{"id":"https://openalex.org/W1000749166","doi":null,"title":"[Cases-Control association study and transmission disequilibrium test of T102C polymorphism in 5HT2A and Tourette syndrome].","display_name":"[Cases-Control association study and transmission disequilibrium test of T102C polymorphism in 5HT2A and Tourette syndrome].","publication_year":2001,"publication_date":"2001-02-01","ids":{"openalex":"https://openalex.org/W1000749166","mag":"1000749166","pmid":"https://pubmed.ncbi.nlm.nih.gov/11172633"},"language":"zh","primary_location":{"id":"pmid:11172633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11172633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics","raw_type":"English Abstract"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5096028972","display_name":"\u9ec4\u9890","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800091995","display_name":"West China Medical Center of Sichuan University","ror":"https://ror.org/040nggs60","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I24185976","https://openalex.org/I2800091995"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Y Huang","raw_affiliation_strings":["Institute of Mental Health, the First University Hospital, West China University of Medical Sciences, Chengdu, Sichuan, 610041 P.R. China. cdwangyun@mail.sc.cninifo.net"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Mental Health, the First University Hospital, West China University of Medical Sciences, Chengdu, Sichuan, 610041 P.R. China. cdwangyun@mail.sc.cninifo.net","institution_ids":["https://openalex.org/I2800091995"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096300998","display_name":"\u5218\u534f\u548c","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X Liu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096048712","display_name":"\u674e\u6d9b","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"T Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096300999","display_name":"\u90ed\u5170\u5a77","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"L Guo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096103760","display_name":"\u5b59\u5b66\u793c","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X Sun","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096301000","display_name":"\u9a6c\u5c0f\u7ea2","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X Xiao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096205677","display_name":"\u738b\u82f1\u6210","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"X Ma","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5096118664","display_name":"\u8096\u4fa0\u660e","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5008683089","display_name":"David Andrew Collier","orcid":"https://orcid.org/0000-0003-4087-1559","observed_orcids":["https://orcid.org/0000-0003-4087-1559"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D A Collier","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3202,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.80677182,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"18","issue":"1","first_page":"11","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11123","display_name":"Obsessive-Compulsive Spectrum Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tourette-syndrome","display_name":"Tourette syndrome","score":0.9890000224113464},{"id":"https://openalex.org/keywords/5-ht2a-receptor","display_name":"5-HT2A receptor","score":0.8539999723434448},{"id":"https://openalex.org/keywords/t102c-polymorphism","display_name":"T102C polymorphism","score":0.8849999904632568},{"id":"https://openalex.org/keywords/serotonin-receptor-gene","display_name":"serotonin receptor gene","score":0.7860000133514404},{"id":"https://openalex.org/keywords/obsessive-compulsive-disorder","display_name":"obsessive-compulsive disorder","score":0.8600000143051147},{"id":"https://openalex.org/keywords/genetic-association","display_name":"genetic association","score":0.7749999761581421},{"id":"https://openalex.org/keywords/transmission-disequilibrium-test","display_name":"transmission disequilibrium test","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C53910766","wikidata":"https://www.wikidata.org/wiki/Q238516","display_name":"5-HT receptor","level":4,"score":0.27397239208221436},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.2561316192150116},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23406848311424255},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.0684736967086792},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005879","descriptor_name":"Tourette Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009771","descriptor_name":"Obsessive-Compulsive Disorder","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011985","descriptor_name":"Receptors, Serotonin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044402","descriptor_name":"Receptor, Serotonin, 5-HT2A","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:11172633","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11172633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics","raw_type":"English Abstract"},{"id":"mag:1000749166","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/92672A/200101/4989445.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541203","display_name":"\u4e2d\u534e\u533b\u5b66\u9057\u4f20\u5b66\u6742\u5fd7","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u534e\u533b\u5b66\u9057\u4f20\u5b66\u6742\u5fd7","raw_type":null},{"id":"mag:2360074276","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11172633","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1043398664","https://openalex.org/W1495420103","https://openalex.org/W3028976562","https://openalex.org/W2468403286","https://openalex.org/W936437286","https://openalex.org/W3030504919","https://openalex.org/W2151187171","https://openalex.org/W1125116804","https://openalex.org/W3030048791","https://openalex.org/W2083944558"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"investigate":[2],"whether":[3],"T102C":[4,93],"polymorphism":[5,94,133,150],"in":[6,25,36,57,80,95,134,139,151],"5HT2A":[7,96,135,152],"(serotonin":[8],"receptor":[9],"2A)":[10],"is":[11,153],"associated":[12,155],"with":[13,39,101,156,160],"Tourette":[14,40,50,74,84,98,157,170],"syndrome.":[15,171],"METHODS:":[16],"Both":[17,60],"case-control":[18],"association":[19,76,91,127],"analysis":[20,110,114,122],"and":[21,31,43,51,65,71,86,97,112,136,142],"Transmission":[22],"Disequilibrium":[23],"Test(TDT),":[24],"addition":[26],"to":[27],"polymerase":[28],"chain":[29],"reaction":[30],"RFLP":[32],"technique":[33],"were":[34,78],"used":[35,56,79],"157":[37],"trios":[38],"syndrome":[41,75,85,99,158],"(TS)":[42],"120":[44],"controls.":[45],"A":[46],"semi-structured":[47],"\"Schedule":[48],"for":[49],"other":[52],"behavioral":[53],"syndrome\"":[54],"was":[55,106,117,146],"family":[58],"history-collecting.":[59],"the":[61,81],"criteria":[62],"of":[63,68,73,83,126,169],"\"Diagnostic":[64],"Statistical":[66],"Manual":[67],"Mental":[69],"Disorders\"(DSM-IV)":[70],"that":[72],"(TSA)":[77],"diagnosis":[82],"related":[87],"disorders.":[88],"RESULTS:":[89],"The":[90],"between":[92,131],"comorbided":[100,159],"obsessive":[102],"compulsive":[103],"disorder":[104],"(OCD)":[105],"found":[107],"by":[108,120],"genotype-wise":[109],"(chi(2)=8.38,P=0.004)":[111],"allele-wise":[113],"(chi(2)=4.84,P=0.028),":[115],"which":[116,163],"further":[118],"confirmed":[119],"TDT":[121],"(chi(2)=5.12,P=0.02).":[123],"No":[124],"evidence":[125],"or":[128],"transmission":[129],"disequilibrium":[130],"102T/C":[132,149],"this":[137],"disease":[138],"pure":[140],"TS":[141,144],"total":[143],"sample":[145],"found.":[147],"CONCLUSION:":[148],"exclusively":[154],"DSM-IV":[161],"OCD,":[162],"may":[164],"constitute":[165],"an":[166],"independent":[167],"subtype":[168]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}
