{"id":"https://openalex.org/W1007086663","doi":null,"title":"Mechanisms of invasion and metastasis in colorectal cancer","display_name":"Mechanisms of invasion and metastasis in colorectal cancer","publication_year":2015,"publication_date":"2015-04-15","ids":{"openalex":"https://openalex.org/W1007086663","mag":"1007086663"},"language":"en","primary_location":{"id":"pmh:oai:diposit.ub.edu:2445/66560","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2445/66560","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tesis Doctorals - Facultat - Medicina","raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/2445/66560","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007301164","display_name":"Xabier Garc\u00eda\u2010Alb\u00e9niz","orcid":"https://orcid.org/0000-0002-9814-2343","observed_orcids":["https://orcid.org/0000-0002-9814-2343"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Xabier Garc\u00eda\u2010Alb\u00e9niz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-9814-2343","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5007301164"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.47510001063346863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13437","display_name":"Mechanisms of cancer metastasis","score":0.47510001063346863,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.31049999594688416,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.17569999396800995,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.9869999885559082},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/lung-metastasis","display_name":"lung metastasis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.7910000085830688},{"id":"https://openalex.org/keywords/erk2","display_name":"ERK2","score":0.9629999995231628},{"id":"https://openalex.org/keywords/kras-mutation","display_name":"KRAS mutation","score":0.8299999833106995},{"id":"https://openalex.org/keywords/sw620-cells","display_name":"SW620 cells","score":0.8619999885559082},{"id":"https://openalex.org/keywords/orthotopic-xenograft-model","display_name":"orthotopic xenograft","score":0.9190000295639038},{"id":"https://openalex.org/keywords/parathyroid-hormone-like-hormone","display_name":"PTHLH","score":0.8119999766349792},{"id":"https://openalex.org/keywords/mkk6","display_name":"MKK6","score":0.996999979019165},{"id":"https://openalex.org/keywords/aif1","display_name":"AIF1","score":0.6880000233650208},{"id":"https://openalex.org/keywords/smad7","display_name":"Smad7","score":0.953000009059906},{"id":"https://openalex.org/keywords/intronic-variants","display_name":"intronic variants","score":0.828000009059906},{"id":"https://openalex.org/keywords/18q21","display_name":"18q21","score":0.7910000085830688}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.757461428642273},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.665291428565979},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4812324047088623},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4523929953575134},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.41193169355392456},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39747536182403564},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.3280180096626282},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32642972469329834}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:diposit.ub.edu:2445/66560","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2445/66560","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tesis Doctorals - Facultat - Medicina","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:dnet:tdr_________::5f7c74c97a8f829db9b020cc08e5718a","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/300900","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"pmh:oai:www.tdx.cat:10803/300900","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10803/300900","pdf_url":null,"source":{"id":"https://openalex.org/S4306401111","display_name":"Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210090028","host_organization_name":"Consorci de Serveis Universitaris de Catalunya","host_organization_lineage":["https://openalex.org/I4210090028"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:1007086663","doi":null,"is_oa":false,"landing_page_url":"http://diposit.ub.edu/dspace/bitstream/2445/66560/1/XGdA_PhD_THESIS.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306531624","display_name":"TDX (Tesis Doctorals en Xarxa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null}],"best_oa_location":{"id":"pmh:oai:diposit.ub.edu:2445/66560","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2445/66560","pdf_url":null,"source":{"id":"https://openalex.org/S4306401653","display_name":"Dip\u00f2sit Digital de la Universitat de Barcelona (Universitat de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I71999127","host_organization_name":"Universitat de Barcelona","host_organization_lineage":["https://openalex.org/I71999127"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tesis Doctorals - Facultat - Medicina","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":111,"referenced_works":["https://openalex.org/W88164830","https://openalex.org/W230828496","https://openalex.org/W1553444759","https://openalex.org/W1566456185","https://openalex.org/W1942368628","https://openalex.org/W1965405931","https://openalex.org/W1968006026","https://openalex.org/W1970885825","https://openalex.org/W1978146894","https://openalex.org/W1978872126","https://openalex.org/W1979081816","https://openalex.org/W1979107813","https://openalex.org/W1980991473","https://openalex.org/W1981968613","https://openalex.org/W1983276635","https://openalex.org/W1985732903","https://openalex.org/W1987257015","https://openalex.org/W2001765718","https://openalex.org/W2005441291","https://openalex.org/W2007196889","https://openalex.org/W2007525390","https://openalex.org/W2010174939","https://openalex.org/W2014691022","https://openalex.org/W2015914850","https://openalex.org/W2023720844","https://openalex.org/W2025268465","https://openalex.org/W2025816890","https://openalex.org/W2027350554","https://openalex.org/W2029857102","https://openalex.org/W2030451543","https://openalex.org/W2034855589","https://openalex.org/W2035826141","https://openalex.org/W2036008499","https://openalex.org/W2036041106","https://openalex.org/W2036797607","https://openalex.org/W2037489902","https://openalex.org/W2038202392","https://openalex.org/W2041514837","https://openalex.org/W2043166238","https://openalex.org/W2043772256","https://openalex.org/W2048352123","https://openalex.org/W2050395200","https://openalex.org/W2052467200","https://openalex.org/W2053352622","https://openalex.org/W2053970131","https://openalex.org/W2054552261","https://openalex.org/W2057151160","https://openalex.org/W2057711788","https://openalex.org/W2059653502","https://openalex.org/W2063011414","https://openalex.org/W2063470457","https://openalex.org/W2069793735","https://openalex.org/W2071732560","https://openalex.org/W2071867803","https://openalex.org/W2074718000","https://openalex.org/W2076679216","https://openalex.org/W2079032404","https://openalex.org/W2081747892","https://openalex.org/W2082225843","https://openalex.org/W2082483448","https://openalex.org/W2082833890","https://openalex.org/W2085633477","https://openalex.org/W2085971602","https://openalex.org/W2089415609","https://openalex.org/W2092180337","https://openalex.org/W2093571282","https://openalex.org/W2095201384","https://openalex.org/W2096661713","https://openalex.org/W2100258195","https://openalex.org/W2105628292","https://openalex.org/W2106572080","https://openalex.org/W2106738771","https://openalex.org/W2106789440","https://openalex.org/W2109740395","https://openalex.org/W2110500424","https://openalex.org/W2113860186","https://openalex.org/W2115735904","https://openalex.org/W2119594675","https://openalex.org/W2119938514","https://openalex.org/W2121708973","https://openalex.org/W2122039687","https://openalex.org/W2122152991","https://openalex.org/W2130615734","https://openalex.org/W2132617827","https://openalex.org/W2134268158","https://openalex.org/W2134361367","https://openalex.org/W2135004249","https://openalex.org/W2141768150","https://openalex.org/W2144495943","https://openalex.org/W2147754310","https://openalex.org/W2147834058","https://openalex.org/W2148169621","https://openalex.org/W2152393981","https://openalex.org/W2153833292","https://openalex.org/W2155311724","https://openalex.org/W2157910818","https://openalex.org/W2163352650","https://openalex.org/W2163472474","https://openalex.org/W2164752398","https://openalex.org/W2168272873","https://openalex.org/W2169416082","https://openalex.org/W2169895148","https://openalex.org/W2170226272","https://openalex.org/W2170306230","https://openalex.org/W2171352366","https://openalex.org/W2316067769","https://openalex.org/W2407945829","https://openalex.org/W2444206556","https://openalex.org/W2502134830","https://openalex.org/W2518767583","https://openalex.org/W3186829888"],"related_works":["https://openalex.org/W2287277119","https://openalex.org/W2442385101","https://openalex.org/W2803005576","https://openalex.org/W2282034724","https://openalex.org/W2089198122","https://openalex.org/W2360475464","https://openalex.org/W2765793823","https://openalex.org/W4247997719","https://openalex.org/W7161167013","https://openalex.org/W2472515081"],"abstract_inverted_index":{"We":[0,17,53,133,176,249,286,309,345,422,562],"studied":[1],"the":[2,5,14,49,67,78,86,114,125,128,155,165,170,180,184,187,218,226,235,243,266,271,274,297,303,320,353,360,376,413,425,497,534,540,551,568,585],"mechanisms":[3,50],"driving":[4],"metastatic":[6,23,130,157,162,189,211,228],"spread":[7],"in":[8,13,19,32,41,44,106,154,172,208,225,328,342,350,355,362,429,501],"colorectal":[9],"cancer":[10,531,548],"(CRC),":[11],"focusing":[12],"MAPK":[15,545],"pathway.":[16],"developed":[18],"vivo":[20,42],"a":[21,27,434],"highly":[22,129,156,188,210,227],"cell":[24,29,110,131,139,158],"line":[25,30,159],"using":[26],"KRAS-mutated":[28],"(SW620)":[31],"an":[33,70],"ortothopic":[34],"xenograft":[35],"mouse":[36],"model":[37],"and":[38,43,80,127,142,213,281,291,302,314,357,382,395,412,419,479,522,538,542],"used":[39,55,287],"both":[40],"vitro":[45],"experiments":[46],"to":[47,65,108,164,169,182,192,233,241,334,536,553,576],"evaluate":[48,66],"of":[51,62,69,73,83,97,136,148,152,201,220,223,255,273,352,359,372,375,393,416,437,486],"metastasis.":[52],"also":[54,481,563],"data":[56],"from":[57,557],"two":[58],"large":[59],"prospective":[60],"cohorts":[61],"incident":[63],"CRC":[64,283,289,444,480,574],"association":[68,272,476],"intronic":[71,276],"variant":[72,277],"SMAD7":[74,275],"(rs4939827,":[75],"18q21)":[76],"with":[77,217,278,323,433,495,506,533,550,567,573,579],"phenotype":[79,280,404],"molecular":[81,284,340,388,523],"characterisitics":[82],"CRC.\\n\\n\\t\\t\\t\\t":[84],"In":[85,265,517],"first":[87],"project,":[88],"we":[89,269,331,519],"inoculated":[90],"SW620":[91],"luciferase-expressing":[92],"cells":[93,259,532,549],"into":[94],"portal":[95,247],"circulation":[96],"immunodeficient":[98],"mice":[99,174],"via":[100,260],"intrasplenic":[101],"injection":[102],"followed":[103],"by":[104,186,195,410,484,584],"splenectomy,":[105],"order":[107],"isolate":[109],"populations":[111],"that":[112,179,251,424,526,565],"target":[113],"liver.":[115],"Comparative":[116],"transcriptomic":[117],"analysis":[118],"identified":[119],"194":[120],"genes":[121],"differentially":[122],"expressed":[123],"between":[124,312,477],"parental":[126],"line.":[132],"found":[134,423],"pathways":[135],"nitrogen":[137],"metabolism,":[138],"adhesion":[140],"molecules":[141],"mitogen-activated":[143],"protein":[144],"kinases":[145],"(MAPKs).":[146],"Downregulation":[147,222],"ERK2":[149,527],"(but":[150],"not":[151,168,456],"ERK1)":[153],"reverted":[160],"its":[161,231,239],"capacity":[163,232,240],"liver,":[166],"but":[167,455],"lung":[171,185,236,555],"our":[173,209],"model.":[175],"thus":[177],"hypothesized":[178],"ability":[181,535,552],"metastasize":[183],"derivative":[190,212,229],"had":[191],"be":[193],"driven":[194],"other":[196],"mechanism.":[197],"\\n\\n\\t\\t\\t\\t":[198,318,421,516],"The":[199,364,386,475],"expression":[200,219,409],"parathyroid":[202],"hormone-like":[203],"hormone":[204],"(PTHLH)":[205],"was":[206,214,431,503],"upregulated":[207],"inversely":[215],"correlated":[216],"MKK6.":[221],"PHTLH":[224],"decreased":[230],"colonize":[234,242,539],"without":[237],"decreasing":[238],"liver":[244,541,560],"after":[245],"intra":[246],"inoculation.":[248],"evidenced":[250],"PTHLH":[252],"induced":[253],"apoptosis":[254],"human":[256],"pulmonary":[257],"endothelial":[258],"apoptosis-inducing":[261],"factor":[262],"mitochondrion-associated":[263],"1.\\n\\n\\t\\t\\t\\t":[264],"second":[267],"project":[268],"evaluated":[270,367,387],"tumor":[279,378,439,457],"several":[282],"characteristics.":[285],"1509":[288,321],"cases":[290,322],"2307":[292],"age-matched":[293],"controls":[294],"nested":[295],"within":[296],"Nurses":[298],"Health":[299,304],"Study":[300,307],"(NHS)":[301],"Professionals":[305],"Follow-up":[306],"(HPFS).":[308],"randomly":[310],"selected":[311],"one":[313],"three":[315],"matched":[316],"controls.":[317],"Among":[319,493],"blood":[324],"or":[325,442,460],"buccal":[326],"samples":[327,354,361],"this":[329],"study,":[330],"were":[332,390],"able":[333],"successfully":[335,349],"obtain":[336],"tissue":[337],"suitable":[338],"for":[339,469,489],"analyses":[341],"658":[343],"cases.":[344],"genotyped":[346],"rs4939827":[347,430,478,502,569],"(TaqMan)":[348],"98%":[351],"NHS":[356],"99.6%":[358],"HPFS.":[363],"phenotipic":[365],"features":[366],"were:":[368],"TNM":[369],"stage,":[370],"grade":[371],"differentiation,":[373],"location":[374],"primary":[377],"(colon":[379],"vs.":[380],"rectum)":[381],"age":[383],"at":[384],"diagnosis.":[385],"characteristics":[389],"DNA":[391],"methylation":[392,485],"RUNX3":[394,487],"LINE-1":[396],"(long":[397],"interspersed":[398],"nucleotide":[399],"element-1),":[400],"CpG":[401],"island":[402],"methylator":[403],"(CIMP),":[405],"microsatellite":[406],"instability,":[407],"TP53":[408],"immunohistochemistry":[411],"mutational":[414],"status":[415],"BRAF,":[417],"KRAS":[418],"PIK3CA.":[420],"minor":[426,498],"allele":[427,499],"(G)":[428,500],"associated":[432,505],"lower":[435],"risk":[436],"developing":[438],"stage":[440,458],"pT1":[441],"pT2":[443],"[multivariate":[445],"odds":[446],"ratio":[447],"(OR),":[448],"0.73;":[449],"95%":[450,465,513],"confidence":[451],"interval":[452],"(CI)":[453],"0.62-0.87]":[454],"pT3":[459],"pT4":[461],"(multivariate":[462],"OR,":[463],"1.07;":[464],"CI":[466],"0.93-1.23,":[467],"P":[468],"heterogeneity":[470,490],"=":[471,491],"1.2":[472],"x":[473],"10-4).":[474],"significantly":[482,504],"differed":[483],"(P":[488],"0.005).":[492],"those":[494],"CRC,":[496],"poorer":[507],"overall":[508],"survival":[509],"(hazards":[510],"ratio,":[511],"1.20;":[512],"CI,":[514],"1.02-1.42).":[515],"conclusion,":[518],"provide":[520],"clinical":[521],"evidence":[524],"showing":[525],"activation":[528],"provides":[529],"colon":[530],"seed":[537],"reduced":[543],"p38":[544],"signalling":[546],"endows":[547],"form":[554],"metastasis":[556],"previously":[558],"established":[559],"lesions.":[561],"show":[564],"patients":[566],"CRC-susceptibility":[570],"locus":[571],"diagnosed":[572],"tend":[575],"develop":[577],"tumors":[578],"greater":[580],"invasiveness":[581],"(as":[582],"measured":[583],"pT":[586],"stage).":[587]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}