{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","description":"This cluster of papers explores the evolution, function, and dysregulation of lysosomal calcium signaling, focusing on the role of two-pore channels, NAADP, TRPML1, and cyclic ADP-ribose in intracellular calcium release and endolysosomal trafficking. It also investigates the implications of these mechanisms in diseases such as mucolipidosis type IV and lysosomal storage disorders.","keywords":[{"id":"https://openalex.org/keywords/cyclic-adp-ribose","display_name":"cyclic ADP-ribose","score":0.5897},{"id":"https://openalex.org/keywords/naadp","display_name":"NAADP","score":0.8083},{"id":"https://openalex.org/keywords/trpml1","display_name":"TRPML1","score":0.6374},{"id":"https://openalex.org/keywords/adp-ribosyl-cyclase","display_name":"ADP-ribosyl cyclase","score":0.5305},{"id":"https://openalex.org/keywords/two-pore-channels","display_name":"two-pore channels","score":0.4219},{"id":"https://openalex.org/keywords/tpc2","display_name":"TPC2","score":0.6601},{"id":"https://openalex.org/keywords/tpc1","display_name":"TPC1","score":0.5474},{"id":"https://openalex.org/keywords/mucolipidosis-type-iv","display_name":"mucolipidosis type IV","score":0.448},{"id":"https://openalex.org/keywords/lysosomal-calcium-release","display_name":"lysosomal calcium release","score":0.5728},{"id":"https://openalex.org/keywords/mucolipin-1","display_name":"MCOLN1","score":0.3368},{"id":"https://openalex.org/keywords/lysosomal-ion-channels","display_name":"lysosomal ion channels","score":0.7294},{"id":"https://openalex.org/keywords/naadp-receptor","display_name":"NAADP receptor","score":0.9079},{"id":"https://openalex.org/keywords/trpml3","display_name":"TRPML3","score":0.6806},{"id":"https://openalex.org/keywords/trpml2","display_name":"TRPML2","score":0.7914},{"id":"https://openalex.org/keywords/lysosomal-calcium","display_name":"lysosomal calcium","score":0.3359},{"id":"https://openalex.org/keywords/pi-3-5-p2","display_name":"PI(3,5)P2","score":0.2532},{"id":"https://openalex.org/keywords/nad-metabolites","display_name":"NAD+ metabolites","score":0.2798},{"id":"https://openalex.org/keywords/trpml","display_name":"TRPML","score":0.2485}],"legacy_keywords":"Lysosomal Calcium Signaling; Two-pore Channels; NAADP; TRPML1; Endolysosomal Trafficking; Cyclic ADP-Ribose; Mucolipidosis Type IV; Intracellular Calcium Release; Nicotinic Acid Adenine Dinucleotide Phosphate; Lysosomal Storage Diseases","ids":{"openalex":"https://openalex.org/T13415","wikipedia":"https://en.wikipedia.org/wiki/Lysosomal_calcium_signaling"},"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling"},{"id":"https://openalex.org/T11505","display_name":"Reproductive biology and impacts on aquatic species"},{"id":"https://openalex.org/T12976","display_name":"Magnetic and Electromagnetic Effects"}],"works_count":5247,"cited_by_count":215566,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T13415","updated_date":"2026-10-22T03:01:35","created_date":"2024-01-23T15:27:18"}