{"id":"https://openalex.org/W1005876323","doi":"https://doi.org/10.1161/circ.116.suppl_16.ii_117","title":"Abstract 637: A Pharmacogenetic Screen for Modifiers of Drug Induced QT Prolongation Reveals 15 Novel Genes.","display_name":"Abstract 637: A Pharmacogenetic Screen for Modifiers of Drug Induced QT Prolongation Reveals 15 Novel Genes.","publication_year":2007,"publication_date":"2007-10-16","ids":{"openalex":"https://openalex.org/W1005876323","doi":"https://doi.org/10.1161/circ.116.suppl_16.ii_117","mag":"1005876323"},"language":"en","primary_location":{"id":"doi:10.1161/circ.116.suppl_16.ii_117","doi":"https://doi.org/10.1161/circ.116.suppl_16.ii_117","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.116.suppl_16.ii_117","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046550930","display_name":"David J. Milan","orcid":"https://orcid.org/0000-0003-0149-3110","observed_orcids":["https://orcid.org/0000-0003-0149-3110"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David J Milan","raw_affiliation_strings":["Massachusetts General Hosp, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hosp, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090605558","display_name":"Ian Lloyd Jones","orcid":"https://orcid.org/0000-0001-5618-1507","observed_orcids":["https://orcid.org/0000-0001-5618-1507"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ian L Jones","raw_affiliation_strings":["Massachusetts General Hosp, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hosp, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021114515","display_name":"Adam Amsterdam","orcid":"https://orcid.org/0000-0002-6806-1518","observed_orcids":["https://orcid.org/0000-0002-6806-1518"]},"institutions":[{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adam H Amsterdam","raw_affiliation_strings":["Massachusetts Institute of Technology, Cambridge, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts Institute of Technology, Cambridge, MA","institution_ids":["https://openalex.org/I63966007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038576548","display_name":"DAVID S. ROSENBAUM","orcid":"https://orcid.org/0000-0003-1549-0762","observed_orcids":["https://orcid.org/0000-0003-1549-0762"]},"institutions":[{"id":"https://openalex.org/I1299218025","display_name":"MetroHealth","ror":"https://ror.org/0377srw41","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299218025"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David S Rosenbaum","raw_affiliation_strings":["MetroHealth Campus, Case Western Reserve Univ, Cleveland, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MetroHealth Campus, Case Western Reserve Univ, Cleveland, OH","institution_ids":["https://openalex.org/I1299218025","https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058141203","display_name":"Dan M. Roden","orcid":"https://orcid.org/0000-0002-6302-0389","observed_orcids":["https://orcid.org/0000-0002-6302-0389"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Roden","raw_affiliation_strings":["Vanderbilt Univ Med Cntr, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vanderbilt Univ Med Cntr, Nashville, TN","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052863636","display_name":"Calum A. MacRae","orcid":"https://orcid.org/0000-0001-5181-2664","observed_orcids":["https://orcid.org/0000-0001-5181-2664"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Calum A MacRae","raw_affiliation_strings":["Massachusetts General Hosp, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hosp, Boston, MA","institution_ids":["https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"116","issue":"suppl_16","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-induced-qt-prolongation","display_name":"drug-induced QT prolongation","score":0.9229999780654907},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.9490000009536743},{"id":"https://openalex.org/keywords/cardiac-repolarization","display_name":"cardiac repolarization","score":0.8220000267028809},{"id":"https://openalex.org/keywords/kcnh2","display_name":"KCNH2","score":0.9660000205039978},{"id":"https://openalex.org/keywords/ikr-block","display_name":"IKr block","score":0.8100000023841858},{"id":"https://openalex.org/keywords/action-potential-prolongation","display_name":"action potential prolongation","score":0.7310000061988831},{"id":"https://openalex.org/keywords/late-sodium-current","display_name":"late sodium current","score":0.7910000085830688},{"id":"https://openalex.org/keywords/dofetilide","display_name":"dofetilide","score":0.9559999704360962},{"id":"https://openalex.org/keywords/repolarization-reserve","display_name":"repolarization reserve","score":0.8650000095367432},{"id":"https://openalex.org/keywords/early-afterdepolarizations","display_name":"early afterdepolarizations","score":0.9639999866485596},{"id":"https://openalex.org/keywords/lipid-rafts","display_name":"lipid rafts","score":0.8619999885559082},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.6980000138282776}],"concepts":[{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.77679443359375},{"id":"https://openalex.org/C2777796741","wikidata":"https://www.wikidata.org/wiki/Q3712521","display_name":"Dofetilide","level":3,"score":0.7740105390548706},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5420021414756775},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.5007481575012207},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4581941068172455},{"id":"https://openalex.org/C118441451","wikidata":"https://www.wikidata.org/wiki/Q12074763","display_name":"QT interval","level":2,"score":0.44525933265686035},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.43914031982421875},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.41897153854370117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.315800279378891},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2765378952026367},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2407691776752472},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.2026144564151764},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1518515646457672}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.116.suppl_16.ii_117","doi":"https://doi.org/10.1161/circ.116.suppl_16.ii_117","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.116.suppl_16.ii_117","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4385342844","https://openalex.org/W2410003879","https://openalex.org/W2058207889","https://openalex.org/W2108838836","https://openalex.org/W2548666730","https://openalex.org/W2059657343","https://openalex.org/W2884582868","https://openalex.org/W2055214047","https://openalex.org/W3004489299","https://openalex.org/W1994683039"],"abstract_inverted_index":{"Introduction:":[0],"Variability":[1],"in":[2,57,123,128,197,208],"response":[3,97,173],"to":[4,15,17,53,73,91,98,174,200,210],"therapeutic":[5],"drugs":[6],"is":[7],"a":[8,62,80,83,126,156,189],"vexing":[9],"problem":[10],"that":[11,28,94,133,170],"has":[12],"recently":[13],"begun":[14],"yield":[16],"intense":[18],"investigatory":[19],"efforts.":[20],"Rigorous":[21],"pharmacogenetic":[22,157],"studies":[23],"will":[24],"require":[25],"model":[26,152],"systems":[27],"recapitulate":[29],"the":[30,40,96,172,181],"complexity":[31],"of":[32,82,86,135,161,180,192],"individual":[33],"drug":[34],"responses.":[35],"Methods:":[36],"We":[37,60,77,130],"have":[38,154,166],"employed":[39],"voltage":[41],"sensitive":[42],"fluorescent":[43],"dye":[44],"di":[45],"4-ANEPPS":[46],"and":[47,71,119,165,204],"high":[48],"speed":[49],"CCD":[50],"camera":[51],"acquisition":[52],"study":[54],"cardiac":[55,75],"repolarization":[56,114],"embryonic":[58],"zebrafish.":[59],"used":[61],"known":[63,84],"zebrafish":[64,89,124,209],"KCNH2":[65],"mutant,":[66],"anemone":[67,140],"toxin":[68,141],"II":[69,142],"(ATXII)":[70],"dofetilide":[72],"perturb":[74],"repolarization.":[76],"also":[78,131],"undertook":[79],"screen":[81,158],"panel":[85],"294":[87],"mutant":[88],"lines":[90],"identify":[92],"genes":[93,169],"modify":[95],"IKr":[99,175],"block.":[100],"Results:":[101],"Using":[102,150],"optical":[103],"mapping,":[104],"we":[105,153],"demonstrate":[106],"action":[107,144],"potential":[108,145],"prolongation":[109],"(Figure":[110,116,147],"1a,b":[111],"),":[112,118],"reduced":[113],"reserve":[115],"1d":[117],"spontaneous":[120],"early":[121],"afterdepolarizations":[122],"harboring":[125],"mutation":[127],"KCNH2.":[129],"show":[132],"augmentation":[134],"late":[136],"sodium":[137],"current":[138],"using":[139],"prolongs":[143],"duration":[146],"1c":[148],").":[149],"this":[151],"conducted":[155],"for":[159],"modifiers":[160],"drug-induced":[162],"QT":[163],"prolongation,":[164],"identified":[167],"15":[168],"modulate":[171],"block,":[176],"including":[177],"three":[178],"members":[179],"heg-san-vtn":[182],"pathway.":[183],"Conclusion:":[184],"Together":[185],"these":[186],"data":[187],"implicate":[188],"complex":[190,212],"network":[191],"non-ion":[193],"channel":[194,202],"proteins":[195],"functioning":[196],"membrane":[198],"microdomains":[199],"regulate":[201],"function,":[203],"validate":[205],"high-throughput":[206],"screening":[207],"dissect":[211],"biologic":[213],"systems.":[214]},"counts_by_year":[{"year":2012,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2016-06-24T00:00:00"}