{"id":"https://openalex.org/W100173179","doi":null,"title":"Simvastatin and side effects.","display_name":"Simvastatin and side effects.","publication_year":1991,"publication_date":"1991-11-27","ids":{"openalex":"https://openalex.org/W100173179","mag":"100173179","pmid":"https://pubmed.ncbi.nlm.nih.gov/1745460"},"language":"en","primary_location":{"id":"pmid:1745460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1745460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New Zealand medical journal","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085690010","display_name":"Russell S. Scott","orcid":"https://orcid.org/0000-0002-2107-6480","observed_orcids":["https://orcid.org/0000-0002-2107-6480"]},"institutions":[{"id":"https://openalex.org/I4210119445","display_name":"Princess Margaret Hospital","ror":"https://ror.org/02h6j4611","country_code":"NZ","type":"healthcare","lineage":["https://openalex.org/I4210119445"]}],"countries":["NZ"],"is_corresponding":false,"raw_author_name":"R S Scott","raw_affiliation_strings":["Princess Margaret Hospital, Christchurch"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Princess Margaret Hospital, Christchurch","institution_ids":["https://openalex.org/I4210119445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112036854","display_name":"Caroline J. Lintott","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C J Lintott","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"M J Wilson","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M J Wilson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3536,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.56788865,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"104","issue":"924","first_page":"493","last_page":"5"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/simvastatin","display_name":"simvastatin","score":1.0},{"id":"https://openalex.org/keywords/statin-adverse-effects","display_name":"statin adverse effects","score":0.7070000171661377},{"id":"https://openalex.org/keywords/myalgia","display_name":"myalgia","score":0.5770000219345093},{"id":"https://openalex.org/keywords/gastrointestinal-symptoms","display_name":"gastrointestinal symptoms","score":0.9729999899864197},{"id":"https://openalex.org/keywords/drug-tolerability","display_name":"drug tolerability","score":0.5860000252723694},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9169999957084656},{"id":"https://openalex.org/keywords/lipid-lowering-therapy","display_name":"lipid-lowering therapy","score":0.8429999947547913},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.6119999885559082},{"id":"https://openalex.org/keywords/patient-reported-symptoms","display_name":"patient-reported symptoms","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9753636121749878},{"id":"https://openalex.org/C2776329913","wikidata":"https://www.wikidata.org/wiki/Q670131","display_name":"Simvastatin","level":2,"score":0.9590656161308289},{"id":"https://openalex.org/C3454156","wikidata":"https://www.wikidata.org/wiki/Q1144241","display_name":"Side effect (computer science)","level":2,"score":0.6906794905662537},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.6824518442153931},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.46593278646469116},{"id":"https://openalex.org/C3020110884","wikidata":"https://www.wikidata.org/wiki/Q695416","display_name":"Outpatient clinic","level":2,"score":0.45847347378730774},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42786312103271484},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.37944263219833374},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.15815404057502747},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000924","descriptor_name":"Anticholesteremic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006937","descriptor_name":"Hypercholesterolemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008148","descriptor_name":"Lovastatin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D008148","descriptor_name":"Lovastatin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008148","descriptor_name":"Lovastatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011795","descriptor_name":"Surveys and Questionnaires","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019161","descriptor_name":"Hydroxymethylglutaryl-CoA Reductase Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019821","descriptor_name":"Simvastatin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:1745460","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1745460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The New Zealand medical journal","raw_type":"Journal Article"},{"id":"mag:100173179","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1745460","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2124531262","https://openalex.org/W2099114718","https://openalex.org/W2038140751","https://openalex.org/W2069884888","https://openalex.org/W2259171108","https://openalex.org/W2957017745","https://openalex.org/W2462870937","https://openalex.org/W2361084638","https://openalex.org/W2352430309","https://openalex.org/W1933463071"],"abstract_inverted_index":{"OBJECT:":[0],"to":[1,56,101,170],"investigate":[2],"the":[3,37,42,47,143,175,186,193],"symptomatic":[4],"and":[5,62,131,164,196],"biochemical":[6,63,138],"side":[7,59,77,119,125,146],"effect":[8],"profile":[9],"of":[10,51,68,72,81,94,111,118,145,177,192],"simvastatin":[11,35,102,160],"(a":[12],"new":[13],"cholesterol":[14],"lowering":[15],"drug)":[16],"following":[17],"routine":[18],"use":[19,151],"in":[20,46,137,156,174],"a":[21,58,108],"specialist":[22],"hospital":[23],"outpatient":[24],"clinic.":[25],"METHODS:":[26],"all":[27],"patients":[28,73,82,95,112],"(n":[29],"=":[30],"110)":[31],"newly":[32],"commenced":[33],"on":[34],"at":[36,41,65],"lipid":[38],"disorders":[39],"clinic":[40],"Princess":[43],"Margaret":[44],"Hospital":[45],"first":[48],"ten":[49],"months":[50,67],"prescription":[52,150],"availability":[53],"were":[54,127],"asked":[55],"complete":[57],"effects":[60,78,126,147],"questionnaire":[61],"evaluation":[64],"six":[66],"therapy.":[69,89],"RESULTS:":[70],"76.4%":[71],"reported":[74,96,124,148],"experiencing":[75,97],"no":[76],"with":[79,149,202],"8%":[80],"spontaneously":[83],"reporting":[84],"feeling":[85],"better":[86],"since":[87],"commencing":[88],"Nineteen":[90],"point":[91],"one":[92],"percent":[93],"symptoms":[98,133,195],"they":[99],"attributed":[100],"but":[103],"had":[104,113],"continued":[105,189],"therapy,":[106],"while":[107],"further":[109],"4.5%":[110],"withdrawn":[114],"from":[115],"therapy":[116],"because":[117],"effects.":[120],"The":[121],"most":[122],"frequently":[123],"muscle":[128],"ache":[129],"(13.6%),":[130],"gastrointestinal":[132],"(4.5%).":[134],"No":[135],"abnormalities":[136],"safety":[139],"tests":[140],"occurred.":[141],"CONCLUSIONS:":[142],"rate":[144],"exceeds":[152],"that":[153],"previously":[154],"encountered":[155],"clinical":[157],"trials.":[158],"Since":[159],"is":[161,168],"considered":[162],"effective":[163],"well":[165],"tolerated":[166],"it":[167],"likely":[169],"receive":[171],"wide":[172],"acceptance":[173],"management":[176],"high":[178],"risk":[179],"hypercholesterolaemic":[180],"patients.":[181],"However,":[182],"this":[183],"study":[184],"indicates":[185],"need":[187],"for":[188],"physician":[190],"awareness":[191],"main":[194],"their":[197],"frequency":[198],"amongst":[199],"those":[200],"treated":[201],"simvastatin.":[203]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}