{"id":"https://openalex.org/W100929131","doi":"https://doi.org/10.1007/978-1-4614-5203-4_18","title":"Cardiac Remodeling in the Hypertrophic Heart: Signal-Dependent Regulation of the Fibrotic Gene Program by CLP-1","display_name":"Cardiac Remodeling in the Hypertrophic Heart: Signal-Dependent Regulation of the Fibrotic Gene Program by CLP-1","publication_year":2012,"publication_date":"2012-10-11","ids":{"openalex":"https://openalex.org/W100929131","doi":"https://doi.org/10.1007/978-1-4614-5203-4_18","mag":"100929131"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-4614-5203-4_18","doi":"https://doi.org/10.1007/978-1-4614-5203-4_18","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4614-5203-4_18","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiac Adaptations","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4205533209","display_name":"Cardiac Adaptations"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Michael Wagner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Wagner","raw_affiliation_strings":["The Center for Cardiovascular and Muscle Research and Department of Cell Biology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, New York, 11203, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Center for Cardiovascular and Muscle Research and Department of Cell Biology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, New York, 11203, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061797233","display_name":"M.A.Q. Siddiqui","orcid":"https://orcid.org/0000-0002-7966-412X","observed_orcids":["https://orcid.org/0000-0002-7966-412X"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"M. A. Q. Siddiqui","raw_affiliation_strings":["The Center for Cardiovascular and Muscle Research and Department of Cell Biology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, New York, 11203, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Center for Cardiovascular and Muscle Research and Department of Cell Biology, State University of New York Downstate Medical Center, 450 Clarkson Avenue, New York, 11203, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061797233"],"corresponding_institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"],"apc_list":null,"apc_paid":null,"fwci":1.4808,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.81421838,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"341","last_page":"359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.8935999870300293,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.08829999715089798,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.7889999747276306},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.8619999885559082},{"id":"https://openalex.org/keywords/hexim1","display_name":"HEXIM1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cdk9","display_name":"CDK9","score":0.8960000276565552},{"id":"https://openalex.org/keywords/rna-polymerase-ii","display_name":"RNA polymerase II","score":0.9229999780654907},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.6449999809265137},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.6010000109672546},{"id":"https://openalex.org/keywords/smad-transcription-factors","display_name":"Smad transcription factors","score":0.699999988079071},{"id":"https://openalex.org/keywords/stress-responsive-genes","display_name":"stress response genes","score":0.6069999933242798},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"signal transduction","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4712938368320465},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4661717712879181},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4392293393611908},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41662395000457764},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.41048717498779297},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4096277952194214},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3354841470718384},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14713740348815918},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.11623045802116394},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-1-4614-5203-4_18","doi":"https://doi.org/10.1007/978-1-4614-5203-4_18","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-4614-5203-4_18","pdf_url":null,"source":{"id":"https://openalex.org/S4306463937","display_name":"Springer eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiac Adaptations","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":75,"referenced_works":["https://openalex.org/W121429037","https://openalex.org/W142638070","https://openalex.org/W1507146282","https://openalex.org/W1552118263","https://openalex.org/W1609684706","https://openalex.org/W1955797432","https://openalex.org/W1965667964","https://openalex.org/W1975318062","https://openalex.org/W1975875223","https://openalex.org/W1976052678","https://openalex.org/W1986057117","https://openalex.org/W1986489016","https://openalex.org/W1994768880","https://openalex.org/W1994898053","https://openalex.org/W1997673607","https://openalex.org/W1998988555","https://openalex.org/W1999506807","https://openalex.org/W2000537144","https://openalex.org/W2005629438","https://openalex.org/W2005874915","https://openalex.org/W2007044718","https://openalex.org/W2011813460","https://openalex.org/W2013958991","https://openalex.org/W2016414323","https://openalex.org/W2016640448","https://openalex.org/W2021420308","https://openalex.org/W2021484300","https://openalex.org/W2024003051","https://openalex.org/W2028761750","https://openalex.org/W2029327578","https://openalex.org/W2034154367","https://openalex.org/W2034469841","https://openalex.org/W2039820053","https://openalex.org/W2052755996","https://openalex.org/W2056539292","https://openalex.org/W2057015990","https://openalex.org/W2057648527","https://openalex.org/W2057714004","https://openalex.org/W2059104750","https://openalex.org/W2060042285","https://openalex.org/W2067136301","https://openalex.org/W2071035473","https://openalex.org/W2073534977","https://openalex.org/W2081088335","https://openalex.org/W2086041680","https://openalex.org/W2086140631","https://openalex.org/W2092340900","https://openalex.org/W2094420876","https://openalex.org/W2094579915","https://openalex.org/W2097469177","https://openalex.org/W2102784194","https://openalex.org/W2104471796","https://openalex.org/W2106146479","https://openalex.org/W2106572088","https://openalex.org/W2106698189","https://openalex.org/W2106929179","https://openalex.org/W2107359871","https://openalex.org/W2111346201","https://openalex.org/W2112707577","https://openalex.org/W2114644843","https://openalex.org/W2116091611","https://openalex.org/W2131042657","https://openalex.org/W2135401778","https://openalex.org/W2140485864","https://openalex.org/W2142393775","https://openalex.org/W2143432231","https://openalex.org/W2148134248","https://openalex.org/W2150428021","https://openalex.org/W2167721417","https://openalex.org/W2171820373","https://openalex.org/W2255671787","https://openalex.org/W2273410316","https://openalex.org/W2325687453","https://openalex.org/W2397384091","https://openalex.org/W2404961380"],"related_works":["https://openalex.org/W75515611","https://openalex.org/W2106698189","https://openalex.org/W1510237593","https://openalex.org/W2027223796","https://openalex.org/W2057714004","https://openalex.org/W2057015990","https://openalex.org/W4414960275","https://openalex.org/W2087501446","https://openalex.org/W3177158831","https://openalex.org/W7170292713"],"abstract_inverted_index":null,"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2016-06-24T00:00:00"}