{"id":"https://openalex.org/W1009835385","doi":null,"title":"Involvement of the Opioid System in High Alcohol Consumption : Environmental and Genetic Influences","display_name":"Involvement of the Opioid System in High Alcohol Consumption : Environmental and Genetic Influences","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W1009835385","mag":"1009835385"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-1653","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1653","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1653","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000992112","display_name":"Karolina Ploj","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Karolina Ploj","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5000992112"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.6869999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.6869999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.2705000042915344,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11541","display_name":"Neuroendocrine regulation and behavior","score":0.019200000911951065,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/opioid-system","display_name":"opioid system","score":0.9940000176429749},{"id":"https://openalex.org/keywords/alcoholism","display_name":"alcoholism","score":0.75},{"id":"https://openalex.org/keywords/ethanol-intake","display_name":"ethanol consumption","score":0.7710000276565552},{"id":"https://openalex.org/keywords/dynorphin-b","display_name":"dynorphin B","score":0.9869999885559082},{"id":"https://openalex.org/keywords/nucleus-accumbens","display_name":"nucleus accumbens","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ventral-tegmental-area","display_name":"ventral tegmental area","score":0.9929999709129333},{"id":"https://openalex.org/keywords/neonatal-handling","display_name":"neonatal handling","score":0.8389999866485596},{"id":"https://openalex.org/keywords/maternal-separation","display_name":"maternal separation","score":0.996999979019165},{"id":"https://openalex.org/keywords/hypothalamic-pituitary-adrenal-axis","display_name":"hypothalamic-pituitary-adrenal axis","score":0.8289999961853027},{"id":"https://openalex.org/keywords/anxiety-like-behavior","display_name":"anxiety-like behavior","score":0.8830000162124634},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.8479999899864197},{"id":"https://openalex.org/keywords/kappa-opioid-receptor","display_name":"kappa opioid receptor","score":0.746999979019165},{"id":"https://openalex.org/keywords/delta-opioid-receptor","display_name":"delta opioid receptor","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chronic-alcohol-consumption","display_name":"chronic alcohol consumption","score":0.6190000176429749},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.503000020980835},{"id":"https://openalex.org/keywords/environmental-factors","display_name":"environmental factors","score":0.4339999854564667}],"concepts":[{"id":"https://openalex.org/C125439840","wikidata":"https://www.wikidata.org/wiki/Q14911984","display_name":"Nociceptin receptor","level":5,"score":0.8581717014312744},{"id":"https://openalex.org/C2781069035","wikidata":"https://www.wikidata.org/wiki/Q1243765","display_name":"Periaqueductal gray","level":4,"score":0.7169507145881653},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7017713189125061},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7004871368408203},{"id":"https://openalex.org/C88016717","wikidata":"https://www.wikidata.org/wiki/Q417189","display_name":"Opioid peptide","level":4,"score":0.6478972434997559},{"id":"https://openalex.org/C25876315","wikidata":"https://www.wikidata.org/wiki/Q15197465","display_name":"Neurochemical","level":2,"score":0.589424192905426},{"id":"https://openalex.org/C2779144063","wikidata":"https://www.wikidata.org/wiki/Q338924","display_name":"Amygdala","level":2,"score":0.5675314664840698},{"id":"https://openalex.org/C151077648","wikidata":"https://www.wikidata.org/wiki/Q324076","display_name":"Dynorphin","level":5,"score":0.4949454665184021},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.4483382999897003},{"id":"https://openalex.org/C2776007765","wikidata":"https://www.wikidata.org/wiki/Q1960495","display_name":"Met-enkephalin","level":5,"score":0.4418938457965851},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.40210115909576416},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3342928886413574},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32935044169425964},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32813721895217896},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.09182977676391602},{"id":"https://openalex.org/C552161191","wikidata":"https://www.wikidata.org/wiki/Q185080","display_name":"Midbrain","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-1653","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1653","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1009835385","doi":null,"is_oa":false,"landing_page_url":"http://www.diva-portal.org/smash/record.jsf?pid=diva2:161258","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-1653","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1653","pdf_url":null,"source":{"id":"https://openalex.org/S4306402042","display_name":"Uppsala University Publications (Uppsala University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I123387679","host_organization_name":"Uppsala University","host_organization_lineage":["https://openalex.org/I123387679"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7098066547","https://openalex.org/W2043773062","https://openalex.org/W57831137","https://openalex.org/W2039892689","https://openalex.org/W2162688555","https://openalex.org/W2596109928","https://openalex.org/W3022200285","https://openalex.org/W4248138651","https://openalex.org/W650235137","https://openalex.org/W7036879763"],"abstract_inverted_index":{"It":[0],"is":[1],"well":[2,281],"accepted":[3],"that":[4,43,247,299],"both":[5,241],"inherent":[6],"and":[7,28,55,76,89,99,119,156,163,211,232,243,291,313],"environmental":[8,135],"factors":[9],"influence":[10],"the":[11,19,22,26,50,59,96,100,171,181,196,205,221,288,292,300,308,311],"pathogenesis":[12],"of":[13,21,30,49,108,110,193,315],"alcohol":[14],"dependence.":[15],"This":[16,188],"thesis":[17],"investigates":[18],"role":[20,306],"opioid":[23,51,261,301],"system":[24,302],"in":[25,42,58,73,80,86,92,138,141,145,160,167,195,204,218,260,276,284,287,307],"initiation":[27,312],"maintenance":[29,314],"high":[31,255,316],"ethanol":[32,71,78,209,215,230,256,268,317],"intake.":[33,257,318],"Ethanol-preferring":[34],"C57BL/6J":[35,74],"mice":[36,41,75],"differ":[37],"from":[38],"ethanol-avoiding":[39],"DBA/2J":[40],"they":[44],"exhibit":[45],"lower":[46],"basal":[47],"levels":[48,91,165],"peptides":[52],"dynorphin":[53,87,161],"B":[54,88,162],"Met-enkephalin-Arg6Phe7":[56],"(MEAP)":[57],"nucleus":[60,97,293],"accumbens,":[61],"which":[62],"may":[63],"contribute":[64],"to":[65,170,180,200,237,240],"their":[66],"divergent":[67],"drug-taking":[68],"behaviour.":[69,153],"Chronic":[70],"intake":[72,216,231],"repeated":[77],"administration":[79],"Sprague-Dawley":[81],"rats":[82,143,203],"induce":[83,158,250],"time-specific":[84],"changes":[85,159,259,283],"MEAP":[90,164],"regions,":[93],"such":[94,270],"as":[95,132,271,280,282],"accumbens":[98],"ventral":[101],"tegmental":[102],"area,":[103],"associated":[104],"with":[105,235],"reinforcing":[106],"effects":[107],"drugs":[109],"abuse.":[111],"Daily":[112],"neonatal":[113],"handling":[114],"for":[115,122,134],"15":[116],"min":[117,124],"(H15)":[118],"maternal":[120],"separation":[121],"360":[123],"(MS360)":[125],"during":[126],"postnatal":[127],"day":[128],"1-21":[129],"were":[130],"used":[131],"models":[133],"manipulation":[136],"early":[137],"life.":[139],"H15":[140,155,222,225,248],"male":[142],"results":[144,297],"decreased":[146],"anxiety-like":[147,152],"behaviour,":[148],"whereas":[149],"MS360":[150,157,206,242],"increases":[151],"Both":[154],"especially":[166],"regions":[168,178],"related":[169,179],"hypothalamic-pituitary-adrenal":[172],"(HPA)":[173],"axis.":[174],"In":[175],"female":[176],"rats,":[177],"HPA":[182,197],"axis":[183,198],"are":[184,264],"unaffected":[185],"by":[186],"H15.":[187],"suggests":[189],"a":[190,213],"gender-specific":[191],"involvement":[192],"opioids":[194],"response":[199],"stress.":[201],"More":[202],"group":[207,226],"initiate":[208],"consumption":[210],"have":[212],"higher":[214],"later":[217],"life":[219],"than":[220],"group.":[223],"The":[224],"has":[227],"particularly":[228],"low":[229],"also":[233],"differs":[234],"regard":[236],"neurochemistry":[238],"compared":[239],"control":[244],"groups,":[245],"suggesting":[246],"can":[249],"long-term":[251],"changes,":[252],"protective":[253],"against":[254],"Specific":[258],"receptor":[262],"density":[263,275,286],"observed":[265],"after":[266],"chronic":[267],"consumption,":[269],"an":[272,304],"increased":[273],"\u03ba-receptor":[274],"several":[277],"brain":[278],"areas,":[279],"\u03b4-receptor":[285],"frontal":[289],"cortex":[290],"accumbens.":[294],"Altogether,":[295],"these":[296],"suggest":[298],"plays":[303],"important":[305],"mechanisms":[309],"underlying":[310]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-04T10:56:28.161419","created_date":"2016-06-24T00:00:00"}