{"id":"https://openalex.org/W1007688492","doi":"https://doi.org/10.3969/j.issn.1673-5374.2013.06.004","title":"Flavonoids from Scutellaria baicalensis Georgi are effective to treat cerebral ischemia/reperfusion.","display_name":"Flavonoids from Scutellaria baicalensis Georgi are effective to treat cerebral ischemia/reperfusion.","publication_year":2013,"publication_date":"2013-02-25","ids":{"openalex":"https://openalex.org/W1007688492","doi":"https://doi.org/10.3969/j.issn.1673-5374.2013.06.004","mag":"1007688492","pmid":"https://pubmed.ncbi.nlm.nih.gov/25206694","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4146055"},"language":"en","primary_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4146055","doi":"https://doi.org/10.3969/j.issn.1673-5374.2013.06.004","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4146055","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Regen Res","raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4146055","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043496571","display_name":"Shang Yazhen","orcid":"https://orcid.org/0000-0002-3093-8361","observed_orcids":["https://orcid.org/0000-0002-3093-8361"]},"institutions":[{"id":"https://openalex.org/I192578869","display_name":"Chengde Medical University","ror":"https://ror.org/02bzkv281","country_code":"CN","type":"education","lineage":["https://openalex.org/I192578869"]},{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yazhen Shang","raw_affiliation_strings":["Department of Pharmacology of Basic Medical School, Wuhan University, Wuhan 430071, Hubei Province, China ; Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Institute of Traditional Chinese Medicine, Chengde Medical College, Chengde 067000, Hebei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology of Basic Medical School, Wuhan University, Wuhan 430071, Hubei Province, China ; Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Institute of Traditional Chinese Medicine, Chengde Medical College, Chengde 067000, Hebei Province, China","institution_ids":["https://openalex.org/I192578869","https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100621411","display_name":"Hong Zhang","orcid":"https://orcid.org/0000-0002-6417-8399","observed_orcids":["https://orcid.org/0000-0002-6417-8399"]},"institutions":[{"id":"https://openalex.org/I4210107741","display_name":"Affiliated Hospital of Chengde Medical College","ror":"https://ror.org/01bgds823","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210107741"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Zhang","raw_affiliation_strings":["Second Department of General Surgery, Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Department of General Surgery, Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province, China","institution_ids":["https://openalex.org/I4210107741"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jianjun Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192578869","display_name":"Chengde Medical University","ror":"https://ror.org/02bzkv281","country_code":"CN","type":"education","lineage":["https://openalex.org/I192578869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianjun Cheng","raw_affiliation_strings":["Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Institute of Traditional Chinese Medicine, Chengde Medical College, Chengde 067000, Hebei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Institute of Traditional Chinese Medicine, Chengde Medical College, Chengde 067000, Hebei Province, China","institution_ids":["https://openalex.org/I192578869"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hong Miao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I192578869","display_name":"Chengde Medical University","ror":"https://ror.org/02bzkv281","country_code":"CN","type":"education","lineage":["https://openalex.org/I192578869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Miao","raw_affiliation_strings":["Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Institute of Traditional Chinese Medicine, Chengde Medical College, Chengde 067000, Hebei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Institute of Traditional Chinese Medicine, Chengde Medical College, Chengde 067000, Hebei Province, China","institution_ids":["https://openalex.org/I192578869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100606518","display_name":"Yongping Liu","orcid":"https://orcid.org/0000-0002-6466-483X","observed_orcids":["https://orcid.org/0000-0002-6466-483X"]},"institutions":[{"id":"https://openalex.org/I192578869","display_name":"Chengde Medical University","ror":"https://ror.org/02bzkv281","country_code":"CN","type":"education","lineage":["https://openalex.org/I192578869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongping Liu","raw_affiliation_strings":["Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Institute of Traditional Chinese Medicine, Chengde Medical College, Chengde 067000, Hebei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Institute of Traditional Chinese Medicine, Chengde Medical College, Chengde 067000, Hebei Province, China","institution_ids":["https://openalex.org/I192578869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101410989","display_name":"Kai Cao","orcid":"https://orcid.org/0000-0002-7939-7279","observed_orcids":["https://orcid.org/0000-0002-7939-7279","https://orcid.org/0000-0001-6384-1227","https://orcid.org/0009-0009-5068-087X"]},"institutions":[{"id":"https://openalex.org/I192578869","display_name":"Chengde Medical University","ror":"https://ror.org/02bzkv281","country_code":"CN","type":"education","lineage":["https://openalex.org/I192578869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Cao","raw_affiliation_strings":["Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Institute of Traditional Chinese Medicine, Chengde Medical College, Chengde 067000, Hebei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebei Province Key Laboratory of Traditional Chinese Medicine Research and Development, Institute of Traditional Chinese Medicine, Chengde Medical College, Chengde 067000, Hebei Province, China","institution_ids":["https://openalex.org/I192578869"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100460656","display_name":"Hui Wang","orcid":"https://orcid.org/0000-0001-5300-8661","observed_orcids":["https://orcid.org/0000-0001-5300-8661","https://orcid.org/0009-0006-6916-3790"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Wang","raw_affiliation_strings":["Department of Pharmacology of Basic Medical School, Wuhan University, Wuhan 430071, Hubei Province, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology of Basic Medical School, Wuhan University, Wuhan 430071, Hubei Province, China","institution_ids":["https://openalex.org/I37461747"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.4904,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.6519521,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"8","issue":"6","first_page":"514","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/scutellaria-baicalensis","display_name":"Scutellaria baicalensis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cerebral-ischemia-reperfusion-injury","display_name":"cerebral ischemia-reperfusion injury","score":0.9330000281333923},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9909999966621399},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.9829999804496765},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8059999942779541},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.7889999747276306},{"id":"https://openalex.org/keywords/memory-impairment","display_name":"memory impairment","score":0.8059999942779541},{"id":"https://openalex.org/keywords/na-k-atpase","display_name":"Na+/K+-ATPase","score":0.9120000004768372},{"id":"https://openalex.org/keywords/ca2-atpase","display_name":"Ca2+-ATPase","score":0.9589999914169312},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9589999914169312},{"id":"https://openalex.org/keywords/neuronal-loss","display_name":"neuronal loss","score":0.49399998784065247},{"id":"https://openalex.org/keywords/ischemic-brain-disease","display_name":"ischemic brain disease","score":0.7519999742507935}],"concepts":[{"id":"https://openalex.org/C2778153525","wikidata":"https://www.wikidata.org/wiki/Q803769","display_name":"Scutellaria baicalensis","level":4,"score":0.9823836088180542},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.6755476593971252},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6425702571868896},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.6353306770324707},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5644987225532532},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5448557734489441},{"id":"https://openalex.org/C2777318727","wikidata":"https://www.wikidata.org/wiki/Q409464","display_name":"Lactate dehydrogenase","level":3,"score":0.5133487582206726},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.48545271158218384},{"id":"https://openalex.org/C2780114680","wikidata":"https://www.wikidata.org/wiki/Q1413991","display_name":"Reperfusion injury","level":3,"score":0.44720637798309326},{"id":"https://openalex.org/C2779450755","wikidata":"https://www.wikidata.org/wiki/Q1209150","display_name":"Cerebral infarction","level":3,"score":0.4430209994316101},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3651813864707947},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3217317461967468},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.31061965227127075},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2546771168708801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1823389232158661},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.17306384444236755},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.15720278024673462},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1038753092288971},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.08194687962532043},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:pubmedcentral.nih.gov:4146055","doi":"https://doi.org/10.3969/j.issn.1673-5374.2013.06.004","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4146055","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Regen Res","raw_type":"Text"},{"id":"pmid:25206694","doi":"https://doi.org/10.3969/j.issn.1673-5374.2013.06.004","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25206694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural regeneration research","raw_type":"Journal Article"},{"id":"mag:1007688492","doi":"https://doi.org/10.3969/j.issn.1673-5374.2013.06.004","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25206694","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4146055","doi":"https://doi.org/10.3969/j.issn.1673-5374.2013.06.004","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4146055","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neural Regen Res","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W1909811943","https://openalex.org/W1940436875","https://openalex.org/W1964520308","https://openalex.org/W1978475121","https://openalex.org/W1983310681","https://openalex.org/W1986748797","https://openalex.org/W2004777846","https://openalex.org/W2011249807","https://openalex.org/W2020699058","https://openalex.org/W2043336768","https://openalex.org/W2060235866","https://openalex.org/W2076219263","https://openalex.org/W2077333000","https://openalex.org/W2081959240","https://openalex.org/W2094344877","https://openalex.org/W2105156741","https://openalex.org/W2136131703","https://openalex.org/W2141727213","https://openalex.org/W2165821586","https://openalex.org/W2169473035","https://openalex.org/W2170014340","https://openalex.org/W2370905032","https://openalex.org/W2950032827"],"related_works":["https://openalex.org/W1490718414","https://openalex.org/W2051485809","https://openalex.org/W2743355884","https://openalex.org/W2083565149","https://openalex.org/W1980265847","https://openalex.org/W2898040433","https://openalex.org/W2391676339","https://openalex.org/W2748150738","https://openalex.org/W2005366486","https://openalex.org/W2387065901"],"abstract_inverted_index":{"Based":[0],"on":[1],"previous":[2],"studies":[3],"that":[4,122],"have":[5],"shown":[6],"flavonoids":[7,100,126],"from":[8,101,127],"the":[9,71,85,92,115,123,145],"stems":[10],"and":[11,65,78,84,107,135],"leaves":[12],"of":[13,36,73,87,94,125,147],"Scutellaria":[14,102,128],"baicalensis":[15,103,129],"Georgi":[16,104,130],"are":[17],"neuroprotective":[18],"agents":[19],"in":[20,26,33,45,131],"a":[21,41],"naturally":[22],"senile,":[23],"D-galactose,":[24],"aging":[25],"vivo":[27],"model,":[28],"as":[29,31],"well":[30],"an":[32],"vitro":[34],"model":[35,44],"oxidative/hypoxic":[37],"injury,":[38],"we":[39],"established":[40],"cerebral":[42,49,133,139],"ischemia/reperfusion":[43,140],"rats":[46,95],"by":[47],"middle":[48],"artery":[50],"occlusion.":[51],"The":[52],"light/electron":[53],"microscopic":[54],"observations":[55],"found":[56],"significant":[57],"neuropathological":[58],"changes":[59],"including":[60],"neuron":[61],"loss":[62],"or":[63],"swelling":[64],"rough":[66],"endoplasmic":[67],"reticulum":[68],"injury.":[69],"Moreover,":[70],"activities":[72],"lactate":[74],"dehydrogenase,":[75],"Na(+)-K(+)-ATPase,":[76],"Ca(2+)-ATPase":[77],"superoxide":[79],"dismutase":[80],"were":[81],"significantly":[82],"lowered,":[83],"levels":[86],"malonaldehyde":[88],"increased.":[89],"In":[90],"addition,":[91],"memory":[93],"worsened.":[96],"However,":[97],"treatment":[98,146],"with":[99],"(35,":[105],"70":[106],"140":[108],"mg/kg)":[109],"for":[110,144],"13":[111],"days":[112],"dramatically":[113],"improved":[114],"above":[116],"abnormal":[117],"changes.":[118],"These":[119],"results":[120],"suggest":[121],"ability":[124],"attenuating":[132],"functional":[134],"morphological":[136],"consequences":[137],"after":[138],"may":[141],"be":[142],"beneficial":[143],"ischemic":[148],"brain":[149],"disease.":[150]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2016-06-24T00:00:00"}
