{"id":"https://openalex.org/W100650577","doi":"https://doi.org/10.1177/030089160409000404","title":"Effects of Interferon-\u03b1-2a on Th3 Cytokine Response in Multiple Myeloma Patients","display_name":"Effects of Interferon-\u03b1-2a on Th3 Cytokine Response in Multiple Myeloma Patients","publication_year":2004,"publication_date":"2004-07-01","ids":{"openalex":"https://openalex.org/W100650577","doi":"https://doi.org/10.1177/030089160409000404","mag":"100650577","pmid":"https://pubmed.ncbi.nlm.nih.gov/15510980"},"language":"en","primary_location":{"id":"doi:10.1177/030089160409000404","doi":"https://doi.org/10.1177/030089160409000404","is_oa":false,"landing_page_url":"https://doi.org/10.1177/030089160409000404","pdf_url":null,"source":{"id":"https://openalex.org/S4210189328","display_name":"Tumori Journal","issn_l":"0300-8916","issn":["0300-8916","2038-2529"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumori Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018463325","display_name":"Mehmet S\u00f6nmez","orcid":"https://orcid.org/0000-0002-2176-4371","observed_orcids":["https://orcid.org/0000-0002-2176-4371","https://orcid.org/0000-0003-3127-666X"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet Sonmez","raw_affiliation_strings":["Division of Hematology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey","institution_ids":["https://openalex.org/I162720556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002962967","display_name":"Bircan S\u00f6nmez","orcid":"https://orcid.org/0000-0001-5948-7923","observed_orcids":["https://orcid.org/0000-0001-5948-7923"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bircan Sonmez","raw_affiliation_strings":["Department of Nuclear Medicine, Trabzon Numune Hospital, Trabzon, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nuclear Medicine, Trabzon Numune Hospital, Trabzon, Turkey","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003132118","display_name":"Necmi Eren","orcid":"https://orcid.org/0000-0002-2708-3470","observed_orcids":["https://orcid.org/0000-0002-2708-3470"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Necmi Eren","raw_affiliation_strings":["Department of Internal Medicine, Karadeniz Technical University, School of Medicine, Trabzon, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Karadeniz Technical University, School of Medicine, Trabzon, Turkey","institution_ids":["https://openalex.org/I162720556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101512650","display_name":"Mustafa Y\u0131lmaz","orcid":"https://orcid.org/0000-0003-3320-108X","observed_orcids":["https://orcid.org/0000-0003-3320-108X"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mustafa Yilmaz","raw_affiliation_strings":["Division of Hematology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey","institution_ids":["https://openalex.org/I162720556"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113060024","display_name":"Suleyman Sami Karti","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"S Sami Karti","raw_affiliation_strings":["Division of Hematology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey","institution_ids":["https://openalex.org/I162720556"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035580081","display_name":"Erc\u00fcment Oval\u0131","orcid":"https://orcid.org/0000-0002-4782-5355","observed_orcids":["https://orcid.org/0000-0002-4782-5355"]},"institutions":[{"id":"https://openalex.org/I162720556","display_name":"Karadeniz Technical University","ror":"https://ror.org/03z8fyr40","country_code":"TR","type":"education","lineage":["https://openalex.org/I162720556"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ercument Ovali","raw_affiliation_strings":["Division of Hematology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology, Karadeniz Technical University, School of Medicine, Trabzon, Turkey","institution_ids":["https://openalex.org/I162720556"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113060024"],"corresponding_institution_ids":["https://openalex.org/I162720556"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.2133,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.53596288,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"90","issue":"4","first_page":"387","last_page":"389"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-alfa-2a","display_name":"interferon alfa-2a","score":0.9070000052452087},{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9990000128746033},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9179999828338623},{"id":"https://openalex.org/keywords/th1-th2-imbalance","display_name":"Th1/Th2 imbalance","score":0.6869999766349792},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"interleukin-2","score":0.8450000286102295},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9950000047683716},{"id":"https://openalex.org/keywords/serum-cytokines","display_name":"serum cytokines","score":0.6949999928474426},{"id":"https://openalex.org/keywords/immunosuppression","display_name":"immunosuppression","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.8439246416091919},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.7933298349380493},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6960808038711548},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6815858483314514},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5457940697669983},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.4990665912628174},{"id":"https://openalex.org/C2909179924","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Alpha interferon","level":3,"score":0.49472710490226746},{"id":"https://openalex.org/C2780841837","wikidata":"https://www.wikidata.org/wiki/Q24741149","display_name":"Interferon gamma","level":3,"score":0.44511306285858154},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.4325132369995117},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3693619668483734},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.36729687452316284},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C159110408","wikidata":"https://www.wikidata.org/wiki/Q121176","display_name":"Nursing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077190","descriptor_name":"Interferon alpha-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007375","descriptor_name":"Interleukin-1","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D007376","descriptor_name":"Interleukin-2","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009101","descriptor_name":"Multiple Myeloma","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016212","descriptor_name":"Transforming Growth Factor beta","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016753","descriptor_name":"Interleukin-10","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016898","descriptor_name":"Interferon-alpha","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018417","descriptor_name":"Th1 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018418","descriptor_name":"Th2 Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1177/030089160409000404","doi":"https://doi.org/10.1177/030089160409000404","is_oa":false,"landing_page_url":"https://doi.org/10.1177/030089160409000404","pdf_url":null,"source":{"id":"https://openalex.org/S4210189328","display_name":"Tumori Journal","issn_l":"0300-8916","issn":["0300-8916","2038-2529"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumori Journal","raw_type":"journal-article"},{"id":"pmid:15510980","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15510980","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumori","raw_type":"Journal Article"},{"id":"pmh:e6b52547-6edd-4109-afa9-3c2636e5edb9","doi":null,"is_oa":false,"landing_page_url":"https://avesis.kocaeli.edu.tr/publication/details/e6b52547-6edd-4109-afa9-3c2636e5edb9/oai","pdf_url":null,"source":{"id":"https://openalex.org/S7407055291","display_name":"Kocaeli \u00dcniversitesi - AVES\u0130S","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W161000714","https://openalex.org/W1484344085","https://openalex.org/W1964751152","https://openalex.org/W1966887091","https://openalex.org/W1973001742","https://openalex.org/W1977367197","https://openalex.org/W1979988119","https://openalex.org/W2000180957","https://openalex.org/W2006382315","https://openalex.org/W2017815853","https://openalex.org/W2049112589","https://openalex.org/W2051694232","https://openalex.org/W2074451115","https://openalex.org/W2076159299","https://openalex.org/W2082192282","https://openalex.org/W2085546686","https://openalex.org/W2115428888","https://openalex.org/W2135537487","https://openalex.org/W2155120317","https://openalex.org/W2258341156","https://openalex.org/W2329362634","https://openalex.org/W2400360654","https://openalex.org/W2466475575"],"related_works":["https://openalex.org/W2049112589","https://openalex.org/W2141547701","https://openalex.org/W2030069996","https://openalex.org/W2344975756","https://openalex.org/W2148476771","https://openalex.org/W2041614988","https://openalex.org/W2015533960","https://openalex.org/W2039319925","https://openalex.org/W2442941918","https://openalex.org/W2416851359"],"abstract_inverted_index":{"AIMS":[0],"AND":[1],"BACKGROUND:":[2],"Multiple":[3],"myeloma":[4,43,78,191],"cells":[5],"increase":[6],"Th3":[7,156],"cytokine":[8,19,59,157,165,187],"response":[9,69,158],"by":[10,110],"secreting":[11],"TGF-beta,":[12],"which":[13],"causes":[14],"defective":[15],"Th1":[16,162],"and":[17,48,61,79,121,124,133,161,163],"Th2":[18,164],"responses.":[20],"Therefore,":[21],"a":[22],"significant":[23],"suppression":[24],"of":[25,41,57,64,116,128,174],"the":[26,39,55,62,67,96,111,117,126,129,143,151],"immune":[27,58,68],"system":[28],"is":[29,36],"seen":[30],"in":[31,38,70,114,119,125,136,169,189],"multiple":[32,42,71,77,190],"myeloma.":[33,72],"Interferon-alpha":[34],"(IFN-alpha)":[35],"used":[37],"treatment":[40],"due":[44],"to":[45,53,95],"its":[46],"immunomodulatory":[47],"anti-tumoral":[49],"effects.":[50],"We":[51],"attempted":[52],"define":[54],"characteristics":[56],"responses":[60,166,188],"effects":[63],"IFN-alpha-2a":[65,175,183],"on":[66],"METHODS:":[73],"Fifteen":[74],"patients":[75,97,118],"with":[76],"15":[80],"healthy":[81],"controls":[82],"were":[83,108,140,148,167],"enrolled.":[84],"IFN-alpha-2a,":[85,139],"3":[86,90],"million":[87],"units/day":[88],"x":[89],"times/week,":[91],"was":[92,159],"administered":[93],"subcutaneously":[94],"for":[98],"2":[99],"weeks.":[100],"Cytokines":[101],"(TGF-beta,":[102],"IL-1,":[103],"IL-2,":[104],"IL-4,":[105],"IL-10,":[106],"IFN-gamma)":[107],"assessed":[109],"ELISA":[112],"method":[113],"sera":[115,127],"pretreatment":[120],"posttreatment":[122],"periods":[123],"controls.":[130,152],"RESULTS:":[131],"IL-2":[132,177],"IL-4":[134],"levels":[135,147],"patients,":[137],"before":[138],"lower":[141],"than":[142,150],"controls,":[144],"whereas":[145],"TGF-beta":[146],"higher":[149],"In":[153],"other":[154],"words,":[155],"increased":[160,176],"decreased":[168],"patients.":[170,192],"A":[171],"short":[172],"course":[173],"levels.":[178],"CONCLUSIONS:":[179],"These":[180],"findings":[181],"suggest":[182],"may":[184],"enhance":[185],"nonTh3":[186]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
