{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","description":"This cluster of papers focuses on the role of Pim oncogenes, particularly Pim-1 and Pim-2 kinases, in promoting tumorigenesis, cancer progression, and metastasis. The cluster also explores the potential of targeting Pim kinases as a therapeutic approach, with a specific emphasis on their involvement in cell survival pathways, phosphorylation of key proteins, and their association with hematological malignancies.","keywords":[{"id":"https://openalex.org/keywords/astrocyte-elevated-gene-1","display_name":"AEG-1","score":0.4388},{"id":"https://openalex.org/keywords/mda-9-syntenin","display_name":"MDA-9/Syntenin","score":0.3122},{"id":"https://openalex.org/keywords/topk-inhibitor","display_name":"TOPK inhibitor","score":0.2128}],"legacy_keywords":"Pim Oncogenes; Tumorigenesis; Metadherin; Astrocyte Elevated Gene-1; Kinase Inhibitors; Cancer Progression; Cell Survival Pathways; Phosphorylation; Metastasis; Hematological Malignancies","ids":{"openalex":"https://openalex.org/T13779","wikipedia":"https://en.wikipedia.org/wiki/PIM1"},"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"},"siblings":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies"},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment"},{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology"},{"id":"https://openalex.org/T10277","display_name":"Vitamin D Research Studies"},{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research"},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion"},{"id":"https://openalex.org/T11134","display_name":"Breast Lesions and Carcinomas"},{"id":"https://openalex.org/T11154","display_name":"Parasitic infections in humans and animals"},{"id":"https://openalex.org/T11207","display_name":"Alcohol Consumption and Health Effects"},{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research"},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases"},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer"},{"id":"https://openalex.org/T11411","display_name":"Tea Polyphenols and Effects"},{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders"},{"id":"https://openalex.org/T11730","display_name":"Autoimmune Bullous Skin Diseases"},{"id":"https://openalex.org/T12193","display_name":"Trigeminal Neuralgia and Treatments"},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation"},{"id":"https://openalex.org/T13363","display_name":"Soft tissue tumors and treatment"},{"id":"https://openalex.org/T13383","display_name":"Tumors and Oncological Cases"},{"id":"https://openalex.org/T13834","display_name":"Whipple's Disease and Interleukins"},{"id":"https://openalex.org/T14199","display_name":"Historical and Scientific Studies"},{"id":"https://openalex.org/T14415","display_name":"Biomedical Research and Pathophysiology"}],"works_count":6218,"cited_by_count":138307,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T13779","updated_date":"2026-10-21T03:01:35","created_date":"2024-01-23T15:27:19"}