{"id":"https://openalex.org/W100756687","doi":null,"title":"Taxol plus radiation for head and neck cancer.","display_name":"Taxol plus radiation for head and neck cancer.","publication_year":1995,"publication_date":"1995-01-01","ids":{"openalex":"https://openalex.org/W100756687","mag":"100756687","pmid":"https://pubmed.ncbi.nlm.nih.gov/8521234"},"language":"en","primary_location":{"id":"pmid:8521234","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8521234","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infusional chemotherapy","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031390646","display_name":"David I. Rosenthal","orcid":"https://orcid.org/0000-0001-7124-7447","observed_orcids":["https://orcid.org/0000-0001-7124-7447"]},"institutions":[{"id":"https://openalex.org/I4390039370","display_name":"Harold C. Simmons Comprehensive Cancer Center","ror":"https://ror.org/03cbz4r60","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D I Rosenthal","raw_affiliation_strings":["Department of Radiation Oncology, Harold C. Simmons Comprehensive Cancer Center, University of Texas, Southwestern Medical Center at Dallas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Harold C. Simmons Comprehensive Cancer Center, University of Texas, Southwestern Medical Center at Dallas, USA","institution_ids":["https://openalex.org/I4390039370","https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5059652753","display_name":"David Paul Carbone","orcid":"https://orcid.org/0000-0003-3002-1921","observed_orcids":["https://orcid.org/0000-0003-3002-1921"]},"institutions":[{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D P Carbone","raw_affiliation_strings":["University of Texas at Austin#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at Austin#TAB#","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.003,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.88975155,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"5","issue":"2","first_page":"46","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9595000147819519,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.03269999846816063,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.996999979019165},{"id":"https://openalex.org/keywords/taxanes","display_name":"taxanes","score":0.9660000205039978},{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.9829999804496765},{"id":"https://openalex.org/keywords/radiosensitization","display_name":"radiosensitization","score":0.8379999995231628},{"id":"https://openalex.org/keywords/concurrent-chemoradiotherapy","display_name":"concurrent chemoradiotherapy","score":0.8339999914169312},{"id":"https://openalex.org/keywords/microtubule-stabilization","display_name":"microtubule stabilization","score":0.8600000143051147},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.890999972820282},{"id":"https://openalex.org/keywords/recurrent-head-and-neck-cancer","display_name":"recurrent head and neck cancer","score":0.8349999785423279},{"id":"https://openalex.org/keywords/locally-advanced-head-and-neck-cancer","display_name":"locally advanced head and neck cancer","score":0.7730000019073486}],"concepts":[{"id":"https://openalex.org/C2776428644","wikidata":"https://www.wikidata.org/wiki/Q2126468","display_name":"Radiosensitizer","level":3,"score":0.9372433423995972},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.90829998254776},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7466157674789429},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.7224080562591553},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.7081819772720337},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6013489365577698},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6012120246887207},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5213167071342468},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5010888576507568},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44230079650878906},{"id":"https://openalex.org/C206684579","wikidata":"https://www.wikidata.org/wiki/Q4387689","display_name":"Radiosensitivity","level":3,"score":0.4234643280506134},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39175063371658325},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.356588214635849}],"mesh":[{"descriptor_ui":"D000972","descriptor_name":"Antineoplastic Agents, Phytogenic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000532","qualifier_name":"radiotherapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:8521234","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8521234","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infusional chemotherapy","raw_type":"Journal Article"},{"id":"mag:100756687","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8521234","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2312423351","https://openalex.org/W2375734800","https://openalex.org/W2408877062","https://openalex.org/W2375148773","https://openalex.org/W2411113428","https://openalex.org/W2409844241","https://openalex.org/W2125815927","https://openalex.org/W2265465296","https://openalex.org/W2416835368","https://openalex.org/W2409482254"],"abstract_inverted_index":{"Taxol":[0],"(paclitaxel)":[1],"is":[2,59,115],"the":[3,12,36,107,111,125,128,205,211,218,225],"prototype":[4],"of":[5,9,16,23,67,78,104,110,221],"a":[6,20,48,76,116,138,188,241],"new":[7],"class":[8],"cancer":[10,46,73],"drugs,":[11],"taxanes.":[13],"This":[14],"group":[15],"anticancer":[17],"agents":[18],"have":[19],"novel":[21],"mechanism":[22],"action,":[24],"broad":[25],"clinical":[26,31,189,208,228],"activity,":[27],"and":[28,44,71,100,123,178,193,196,207,214,223,246],"potential":[29,186,215,242],"as":[30,83,187,240],"radiosensitizers.":[32],"Paclitaxel":[33,97,132],"may":[34],"be":[35,137,168],"most":[37],"efficacious":[38],"single":[39],"chemotherapy":[40,80],"agent":[41],"for":[42,52,119,142,154,175,191,217,244],"head":[43,70,192,245],"neck":[45,72,194,247],"with":[47,54,65,88,127,236],"40%":[49],"response":[50],"rate":[51],"patients":[53],"recurrent":[55],"disease.":[56],"As":[57],"it":[58],"possible":[60],"to":[61,93,102,136,161],"achieve":[62],"durable":[63],"control":[64],"radiotherapy":[66,89],"locally":[68],"advanced":[69],"in":[74,90,140,201],"only":[75],"minority":[77],"cases,":[79],"drugs":[81],"such":[82],"paclitaxel":[84,155,184,222,239],"are":[85,200],"being":[86],"used":[87],"an":[91],"attempt":[92],"improve":[94],"tumor":[95],"control.":[96],"stabilizes":[98],"microtubules":[99],"leads":[101],"accumulation":[103],"cells":[105],"at":[106],"G2/mitosis":[108],"phase":[109,126,197,233],"cell":[112,147],"cycle,":[113],"which":[114],"necessary":[117],"condition":[118],"its":[120],"antitumor":[121],"effect,":[122],"also":[124],"greatest":[129],"relative":[130],"radiosensitivity.":[131],"has":[133,185],"been":[134],"shown":[135],"radiosensitizer":[139,190,243],"vitro":[141,151],"some":[143],"but":[144],"not":[145],"all":[146],"lines":[148],"studied.":[149],"In":[150],"dose-response":[152],"data":[153,181],"paradoxically":[156],"suggest":[157,182],"that":[158,183],"prolonged":[159],"exposure":[160],"relatively":[162],"low":[163],"concentrations--those":[164],"easily":[165],"achievable":[166],"clinically--may":[167],"more":[169],"effective":[170],"than":[171],"higher":[172],"doses":[173],"both":[174],"direct":[176],"cytotoxicity":[177],"radiosensitization.":[179],"These":[180],"cancer,":[195],"I":[198,234],"trials":[199,235],"progress.":[202],"We":[203],"review":[204],"laboratory":[206],"studies":[209],"supplying":[210],"rationale,":[212],"risks,":[213],"benefits":[216],"concurrent":[219],"use":[220],"radiotherapy,":[224],"current":[226],"investigational":[227],"trials,":[229],"including":[230],"our":[231],"NCI-sponsored":[232],"continuous":[237],"infusion":[238],"cancer.(ABSTRACT":[248],"TRUNCATED":[249],"AT":[250],"250":[251],"WORDS)":[252]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}