{"id":"https://openalex.org/W100286755","doi":"https://doi.org/10.1042/bss0670131","title":"Regulation of gene expression by muscarinic acetylcholine receptors","display_name":"Regulation of gene expression by muscarinic acetylcholine receptors","publication_year":2001,"publication_date":"2001-02-01","ids":{"openalex":"https://openalex.org/W100286755","doi":"https://doi.org/10.1042/bss0670131","mag":"100286755","pmid":"https://pubmed.ncbi.nlm.nih.gov/11447829"},"language":"en","primary_location":{"id":"doi:10.1042/bss0670131","doi":"https://doi.org/10.1042/bss0670131","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bss0670131","pdf_url":null,"source":{"id":"https://openalex.org/S194663005","display_name":"Biochemical Society Symposia","issn_l":"0067-8694","issn":["0067-8694","1744-1439"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society Symposia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113582408","display_name":"Heinz von der Kammer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heinz von der Kammer","raw_affiliation_strings":["Center for Molecular Neurobiology, University of Hamburg, Martinistrasse 51, D-20246 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Neurobiology, University of Hamburg, Martinistrasse 51, D-20246 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102799616","display_name":"C\u00fcneyt Demiralay","orcid":"https://orcid.org/0000-0002-8204-5477","observed_orcids":["https://orcid.org/0000-0002-8204-5477"]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"C\u00fcneyt Demiralay","raw_affiliation_strings":["Center for Molecular Neurobiology, University of Hamburg, Martinistrasse 51, D-20246 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Neurobiology, University of Hamburg, Martinistrasse 51, D-20246 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000996814","display_name":"Barbara Andresen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Barbara Andresen","raw_affiliation_strings":["Center for Molecular Neurobiology, University of Hamburg, Martinistrasse 51, D-20246 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Neurobiology, University of Hamburg, Martinistrasse 51, D-20246 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101924020","display_name":"Claudia Albrecht","orcid":"https://orcid.org/0009-0005-6045-9360","observed_orcids":["https://orcid.org/0009-0005-6045-9360"]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Claudia Albrecht","raw_affiliation_strings":["Center for Molecular Neurobiology, University of Hamburg, Martinistrasse 51, D-20246 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Neurobiology, University of Hamburg, Martinistrasse 51, D-20246 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010690625","display_name":"Manuel Mayhaus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I159176309","display_name":"Universit\u00e4t Hamburg","ror":"https://ror.org/00g30e956","country_code":"DE","type":"education","lineage":["https://openalex.org/I159176309"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Manuel Mayhaus","raw_affiliation_strings":["Center for Molecular Neurobiology, University of Hamburg, Martinistrasse 51, D-20246 Hamburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Neurobiology, University of Hamburg, Martinistrasse 51, D-20246 Hamburg, Germany","institution_ids":["https://openalex.org/I159176309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109156775","display_name":"Roger M. Nitsch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Roger M. Nitsch","raw_affiliation_strings":["Department of Psychiatry Research, University of Z\u00fcrich, August-Forel-Strasse 1, CH-8008 Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry Research, University of Z\u00fcrich, August-Forel-Strasse 1, CH-8008 Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I202697423"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5000996814","https://openalex.org/A5010690625","https://openalex.org/A5101924020"],"corresponding_institution_ids":["https://openalex.org/I159176309"],"apc_list":null,"apc_paid":null,"fwci":0.9617,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.69953218,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"67","issue":"67","first_page":"131","last_page":"140"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.6991999745368958,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.2791000008583069,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscarinic-receptors","display_name":"muscarinic receptors","score":1.0},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/immediate-early-genes","display_name":"immediate early genes","score":0.8830000162124634},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7860000133514404},{"id":"https://openalex.org/keywords/cholinergic-transmission","display_name":"cholinergic neurotransmission","score":0.8740000128746033},{"id":"https://openalex.org/keywords/acetylcholinesterase","display_name":"acetylcholinesterase","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cholinomimetic-drugs","display_name":"cholinomimetic drugs","score":0.8450000286102295},{"id":"https://openalex.org/keywords/egr-transcription-factors","display_name":"Egr transcription factors","score":0.7080000042915344},{"id":"https://openalex.org/keywords/c-jun","display_name":"c-Jun","score":0.7649999856948853},{"id":"https://openalex.org/keywords/nr4a1","display_name":"Nur77","score":0.6309999823570251},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.765999972820282},{"id":"https://openalex.org/keywords/memory","display_name":"memory","score":0.335999995470047},{"id":"https://openalex.org/keywords/differential-display","display_name":"differential display","score":0.5139999985694885}],"concepts":[{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.8628209829330444},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.7310678958892822},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.6633989810943604},{"id":"https://openalex.org/C64123433","wikidata":"https://www.wikidata.org/wiki/Q17861965","display_name":"Muscarinic acetylcholine receptor M4","level":4,"score":0.6415135860443115},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5670321583747864},{"id":"https://openalex.org/C2778816929","wikidata":"https://www.wikidata.org/wiki/Q22676679","display_name":"Acetylcholinesterase","level":3,"score":0.5620253086090088},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.49057453870773315},{"id":"https://openalex.org/C47488739","wikidata":"https://www.wikidata.org/wiki/Q17861931","display_name":"Muscarinic acetylcholine receptor M2","level":4,"score":0.48877713084220886},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4565716087818146},{"id":"https://openalex.org/C80161118","wikidata":"https://www.wikidata.org/wiki/Q408520","display_name":"Acetylcholine receptor","level":3,"score":0.4550231397151947},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4195237159729004},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.41520655155181885},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40129363536834717},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3807171583175659},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20207267999649048},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.19521594047546387},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09652972221374512},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011976","descriptor_name":"Receptors, Muscarinic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017781","descriptor_name":"Genes, Immediate-Early","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018678","descriptor_name":"Cholinergic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1042/bss0670131","doi":"https://doi.org/10.1042/bss0670131","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bss0670131","pdf_url":null,"source":{"id":"https://openalex.org/S194663005","display_name":"Biochemical Society Symposia","issn_l":"0067-8694","issn":["0067-8694","1744-1439"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society Symposia","raw_type":"journal-article"},{"id":"pmid:11447829","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11447829","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Society symposium","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W1810712239"],"related_works":["https://openalex.org/W1999267798","https://openalex.org/W2104001105","https://openalex.org/W2004954392","https://openalex.org/W2170030276","https://openalex.org/W2014127226","https://openalex.org/W1996117707","https://openalex.org/W2135556934","https://openalex.org/W2964063095","https://openalex.org/W986242436","https://openalex.org/W1591188241"],"abstract_inverted_index":{"In":[0,18,30],"the":[1,23,34,51,80,90,94,105,116,129,168,192,201,216,219,244,252,271],"brain,":[2],"muscarinic":[3,228],"acetylcholine":[4,165],"receptors":[5,229],"(mAChRs)":[6],"are":[7,127,209],"involved":[8,53,242],"in":[9,54,142,173,243,257,279],"higher":[10],"cognitive":[11],"functions":[12,256],"including":[13],"synaptic":[14],"plasticity":[15],"and":[16,63,88,103,115,133,161,196,233,273],"memory.":[17],"Alzheimer's":[19],"disease":[20],"(AD)":[21],"patients":[22],"cholinergic":[24,35,169,174,247,259],"nervous":[25],"system":[26],"is":[27],"severely":[28],"damaged.":[29],"order":[31],"to":[32,41,45,146,266],"reinforce":[33],"system,":[36],"clinical":[37],"tests":[38],"were":[39,68],"started":[40],"use":[42],"cholinomimetic":[43,277],"drugs":[44],"treat":[46],"AD":[47,280],"patients.":[48,281],"To":[49],"identify":[50],"genes":[52,66,126,138,194,208,211],"mAChR":[55,72,180],"signalling,":[56],"we":[57],"used":[58],"a":[59,154,182,231,267],"differential":[60],"display":[61],"approach":[62],"found":[64],"11":[65],"that":[67,123,136,227,239],"readily":[69],"activated":[70],"by":[71],"with":[73],"1":[74],"hour":[75],"of":[76,131,164,185,218,236,246,254,270,276],"activation.":[77],"These":[78,262],"included":[79,191],"transcription":[81],"factors":[82,96],"Egr-1,":[83],"Egr-2,":[84],"Egr-3,":[85],"c-Jun,":[86],"Jun-D":[87],"Gos-3;":[89],"growth":[91,99],"regulator":[92],"hCyr61;":[93],"signalling":[95],"NGFi-B":[97],"(nerve":[98],"factor":[100],"induced":[101,112],"gene-B)":[102],"Etr101;":[104],"unknown":[106],"gene":[107,113,118,186,237],"Gig-2":[108],"(for":[109],"G-protein-coupled":[110],"receptor":[111,144],"2);":[114],"acetylcholinesterase":[117],"(ACHE).":[119],"Our":[120],"data":[121,225],"show":[122,226],"multiple":[124],"immediate-early":[125,221],"under":[128,215],"control":[130,217,253],"mAChRs,":[132],"they":[134],"suggest":[135,153],"these":[137,207],"play":[139],"important":[140],"roles":[141],"coupling":[143],"stimulation":[145],"long-term":[147],"neuronal":[148],"responses.":[149],"The":[150],"results":[151,263],"also":[152],"feedback":[155],"mechanism":[156],"where":[157],"up-regulated":[158],"ACHE":[159],"expression":[160,187,238],"accelerated":[162],"breakdown":[163],"(ACh)":[166],"at":[167],"synapses":[170],"limits":[171],"increases":[172],"transmission.":[175],"Three":[176],"hours":[177],"after":[178],"m1":[179],"activation":[181],"different":[183],"pattern":[184,235],"was":[188],"demonstrated.":[189],"It":[190],"novel":[193],"Gig-3":[195],"Gig-4,":[197],"as":[198,200,249,251],"well":[199,250],"LIM-only":[202],"protein":[203],"LM04.":[204],"Like":[205],"ACHE,":[206],"target":[210,260],"which":[212],"may":[213,240,264],"be":[214,241],"above":[220],"genes.":[222],"Together,":[223],"our":[224],"induce":[230],"complex":[232],"sustained":[234],"regulation":[245],"transmission":[248],"cellular":[255],"post-synaptic":[258],"cells.":[261],"contribute":[265],"better":[268],"understanding":[269],"effects":[272,275],"side":[274],"treatment":[278]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}