{"id":"https://openalex.org/W101319486","doi":"https://doi.org/10.1007/978-1-59745-309-7_14","title":"Novel Molecular Signaling and Classification of Human Clinically Nonfunctioning Pituitary Adenomas Identified by Microarray and Reverse Transcription-Quantitative Polymerase Chain Reaction","display_name":"Novel Molecular Signaling and Classification of Human Clinically Nonfunctioning Pituitary Adenomas Identified by Microarray and Reverse Transcription-Quantitative Polymerase Chain Reaction","publication_year":2007,"publication_date":"2007-12-25","ids":{"openalex":"https://openalex.org/W101319486","doi":"https://doi.org/10.1007/978-1-59745-309-7_14","mag":"101319486"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59745-309-7_14","doi":"https://doi.org/10.1007/978-1-59745-309-7_14","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59745-309-7_14","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Contemporary Endocrinology","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2481153929","display_name":"Genomics in Endocrinology"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111740928","display_name":"Chheng-Orn Evans","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chheng-Orn Evans","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056719621","display_name":"Carlos S. Moreno","orcid":"https://orcid.org/0000-0002-5582-0028","observed_orcids":["https://orcid.org/0000-0002-5582-0028"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carlos S. Moreno","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5091679209","display_name":"Nelson M. Oyesiku","orcid":"https://orcid.org/0000-0002-9907-5461","observed_orcids":["https://orcid.org/0000-0002-9907-5461"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nelson M. Oyesiku","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.03481013,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"263","last_page":"270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11054","display_name":"Adrenal and Paraganglionic Tumors","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nonfunctioning-pituitary-adenoma","display_name":"non-functioning pituitary adenoma","score":0.9660000205039978},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.8769999742507935},{"id":"https://openalex.org/keywords/molecular-classification","display_name":"molecular classification","score":0.8080000281333923},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.8640000224113464},{"id":"https://openalex.org/keywords/notch-signaling","display_name":"Notch signaling","score":0.9850000143051147},{"id":"https://openalex.org/keywords/sfrp1","display_name":"SFRP1","score":0.9470000267028809},{"id":"https://openalex.org/keywords/pitx2","display_name":"PITX2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/notch3","display_name":"Notch3","score":0.9890000224113464},{"id":"https://openalex.org/keywords/delta-like-1","display_name":"Delta-like 1","score":0.9520000219345093},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.7379999756813049},{"id":"https://openalex.org/keywords/therapeutic-targeting","display_name":"therapeutic targeting","score":0.7039999961853027}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.638450562953949},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5782809257507324},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.568328320980072},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.5662227869033813},{"id":"https://openalex.org/C2781449511","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary tumors","level":2,"score":0.5418816804885864},{"id":"https://openalex.org/C4692481","wikidata":"https://www.wikidata.org/wiki/Q169526","display_name":"Reverse transcription polymerase chain reaction","level":4,"score":0.5092038512229919},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49030521512031555},{"id":"https://openalex.org/C2779318953","wikidata":"https://www.wikidata.org/wiki/Q864296","display_name":"Pituitary adenoma","level":3,"score":0.4798973798751831},{"id":"https://openalex.org/C8415881","wikidata":"https://www.wikidata.org/wiki/Q6839217","display_name":"Microarray analysis techniques","level":4,"score":0.47783470153808594},{"id":"https://openalex.org/C2908910360","wikidata":"https://www.wikidata.org/wiki/Q7199538","display_name":"Pituitary neoplasm","level":4,"score":0.45945578813552856},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42660781741142273},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.41363051533699036},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.411953866481781},{"id":"https://openalex.org/C2777658017","wikidata":"https://www.wikidata.org/wiki/Q156871","display_name":"Pituitary gland","level":3,"score":0.32240474224090576},{"id":"https://openalex.org/C2777428134","wikidata":"https://www.wikidata.org/wiki/Q272741","display_name":"Adenoma","level":2,"score":0.2909415364265442},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.25217700004577637},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.23129123449325562},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15774929523468018},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1196448802947998}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-59745-309-7_14","doi":"https://doi.org/10.1007/978-1-59745-309-7_14","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59745-309-7_14","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Contemporary Endocrinology","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W238668910","https://openalex.org/W1671881844","https://openalex.org/W1963747253","https://openalex.org/W1970156673","https://openalex.org/W2003589817","https://openalex.org/W2007947633","https://openalex.org/W2016037858","https://openalex.org/W2043754674","https://openalex.org/W2045691764","https://openalex.org/W2059650306","https://openalex.org/W2085374650","https://openalex.org/W2103557849","https://openalex.org/W2157795344","https://openalex.org/W2170989872","https://openalex.org/W2410971700","https://openalex.org/W4255637073","https://openalex.org/W4294107304"],"related_works":["https://openalex.org/W2045691764","https://openalex.org/W3013549136","https://openalex.org/W2593409370","https://openalex.org/W2016037858","https://openalex.org/W7166724664","https://openalex.org/W2064167884","https://openalex.org/W2379739663","https://openalex.org/W2069587971","https://openalex.org/W1981960074","https://openalex.org/W2351091865"],"abstract_inverted_index":{"Pituitary":[0],"adenomas":[1,18,63,91],"comprise":[2],"10%":[3],"of":[4,12,30,48,104,117,140,150,179,188],"intracranial":[5],"tumors":[6,50],"and":[7,51,64,92,107,122,130,135,159,176,183],"occur":[8],"in":[9,101,109,115,166],"about":[10],"20%":[11],"the":[13,40,46,79,102,127,138,174,189],"population.":[14],"Nonfunctioning":[15],"(NF)":[16],"pituitary":[17,31,62,67,95,142,153,181],"do":[19],"not":[20],"cause":[21],"clinical":[22],"hormone":[23],"hypersecretion,":[24],"they":[25],"account":[26],"for":[27,137,195],"approximately":[28],"30%":[29],"tumors.":[32,197],"Their":[33],"molecular":[34,41,56,177],"pathogenesis":[35,175],"is":[36],"unclear.":[37],"To":[38],"elucidate":[39],"changes":[42,114],"that":[43,126,162,185],"contribute":[44],"to":[45,156],"development":[47],"these":[49,196],"classify":[52],"them":[53],"by":[54],"their":[55],"characteristics,":[57],"we":[58],"investigated":[59],"11":[60],"NF":[61,90,141,152,180],"eight":[65,93],"normal":[66,94],"glands,":[68],"using":[69,88],"33":[70],"oligonucleotide":[71],"GeneChip":[72],"microarrays.":[73],"We":[74,112,144],"validated":[75],"microarray":[76],"results":[77,169],"with":[78],"reverse":[80],"transcription-real":[81],"time":[82],"quantitative":[83],"polymerase":[84],"chain":[85],"reaction":[86],"(RT-qPCR)":[87],"23":[89],"glands.Microarray":[96],"analysis":[97],"identified":[98,160],"significant":[99],"increases":[100],"expression":[103,116,148],"115":[105],"genes":[106,161],"decreases":[108],"169":[110],"genes.":[111],"observed":[113],"SFRP1,":[118],"TLE2,":[119],"PITX2,":[120],"Notch3,":[121],"delta-like":[123],"1,":[124],"suggesting":[125],"developmental":[128],"Wnt":[129],"Notch":[131,190],"pathways":[132],"are":[133],"activated":[134],"important":[136],"progression":[139],"adenomas.":[143],"further":[145],"analyzed":[146],"gene":[147],"profiles":[149],"all":[151],"subtypes":[154],"compared":[155],"each":[157,167],"other":[158],"were":[163],"uniquely":[164],"altered":[165],"subtype.The":[168],"provide":[170],"new":[171],"insight":[172],"into":[173],"classification":[178],"adenomas,":[182],"suggest":[184],"therapeutic":[186],"targeting":[187],"pathway":[191],"could":[192],"be":[193],"effective":[194]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}