{"id":"https://openalex.org/T13637","display_name":"Calpain Protease Function and Regulation","description":"This cluster of papers explores the role of calpain, a calcium-dependent protease, in regulating various cellular processes such as cell migration, neurodegeneration, apoptosis, and its involvement in diseases including diabetes, cancer, and cardiovascular remodeling. The papers also discuss the structure, activation, and inhibition of calpain as a potential therapeutic target.","keywords":[{"id":"https://openalex.org/keywords/calpain","display_name":"calpain","score":0.3412},{"id":"https://openalex.org/keywords/calpain-1","display_name":"calpain-1","score":0.4085},{"id":"https://openalex.org/keywords/calpain-2","display_name":"m-calpain","score":0.5422},{"id":"https://openalex.org/keywords/calpastatin","display_name":"calpastatin","score":0.4302},{"id":"https://openalex.org/keywords/calpain-inhibitors","display_name":"calpain inhibitors","score":0.5824},{"id":"https://openalex.org/keywords/calpain-inhibition","display_name":"calpain inhibition","score":0.4679},{"id":"https://openalex.org/keywords/calpain-activation","display_name":"calpain activation","score":0.4863},{"id":"https://openalex.org/keywords/calcium-dependent-proteolysis","display_name":"calcium-dependent proteolysis","score":0.4516},{"id":"https://openalex.org/keywords/capn10","display_name":"CAPN10","score":0.3899},{"id":"https://openalex.org/keywords/calcium-dependent-protease","display_name":"calcium-dependent protease","score":0.3539},{"id":"https://openalex.org/keywords/calpeptin","display_name":"calpeptin","score":0.3702},{"id":"https://openalex.org/keywords/calpain-substrates","display_name":"calpain substrates","score":0.9142},{"id":"https://openalex.org/keywords/calcium-dependent-cysteine-protease","display_name":"calcium-dependent cysteine protease","score":0.7344},{"id":"https://openalex.org/keywords/calpain-isoforms","display_name":"calpain isoforms","score":0.9155},{"id":"https://openalex.org/keywords/calpain-autolysis","display_name":"calpain autolysis","score":0.74},{"id":"https://openalex.org/keywords/mdl28170","display_name":"MDL28170","score":0.2778},{"id":"https://openalex.org/keywords/calpain-activity","display_name":"calpain activity","score":0.2598},{"id":"https://openalex.org/keywords/pd150606","display_name":"PD150606","score":0.5571},{"id":"https://openalex.org/keywords/calpain-inhibitor-i","display_name":"calpain inhibitor I","score":0.4266},{"id":"https://openalex.org/keywords/calpain-mediated-proteolysis","display_name":"calpain-mediated proteolysis","score":0.377},{"id":"https://openalex.org/keywords/calpain-system","display_name":"calpain system","score":0.2456},{"id":"https://openalex.org/keywords/capns1","display_name":"CAPNS1","score":0.3466},{"id":"https://openalex.org/keywords/calcium-dependent-proteinase","display_name":"calcium-dependent proteinase","score":0.336},{"id":"https://openalex.org/keywords/calpain-proteolysis","display_name":"calpain proteolysis","score":0.2976},{"id":"https://openalex.org/keywords/spectrin-breakdown-products","display_name":"spectrin breakdown products","score":0.2478}],"legacy_keywords":"Calpain; Cell Migration; Neurodegeneration; Proteolytic System; Apoptosis; Diabetes; Cancer; Mitochondria; Inhibitors; Cardiovascular Remodeling","ids":{"openalex":"https://openalex.org/T13637","wikipedia":"https://en.wikipedia.org/wiki/Calpain"},"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions"},{"id":"https://openalex.org/T10492","display_name":"Microtubule and mitosis dynamics"},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion"},{"id":"https://openalex.org/T10825","display_name":"Plant Pathogens and Fungal Diseases"},{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research"},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation"},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease"},{"id":"https://openalex.org/T11399","display_name":"Muscle metabolism and nutrition"},{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research"},{"id":"https://openalex.org/T11685","display_name":"Zebrafish Biomedical Research Applications"},{"id":"https://openalex.org/T12065","display_name":"Hippo pathway signaling and YAP/TAZ"},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function"},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine"},{"id":"https://openalex.org/T12712","display_name":"Myofascial pain diagnosis and treatment"},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes"},{"id":"https://openalex.org/T13127","display_name":"Biotin and Related Studies"}],"works_count":5778,"cited_by_count":169285,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T13637","updated_date":"2026-10-16T03:01:39","created_date":"2024-01-23T15:27:19"}