{"id":"https://openalex.org/W1004808401","doi":null,"title":"The Life History Significance of Human Breast Milk: Immune and endocrine factors as indicators of maternal condition and predictors of infant health and growth","display_name":"The Life History Significance of Human Breast Milk: Immune and endocrine factors as indicators of maternal condition and predictors of infant health and growth","publication_year":2015,"publication_date":"2015-05-15","ids":{"openalex":"https://openalex.org/W1004808401","mag":"1004808401"},"language":"en","primary_location":{"id":"pmh:oai:dash.harvard.edu:1/17467473","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467473","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467473","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467473","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071781951","display_name":"Alicia A. Breakey","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Alicia A. Breakey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5071781951"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9023000001907349,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10979","display_name":"Breastfeeding Practices and Influences","score":0.08709999918937683,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10596","display_name":"Child Nutrition and Water Access","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-milk","display_name":"breast milk","score":0.9309999942779541},{"id":"https://openalex.org/keywords/life-history-theory","display_name":"life history theory","score":0.9409999847412109},{"id":"https://openalex.org/keywords/cortisol","display_name":"cortisol","score":0.5879999995231628},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-i","display_name":"insulin-like growth factor I","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lactoferrin","display_name":"lactoferrin","score":1.0},{"id":"https://openalex.org/keywords/secretory-iga","display_name":"secretory IgA","score":0.9959999918937683},{"id":"https://openalex.org/keywords/infant-growth","display_name":"infant growth","score":0.8209999799728394},{"id":"https://openalex.org/keywords/infant-diseases","display_name":"infant illness","score":0.9350000023841858},{"id":"https://openalex.org/keywords/primiparity","display_name":"primiparity","score":0.7580000162124634},{"id":"https://openalex.org/keywords/body-mass-index","display_name":"body mass index","score":0.8519999980926514},{"id":"https://openalex.org/keywords/toba-people","display_name":"Toba people","score":0.7680000066757202},{"id":"https://openalex.org/keywords/maternal-health-indicators","display_name":"maternal health indicators","score":0.41999998688697815}],"concepts":[{"id":"https://openalex.org/C2779170986","wikidata":"https://www.wikidata.org/wiki/Q410246","display_name":"Lactoferrin","level":2,"score":0.9126324653625488},{"id":"https://openalex.org/C2775871700","wikidata":"https://www.wikidata.org/wiki/Q22728","display_name":"Breast milk","level":2,"score":0.5703418254852295},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49595293402671814},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.4887094497680664},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.4694482982158661},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4495481550693512},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4214571714401245},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2880045771598816},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28449079394340515},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.2810896337032318},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:dash.harvard.edu:1/17467473","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467473","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467473","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},{"id":"mag:1004808401","doi":null,"is_oa":false,"landing_page_url":"https://dash.harvard.edu/bitstream/handle/1/17467473/BREAKEY-DISSERTATION-2015.pdf?sequence=1","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:dash.harvard.edu:1/17467473","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467473","pdf_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:17467473","source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis or Dissertation"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Zero hunger","score":0.7142999768257141,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1004808401.pdf","grobid_xml":"https://content.openalex.org/works/W1004808401.grobid-xml"},"referenced_works_count":211,"referenced_works":["https://openalex.org/W16631805","https://openalex.org/W101883774","https://openalex.org/W174309365","https://openalex.org/W181621930","https://openalex.org/W197265857","https://openalex.org/W203953523","https://openalex.org/W236280379","https://openalex.org/W861305176","https://openalex.org/W1481809251","https://openalex.org/W1510419162","https://openalex.org/W1516009011","https://openalex.org/W1528458776","https://openalex.org/W1544815196","https://openalex.org/W1552033470","https://openalex.org/W1576001689","https://openalex.org/W1586060400","https://openalex.org/W1610975395","https://openalex.org/W1745264954","https://openalex.org/W1748970894","https://openalex.org/W1899187159","https://openalex.org/W1919510074","https://openalex.org/W1925477831","https://openalex.org/W1927104679","https://openalex.org/W1930423902","https://openalex.org/W1939793850","https://openalex.org/W1961748990","https://openalex.org/W1963670241","https://openalex.org/W1965075385","https://openalex.org/W1965741827","https://openalex.org/W1967971775","https://openalex.org/W1968506444","https://openalex.org/W1969669281","https://openalex.org/W1970741699","https://openalex.org/W1971606855","https://openalex.org/W1977212063","https://openalex.org/W1977571368","https://openalex.org/W1980463660","https://openalex.org/W1980695189","https://openalex.org/W1981976025","https://openalex.org/W1981998586","https://openalex.org/W1982383633","https://openalex.org/W1982438980","https://openalex.org/W1982619553","https://openalex.org/W1983068958","https://openalex.org/W1984535608","https://openalex.org/W1987135711","https://openalex.org/W1987910229","https://openalex.org/W1988331683","https://openalex.org/W1988964205","https://openalex.org/W1989308141","https://openalex.org/W1989426952","https://openalex.org/W1990968763","https://openalex.org/W1991244419","https://openalex.org/W1992127189","https://openalex.org/W1993101828","https://openalex.org/W1994045643","https://openalex.org/W1995173030","https://openalex.org/W1995555012","https://openalex.org/W1995934713","https://openalex.org/W1996525939","https://openalex.org/W1998628730","https://openalex.org/W1999283861","https://openalex.org/W1999523219","https://openalex.org/W1999531019","https://openalex.org/W1999718090","https://openalex.org/W2001151007","https://openalex.org/W2002014565","https://openalex.org/W2002511420","https://openalex.org/W2004837477","https://openalex.org/W2006190738","https://openalex.org/W2006888533","https://openalex.org/W2009206696","https://openalex.org/W2009960819","https://openalex.org/W2013743258","https://openalex.org/W2014718498","https://openalex.org/W2015932381","https://openalex.org/W2019028247","https://openalex.org/W2021072501","https://openalex.org/W2021238218","https://openalex.org/W2021428788","https://openalex.org/W2025373415","https://openalex.org/W2026144395","https://openalex.org/W2026677009","https://openalex.org/W2026870334","https://openalex.org/W2028431435","https://openalex.org/W2029328804","https://openalex.org/W2033058878","https://openalex.org/W2033405828","https://openalex.org/W2034137043","https://openalex.org/W2034571940","https://openalex.org/W2034670942","https://openalex.org/W2038293359","https://openalex.org/W2039202948","https://openalex.org/W2040702442","https://openalex.org/W2041905723","https://openalex.org/W2043357396","https://openalex.org/W2045390090","https://openalex.org/W2045859514","https://openalex.org/W2048110754","https://openalex.org/W2048218644","https://openalex.org/W2048655147","https://openalex.org/W2049661270","https://openalex.org/W2055216053","https://openalex.org/W2055973190","https://openalex.org/W2059614780","https://openalex.org/W2062394657","https://openalex.org/W2062533354","https://openalex.org/W2062997876","https://openalex.org/W2064351403","https://openalex.org/W2069311788","https://openalex.org/W2069384842","https://openalex.org/W2071506083","https://openalex.org/W2072153460","https://openalex.org/W2073902178","https://openalex.org/W2073993963","https://openalex.org/W2074537381","https://openalex.org/W2075845574","https://openalex.org/W2076349522","https://openalex.org/W2076969034","https://openalex.org/W2077735596","https://openalex.org/W2078406490","https://openalex.org/W2078524781","https://openalex.org/W2078550218","https://openalex.org/W2078584920","https://openalex.org/W2078650765","https://openalex.org/W2082172227","https://openalex.org/W2082530833","https://openalex.org/W2085181197","https://openalex.org/W2085263701","https://openalex.org/W2085832350","https://openalex.org/W2086341384","https://openalex.org/W2086884527","https://openalex.org/W2087326265","https://openalex.org/W2087408553","https://openalex.org/W2088569914","https://openalex.org/W2088994885","https://openalex.org/W2090592481","https://openalex.org/W2090781132","https://openalex.org/W2091616139","https://openalex.org/W2093004660","https://openalex.org/W2095060828","https://openalex.org/W2095814042","https://openalex.org/W2100708531","https://openalex.org/W2101082219","https://openalex.org/W2101540108","https://openalex.org/W2103180914","https://openalex.org/W2104019079","https://openalex.org/W2104105484","https://openalex.org/W2104176482","https://openalex.org/W2106097512","https://openalex.org/W2106626003","https://openalex.org/W2108249923","https://openalex.org/W2109039647","https://openalex.org/W2109476071","https://openalex.org/W2111170412","https://openalex.org/W2111289387","https://openalex.org/W2112663684","https://openalex.org/W2114175548","https://openalex.org/W2117395216","https://openalex.org/W2117537894","https://openalex.org/W2119008756","https://openalex.org/W2121215230","https://openalex.org/W2121350851","https://openalex.org/W2121686599","https://openalex.org/W2123168484","https://openalex.org/W2125320344","https://openalex.org/W2128516816","https://openalex.org/W2129097378","https://openalex.org/W2130221423","https://openalex.org/W2131786754","https://openalex.org/W2133603659","https://openalex.org/W2134206097","https://openalex.org/W2134581787","https://openalex.org/W2134967262","https://openalex.org/W2136483207","https://openalex.org/W2136578646","https://openalex.org/W2139343763","https://openalex.org/W2141485414","https://openalex.org/W2142861518","https://openalex.org/W2146573911","https://openalex.org/W2155284161","https://openalex.org/W2156426485","https://openalex.org/W2156538377","https://openalex.org/W2157079783","https://openalex.org/W2157882808","https://openalex.org/W2157974636","https://openalex.org/W2158182210","https://openalex.org/W2160205379","https://openalex.org/W2161763667","https://openalex.org/W2163511143","https://openalex.org/W2163801274","https://openalex.org/W2164671842","https://openalex.org/W2164809487","https://openalex.org/W2166359423","https://openalex.org/W2166789479","https://openalex.org/W2168607757","https://openalex.org/W2170746536","https://openalex.org/W2170797914","https://openalex.org/W2228325674","https://openalex.org/W2244341608","https://openalex.org/W2298661755","https://openalex.org/W2329822104","https://openalex.org/W2334123773","https://openalex.org/W2339818830","https://openalex.org/W2396010728","https://openalex.org/W2404863127","https://openalex.org/W2410409002","https://openalex.org/W2411930626","https://openalex.org/W2769624863","https://openalex.org/W2906494796","https://openalex.org/W4297598437"],"related_works":["https://openalex.org/W7223181517","https://openalex.org/W2888333524","https://openalex.org/W7157708552","https://openalex.org/W2330374571","https://openalex.org/W3006141515","https://openalex.org/W4415495639","https://openalex.org/W2067057580","https://openalex.org/W3010960967","https://openalex.org/W3125630050","https://openalex.org/W1937008441"],"abstract_inverted_index":{"This":[0,40],"dissertation":[1],"explores":[2],"the":[3,21,32,43,55,74,84,121,129,232,244],"relationships":[4,96,122],"between":[5,123,158,173],"maternal":[6,77,180],"energetic":[7,78,181],"condition,":[8],"four":[9,88],"bioactive":[10],"compounds":[11,89],"in":[12,37,70,90,217],"milk,":[13],"and":[14,17,65,103,112,128,134,150,163,176,179,183,219,226,238,250],"infant":[15,124,164,174,194],"health":[16,252],"growth":[18,60,165,177,184,196,207],"outcomes":[19],"through":[20,231],"lens":[22,53,233],"of":[23,34,45,57,76,83,86,126,148,160,234,246],"human":[24,71],"life":[25,50,235,247],"history":[26,51,236,248],"theory.":[27],"Research":[28],"was":[29],"conducted":[30],"among":[31,42,105,117],"Toba":[33],"Barrio":[35],"Namqom":[36],"Formosa,":[38],"Argentina.":[39],"is":[41,92,139,188,200,211],"first":[44],"studies":[46],"to":[47,54,141,190,202],"apply":[48],"a":[49,81,143,153,222],"biology":[52,237,249],"dynamics":[56],"cortisol,":[58],"insulin-like":[59],"factor":[61],"1":[62],"(IGF-1),":[63],"lactoferrin,":[64],"secretory":[66],"immunoglobulin":[67],"A":[68],"(sIgA)":[69],"milk.":[72],"First,":[73],"role":[75],"condition":[79,182],"as":[80,169,171],"predictor":[82],"concentration":[85,159],"these":[87],"milk":[91,101,115,131,161],"explored.":[93],"Several":[94],"interesting":[95],"emerge,":[97],"including":[98],"significantly":[99,113,214],"lower":[100],"cortisol":[102,116],"IGF-1":[104,187],"women":[106],"with":[107,146,193,205,213],"higher":[108,114],"body":[109],"mass":[110,220],"index,":[111],"primiparous":[118],"mothers.":[119],"Next,":[120],"symptoms":[125,147],"illness":[127,175],"two":[130],"immunofactors,":[132],"lactoferrin":[133],"sIgA,":[135],"are":[136,167,229,253],"investigated.":[137],"Lactoferrin":[138],"found":[140,189,201],"exhibit":[142],"positive":[144],"association":[145],"illness,":[149],"sIgA":[151],"shows":[152],"negative":[154],"association.":[155],"Finally,":[156],"associations":[157,172],"bioactives":[162],"rate":[166],"tested,":[168],"well":[170],"rate,":[178],"rate.":[185,197,208],"Milk":[186],"positively":[191],"associate":[192,204],"linear":[195,206],"Maternal":[198],"parity":[199],"negatively":[203],"First-born":[209],"status":[210],"associated":[212],"greater":[215],"gains":[216],"length":[218],"over":[221],"four-month":[223],"period.":[224],"These":[225],"other":[227],"results":[228],"discussed":[230],"avenues":[239],"for":[240],"future":[241],"research":[242],"at":[243],"intersection":[245],"public":[251],"identified.":[254]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}