{"id":"https://openalex.org/T13834","display_name":"Whipple's Disease and Interleukins","description":"This cluster of papers focuses on the pathogenesis, diagnosis, and treatment of Whipple's disease, caused by the bacterium Tropheryma whipplei. It covers topics such as bacterial cultivation, genome sequencing, interleukin-16 involvement, central nervous system manifestations, PCR diagnosis, microbial susceptibility to antibiotics, and the immune reconstitution inflammatory syndrome. The research also delves into the association of Whipple's disease with immunosuppressive therapy and explores potential genetic biomarkers for disease susceptibility.","keywords":[{"id":"https://openalex.org/keywords/whipple-disease","display_name":"Whipple's disease","score":0.8443},{"id":"https://openalex.org/keywords/tropheryma-whipplei","display_name":"Tropheryma whipplei","score":0.8974},{"id":"https://openalex.org/keywords/pas-positive-macrophages","display_name":"PAS-positive macrophages","score":0.8069}],"legacy_keywords":"Whipple's Disease; Tropheryma whipplei; Interleukin-16; Bacterial Cultivation; Genome Sequencing; Immunosuppressive Therapy; Central Nervous System Involvement; PCR Diagnosis; Microbial Susceptibility; Immune Reconstitution Inflammatory Syndrome","ids":{"openalex":"https://openalex.org/T13834","wikipedia":"https://en.wikipedia.org/wiki/Whipple%27s_disease"},"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"},"siblings":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies"},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment"},{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology"},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies"},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research"},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion"},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas"},{"id":"https://openalex.org/T11154","display_name":"Parasitic infections in humans and animals"},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects"},{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research"},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases"},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer"},{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects"},{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders"},{"id":"https://openalex.org/T11730","display_name":"Autoimmune Bullous Skin Diseases"},{"id":"https://openalex.org/T12193","display_name":"Trigeminal Neuralgia and Treatments"},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation"},{"id":"https://openalex.org/T13363","display_name":"Soft tissue tumors and treatment"},{"id":"https://openalex.org/T13383","display_name":"Tumors and Oncological Cases"},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy"},{"id":"https://openalex.org/T14199","display_name":"Historical and Scientific Studies"},{"id":"https://openalex.org/T14415","display_name":"Biomedical Research and Pathophysiology"}],"works_count":3331,"cited_by_count":39636,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T13834","updated_date":"2026-10-19T03:01:26","created_date":"2024-01-23T15:27:20"}