{"id":"https://openalex.org/W100972702","doi":null,"title":"Role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine: additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney.","display_name":"Role of cytochromes P450 and peroxidases in metabolism of the anticancer drug ellipticine: additional evidence of their contribution to ellipticine activation in rat liver, lung and kidney.","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W100972702","mag":"100972702","pmid":"https://pubmed.ncbi.nlm.nih.gov/21187821"},"language":"en","primary_location":{"id":"pmid:21187821","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21187821","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009212415","display_name":"Marie Stiborov\u00e1","orcid":"https://orcid.org/0000-0001-5430-4403","observed_orcids":["https://orcid.org/0000-0001-5430-4403"]},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Marie Stiborova","raw_affiliation_strings":["Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic. stiborov@natur.cuni.cz"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic. stiborov@natur.cuni.cz","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028762636","display_name":"Michaela Moserov\u00e1","orcid":"https://orcid.org/0000-0001-6273-135X","observed_orcids":["https://orcid.org/0000-0001-6273-135X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michaela Moserova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008372519","display_name":"Barbora Mr\u00e1zov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbora Mrazova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113561886","display_name":"V\u011bra Kotrbov\u00e1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vera Kotrbova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5055879543","display_name":"Eva Frei","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eva Frei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.6328,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.6304937,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"31 Suppl 2","issue":null,"first_page":"26","last_page":"35"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9047999978065491,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.04600000008940697,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13188","display_name":"Synthesis and bioactivity of alkaloids","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ellipticine","display_name":"ellipticine","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.9079999923706055},{"id":"https://openalex.org/keywords/peroxidase","display_name":"peroxidase","score":0.9570000171661377},{"id":"https://openalex.org/keywords/oxidative-activation","display_name":"oxidative activation","score":0.8069999814033508},{"id":"https://openalex.org/keywords/dna-adducts","display_name":"DNA adducts","score":0.902999997138977},{"id":"https://openalex.org/keywords/prodrug-activation","display_name":"prodrug activation","score":0.5960000157356262},{"id":"https://openalex.org/keywords/cyp1a","display_name":"CYP1A","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cyp3a","display_name":"CYP3A","score":1.0},{"id":"https://openalex.org/keywords/cyclooxygenase","display_name":"cyclooxygenase","score":0.9909999966621399},{"id":"https://openalex.org/keywords/lung-microsomes","display_name":"lung microsomes","score":0.7699999809265137},{"id":"https://openalex.org/keywords/kidney-microsomes","display_name":"kidney microsomes","score":0.9629999995231628},{"id":"https://openalex.org/keywords/liver-microsomes","display_name":"liver microsomes","score":0.9700000286102295},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.8669999837875366},{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.8510000109672546},{"id":"https://openalex.org/keywords/32p-postlabeling","display_name":"32P-postlabeling","score":0.6859999895095825},{"id":"https://openalex.org/keywords/rat-model","display_name":"rat model","score":0.3479999899864197}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7719972729682922},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.6654307246208191},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.592078685760498},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5920572876930237},{"id":"https://openalex.org/C162008176","wikidata":"https://www.wikidata.org/wiki/Q419305","display_name":"Peroxidase","level":3,"score":0.5233989357948303},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.5049918293952942},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.49516621232032776},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.47254109382629395},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4573078453540802},{"id":"https://openalex.org/C2781247443","wikidata":"https://www.wikidata.org/wiki/Q4153410","display_name":"DNA adduct","level":3,"score":0.4319838285446167},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4087618589401245},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15927305817604065},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001711","descriptor_name":"Biotransformation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003577","descriptor_name":"Cytochrome P-450 Enzyme System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004611","descriptor_name":"Ellipticines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008168","descriptor_name":"Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008861","descriptor_name":"Microsomes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008861","descriptor_name":"Microsomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010084","descriptor_name":"Oxidation-Reduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018736","descriptor_name":"DNA Adducts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D023421","descriptor_name":"Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:21187821","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21187821","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro endocrinology letters","raw_type":"Journal Article"},{"id":"mag:100972702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21187821","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2031291993","https://openalex.org/W2023322848","https://openalex.org/W2183859875","https://openalex.org/W2093852491","https://openalex.org/W7100512809","https://openalex.org/W2514873327","https://openalex.org/W2039686043","https://openalex.org/W2088961696","https://openalex.org/W7097491789","https://openalex.org/W2014330039"],"abstract_inverted_index":{"OBJECTIVE:":[0],"Ellipticine":[1,101],"is":[2,90],"a":[3,18,51,64,128,210,243,255,332],"potent":[4],"antineoplastic":[5],"agent":[6,14],"exhibiting":[7],"multiple":[8],"mechanisms":[9],"of":[10,45,53,70,78,119,131,134,138,152,156,195,225,228,257,265,273,278,294,315],"action.":[11],"This":[12],"anticancer":[13],"should":[15],"be":[16],"considered":[17],"pro-drug,":[19],"whose":[20],"pharmacological":[21],"efficiency":[22],"and/or":[23,34],"genotoxic":[24],"side":[25],"effects":[26],"are":[27,320],"dependent":[28],"on":[29,286],"its":[30],"cytochrome":[31],"P450":[32],"(CYP)-":[33],"peroxidase-mediated":[35],"activation":[36,61,89,174,215,248,261,293],"to":[37,49,86,166,216,301,304],"species":[38,217],"forming":[39,218],"covalent":[40],"DNA":[41,104,182,219,280],"adducts.":[42],"The":[43,76,308],"target":[44],"this":[46,336],"study":[47],"was":[48,145],"investigate":[50],"role":[52,212,245,334],"CYP":[54,305,313],"and":[55,80,83,92,103,117,150,158,179,192,198,206,233,298,317,340],"peroxidase":[56,84,329],"enzymes":[57,85,169,208,230,314,323],"in":[58,62,72,74,97,107,171,175,213,221,231,246,249,262,282,296,326,335,338],"ellipticine":[59,71,87,135,153,172,214,247,260,295,325],"oxidative":[60,173],"rats,":[63,120],"suitable":[65],"model":[66],"mimicking":[67],"the":[68,98,148,168,204,263,291,321],"fate":[69],"humans,":[73],"details.":[75],"contribution":[77],"pulmonary":[79],"renal":[81],"CYP-":[82],"metabolic":[88],"investigated":[91,110],"compared":[93],"with":[94,127,142],"that":[95,203,311],"found":[96,202],"liver.":[99],"METHODS:":[100],"oxidation":[102],"adduct":[105,281],"formation":[106,277],"vitro":[108],"were":[109,164,184],"using":[111],"microsomes":[112,264,300],"isolated":[113],"from":[114],"liver,":[115,177],"lung":[116,178,297],"kidney":[118,299],"either":[121],"control":[122],"(untreated)":[123],"or":[124],"treated":[125],"i.p.":[126],"single":[129],"dose":[130],"40":[132],"mg":[133],"per":[136],"kg":[137],"body":[139],"weight.":[140],"HPLC":[141],"UV":[143],"detection":[144],"employed":[146],"for":[147],"separation":[149],"characterization":[151],"metabolites.":[154],"Inhibitors":[155],"CYPs":[157],"cyclooxygenase":[159],"(prostaglandin":[160],"H":[161],"synthase,":[162],"COX)":[163],"used":[165],"characterize":[167],"participating":[170],"rat":[176,327],"kidney.":[180],"Ellipticine-derived":[181],"adducts":[183,220],"detected":[185],"by":[186,239],"32P-postlabeling.":[187],"RESULTS:":[188],"Using":[189],"\u03b1-naphthoflavone,":[190],"furafylline":[191],"ketoconazole,":[193],"inhibitors":[194],"CYP1A,":[196],"1A2":[197],"3A,":[199],"respectively,":[200],"we":[201,289],"CYP1A":[205],"3A":[207,318],"play":[209,242],"major":[211,322],"liver":[222],"microsomes.":[223,284],"Because":[224],"lower":[226],"expression":[227],"these":[229,250,283,287],"lungs":[232,339],"kidneys,":[234],"even":[235],"after":[236],"their":[237],"induction":[238],"ellipticine,":[240],"they":[241],"minor":[244],"extrahepatic":[251,266],"tissues.":[252,267],"Arachidonic":[253],"acid,":[254],"cofactor":[256],"COX,":[258,274],"increased":[259],"In":[268],"addition,":[269],"indomethacin,":[270],"an":[271],"inhibitor":[272],"efficiently":[275],"inhibited":[276],"ellipticine-derived":[279],"Based":[285],"results,":[288],"attribute":[290],"higher":[292],"COX":[302,330],"than":[303],"enzymes.":[306],"CONCLUSION:":[307],"results":[309],"demonstrate":[310],"whereas":[312],"1A":[316],"subfamilies":[319],"activating":[324],"livers,":[328],"plays":[331],"significant":[333],"process":[337],"kidneys.":[341]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
