{"id":"https://openalex.org/W100522171","doi":null,"title":"A novel hydrogel vehicle formulated for the treatment of atopic dermatitis.","display_name":"A novel hydrogel vehicle formulated for the treatment of atopic dermatitis.","publication_year":2007,"publication_date":"2007-07-01","ids":{"openalex":"https://openalex.org/W100522171","mag":"100522171","pmid":"https://pubmed.ncbi.nlm.nih.gov/17763596"},"language":"en","primary_location":{"id":"pmid:17763596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17763596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of drugs in dermatology : JDD","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058903008","display_name":"Leon Kircik","orcid":"https://orcid.org/0000-0002-0831-2151","observed_orcids":["https://orcid.org/0000-0002-0831-2151"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leon Kircik","raw_affiliation_strings":["Indiana University School of Medicine, Madison, IN, USA. smoore@physicianresources.org"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine, Madison, IN, USA. smoore@physicianresources.org","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007581860","display_name":"J.Q. Del Rosso","orcid":"https://orcid.org/0000-0003-4215-7340","observed_orcids":["https://orcid.org/0000-0003-4215-7340"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"James Del Rosso","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.0242,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.74228029,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"6","issue":"7","first_page":"718","last_page":"22"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.8598999977111816,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.8598999977111816,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.13760000467300415,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/desonide","display_name":"desonide","score":0.9789999723434448},{"id":"https://openalex.org/keywords/topical-corticosteroids","display_name":"topical corticosteroids","score":0.972000002861023},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.6439999938011169},{"id":"https://openalex.org/keywords/transepidermal-water-loss","display_name":"transepidermal water loss","score":0.9340000152587891},{"id":"https://openalex.org/keywords/corneometry","display_name":"corneometry","score":0.847000002861023},{"id":"https://openalex.org/keywords/moisturization","display_name":"moisturization","score":0.7229999899864197},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.6290000081062317},{"id":"https://openalex.org/keywords/pediatric-dermatology","display_name":"pediatric dermatology","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9358936548233032},{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.8781770467758179},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.7117888927459717},{"id":"https://openalex.org/C2777014857","wikidata":"https://www.wikidata.org/wiki/Q1383410","display_name":"Exacerbation","level":2,"score":0.6410169005393982},{"id":"https://openalex.org/C128057223","wikidata":"https://www.wikidata.org/wiki/Q420566","display_name":"Calcineurin","level":3,"score":0.5756152868270874},{"id":"https://openalex.org/C2778484676","wikidata":"https://www.wikidata.org/wiki/Q20707196","display_name":"Nonsteroidal","level":2,"score":0.5379375219345093},{"id":"https://openalex.org/C2991981033","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Skin barrier","level":2,"score":0.4776502847671509},{"id":"https://openalex.org/C2780576536","wikidata":"https://www.wikidata.org/wiki/Q7451065","display_name":"Sensitive skin","level":2,"score":0.42628708481788635},{"id":"https://openalex.org/C95150158","wikidata":"https://www.wikidata.org/wiki/Q7833972","display_name":"Transepidermal water loss","level":3,"score":0.41793692111968994},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.22363030910491943},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.15476882457733154},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.11717855930328369},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.09547597169876099},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07925593852996826},{"id":"https://openalex.org/C2778370115","wikidata":"https://www.wikidata.org/wiki/Q2038676","display_name":"Stratum corneum","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003898","descriptor_name":"Desonide","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D003898","descriptor_name":"Desonide","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014870","descriptor_name":"Water Loss, Insensible","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017326","descriptor_name":"Clinical Trials, Phase III as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020136","descriptor_name":"Hydrogel, Polyethylene Glycol Dimethacrylate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:17763596","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17763596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of drugs in dermatology : JDD","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4233702927","https://openalex.org/W4240633501","https://openalex.org/W6554109","https://openalex.org/W44972164","https://openalex.org/W3158533048","https://openalex.org/W2054385633","https://openalex.org/W4246705887","https://openalex.org/W2341150383","https://openalex.org/W1558781590","https://openalex.org/W4255533579"],"abstract_inverted_index":{"Atopic":[0],"dermatitis":[1],"(AD)":[2],"is":[3,11,107],"a":[4,93],"chronic":[5],"cyclical":[6],"inflammatory":[7],"skin":[8,68,132],"disease":[9,51],"that":[10,121,152],"increasing":[12],"in":[13,101,161],"incidence.":[14],"Twenty":[15],"percent":[16],"of":[17,30,48,54,69,75,92,109,136,156],"those":[18],"affected":[19],"with":[20,62,164],"AD":[21,70,165],"are":[22,138],"infants":[23],"and":[24,52,60,77,90,111,114,131,143,147],"young":[25],"children.":[26],"Despite":[27],"the":[28,42,46,73,88,153],"development":[29],"newer":[31],"nonsteroidal":[32],"topical":[33,39,79],"therapies,":[34],"such":[35],"as":[36],"calcineurin":[37],"inhibitors,":[38],"corticosteroids":[40],"remain":[41],"gold":[43],"standard":[44],"for":[45,98],"treatment":[47],"active":[49],"eczematous":[50,142],"management":[53],"exacerbation":[55],"due":[56],"to":[57,103],"established":[58],"efficacy":[59,91],"safety":[61,89],"appropriate":[63],"use.":[64],"The":[65],"xerotic,":[66],"sensitive":[67],"patients":[71],"mandates":[72],"use":[74],"nonirritating":[76],"nondrying":[78],"vehicles.":[80],"Recently,":[81],"phase":[82],"III":[83],"clinical":[84],"studies":[85,118],"have":[86,119],"demonstrated":[87,120],"novel":[94,154],"aqueous":[95],"hydrogel":[96,124],"vehicle":[97,125,158],"desonide":[99],"delivery":[100],"mild":[102],"moderate":[104],"AD,":[105],"which":[106,137],"free":[108],"fragrances":[110],"surfactants.":[112],"Corneometry":[113],"transepidermal":[115],"water":[116],"loss":[117],"this":[122,157],"patented":[123],"alone":[126],"offers":[127],"advantages":[128],"including":[129],"moisturization":[130],"barrier":[133],"enhancement,":[134],"both":[135],"significant":[139],"when":[140],"treating":[141],"xerotic":[144],"skin.":[145],"Patient":[146],"physician":[148],"preference":[149],"surveys":[150],"suggest":[151],"properties":[155],"may":[159],"aid":[160],"patient":[162],"compliance":[163],"therapy.":[166]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}