{"id":"https://openalex.org/W1010834136","doi":null,"title":"\u5438\u5165\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5bf9\u54ee\u5598\u513f\u7ae5\u5916\u5468\u8840Foxp3+\u8c03\u8282\u6027T\u7ec6\u80de\u53caIL-2\u3001IL-6\u7684\u5f71\u54cd\u53ca\u5176\u673a\u5236\u7814\u7a76","display_name":"\u5438\u5165\u7cd6\u76ae\u8d28\u6fc0\u7d20\u5bf9\u54ee\u5598\u513f\u7ae5\u5916\u5468\u8840Foxp3+\u8c03\u8282\u6027T\u7ec6\u80de\u53caIL-2\u3001IL-6\u7684\u5f71\u54cd\u53ca\u5176\u673a\u5236\u7814\u7a76","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W1010834136","mag":"1010834136"},"language":"zh","primary_location":{"id":"mag:1010834136","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/95699A/200805/1000547225.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306554681","display_name":"\u73b0\u4ee3\u514d\u75ab\u5b66","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u73b0\u4ee3\u514d\u75ab\u5b66","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007552371","display_name":"\u4f55\u4e91","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u4f55\u4e91","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090705291","display_name":"\u5218\u6069\u6885","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5218\u6069\u6885","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077602147","display_name":"\u6768\u9521\u5f3a","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u6768\u9521\u5f3a","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029516239","display_name":"Xin Li","orcid":"https://orcid.org/0000-0001-6334-0369","observed_orcids":["https://orcid.org/0000-0001-6334-0369"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xin Li","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6334-0369","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14869433,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":"5","first_page":"381","last_page":"384"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.9657999873161316,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.02889999933540821,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.5559999942779541},{"id":"https://openalex.org/keywords/inhaled-corticosteroids","display_name":"inhaled corticosteroids","score":0.8970000147819519},{"id":"https://openalex.org/keywords/fluticasone-propionate","display_name":"fluticasone propionate","score":0.9629999995231628},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.8999999761581421},{"id":"https://openalex.org/keywords/foxp3","display_name":"Foxp3","score":0.9520000219345093},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.9639999866485596},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7369999885559082},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":1.0},{"id":"https://openalex.org/keywords/stat5-phosphorylation","display_name":"STAT5 phosphorylation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/peripheral-blood-mononuclear-cells","display_name":"peripheral blood mononuclear cells","score":0.9739999771118164},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.5230000019073486}],"concepts":[{"id":"https://openalex.org/C98119934","wikidata":"https://www.wikidata.org/wiki/Q14907167","display_name":"Interleukin 15","level":4,"score":0.3385974168777466},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.27089762687683105},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23050743341445923},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2222042679786682},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.13349482417106628}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:1010834136","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/95699A/200805/1000547225.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306554681","display_name":"\u73b0\u4ee3\u514d\u75ab\u5b66","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u73b0\u4ee3\u514d\u75ab\u5b66","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2351926341","https://openalex.org/W2390612594","https://openalex.org/W2748825920","https://openalex.org/W938707764","https://openalex.org/W3029239427","https://openalex.org/W958111922","https://openalex.org/W1606632053","https://openalex.org/W3028761336","https://openalex.org/W1037395124","https://openalex.org/W949825231"],"abstract_inverted_index":{"\u7814\u7a76\u5438\u5165\u4e19\u9178\u6c1f\u66ff\u5361\u677e(FP)\u5bf9\u54ee\u5598\u60a3\u513f\u5916\u5468\u8840\u5355\u4e2a\u6838\u7ec6\u80de(PBMC)\u4e2dCD4+":[0],"Foxp3+\u8c03\u8282T\u7ec6\u80de\u3001\u7ec6\u80de\u56e0\u5b50IL-2,IL-6\u4ee5\u53ca\u8f6c\u5f55\u56e0\u5b50STAT5\u7684\u5f71\u54cd.\u4ee530\u4f8b\u786e\u8bca\u4e3a\u652f\u6c14\u7ba1\u54ee\u5598\u7684\u60a3\u513f\u4e3a\u7814\u7a76\u5bf9\u8c61,\u968f\u673a\u5206\u4e3a\u672a\u6cbb\u7597\u54ee\u5598\u7ec4(15\u4f8b)\u3001\u5438\u5165FP\u7f13\u89e3\u7ec4(15\u4f8b),10\u4f8b\u540c\u671f\u6b63\u5e38\u513f\u7ae5\u4e3a\u5bf9\u7167\u7ec4.\u6d41\u5f0f\u7ec6\u80de\u4eea\u68c0\u6d4b\u5916\u5468\u8840PBMC\u4e2d\u7684CD4+":[1],"Foxp3+\u8c03\u8282T\u7ec6\u80de\u6bd4\u7387,ELISA\u68c0\u6d4b\u8840\u6d46\u6216\u57f9\u517b\u4e0a\u6e05\u4e2dIL-2\u3001IL-6\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73,Western":[2],"blot\u68c0\u6d4bPBMC\u4e2d\u78f7\u9178\u5316\u53ca\u975e\u78f7\u9178\u5316STAT5\u7684\u6c34\u5e73\u7ed3\u679c1.\u672a\u6cbb\u7597\u54ee\u5598\u7ec4PBMC\u4e2dCD4+Foxp3+T\u7ec6\u80de\u767e\u5206\u7387\u5728PHA\u523a\u6fc0\u57f9\u517b\u524d\u540e\u5747\u660e\u663e\u4f4e\u4e8e\u6b63\u5e38\u5bf9\u7167\u7ec4,\u5438\u5165FP\u7f13\u89e3\u7ec4\u660e\u663e\u5347\u9ad8,\u4e0e\u6b63\u5e38\u5bf9\u7167\u7ec4\u6ca1\u6709\u5dee\u5f02;\u5404\u7ec4\u523a\u6fc0\u540eCD4+":[3],"Foxp3+T\u7ec6\u80de\u767e\u5206\u7387\u5747\u6709\u5347\u9ad8,\u5438\u5165FP\u7f13\u89e3\u7ec4\u3001\u6b63\u5e38\u5bf9\u7167\u7ec4\u5206\u522b\u5347\u9ad8\u7ea61.89\u30012.01\u500d,\u800c\u672a\u6cbb\u7597\u54ee\u5598\u7ec4\u5347\u9ad8\u4ec51.56\u500d;2.\u672a\u6cbb\u7597\u54ee\u5598\u7ec4\u8840\u6d46\u4e2dIL-6\u6c34\u5e73\u660e\u663e\u9ad8\u4e8e\u6b63\u5e38\u7ec4\u53ca\u5438\u5165FP\u7f13\u89e3\u7ec4,\u800cIL-2\u6c34\u5e73\u6ca1\u6709\u660e\u663e\u5dee\u5f02;3.PHA\u523a\u6fc024":[4],"h\u540e\u672a\u6cbb\u7597\u54ee\u5598\u7ec4\u78f7\u9178\u5316STAT5(p-STAT)\u8868\u8fbe\u6c34\u5e73\u660e\u663e\u4f4e\u4e8e\u5438\u5165FP\u7ec4\u53ca\u6b63\u5e38\u5bf9\u7167\u7ec4,\u800c\u5404\u7ec4STAT5\u8868\u8fbe\u6c34\u5e73\u6ca1\u6709\u660e\u663e\u5dee\u5f02,\u7ed3\u8bba\u5438\u5165FP\u80fd\u589e\u52a0\u54ee\u5598\u60a3\u513f\u5916\u5468\u8840PBMC\u4e2dCD4+Foxp3+\u8c03\u8282T\u7ec6\u80de\u6570\u91cf,\u5176\u673a\u5236\u53ef\u80fd\u4e0e\u964d\u4f4e\u8840\u6d46IL-6,\u4e0a\u8c03STAT5\u78f7\u9178\u5316\u6c34\u5e73\u6709\u5173.":[5]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}