{"id":"https://openalex.org/W1010635479","doi":"https://doi.org/10.1016/s0021-9258(18)54257-5","title":"Production of diacylglycerol by exogenous phospholipase C stimulates CTP:phosphocholine cytidylyltransferase activity and phosphatidylcholine synthesis in human neuroblastoma cells.","display_name":"Production of diacylglycerol by exogenous phospholipase C stimulates CTP:phosphocholine cytidylyltransferase activity and phosphatidylcholine synthesis in human neuroblastoma cells.","publication_year":1991,"publication_date":"1991-12-01","ids":{"openalex":"https://openalex.org/W1010635479","doi":"https://doi.org/10.1016/s0021-9258(18)54257-5","mag":"1010635479","pmid":"https://pubmed.ncbi.nlm.nih.gov/1662212"},"language":"en","primary_location":{"id":"doi:10.1016/s0021-9258(18)54257-5","doi":"https://doi.org/10.1016/s0021-9258(18)54257-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)54257-5","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1016/s0021-9258(18)54257-5","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043095398","display_name":"Barbara E. Slack","orcid":"https://orcid.org/0000-0002-7619-410X","observed_orcids":["https://orcid.org/0000-0002-7619-410X"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B.E. Slack","raw_affiliation_strings":["Department of Brain and Cognitive Sciences,#N#Massachusetts Institute of Technology, Cambridge 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Brain and Cognitive Sciences,#N#Massachusetts Institute of Technology, Cambridge 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110236019","display_name":"Jeff J Breu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. Breu","raw_affiliation_strings":["Department of Brain and Cognitive Sciences,#N#Massachusetts Institute of Technology, Cambridge 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Brain and Cognitive Sciences,#N#Massachusetts Institute of Technology, Cambridge 02139","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109899809","display_name":"Richard Jay Wurtman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R.J. Wurtman","raw_affiliation_strings":["Department of Brain and Cognitive Sciences,#N#Massachusetts Institute of Technology, Cambridge 02139"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Brain and Cognitive Sciences,#N#Massachusetts Institute of Technology, Cambridge 02139","institution_ids":["https://openalex.org/I63966007"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I63966007"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":2.2402,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.8749004,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"266","issue":"36","first_page":"24503","last_page":"24508"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diacylglycerol","display_name":"diacylglycerol","score":0.9629999995231628},{"id":"https://openalex.org/keywords/phospholipase-c","display_name":"phospholipase C","score":0.9480000138282776},{"id":"https://openalex.org/keywords/ctp-phosphocholine-cytidylyltransferase","display_name":"CTP:phosphocholine cytidylyltransferase","score":0.9700000286102295},{"id":"https://openalex.org/keywords/phosphatidylcholine-biosynthesis","display_name":"phosphatidylcholine synthesis","score":0.9879999756813049},{"id":"https://openalex.org/keywords/neuroblastoma-cells","display_name":"neuroblastoma cells","score":0.8790000081062317},{"id":"https://openalex.org/keywords/oleic-acid","display_name":"oleic acid","score":0.7329999804496765},{"id":"https://openalex.org/keywords/dioctanoylglycerol","display_name":"dioctanoylglycerol","score":0.9660000205039978},{"id":"https://openalex.org/keywords/choline-incorporation","display_name":"choline incorporation","score":0.7580000162124634},{"id":"https://openalex.org/keywords/phosphatidylcholine-turnover","display_name":"phosphatidylcholine turnover","score":0.5870000123977661},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.3779999911785126},{"id":"https://openalex.org/keywords/enzyme-activation","display_name":"enzyme activation","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2776923060","wikidata":"https://www.wikidata.org/wiki/Q576895","display_name":"Phosphocholine","level":5,"score":0.9288573265075684},{"id":"https://openalex.org/C36020004","wikidata":"https://www.wikidata.org/wiki/Q106951674","display_name":"Diacylglycerol kinase","level":4,"score":0.8177553415298462},{"id":"https://openalex.org/C2778597717","wikidata":"https://www.wikidata.org/wiki/Q420248","display_name":"Phospholipase C","level":3,"score":0.6340245604515076},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.5866761803627014},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5412253141403198},{"id":"https://openalex.org/C12927208","wikidata":"https://www.wikidata.org/wiki/Q210430","display_name":"Phospholipase","level":3,"score":0.5217486619949341},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5101916790008545},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.4570401608943939},{"id":"https://openalex.org/C2776715637","wikidata":"https://www.wikidata.org/wiki/Q938205","display_name":"Neuroblastoma","level":3,"score":0.45060938596725464},{"id":"https://openalex.org/C6182249","wikidata":"https://www.wikidata.org/wiki/Q700007","display_name":"Phospholipase D","level":3,"score":0.4285673499107361},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.38256147503852844},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3281441330909729},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.276113361120224},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.21446964144706726},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.15417850017547607},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.04593876004219055},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004075","descriptor_name":"Diglycerides","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009713","descriptor_name":"Nucleotidyltransferases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009829","descriptor_name":"Oleic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010713","descriptor_name":"Phosphatidylcholines","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D010738","descriptor_name":"Type C Phospholipases","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D019301","descriptor_name":"Oleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019916","descriptor_name":"Choline-Phosphate Cytidylyltransferase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0021-9258(18)54257-5","doi":"https://doi.org/10.1016/s0021-9258(18)54257-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)54257-5","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:1662212","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1662212","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1016/s0021-9258(18)54257-5","doi":"https://doi.org/10.1016/s0021-9258(18)54257-5","is_oa":true,"landing_page_url":"https://doi.org/10.1016/s0021-9258(18)54257-5","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2094033601","display_name":null,"funder_award_id":"MH 28783","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W203002877","https://openalex.org/W1499341011","https://openalex.org/W1503404080","https://openalex.org/W1511715997","https://openalex.org/W1521015756","https://openalex.org/W1556599431","https://openalex.org/W1568827882","https://openalex.org/W1572476018","https://openalex.org/W1581680249","https://openalex.org/W1581909083","https://openalex.org/W1598507095","https://openalex.org/W1601458675","https://openalex.org/W1605640867","https://openalex.org/W1623950794","https://openalex.org/W1650042168","https://openalex.org/W1671239779","https://openalex.org/W1676701054","https://openalex.org/W1910192122","https://openalex.org/W1973043673","https://openalex.org/W1977695709","https://openalex.org/W1998225973","https://openalex.org/W2001692359","https://openalex.org/W2007457073","https://openalex.org/W2012858142","https://openalex.org/W2037057038","https://openalex.org/W2040150937","https://openalex.org/W2043570857","https://openalex.org/W2049409090","https://openalex.org/W2053108406","https://openalex.org/W2064889318","https://openalex.org/W2068526151","https://openalex.org/W2085614003"],"related_works":["https://openalex.org/W2040150937","https://openalex.org/W1525648980","https://openalex.org/W3019690100","https://openalex.org/W2051056536","https://openalex.org/W1572476018","https://openalex.org/W2042335811","https://openalex.org/W2015696474","https://openalex.org/W2016437170","https://openalex.org/W2049409090","https://openalex.org/W1581680249"],"abstract_inverted_index":{"The":[0,104,178,251],"involvement":[1],"of":[2,9,29,44,91,93,102,107,109,116,135,166,180,194,209,214,237,257,268],"endogenous":[3],"diacylglycerol":[4,47,94,152,258,272],"production":[5,118,267],"in":[6,119,148,157,277,282],"the":[7,45,77,84,89,146,207,212,215,247,255,265],"stimulation":[8,179],"phosphatidylcholine":[10,176,285],"synthesis":[11],"by":[12,83,111,163,183,259],"exogenous":[13,260],"phospholipase":[14,57,71,96,112,167,184,203,261],"C":[15,25,72,97,113,185,204,262],"was":[16,79,130,161,188,199],"examined":[17],"using":[18],"a":[19,99,228],"neuroblastoma":[20],"(LA-N-2)":[21],"cell":[22],"line.":[23],"Phospholipase":[24],"treatment":[26,73],"(0.1":[27],"unit/ml)":[28,173],"intact":[30],"cells":[31,54,120,279],"stimulated":[32],"CTP:phosphocholine":[33],"cytidylyltransferase":[34,66,110,149,181,275],"activity":[35,67,150,182,276],"significantly":[36,174],"more":[37,200],"effectively":[38],"than":[39,144,202],"did":[40,145],"maximally":[41,81],"effective":[42,201],"concentrations":[43,171],"synthetic":[46],"sn-1,2-dioctanoylglycerol":[48],"(1":[49],"mM).":[50],"When":[51],"added":[52],"to":[53,70],"together":[55],"with":[56,68,125,191],"C,":[58,168],"oleic":[59],"acid,":[60],"but":[61,169],"not":[62,80,288],"dioctanoylglycerol,":[63],"further":[64,221],"increased":[65],"respect":[69],"alone,":[74],"indicating":[75],"that":[76,88,115,224,254],"enzyme":[78],"activated":[82],"lipase.":[85],"This":[86],"suggests":[87],"lack":[90],"additivity":[92,249],"and":[95,138,151,211,239],"reflects":[98],"common":[100],"mechanism":[101],"action.":[103],"time":[105],"course":[106],"activation":[108],"paralleled":[114],"[3H]diacylglycerol":[117],"prelabeled":[121],"for":[122,230,244],"24":[123],"h":[124],"[3H]oleic":[126,136],"acid.":[127],"Diacylglycerol":[128],"mass":[129],"similarly":[131],"increased.":[132],"Significant":[133],"elevations":[134],"acid":[137],"total":[139,158],"fatty":[140,269],"acids":[141,270],"occurred":[142],"later":[143],"increases":[147],"levels.":[153],"No":[154],"significant":[155],"reduction":[156],"or":[159,186],"[3H]phosphatidylcholine":[160],"elicited":[162],"this":[164,245],"concentration":[165],"higher":[170],"(0.5":[172],"reduced":[175],"content.":[177],"dioctanoylglycerol":[187,225],"also":[189],"associated":[190],"enhanced":[192],"incorporation":[193],"[methyl-14C]choline":[195],"into":[196],"phosphatidylcholine.":[197],"Dioctanoylglycerol":[198],"at":[205],"stimulating":[206],"formation":[208],"[14C]phosphatidylcholine,":[210],"effects":[213],"two":[216],"treatments":[217],"were":[218,242],"additive.":[219],"However,":[220],"analysis":[222],"revealed":[223],"served":[226],"as":[227,232,234],"precursor":[229],"[14C]dioctanoylphosphatidylcholine":[231],"well":[233],"an":[235],"activator":[236],"cytidylyltransferase;":[238],"when":[240],"corrections":[241],"made":[243],"effect,":[246],"apparent":[248],"disappeared.":[250],"results":[252],"indicate":[253],"generation":[256],"(and":[263],"possibly":[264],"subsequent":[266],"via":[271],"metabolism)":[273],"activates":[274],"neuronal":[278],"under":[280],"conditions":[281],"which":[283],"membrane":[284],"content":[286],"is":[287],"measurably":[289],"reduced.":[290]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
