{"id":"https://openalex.org/W100270260","doi":null,"title":"Tertiary Alcohol- or \u03b2-Hydroxy \u03b3-Lactam-Based HIV-1 Protease Inhibitors Microwave Applications in Batch and Continuous Flow Organic Synthesis","display_name":"Tertiary Alcohol- or \u03b2-Hydroxy \u03b3-Lactam-Based HIV-1 Protease Inhibitors Microwave Applications in Batch and Continuous Flow Organic Synthesis","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W100270260","mag":"100270260"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:uu-160190","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160190","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160190","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058891726","display_name":"Per \u00d6hrngren","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Per \u00d6hrngren","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5058891726"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.8906000256538391,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12270","display_name":"Microwave-Assisted Synthesis and Applications","score":0.04500000178813934,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-protease-inhibitors","display_name":"HIV-1 protease inhibitors","score":1.0},{"id":"https://openalex.org/keywords/microwave-assisted-synthesis","display_name":"microwave-assisted synthesis","score":0.7749999761581421},{"id":"https://openalex.org/keywords/antiretroviral-drug-design","display_name":"antiretroviral drug design","score":0.7350000143051147},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.7310000061988831},{"id":"https://openalex.org/keywords/reaction-condition-optimization","display_name":"reaction condition optimization","score":0.4830000102519989}],"concepts":[{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.564653217792511},{"id":"https://openalex.org/C89623803","wikidata":"https://www.wikidata.org/wiki/Q12184","display_name":"Pandemic","level":5,"score":0.5144712924957275},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5006966590881348},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4687854051589966},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.4347293972969055},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.43442028760910034},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3559165596961975},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.3160080313682556},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30671846866607666},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22898167371749878},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.20089063048362732},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19704750180244446},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.18444880843162537},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.18359991908073425},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.1685052514076233}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:uu-160190","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160190","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:100270260","doi":null,"is_oa":false,"landing_page_url":"http://uu.diva-portal.org/smash/get/diva2:453212/FULLTEXT01.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:uu-160190","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-160190","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2041092566","https://openalex.org/W334846575","https://openalex.org/W2102646147","https://openalex.org/W2911590528","https://openalex.org/W2082529161","https://openalex.org/W1992664859","https://openalex.org/W2914225826","https://openalex.org/W620227209","https://openalex.org/W2038314839","https://openalex.org/W4240057931"],"abstract_inverted_index":{"Since":[0],"the":[1,4,8,10,14,30,34,75,102,120,127,133,137,190,207,221,224,244,281],"outbreak":[2],"of":[3,16,74,77,115,123,132,177,200,211,240,246,267],"HIV/AIDS":[5,37],"pandemic":[6],"in":[7,84,149,206],"1980s,":[9],"disease":[11],"has":[12],"cost":[13],"lives":[15],"over":[17],"30":[18],"million":[19,25],"people,":[20],"and":[21,54,80,160,168,172,203,232,262,274],"a":[22,43,107,157,161,247],"further":[23],"33":[24],"are":[26,60,81,98],"currently":[27,61],"living":[28],"with":[29,92,126,272,290],"HIV":[31,68,78],"infection.":[32],"With":[33],"appropriate":[35],"treatment,":[36,79],"can":[38],"today":[39],"be":[40],"regarded":[41],"as":[42],"chronic":[44],"but":[45],"manageable":[46],"disease.":[47],"However,":[48],"treatment":[49],"is":[50,105],"not":[51],"available":[52],"globally":[53],"UNAIDS":[55],"still":[56,106],"estimates":[57],"that":[58,280],"there":[59,97,104],"5000":[62],"AIDS-related":[63],"deaths":[64],"worldwide":[65],"per":[66],"day.":[67],"protease":[69],"inhibitors":[70,178,188,216],"(PIs)":[71],"constitute":[72],"one":[73],"fundaments":[76],"commonly":[82,128],"used":[83],"so-called":[85],"highly":[86],"active":[87],"antiretroviral":[88],"therapy":[89],"(HAART),":[90],"together":[91,125,289],"reverse":[93],"transcriptase":[94],"inhibitors.":[95],"Although":[96],"ten":[99],"PIs":[100],"on":[101,184],"market,":[103],"need":[108,138],"for":[109,300],"novel":[110,145,248],"structures.":[111,143],"The":[112,187,214,237,253],"rapid":[113,286],"development":[114],"resistant":[116],"strains,":[117],"due":[118],"to":[119,139],"high":[121],"frequency":[122],"mutations,":[124],"observed":[129],"adverse":[130],"effects":[131],"drugs":[134],"available,":[135],"illustrate":[136],"develop":[140],"new":[141],"potent":[142],"Two":[144],"scaffolds":[146],"were":[147,165,270],"investigated":[148],"this":[150],"work.":[151],"A":[152,265],"tertiary":[153,191],"alcohol-containing":[154],"scaffold":[155,164],"comprising":[156],"three-carbon":[158],"tether,":[159],"\u03b2-hydroxy":[162],"\u03b3-lactam-based":[163,215],"designed,":[166],"synthesized":[167],"evaluated":[169],"using":[170],"enzyme-":[171],"cell-based":[173,208],"assays.":[174],"X-ray":[175],"analyses":[176],"from":[179],"each":[180],"class":[181],"provided":[182,193],"information":[183],"inhibitor\u2013protease":[185],"interactions.":[186],"containing":[189],"alcohol":[192],"at":[194],"best":[195,225],"an":[196,204,297],"enzymatic":[197],"inhibition":[198,205,219],"(Ki)":[199],"2.3":[201],"nM,":[202],"assay":[209],"(EC50)":[210],"0.17":[212],"\u00b5M.":[213,236],"exhibited":[217],"better":[218],"than":[220],"first":[222],"series;":[223],"values":[226],"being":[227],"Ki":[228],"=":[229,234],"0.7":[230],"nM":[231],"EC50":[233],"0.04":[235],"second":[238],"part":[239],"these":[241],"studies":[242],"involved":[243],"evaluation":[245],"non-resonance":[249],"continuous-flow":[250],"microwave":[251,282],"instrument.":[252],"instrument":[254],"was":[255,278],"validated":[256],"regarding":[257],"heating":[258,283],"capacity,":[259],"temperature":[260,263,287],"stability":[261],"homogeneity.":[264],"number":[266],"model":[268],"reactions":[269],"performed":[271],"low-":[273],"high-microwave-absorbing":[275],"solvents.":[276],"It":[277],"found":[279],"source":[284],"allowed":[285],"adjustment,":[288],"easily":[291],"regulated,":[292],"flow-dependent":[293],"reaction":[294,301],"times,":[295],"providing":[296],"efficient":[298],"tool":[299],"optimisation.":[302]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2016-06-24T00:00:00"}