{"id":"https://openalex.org/T13481","display_name":"Neurological diseases and metabolism","description":"This cluster of papers focuses on neurodegenerative disorders associated with brain iron accumulation, particularly emphasizing the genetic mutations in genes such as Pantothenate Kinase (PANK2), Coenzyme A biosynthesis, and Phospholipase A2 (PLA2G6). The research also explores the clinical, radiographic, and neuroimaging features of these disorders.","keywords":[{"id":"https://openalex.org/keywords/fahr-disease","display_name":"Fahr disease","score":0.5107},{"id":"https://openalex.org/keywords/neurodegeneration-with-brain-iron-accumulation","display_name":"neurodegeneration with brain iron accumulation","score":0.655},{"id":"https://openalex.org/keywords/basal-ganglia-calcification","display_name":"basal ganglia calcification","score":0.2803},{"id":"https://openalex.org/keywords/pantothenate-kinase-associated-neurodegeneration","display_name":"pantothenate kinase-associated neurodegeneration","score":0.757},{"id":"https://openalex.org/keywords/hallervorden-spatz-disease","display_name":"Hallervorden-Spatz disease","score":0.7128},{"id":"https://openalex.org/keywords/brain-iron-accumulation","display_name":"brain iron accumulation","score":0.3108},{"id":"https://openalex.org/keywords/pank2","display_name":"PANK2","score":0.7913},{"id":"https://openalex.org/keywords/coenzyme-a-biosynthesis","display_name":"coenzyme A biosynthesis","score":0.2632},{"id":"https://openalex.org/keywords/slc20a2","display_name":"SLC20A2","score":0.6032},{"id":"https://openalex.org/keywords/eye-of-the-tiger-sign","display_name":"eye-of-the-tiger sign","score":0.8474},{"id":"https://openalex.org/keywords/pla2g6","display_name":"PLA2G6","score":0.3488},{"id":"https://openalex.org/keywords/neuroferritinopathy","display_name":"neuroferritinopathy","score":0.6521},{"id":"https://openalex.org/keywords/aceruloplasminemia","display_name":"aceruloplasminemia","score":0.3843},{"id":"https://openalex.org/keywords/infantile-neuroaxonal-dystrophy","display_name":"infantile neuroaxonal dystrophy","score":0.2935},{"id":"https://openalex.org/keywords/beta-propeller-protein-associated-neurodegeneration","display_name":"beta-propeller protein-associated neurodegeneration","score":0.5928},{"id":"https://openalex.org/keywords/pank2-mutations","display_name":"PANK2 mutations","score":0.8661},{"id":"https://openalex.org/keywords/pantothenate-kinase","display_name":"pantothenate kinase","score":0.2898},{"id":"https://openalex.org/keywords/cerebellar-calcification","display_name":"cerebellar calcification","score":0.2877},{"id":"https://openalex.org/keywords/basal-ganglia-iron-accumulation","display_name":"basal ganglia iron accumulation","score":0.8376},{"id":"https://openalex.org/keywords/wdr45","display_name":"WDR45","score":0.4159},{"id":"https://openalex.org/keywords/c19orf12","display_name":"C19orf12","score":0.5761},{"id":"https://openalex.org/keywords/pla2g6-associated-neurodegeneration","display_name":"PLA2G6-associated neurodegeneration","score":0.7511},{"id":"https://openalex.org/keywords/xpr1","display_name":"XPR1","score":0.2555},{"id":"https://openalex.org/keywords/basal-ganglia-iron-deposition","display_name":"basal ganglia iron deposition","score":0.6531},{"id":"https://openalex.org/keywords/thalamic-calcification","display_name":"thalamic calcification","score":0.2851}],"legacy_keywords":"Neurodegeneration; Brain Iron Accumulation; Pantothenate Kinase; Coenzyme A; Genetic Mutations; Phospholipase A2; Ferritin; Neuroimaging; Mitochondrial Dysfunction; Parkinsonism","ids":{"openalex":"https://openalex.org/T13481","wikipedia":"https://en.wikipedia.org/wiki/Neurodegeneration_with_brain_iron_accumulation"},"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T10542","display_name":"Vestibular and auditory disorders"},{"id":"https://openalex.org/T10614","display_name":"Transcranial Magnetic Stimulation Studies"},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms"},{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies"},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research"},{"id":"https://openalex.org/T12702","display_name":"Brain Tumor Detection and Classification"},{"id":"https://openalex.org/T12854","display_name":"Neurology and Historical Studies"},{"id":"https://openalex.org/T13796","display_name":"Neurological Disorders and Treatments"},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments"}],"works_count":7103,"cited_by_count":112705,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T13481","updated_date":"2026-10-19T03:01:26","created_date":"2024-01-23T15:27:18"}