{"id":"https://openalex.org/W101289525","doi":"https://doi.org/10.1182/blood.v45.3.355.355","title":"Selection of patients for bone marrow transplantation in severe aplastic anemia","display_name":"Selection of patients for bone marrow transplantation in severe aplastic anemia","publication_year":1975,"publication_date":"1975-03-01","ids":{"openalex":"https://openalex.org/W101289525","doi":"https://doi.org/10.1182/blood.v45.3.355.355","mag":"101289525","pmid":"https://pubmed.ncbi.nlm.nih.gov/1090310"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v45.3.355.355","doi":"https://doi.org/10.1182/blood.v45.3.355.355","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v45.3.355.355","pdf_url":"https://ashpublications.org/blood/article-pdf/45/3/355/579016/355.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/45/3/355/579016/355.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113499483","display_name":"Bruce Matthew Camitta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"BM Camitta","raw_affiliation_strings":["Division of Hematology-Oncology. Childrens Hospital Medical Center . 300 Longwood A venue , Boston . Mass. 02115 "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology. Childrens Hospital Medical Center . 300 Longwood A venue , Boston . Mass. 02115 ","institution_ids":["https://openalex.org/I1288882113"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110897189","display_name":"JM Rappeport","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"JM Rappeport","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045306382","display_name":"Robertson Parkman","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"R Parkman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5112135585","display_name":"DG Nathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"DG Nathan","raw_affiliation_strings":["Division of Hematology-Oncology. Childrens Hospital Medical Center . 300 Longwood A venue , Boston . Mass. 02115 "],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology-Oncology. Childrens Hospital Medical Center . 300 Longwood A venue , Boston . Mass. 02115 ","institution_ids":["https://openalex.org/I1288882113"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":6.4161,"has_fulltext":true,"cited_by_count":309,"citation_normalized_percentile":{"value":0.96255819,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"45","issue":"3","first_page":"355","last_page":"363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-aplastic-anemia","display_name":"severe aplastic anemia","score":0.9750000238418579},{"id":"https://openalex.org/keywords/bone-marrow-transplantation","display_name":"bone marrow transplantation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/patient-selection","display_name":"patient selection","score":0.9710000157356262},{"id":"https://openalex.org/keywords/early-transplantation","display_name":"early transplantation","score":0.7099999785423279},{"id":"https://openalex.org/keywords/spontaneous-regression","display_name":"spontaneous regression","score":0.8169999718666077},{"id":"https://openalex.org/keywords/androgen-therapy","display_name":"androgen therapy","score":0.6460000276565552},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7586833238601685},{"id":"https://openalex.org/C2781440808","wikidata":"https://www.wikidata.org/wiki/Q846316","display_name":"Aplastic anemia","level":3,"score":0.7346614003181458},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6729581356048584},{"id":"https://openalex.org/C2994180119","wikidata":"https://www.wikidata.org/wiki/Q1128050","display_name":"Bone marrow transplantation","level":3,"score":0.5999947190284729},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.548399031162262},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.5222336053848267},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.5195863246917725},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5142869353294373},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3912985026836395},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3375086188316345},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.13539734482765198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0960921049118042},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000728","descriptor_name":"Androgens","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000741","descriptor_name":"Anemia, Aplastic","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000961","descriptor_name":"Antilymphocyte Serum","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001856","descriptor_name":"Bone Marrow Examination","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003520","descriptor_name":"Cyclophosphamide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006084","descriptor_name":"Graft Rejection","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D006648","descriptor_name":"Histocompatibility","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007165","descriptor_name":"Immunosuppression Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011344","descriptor_name":"Procarbazine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011878","descriptor_name":"Radiotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014184","descriptor_name":"Transplantation, Homologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016026","descriptor_name":"Bone Marrow Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood.v45.3.355.355","doi":"https://doi.org/10.1182/blood.v45.3.355.355","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v45.3.355.355","pdf_url":"https://ashpublications.org/blood/article-pdf/45/3/355/579016/355.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"doi:10.1182/blood.v45.3.355.bloodjournal453355","doi":"https://doi.org/10.1182/blood.v45.3.355.bloodjournal453355","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v45.3.355.bloodjournal453355","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:1090310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1090310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/blood.v45.3.355.355","doi":"https://doi.org/10.1182/blood.v45.3.355.355","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood.v45.3.355.355","pdf_url":"https://ashpublications.org/blood/article-pdf/45/3/355/579016/355.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W101289525.pdf","grobid_xml":"https://content.openalex.org/works/W101289525.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W95192746","https://openalex.org/W113714312","https://openalex.org/W1490072157","https://openalex.org/W1543094215","https://openalex.org/W1561728293","https://openalex.org/W1573785776","https://openalex.org/W1575851195","https://openalex.org/W1963570979","https://openalex.org/W1978687603","https://openalex.org/W1981101052","https://openalex.org/W1997148907","https://openalex.org/W2026048141","https://openalex.org/W2040383783","https://openalex.org/W2313202361","https://openalex.org/W2465013747","https://openalex.org/W2470401749"],"related_works":["https://openalex.org/W2426053035","https://openalex.org/W196567407","https://openalex.org/W113714312","https://openalex.org/W1517672097","https://openalex.org/W1545839164","https://openalex.org/W1573061251","https://openalex.org/W2416530022","https://openalex.org/W2150485256","https://openalex.org/W2017381889","https://openalex.org/W1604548014"],"abstract_inverted_index":{"Despite":[0],"androgens":[1],"and":[2,45,57],"intensive":[3],"supportive":[4],"care,":[5],"satisfactory":[6],"survival":[7],"in":[8,25],"severe":[9,30,84],"aplastic":[10,85],"anemia":[11],"remains":[12],"at":[13],"20%":[14],"or":[15],"less.":[16],"Histocompatible":[17],"bone":[18,74],"marrow":[19,75],"transplantation":[20,34,62,76],"can":[21],"restore":[22],"normal":[23],"hematopoiesis":[24],"approximately":[26],"40%":[27],"of":[28,33,54,66,81],"similarly":[29],"individuals.":[31],"Delay":[32],"for":[35,42,46,60,83],"3":[36],"wk":[37],"after":[38],"diagnosis":[39],"allows":[40],"time":[41],"proper":[43],"evaluation":[44],"many":[47],"spontaneous":[48,67],"recoveries.":[49],"Further":[50],"delay":[51],"increases":[52],"risks":[53],"fatal":[55],"complications":[56],"decreases":[58],"chances":[59],"successful":[61],"while":[63],"the":[64,79],"incidence":[65],"remission":[68],"declines.":[69],"When":[70],"available,":[71],"early":[72],"histocompatible":[73],"may":[77],"be":[78],"treatment":[80],"choice":[82],"anemia.":[86]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":14},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":13},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":12},{"year":2012,"cited_by_count":8}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}