{"id":"https://openalex.org/T13971","display_name":"Synthesis and Biological Activity","description":"This cluster of papers focuses on the chemistry, biology, and synthesis of antitumor antibiotics, particularly tetrahydroisoquinoline compounds such as Ecteinascidin. It covers topics such as total synthesis, marine-derived compounds, asymmetric synthesis, and DNA binding mechanisms. The research also explores the pharmacological activities and potential clinical utility of these compounds.","keywords":[{"id":"https://openalex.org/keywords/tetrahydroisoquinolines","display_name":"tetrahydroisoquinolines","score":0.3467},{"id":"https://openalex.org/keywords/isoquinoline-alkaloids","display_name":"isoquinoline alkaloids","score":0.2481},{"id":"https://openalex.org/keywords/isoquinoline-derivatives","display_name":"isoquinoline derivatives","score":0.3185},{"id":"https://openalex.org/keywords/isoquinoline-synthesis","display_name":"isoquinoline synthesis","score":0.4539},{"id":"https://openalex.org/keywords/tetrahydroisoquinoline-alkaloids","display_name":"tetrahydroisoquinoline alkaloids","score":0.4028},{"id":"https://openalex.org/keywords/tetrahydroisoquinoline-derivatives","display_name":"tetrahydroisoquinoline derivatives","score":0.3824},{"id":"https://openalex.org/keywords/3-4-dihydroisoquinolines","display_name":"3,4-dihydroisoquinolines","score":0.3978},{"id":"https://openalex.org/keywords/tetrahydroisoquinoline-synthesis","display_name":"tetrahydroisoquinoline synthesis","score":0.6991},{"id":"https://openalex.org/keywords/bischler-napieralski-reaction","display_name":"Bischler-Napieralski reaction","score":0.3603},{"id":"https://openalex.org/keywords/dihydroisoquinolines","display_name":"dihydroisoquinolines","score":0.2984},{"id":"https://openalex.org/keywords/bischler-napieralski-cyclization","display_name":"Bischler-Napieralski cyclization","score":0.3464},{"id":"https://openalex.org/keywords/naphthylisoquinoline-alkaloids","display_name":"naphthylisoquinoline alkaloids","score":0.2834},{"id":"https://openalex.org/keywords/1-2-dihydroisoquinolines","display_name":"1,2-dihydroisoquinolines","score":0.2977},{"id":"https://openalex.org/keywords/isoquinolinium-salts","display_name":"isoquinolinium salts","score":0.2038},{"id":"https://openalex.org/keywords/homoveratrylamine","display_name":"homoveratrylamine","score":0.2857},{"id":"https://openalex.org/keywords/protoberberines","display_name":"protoberberines","score":0.227},{"id":"https://openalex.org/keywords/decahydroisoquinoline","display_name":"decahydroisoquinoline","score":0.2912},{"id":"https://openalex.org/keywords/tetrahydroprotoberberines","display_name":"tetrahydroprotoberberines","score":0.2006},{"id":"https://openalex.org/keywords/salsolidine","display_name":"salsolidine","score":0.2782},{"id":"https://openalex.org/keywords/ecteinascidins","display_name":"ecteinascidins","score":0.2323},{"id":"https://openalex.org/keywords/phthalideisoquinoline-alkaloids","display_name":"phthalideisoquinoline alkaloids","score":0.3499},{"id":"https://openalex.org/keywords/xylopinine","display_name":"xylopinine","score":0.2698},{"id":"https://openalex.org/keywords/benzyltetrahydroisoquinoline-alkaloids","display_name":"benzyltetrahydroisoquinoline alkaloids","score":0.2307},{"id":"https://openalex.org/keywords/aromatic-amine-synthesis","display_name":"aromatic amine synthesis","score":0.4724}],"legacy_keywords":"Tetrahydroisoquinoline; Ecteinascidin; Total Synthesis; Anticancer Drug; Marine-derived Compound; Cycloaddition Reactions; Asymmetric Synthesis; Isocoumarins; Pharmacology; DNA Binding","ids":{"openalex":"https://openalex.org/T13971","wikipedia":"https://en.wikipedia.org/wiki/Tetrahydroisoquinoline_antitumor_antibiotics"},"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation"},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies"},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment"},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research"},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms"},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism"},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics"},{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies"},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways"},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism"},{"id":"https://openalex.org/T13350","display_name":"Myxozoan Parasites in Aquatic Species"},{"id":"https://openalex.org/T13943","display_name":"Beetle Biology and Toxicology Studies"}],"works_count":12786,"cited_by_count":115172,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T13971","updated_date":"2026-10-16T03:01:39","created_date":"2024-01-23T15:27:20"}