{"id":"https://openalex.org/W100525959","doi":null,"title":"Bone and plasma calcium homeostasis.","display_name":"Bone and plasma calcium homeostasis.","publication_year":1987,"publication_date":"1987-01-01","ids":{"openalex":"https://openalex.org/W100525959","mag":"100525959","pmid":"https://pubmed.ncbi.nlm.nih.gov/2961352"},"language":"en","primary_location":{"id":"pmid:2961352","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2961352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109198734","display_name":"A. MICHAEL PARFITT","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2803043754","display_name":"Henry Ford Hospital","ror":"https://ror.org/0193sb042","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I154057602","https://openalex.org/I2803043754"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"A M Parfitt","raw_affiliation_strings":["Henry Ford Hospital, Bone and Mineral Research Laboratory, Detroit, MI 48202"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Henry Ford Hospital, Bone and Mineral Research Laboratory, Detroit, MI 48202","institution_ids":["https://openalex.org/I2803043754"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109198734"],"corresponding_institution_ids":["https://openalex.org/I2803043754"],"apc_list":null,"apc_paid":null,"fwci":5.5937,"has_fulltext":false,"cited_by_count":140,"citation_normalized_percentile":{"value":0.96210938,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8 Suppl 1","issue":null,"first_page":"S1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.899399995803833,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.05700000002980232,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies","score":0.01600000075995922,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calcium-homeostasis","display_name":"calcium homeostasis","score":0.9760000109672546},{"id":"https://openalex.org/keywords/circadian-rhythm","display_name":"circadian rhythm","score":0.6909999847412109},{"id":"https://openalex.org/keywords/calcium-set-point","display_name":"calcium set point","score":0.7609999775886536},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.8820000290870667},{"id":"https://openalex.org/keywords/calcitonin","display_name":"calcitonin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vitamin-d","display_name":"vitamin D","score":0.9879999756813049},{"id":"https://openalex.org/keywords/bone-remodeling","display_name":"bone remodeling","score":0.6930000185966492},{"id":"https://openalex.org/keywords/bone-surface","display_name":"bone surface","score":0.40799999237060547},{"id":"https://openalex.org/keywords/renal-calcium-reabsorption","display_name":"renal calcium reabsorption","score":0.7429999709129333},{"id":"https://openalex.org/keywords/intestinal-calcium-absorption","display_name":"intestinal calcium absorption","score":0.8130000233650208},{"id":"https://openalex.org/keywords/hypocalcemia","display_name":"hypocalcemia","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hypercalcemia","display_name":"hypercalcemia","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.7076892256736755},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.6890103816986084},{"id":"https://openalex.org/C87975464","wikidata":"https://www.wikidata.org/wiki/Q910704","display_name":"Calcium metabolism","level":3,"score":0.6170644760131836},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.59860759973526},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.5550485253334045},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5489563941955566},{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.5379112362861633},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5010006427764893},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.49921655654907227},{"id":"https://openalex.org/C2779627488","wikidata":"https://www.wikidata.org/wiki/Q315860","display_name":"Calcitonin","level":2,"score":0.45724013447761536},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.41204580664634705},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2420397400856018},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.21380198001861572},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1218390166759491}],"mesh":[{"descriptor_ui":"D001842","descriptor_name":"Bone and Bones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001861","descriptor_name":"Bone Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004002","descriptor_name":"Clodronic Acid","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D004164","descriptor_name":"Diphosphonates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010281","descriptor_name":"Parathyroid Hormone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:2961352","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2961352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone","raw_type":"Journal Article"},{"id":"mag:100525959","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2961352","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2093533785","https://openalex.org/W2014689496","https://openalex.org/W2149765202","https://openalex.org/W2339971016","https://openalex.org/W70156662","https://openalex.org/W2000607010","https://openalex.org/W2051675845","https://openalex.org/W4249129706","https://openalex.org/W2127955916","https://openalex.org/W2809789771"],"abstract_inverted_index":{"Regulation":[0],"of":[1,29,40,56,76,95,101,111,125,156,165,199,224],"plasma":[2,213],"free":[3],"calcium":[4,141,157,205,214],"concentration":[5],"displays":[6],"the":[7,30,43,89,109,117,140,145,163,176,180,191,203,209,212,218,236,242],"following":[8],"features:":[9],"(1)":[10],"The":[11,173],"level":[12,91],"in":[13,108,162,195],"an":[14,49],"individual":[15,31],"varies":[16],"within":[17],"fairly":[18],"narrow":[19],"limits":[20],"and":[21,34,129,152,160,179,201,217],"is":[22,48,54,78,119,187,226],"characterized":[23],"by":[24,135,171,208,232,244],"a":[25,35,136],"mean":[26],"(an":[27,38],"estimate":[28,39],"set":[32,44,215],"point)":[33],"standard":[36],"deviation":[37],"oscillation":[41,52],"about":[42],"point).":[45],"(2)":[46],"There":[47],"intrinsic":[50],"circadian":[51],"that":[53,138,183],"independent":[55],"external":[57],"disturbing":[58],"signals.":[59],"(3)":[60],"Individual":[61],"values":[62],"(set":[63],"points)":[64],"are":[65,132],"partly":[66],"under":[67],"genetic":[68],"control":[69],"with":[70,105,122],"significant":[71],"between-family":[72],"differences.":[73],"(4)":[74],"Correction":[75,100],"errors":[77,102],"rather":[79],"slow-it":[80],"usually":[81],"takes":[82],"at":[83,144],"least":[84],"12":[85],"hours":[86],"to":[87,229],"restore":[88],"basal":[90],"after":[92],"experimental":[93],"induction":[94],"hyper-":[96],"or":[97,114],"hypocalcemia.":[98],"(5)":[99],"can":[103,168,193],"occur":[104],"normal":[106],"efficiency":[107],"absence":[110,164],"parathyroid":[112],"hormone":[113],"calcitonin,":[115],"provided":[116],"system":[118,143,178,182,238],"adequately":[120],"primed":[121],"some":[123],"form":[124],"vitamin":[126],"D.":[127],"These":[128],"other":[130],"facts":[131],"best":[133],"explained":[134],"concept":[137],"locates":[139],"homeostatic":[142,177],"quiescent":[146],"bone":[147,161,185],"surface.":[148],"Across":[149],"this":[150],"cellular":[151],"tissue":[153],"barrier":[154],"exchange":[155],"between":[158,175,211],"blood":[159],"net":[166,233],"flux":[167],"be":[169,230],"demonstrated":[170],"autoradiography.":[172],"distinction":[174],"remodeling":[181,237],"regulates":[184],"mass":[186],"not":[188],"absolute,":[189],"since":[190],"latter":[192],"participate":[194],"short":[196],"term":[197],"correction":[198],"errors,":[200],"if":[202],"obligatory":[204],"loss":[206],"(determined":[207],"difference":[210,243],"point":[216],"threshold":[219],"for":[220],"renal":[221],"tubular":[222],"reabsorption":[223],"calcium)":[225],"too":[227],"high":[228],"satisfied":[231],"intestinal":[234],"absorption,":[235],"must":[239],"make":[240],"up":[241],"sacrificing":[245],"bone.(ABSTRACT":[246],"TRUNCATED":[247],"AT":[248],"250":[249],"WORDS)":[250]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}