{"id":"https://openalex.org/W101035576","doi":null,"title":"Wnt signaling and metaphyseal bone healing","display_name":"Wnt signaling and metaphyseal bone healing","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W101035576","mag":"101035576"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:liu-71287","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-71287","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-71287","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045131956","display_name":"Fredrik Agholme","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fredrik Agholme","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5045131956"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.49219998717308044,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.49219998717308044,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.2890999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.10360000282526016,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":1.0},{"id":"https://openalex.org/keywords/fracture-healing","display_name":"fracture healing","score":0.8709999918937683},{"id":"https://openalex.org/keywords/sclerostin","display_name":"sclerostin","score":0.996999979019165},{"id":"https://openalex.org/keywords/dkk1","display_name":"DKK1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.7419999837875366},{"id":"https://openalex.org/keywords/bone-unloading","display_name":"bone unloading","score":0.578000009059906},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.8870000243186951},{"id":"https://openalex.org/keywords/trauma-physical-injury","display_name":"trauma (physical injury)","score":0.49399998784065247},{"id":"https://openalex.org/keywords/bone-volume-density","display_name":"bone volume density","score":0.7480000257492065}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8741121292114258},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.5907847285270691},{"id":"https://openalex.org/C182819311","wikidata":"https://www.wikidata.org/wiki/Q18028670","display_name":"LRP5","level":4,"score":0.4398394525051117},{"id":"https://openalex.org/C2993291840","wikidata":"https://www.wikidata.org/wiki/Q1121544","display_name":"Bone formation","level":2,"score":0.4105335474014282},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39329397678375244},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3925742506980896},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3680926561355591},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3596542477607727},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.25999748706817627},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19457653164863586}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:liu-71287","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-71287","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:101035576","doi":null,"is_oa":false,"landing_page_url":"http://liu.diva-portal.org/smash/get/diva2:447010/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:liu-71287","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-71287","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7246000170707703}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":114,"referenced_works":["https://openalex.org/W1557541313","https://openalex.org/W1564357553","https://openalex.org/W1589352523","https://openalex.org/W1736526707","https://openalex.org/W1966994557","https://openalex.org/W1969026751","https://openalex.org/W1970357295","https://openalex.org/W1970708343","https://openalex.org/W1976882531","https://openalex.org/W1979242330","https://openalex.org/W1980292336","https://openalex.org/W1983220846","https://openalex.org/W1984543735","https://openalex.org/W1986817752","https://openalex.org/W1987189093","https://openalex.org/W1987504060","https://openalex.org/W1989610585","https://openalex.org/W1990752488","https://openalex.org/W1990985899","https://openalex.org/W1991540139","https://openalex.org/W1993817188","https://openalex.org/W1995358650","https://openalex.org/W1996161852","https://openalex.org/W1996821483","https://openalex.org/W1998758244","https://openalex.org/W1999322873","https://openalex.org/W1999418860","https://openalex.org/W2000159893","https://openalex.org/W2002073678","https://openalex.org/W2002725330","https://openalex.org/W2007649924","https://openalex.org/W2008262189","https://openalex.org/W2008274313","https://openalex.org/W2008432341","https://openalex.org/W2010517016","https://openalex.org/W2011823975","https://openalex.org/W2012884263","https://openalex.org/W2013293643","https://openalex.org/W2019451761","https://openalex.org/W2020498098","https://openalex.org/W2020940130","https://openalex.org/W2021829493","https://openalex.org/W2029179236","https://openalex.org/W2029614230","https://openalex.org/W2031897899","https://openalex.org/W2032956576","https://openalex.org/W2037750372","https://openalex.org/W2039215669","https://openalex.org/W2040400629","https://openalex.org/W2043162569","https://openalex.org/W2043945700","https://openalex.org/W2043991983","https://openalex.org/W2044350451","https://openalex.org/W2046627081","https://openalex.org/W2048427203","https://openalex.org/W2051748491","https://openalex.org/W2055746941","https://openalex.org/W2060168413","https://openalex.org/W2060336303","https://openalex.org/W2062573880","https://openalex.org/W2064167215","https://openalex.org/W2065461408","https://openalex.org/W2068221099","https://openalex.org/W2068916684","https://openalex.org/W2069543462","https://openalex.org/W2072100512","https://openalex.org/W2074494444","https://openalex.org/W2075831237","https://openalex.org/W2078883007","https://openalex.org/W2084517025","https://openalex.org/W2086694435","https://openalex.org/W2087124418","https://openalex.org/W2087905468","https://openalex.org/W2090135807","https://openalex.org/W2091514824","https://openalex.org/W2094427465","https://openalex.org/W2103198077","https://openalex.org/W2105054202","https://openalex.org/W2109050104","https://openalex.org/W2109293470","https://openalex.org/W2110495233","https://openalex.org/W2111026403","https://openalex.org/W2113263838","https://openalex.org/W2113660809","https://openalex.org/W2116610925","https://openalex.org/W2119284420","https://openalex.org/W2119413986","https://openalex.org/W2123861916","https://openalex.org/W2129584348","https://openalex.org/W2134473688","https://openalex.org/W2134478449","https://openalex.org/W2135671879","https://openalex.org/W2136953476","https://openalex.org/W2137289358","https://openalex.org/W2138749227","https://openalex.org/W2140672532","https://openalex.org/W2144759503","https://openalex.org/W2147373137","https://openalex.org/W2150902176","https://openalex.org/W2152136687","https://openalex.org/W2154980296","https://openalex.org/W2155012110","https://openalex.org/W2155377428","https://openalex.org/W2158021558","https://openalex.org/W2158734690","https://openalex.org/W2160306549","https://openalex.org/W2160664367","https://openalex.org/W2163768016","https://openalex.org/W2167572811","https://openalex.org/W2169373397","https://openalex.org/W2170298287","https://openalex.org/W2188602644","https://openalex.org/W2246647439","https://openalex.org/W2985684595"],"related_works":["https://openalex.org/W4376121891","https://openalex.org/W10574995","https://openalex.org/W2139710747","https://openalex.org/W3103506900","https://openalex.org/W2010999937","https://openalex.org/W2118492754","https://openalex.org/W3036772847","https://openalex.org/W3023306231","https://openalex.org/W2398309765","https://openalex.org/W2140211083"],"abstract_inverted_index":{"This":[0],"thesis":[1],"relates":[2],"to":[3,22,54,93,112,124,142,181,225,237,273,276,283,315],"some":[4,285],"new":[5],"aspects":[6],"on":[7,156,171,186,261],"the":[8,14,47,120,125,129,158,168,172,175,217,242,245,250,262,289,292,299,303],"regulation":[9],"of":[10,46,61,70,96,128,136,167,219,239,241,291,302],"bone":[11,28,36,52,71,82,114,144,148,162,187,279,304],"healing.":[12,115,149,280],"In":[13,253,265],"last":[15],"few":[16],"years,":[17],"Wnt-signaling":[18,40],"has":[19,41],"been":[20,42],"shown":[21],"play":[23],"a":[24,74,183,194,310],"central":[25],"role":[26,195],"in":[27,35,88,164,190,197,204,229,249,287],"biology.":[29],"As":[30],"well":[31],"as":[32,44],"being":[33],"involved":[34],"maintenance":[37],"and":[38,64,98,100,146,207,227,270],"repair,":[39],"presented":[43],"one":[45],"key":[48],"pathways":[49],"through":[50],"which":[51],"responds":[53],"mechanical":[55],"load.":[56],"Two":[57],"secreted":[58],"extracellular":[59],"inhibitors":[60],"Wnt-signaling,":[62],"sclerostin":[63,97,138,200,263,269],"dickkopf-1":[65,140,271],"are":[66,305],"potent":[67],"negative":[68],"regulators":[69],"formation.":[72],"Using":[73],"rat":[75],"fracture":[76,317],"model":[77],"we":[78,105,117,214],"investigated":[79,106,118],"how":[80,216,288],"metaphyseal":[81,230,278],"healing":[83,318],"is":[84],"influenced":[85],"by":[86],"changes":[87],"Wnt-signaling.":[89,103],"Antibodies":[90],"were":[91,177],"used":[92],"suppress":[94],"levels":[95],"dickkopf-1,":[99],"thereby":[101],"increase":[102],"Primarily,":[104],"if":[107,119,298],"those":[108],"antibody":[109],"treatments":[110],"lead":[111],"improved":[113,147,161],"Also,":[116],"response":[121],"was":[122,257],"coupled":[123],"loading":[126,173,300],"conditions":[127,301],"bone.":[130,209,231,252],"Our":[131],"findings":[132,308],"suggest":[133,309],"that":[134,234],"suppression":[135],"either":[137],"or":[139],"leads":[141],"increased":[143],"formation":[145,163],"Apart":[150],"from":[151],"just":[152],"having":[153],"an":[154,259],"effect":[155,185,203,247,260,290],"healing,":[157],"treatment":[159],"also":[160],"other":[165],"parts":[166],"skeleton.":[169],"Depending":[170],"conditions,":[174],"effects":[176],"different.":[178],"Dickkopf-1":[179],"appeared":[180],"have":[182],"stronger":[184],"volume":[188],"density":[189],"unloaded":[191,208,251],"bone,":[192,255],"implying":[193],"mainly":[196,258],"mechano-transduction,":[198],"while":[199],"had":[201],"similar":[202],"both":[205],"loaded":[206],"To":[210],"confirm":[211],"these":[212],"findings,":[213],"studied":[215],"expression":[218],"several":[220],"Wnt-related":[221],"genes":[222,243],"changed":[223],"due":[224],"trauma":[226,235],"unloading":[228],"We":[232],"found":[233],"led":[236],"upregulation":[238],"most":[240],"with":[244],"largest":[246],"seen":[248],"untraumatized":[254],"there":[256],"gene.":[264],"conclusion,":[266],"antibodies":[267,294],"against":[268],"appear":[272,282],"be":[274,284],"able":[275],"improve":[277],"There":[281],"differences":[286],"two":[293],"manifests":[295],"itself,":[296],"especially":[297],"altered.":[306],"These":[307],"potential":[311],"for":[312],"clinical":[313],"use":[314],"shorten":[316],"time.":[319]},"counts_by_year":[],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2016-06-24T00:00:00"}