{"id":"https://openalex.org/W1009984683","doi":null,"title":"Kinetics of acute inflammation induced by Escherichia coli in rabbits. II. The effect of hyperimmunization, complement depletion, and depletion of leukocytes.","display_name":"Kinetics of acute inflammation induced by Escherichia coli in rabbits. II. The effect of hyperimmunization, complement depletion, and depletion of leukocytes.","publication_year":1983,"publication_date":"1983-01-01","ids":{"openalex":"https://openalex.org/W1009984683","mag":"1009984683","pmid":"https://pubmed.ncbi.nlm.nih.gov/6336905","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1916122"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1916122","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1916122","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1916122","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030657618","display_name":"M. M. Kopaniak","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M M Kopaniak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5010433389","display_name":"Henry Z. Movat","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"H Z Movat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8361,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.85446126,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"110","issue":"1","first_page":"13","last_page":"29"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8525000214576721,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8525000214576721,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10993","display_name":"Complement system in diseases","score":0.05249999836087227,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14165","display_name":"Inflammation biomarkers and pathways","score":0.037700001150369644,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-inflammation","display_name":"acute inflammation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9850000143051147},{"id":"https://openalex.org/keywords/hyperimmunization","display_name":"hyperimmunization","score":0.9309999942779541},{"id":"https://openalex.org/keywords/complement-depletion","display_name":"complement depletion","score":0.8230000138282776},{"id":"https://openalex.org/keywords/cobra-venom-factor","display_name":"cobra venom factor","score":0.8510000109672546},{"id":"https://openalex.org/keywords/leukopenia","display_name":"leukopenia","score":0.9369999766349792},{"id":"https://openalex.org/keywords/nitrogen-mustard","display_name":"nitrogen mustard","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hyperemia","display_name":"hyperemia","score":0.7379999756813049},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.996999979019165},{"id":"https://openalex.org/keywords/leukocyte-infiltration","display_name":"leukocyte infiltration","score":0.9279999732971191},{"id":"https://openalex.org/keywords/hemorrhage","display_name":"hemorrhage","score":0.9440000057220459},{"id":"https://openalex.org/keywords/neutrophils","display_name":"neutrophils","score":0.8130000233650208},{"id":"https://openalex.org/keywords/abscess-formation","display_name":"abscess formation","score":0.9559999704360962},{"id":"https://openalex.org/keywords/bacterial-phagocytosis","display_name":"bacterial phagocytosis","score":0.6710000038146973},{"id":"https://openalex.org/keywords/host-defense","display_name":"host defense","score":0.5490000247955322},{"id":"https://openalex.org/keywords/rabbit-skin","display_name":"rabbit skin","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C2910058513","wikidata":"https://www.wikidata.org/wiki/Q458138","display_name":"Hyperimmunization","level":3,"score":0.7230473160743713},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.659262478351593},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.5847762823104858},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5254292488098145},{"id":"https://openalex.org/C2780050494","wikidata":"https://www.wikidata.org/wiki/Q201382","display_name":"Turpentine","level":2,"score":0.4973900616168976},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.46842774748802185},{"id":"https://openalex.org/C2778923028","wikidata":"https://www.wikidata.org/wiki/Q974869","display_name":"Leukocytosis","level":2,"score":0.4453945457935333},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.44400933384895325},{"id":"https://openalex.org/C2777300124","wikidata":"https://www.wikidata.org/wiki/Q600813","display_name":"Cellular infiltration","level":3,"score":0.4386325478553772},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.4289878010749817},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3858378529548645},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28526556491851807},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.23008158802986145},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11548241972923279},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002199","descriptor_name":"Capillary Permeability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D003165","descriptor_name":"Complement System Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003872","descriptor_name":"Dermatitis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004306","descriptor_name":"Dose-Response Relationship, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006470","descriptor_name":"Hemorrhage","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006940","descriptor_name":"Hyperemia","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007114","descriptor_name":"Immunization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007962","descriptor_name":"Leukocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007970","descriptor_name":"Leukopenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D007970","descriptor_name":"Leukopenia","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D009504","descriptor_name":"Neutrophils","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:1916122","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1916122","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},{"id":"pmid:6336905","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6336905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of pathology","raw_type":"Journal Article"},{"id":"mag:1009984683","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6336905","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:1916122","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1916122","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Pathol","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W70121071","https://openalex.org/W110411724","https://openalex.org/W203735546","https://openalex.org/W283389292","https://openalex.org/W1543907558","https://openalex.org/W1791871171","https://openalex.org/W1896082656","https://openalex.org/W1920256817","https://openalex.org/W1948427568","https://openalex.org/W1967895470","https://openalex.org/W2009072203","https://openalex.org/W2023192608","https://openalex.org/W2024608615","https://openalex.org/W2052327108","https://openalex.org/W2058310630","https://openalex.org/W2092556159","https://openalex.org/W2105146448","https://openalex.org/W2105748362","https://openalex.org/W2107734066","https://openalex.org/W2171984962","https://openalex.org/W2175881577","https://openalex.org/W2265837777","https://openalex.org/W2316809950","https://openalex.org/W2325422734","https://openalex.org/W2335617265","https://openalex.org/W2405011991","https://openalex.org/W2417828229","https://openalex.org/W2417936308","https://openalex.org/W2433616953"],"related_works":["https://openalex.org/W2175881577","https://openalex.org/W2102389545","https://openalex.org/W2884945098","https://openalex.org/W1995049908","https://openalex.org/W2076952633","https://openalex.org/W2407326572","https://openalex.org/W344176941","https://openalex.org/W2035606297","https://openalex.org/W2163849924","https://openalex.org/W2184158162"],"abstract_inverted_index":{"The":[0,77],"inflammatory":[1,126],"response":[2],"to":[3,63,82,117],"Escherichia":[4],"coli":[5,137],"was":[6,132,140,153,171,191,221,234,296],"quantitated":[7,35],"in":[8,86,101,110,115,163,176,184,195,208,213,227,237,248,270,278,285,289,306],"the":[9,15,46,87,98,104,119,122,125,135,164,169,224,228,243,251,257,286,290],"skin":[10],"of":[11,48,113,124,130,143,230,242,256,308,315],"normal":[12,177,205,225,249,291,299],"rabbits":[13,114,186,198,210],"and":[14,32,50,67,72,150,187,259,273],"kinetics":[16],"established":[17],"as":[18],"described":[19,100],"previously.":[20],"Hyperemia,":[21],"measured":[22,58],"with":[23,29,36,59,134,146,156,303],"radiolabeled":[24],"microspheres;":[25],"vascular":[26,202,214],"permeability,":[27],"estimated":[28],"125":[30],"I-albumin;":[31],"leukocyte":[33],"infiltration,":[34],"51Cr-labeled":[37],"autologous":[38],"leukocytes,":[39],"reached":[40,74],"maximal":[41],"values":[42],"3":[43],"hours":[44,69],"after":[45,70],"injection":[47,71],"bacteria":[49,258,275],"subsided":[51],"almost":[52],"completely":[53],"by":[54,168,263],"6":[55,68],"hours.":[56],"Hemorrhage,":[57],"homologous":[60],"59Fe-erythrocytes,":[61],"continued":[62],"increase":[64,181,212],"between":[65],"1":[66,189],"then":[73],"plateau":[75],"levels.":[76],"lesions":[78,166,229,244],"were":[79,92,108,268,276,283,301,317],"studied":[80],"up":[81],"8":[83],"hours,":[84,265],"since":[85],"previous":[88],"study":[89,99],"no":[90,211],"changes":[91],"observed":[93],"beyond":[94],"that":[95,246],"time.":[96],"In":[97,159],"this":[102,294],"paper,":[103],"host":[105],"mediation":[106],"systems":[107],"manipulated":[109],"various":[111],"groups":[112],"order":[116],"elucidate":[118],"mechanisms":[120],"underlying":[121],"development":[123],"reaction.":[127],"One":[128],"group":[129],"animals":[131,161,226,250,300],"hyperimmunized":[133,160,185,231,287],"E":[136],"organisms,":[138],"another":[139,152],"partially":[141],"depleted":[142],"hemolytic":[144],"complement":[145],"cobra":[147],"venom":[148],"factor,":[149],"yet":[151],"rendered":[154],"leukopenic":[155,209,238,271,304],"nitrogen":[157],"mustard.":[158],"hyperemia":[162],"dermal":[165],"induced":[167],"microorganisms":[170],"significantly":[172,192,200,235],"more":[173,281],"intense":[174],"than":[175,194,204,288],"rabbits.":[178,232,239],"Vascular":[179],"permeability":[180,203,215],"occurred":[182],"earlier":[183],"at":[188],"hour":[190],"greater":[193],"normals.":[196],"Decomplemented":[197],"had":[199],"less":[201],"animals,":[206,272,305],"whereas":[207,247],"could":[216],"be":[217],"elicited.":[218],"Leukocyte":[219],"accumulation":[220],"increased":[222],"over":[223],"Hemorrhage":[233],"decreased":[236],"Histologic":[240],"examination":[241],"revealed":[245],"infiltrating":[252],"neutrophils":[253,282,316],"ingested":[254],"most":[255],"formed":[260],"definite":[261],"abscesses":[262,267],"6-8":[264],"these":[266],"absent":[269],"free-lying":[274],"demonstrable":[277],"lesions.":[279],"Histologically":[280],"present":[284],"rabbits,":[292],"but":[293],"difference":[295],"striking":[297],"when":[298],"compared":[302],"some":[307],"which":[309],"only":[310],"very":[311],"occasional":[312],"small":[313],"accumulations":[314],"present.":[318]},"counts_by_year":[{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
