,594],"transgenic":[477,549,581],"may":[479,510],"results":[480,643],"expansion":[482,585],"CK14":[486,587],"CK6":[491],"thus":[492],"resulting":[493],"lineage":[497],"differentiation":[498],"tumor.":[501],"We":[502,596],"hypothesized":[503],"difference":[506],"histology":[509],"relate":[511],"transformation":[514],"ErbB2.":[523],"investigate":[525],"system":[533],"using":[534,608,632],"avian":[535,553],"RCAS":[536],"retrovirus":[537],"vehicle":[539],"deliver":[541],"into":[545,579],"glands":[547],"TVA":[555],"under":[556],"control":[558],"MMTV":[561],"promoter.":[562],"allows":[564],"retroviral":[565],"infection":[566],"specific":[568],"Mammary":[574],"intraductal":[575],"injection":[576],"RCAS-CD8-IGF-IR":[578],"MMTV-TVA":[580],"resulted":[583],"disruption":[590],"normal":[592],"architecture.":[595],"currently":[598],"investigating":[599],"differences":[601],"ErbB2-induced":[605],"novel":[610],"viral":[611],"transduction":[612],"system.":[613],"In":[614,647],"summary,":[615],"shown":[618],"pathway":[622],"inhibition":[629],"small":[634],"molecule":[635],"regression.":[646],"addition,":[648],"interact":[654],"promote":[658],"studies":[665,671,682],"ErbB2-positive":[678],"Future":[681],"will":[683,709],"tissue":[685],"these":[690],"inhibitors":[691],"biomarkers":[694],"predict":[696],"response":[697],"It":[700],"anticipated":[702],"successful":[704],"use":[705],"improve":[710],"outcome.":[713]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
