{"id":"https://openalex.org/W100043787","doi":null,"title":"Effect of red pepper and black pepper on the stomach.","display_name":"Effect of red pepper and black pepper on the stomach.","publication_year":1987,"publication_date":"1987-03-01","ids":{"openalex":"https://openalex.org/W100043787","mag":"100043787","pmid":"https://pubmed.ncbi.nlm.nih.gov/3103424"},"language":"en","primary_location":{"id":"pmid:3103424","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3103424","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Clinical Trial"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"B M Myers","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B M Myers","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040042317","display_name":"J L Smith","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J L Smith","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5053556585","display_name":"David Yates Graham","orcid":"https://orcid.org/0000-0002-6908-8317","observed_orcids":["https://orcid.org/0000-0002-6908-8317"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Y Graham","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7203,"has_fulltext":false,"cited_by_count":76,"citation_normalized_percentile":{"value":0.81104167,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"82","issue":"3","first_page":"211","last_page":"4"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.37959998846054077,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T13037","display_name":"Piperaceae Chemical and Biological Studies","score":0.37959998846054077,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.3131999969482422,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.05649999901652336,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/red-pepper","display_name":"red pepper","score":0.9760000109672546},{"id":"https://openalex.org/keywords/black-pepper","display_name":"black pepper","score":1.0},{"id":"https://openalex.org/keywords/spices","display_name":"spices","score":0.9269999861717224},{"id":"https://openalex.org/keywords/gastric-mucosal-injury","display_name":"gastric mucosal injury","score":0.8939999938011169},{"id":"https://openalex.org/keywords/pepsin-secretion","display_name":"pepsin secretion","score":0.925000011920929},{"id":"https://openalex.org/keywords/urinary-potassium-excretion","display_name":"potassium excretion","score":0.7749999761581421},{"id":"https://openalex.org/keywords/gastric-hemorrhage","display_name":"gastric bleeding","score":0.8149999976158142},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.8199999928474426},{"id":"https://openalex.org/keywords/dose-dependent-effects","display_name":"dose-dependent effects","score":0.4480000138282776}],"concepts":[{"id":"https://openalex.org/C2776242653","wikidata":"https://www.wikidata.org/wiki/Q22907699","display_name":"Pepper","level":2,"score":0.886101245880127},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6738834381103516},{"id":"https://openalex.org/C2781443798","wikidata":"https://www.wikidata.org/wiki/Q383249","display_name":"Gastric mucosa","level":3,"score":0.5519641041755676},{"id":"https://openalex.org/C2780133158","wikidata":"https://www.wikidata.org/wiki/Q414501","display_name":"Piperine","level":2,"score":0.545600175857544},{"id":"https://openalex.org/C2777628954","wikidata":"https://www.wikidata.org/wiki/Q18216","display_name":"Aspirin","level":2,"score":0.4804789125919342},{"id":"https://openalex.org/C2779422922","wikidata":"https://www.wikidata.org/wiki/Q1029907","display_name":"Stomach","level":2,"score":0.4394327700138092},{"id":"https://openalex.org/C16311235","wikidata":"https://www.wikidata.org/wiki/Q190265","display_name":"Pepsin","level":3,"score":0.4229051470756531},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.4104841947555542},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.37090161442756653},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33053284883499146},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.2200627624988556},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18849822878837585},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1883068084716797},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002212","descriptor_name":"Capsicum","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D003212","descriptor_name":"Condiments","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005744","descriptor_name":"Gastric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006471","descriptor_name":"Gastrointestinal Hemorrhage","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010434","descriptor_name":"Pepsin A","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010945","descriptor_name":"Plants, Edible","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010946","descriptor_name":"Plants, Medicinal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011188","descriptor_name":"Potassium","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013270","descriptor_name":"Stomach","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013270","descriptor_name":"Stomach","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true}],"locations_count":2,"locations":[{"id":"pmid:3103424","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3103424","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of gastroenterology","raw_type":"Clinical Trial"},{"id":"mag:100043787","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3103424","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W65261117","https://openalex.org/W147859622","https://openalex.org/W2413228197","https://openalex.org/W2038677036","https://openalex.org/W2404888054","https://openalex.org/W2410630282","https://openalex.org/W2464360090","https://openalex.org/W7214241256","https://openalex.org/W4253401500","https://openalex.org/W153570028"],"abstract_inverted_index":{"Spices":[0],"have":[1,221],"long":[2],"been":[3],"implicated":[4],"as":[5,54],"a":[6],"cause":[7],"of":[8,16,29,171,198,203],"gastric":[9,23,61,70,113,145,173,228],"mucosal":[10],"injury.":[11],"We":[12],"assessed":[13],"the":[14,22,123,163,172,195,227],"effects":[15],"red":[17,33,88,118,126,149],"and":[18,49,56,69,83,90,101,139,151,232],"black":[19,38,91,120,152],"pepper":[20,34,39,89,92,121,127,150,153,205],"on":[21,226],"mucosa":[24,229],"using":[25],"double-blind":[26],"intragastric":[27],"administration":[28,68,128,138],"test":[30,66,164],"meals":[31],"containing":[32],"(0.1-1.5":[35],"g)":[36,41],"or":[37,119,175,220],"(1.5":[40],"to":[42,194],"healthy":[43],"human":[44],"volunteers;":[45],"aspirin":[46,185,191],"(655":[47],"mg)":[48],"distilled":[50],"water":[51],"were":[52,63,72,156],"used":[53],"positive":[55],"negative":[57],"controls,":[58],"respectively.":[59],"Serial":[60],"washes":[62],"performed":[64],"after":[65,117,125,136,147],"meal":[67],"contents":[71],"analyzed":[73],"for":[74],"DNA,":[75],"pepsin,":[76],"blood,":[77],"sodium,":[78],"potassium,":[79],"parietal":[80,97],"cell":[81,85,105],"secretion,":[82,98,100],"nonparietal":[84,167],"secretion.":[86,177],"Both":[87],"caused":[93],"significant":[94,158,223],"increases":[95],"in":[96,109,166,186],"pepsin":[99],"potassium":[102],"loss.":[103],"Gastric":[104],"exfoliation":[106],"(as":[107],"reflected":[108],"DNA":[110],"loss":[111],"into":[112],"contents)":[114],"was":[115,129,134,181,192],"increased":[116],"administration;":[122],"increase":[124],"dose":[130],"dependent.":[131],"Mucosal":[132],"microbleeding":[133],"seen":[135],"spice":[137,180],"one":[140],"subject":[141],"had":[142],"grossly":[143],"visible":[144],"bleeding":[146],"both":[148],"administration.":[154],"There":[155],"no":[157,179,222],"differences":[159],"from":[160,184],"control":[161],"between":[162],"meals,":[165],"volume,":[168],"fractional":[169],"recovery":[170],"secretions,":[174],"sodium":[176],"Finally,":[178],"significantly":[182],"different":[183],"any":[187],"parameter":[188],"studied;":[189],"indeed,":[190],"comparable":[193],"higher":[196],"doses":[197],"pepper.":[199],"The":[200],"long-term":[201,224],"result":[202],"daily":[204],"ingestion":[206],"is":[207,230],"unknown.":[208],"Whether":[209],"spices":[210],"are":[211],"detrimental,":[212],"beneficial":[213],"(e.g.,":[214],"inducing":[215],"an":[216],"adaptive":[217],"cytoprotective":[218],"response),":[219],"effect":[225],"unknown":[231],"deserves":[233],"further":[234],"study.":[235]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}