{"id":"https://openalex.org/W101164856","doi":"https://doi.org/10.1096/fasebj.21.6.a1255-c","title":"THE EFFECT OF AGING ON THE HEXOSAMINE BIOSYNTHESIS PATHWAY AND ON O\u2010LINKED N\u2010ACETYLGLUCOSAMINE LEVELS IN RATS","display_name":"THE EFFECT OF AGING ON THE HEXOSAMINE BIOSYNTHESIS PATHWAY AND ON O\u2010LINKED N\u2010ACETYLGLUCOSAMINE LEVELS IN RATS","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W101164856","doi":"https://doi.org/10.1096/fasebj.21.6.a1255-c","mag":"101164856"},"language":"en","primary_location":{"id":"doi:10.1096/fasebj.21.6.a1255-c","doi":"https://doi.org/10.1096/fasebj.21.6.a1255-c","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a1255-c","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068811763","display_name":"Norbert F\u00fcl\u00f6p","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norbert F\u00fcl\u00f6p","raw_affiliation_strings":["Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101769439","display_name":"Wenguang Feng","orcid":"https://orcid.org/0000-0003-2014-6763","observed_orcids":["https://orcid.org/0000-0003-2014-6763"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenguang Feng","raw_affiliation_strings":["Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101669910","display_name":"Dongqi Xing","orcid":"https://orcid.org/0000-0003-2227-3571","observed_orcids":["https://orcid.org/0000-0003-2227-3571"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Dongqi Xing","raw_affiliation_strings":["Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kai He","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kai He","raw_affiliation_strings":["Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027431998","display_name":"L\u00e1szl\u00f3 G. N\u00f6t","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L\u00e1szl\u00f3 G N\u00f5t","raw_affiliation_strings":["Cell Biology University of Alabama at Birmingham 1900 University blvd Birmingham AL 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology University of Alabama at Birmingham 1900 University blvd Birmingham AL 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015991214","display_name":"Charlye A Brocks","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charlye A Brocks","raw_affiliation_strings":["Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113721127","display_name":"Richard B. Marchase","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard B Marchase","raw_affiliation_strings":["Cell Biology University of Alabama at Birmingham 1900 University blvd Birmingham AL 35294"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology University of Alabama at Birmingham 1900 University blvd Birmingham AL 35294","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105368043","display_name":"Andrew P. Miller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Andrew P Miller","raw_affiliation_strings":["Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicine","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016096111","display_name":"John C. Chatham","orcid":"https://orcid.org/0000-0001-7180-9948","observed_orcids":["https://orcid.org/0000-0001-7180-9948"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C Chatham","raw_affiliation_strings":["Cell Biology University of Alabama at Birmingham 1900 University blvd Birmingham AL 35294","Medicine","Cell BiologyUniversity of Alabama at Birmingham1900 University blvdBirminghamAL35294; Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Biology University of Alabama at Birmingham 1900 University blvd Birmingham AL 35294","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Medicine","institution_ids":[]},{"raw_affiliation_string":"Cell BiologyUniversity of Alabama at Birmingham1900 University blvdBirminghamAL35294; Medicine","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3740,"currency":"USD","value_usd":3740},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.01157325,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10945","display_name":"Lysosomal Storage Disorders Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/o-glcnac","display_name":"O-GlcNAc","score":0.8790000081062317},{"id":"https://openalex.org/keywords/n-acetylglucosamine","display_name":"N-acetylglucosamine","score":0.8560000061988831},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6909999847412109},{"id":"https://openalex.org/keywords/o-glcnac-transferase","display_name":"O-GlcNAc transferase","score":0.8889999985694885},{"id":"https://openalex.org/keywords/hexosamine-biosynthesis-pathway","display_name":"hexosamine biosynthetic pathway","score":0.8970000147819519},{"id":"https://openalex.org/keywords/udp-n-acetylglucosamine","display_name":"UDP-N-acetylglucosamine","score":0.8999999761581421},{"id":"https://openalex.org/keywords/heart","display_name":"heart","score":0.7839999794960022},{"id":"https://openalex.org/keywords/aorta","display_name":"aorta","score":0.9990000128746033},{"id":"https://openalex.org/keywords/skeletal-muscle","display_name":"skeletal muscle","score":0.7620000243186951},{"id":"https://openalex.org/keywords/brain","display_name":"brain","score":0.9940000176429749},{"id":"https://openalex.org/keywords/cardiovascular-dysfunction","display_name":"cardiovascular dysfunction","score":0.6880000233650208},{"id":"https://openalex.org/keywords/senescence","display_name":"senescence","score":0.8270000219345093}],"concepts":[{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.5341443419456482},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5288943648338318},{"id":"https://openalex.org/C2776732574","wikidata":"https://www.wikidata.org/wiki/Q202043","display_name":"Hexosamines","level":3,"score":0.527427077293396},{"id":"https://openalex.org/C2778815778","wikidata":"https://www.wikidata.org/wiki/Q284367","display_name":"N-Acetylglucosamine","level":3,"score":0.5143828988075256},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34485703706741333},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.32995590567588806},{"id":"https://openalex.org/C2778125326","wikidata":"https://www.wikidata.org/wiki/Q327506","display_name":"Glucosamine","level":2,"score":0.24064233899116516},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.04588314890861511}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1096/fasebj.21.6.a1255-c","doi":"https://doi.org/10.1096/fasebj.21.6.a1255-c","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fasebj.21.6.a1255-c","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1999823573","https://openalex.org/W2345961390","https://openalex.org/W2999356756","https://openalex.org/W6944921232","https://openalex.org/W3088410900","https://openalex.org/W2089465141","https://openalex.org/W7128927383","https://openalex.org/W2094005996","https://openalex.org/W1997304347","https://openalex.org/W4387033654"],"abstract_inverted_index":{"Changes":[0],"in":[1,17,37,39,60,81,86,109,131,142,144,169,173,191,196,205],"O":[2,8],"\u2010linked":[3],"attachment":[4],"of":[5,20,29,55,66,75,84],"N\u2010acetyl\u2010glucosamine":[6],"(":[7],"\u2010GlcNAc)":[9],"on":[10,57],"nucleocytoplasmic":[11],"protein":[12],"plays":[13],"an":[14],"important":[15],"role":[16],"the":[18,27,40,53,61,64,73,82,87,110,118,140,203],"regulation":[19,83],"cell":[21],"function":[22,190],"and":[23,95,102,113,134,154,171,176],"is":[24,48,77],"associated":[25,78,124,147,186],"with":[26,79,107,125,148,187,209],"development":[28,74],"disease.":[30],"Although":[31],"we":[32],"have":[33,184],"recently":[34],"described":[35],"changes":[36,80,168],"O\u2010GlcNAc":[38,58,85,103,127,143,170,182,197],"rat":[41],"heart":[42,111,132],"from":[43,93],"adolescence":[44],"to":[45,70,117,202],"adulthood,":[46],"there":[47],"very":[49],"little":[50],"known":[51],"about":[52],"effect":[54],"aging":[56],"levels":[59,104,156,183],"heart.":[62],"Therefore":[63],"goal":[65],"this":[67,122,194],"study":[68],"was":[69,123,146],"determine":[71],"whether":[72],"senescence":[76],"cardiovascular":[88,206],"system.":[89],"Tissues":[90],"were":[91,105,165],"harvested":[92],"5":[94],"24":[96,138],"month":[97],"old":[98],"male":[99],"Brown\u2010Norway":[100],"rats":[101],"increased":[106,149],"age":[108],"(207\u00b133%)":[112],"aorta":[114,135],"(164\u00b118%)":[115],"compared":[116],"younger":[119],"animals;":[120],"surprisingly":[121],"decreased":[126],"transferase":[128],"(OGT)":[129],"expression":[130],"(69\u00b14%),":[133],"(71\u00b15%).":[136],"At":[137],"months":[139],"increase":[141,195,204],"hearts":[145],"glutamine:fructose\u20106\u2010phosphate":[150],"amidotransferase\u20102":[151],"mRNA":[152],"(480\u00b1100%)":[153],"UDP\u2010N\u2010acetylglucosamine":[155],"(50.8\u00b11.7":[157],"vs.":[158],"67.4\u00b16.8":[159],"nmol/g":[160],"tissue":[161],"wet":[162],"weight).":[163],"There":[164],"similar":[166],"age\u2010dependent":[167],"OGT":[172],"skeletal":[174],"muscle":[175],"brain":[177],"but":[178],"not":[179],"liver.":[180],"Increased":[181],"been":[185],"impaired":[188],"cardiomyocyte":[189],"diabetes;":[192],"thus":[193],"seen":[198,208],"here":[199],"may":[200],"contribute":[201],"dysfunction":[207],"age.":[210]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}