{"id":"https://openalex.org/T12989","display_name":"Ocular Disorders and Treatments","description":"This cluster of papers focuses on genetic and clinical studies related to ocular development, particularly microphthalmia, anophthalmia, and associated syndromes such as Fraser syndrome. It explores the genetic mutations in genes like SOX2 and BCOR, as well as the use of orbital implants in surgical management of eye malformations. The research also delves into epidermal adhesion and its role in ocular development.","keywords":[{"id":"https://openalex.org/keywords/congenital-eye-malformation","display_name":"congenital eye malformation","score":0.647},{"id":"https://openalex.org/keywords/microphthalmia","display_name":"microphthalmia","score":0.4723},{"id":"https://openalex.org/keywords/eye-development","display_name":"eye development","score":0.2262},{"id":"https://openalex.org/keywords/ocular-prosthesis","display_name":"ocular prosthesis","score":0.3669},{"id":"https://openalex.org/keywords/anophthalmia","display_name":"anophthalmia","score":0.6072},{"id":"https://openalex.org/keywords/coloboma","display_name":"coloboma","score":0.4752},{"id":"https://openalex.org/keywords/ocular-malformations","display_name":"ocular malformations","score":0.5828},{"id":"https://openalex.org/keywords/aniridia","display_name":"aniridia","score":0.3886},{"id":"https://openalex.org/keywords/orbital-implants","display_name":"orbital implants","score":0.5607},{"id":"https://openalex.org/keywords/hereditary-eye-disease","display_name":"hereditary eye disease","score":0.208},{"id":"https://openalex.org/keywords/congenital-ptosis","display_name":"congenital ptosis","score":0.3393},{"id":"https://openalex.org/keywords/lens-development","display_name":"lens development","score":0.2189},{"id":"https://openalex.org/keywords/optic-nerve-hypoplasia","display_name":"optic nerve hypoplasia","score":0.3334},{"id":"https://openalex.org/keywords/pediatric-eye-disease","display_name":"pediatric eye disease","score":0.2004},{"id":"https://openalex.org/keywords/anterior-segment-dysgenesis","display_name":"anterior segment dysgenesis","score":0.7074},{"id":"https://openalex.org/keywords/iris-coloboma","display_name":"iris coloboma","score":0.5309},{"id":"https://openalex.org/keywords/congenital-aniridia","display_name":"congenital aniridia","score":0.6339},{"id":"https://openalex.org/keywords/eyelid-malformation","display_name":"eyelid malformation","score":0.6492},{"id":"https://openalex.org/keywords/orbital-prosthesis","display_name":"orbital prosthesis","score":0.427},{"id":"https://openalex.org/keywords/persistent-hyperplastic-primary-vitreous","display_name":"persistent hyperplastic primary vitreous","score":0.6416},{"id":"https://openalex.org/keywords/axenfeld-rieger-syndrome","display_name":"Axenfeld-Rieger syndrome","score":0.5821},{"id":"https://openalex.org/keywords/microcornea","display_name":"microcornea","score":0.5066},{"id":"https://openalex.org/keywords/anophthalmic-socket","display_name":"anophthalmic socket","score":0.7989},{"id":"https://openalex.org/keywords/optic-disc-anomaly","display_name":"optic disc anomaly","score":0.5679},{"id":"https://openalex.org/keywords/implant-exposure","display_name":"implant exposure","score":0.3073}],"legacy_keywords":"Ocular Development; Microphthalmia; Anophthalmia; Genetic Mutations; Fraser Syndrome; Orbital Implants; SOX2 Gene; BCOR Gene; Eye Malformations; Epidermal Adhesion","ids":{"openalex":"https://openalex.org/T12989","wikipedia":"https://en.wikipedia.org/wiki/Microphthalmia"},"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"},"siblings":[{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure"},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology"},{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease"},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology"},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock"},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research"},{"id":"https://openalex.org/T10702","display_name":"Insect and Arachnid Ecology and Behavior"},{"id":"https://openalex.org/T10751","display_name":"Forensic and Genetic Research"},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects"},{"id":"https://openalex.org/T10769","display_name":"BRCA gene mutations in cancer"},{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities"},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders"},{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities"},{"id":"https://openalex.org/T11214","display_name":"Human-Animal Interaction Studies"},{"id":"https://openalex.org/T11310","display_name":"Connective tissue disorders research"},{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies"},{"id":"https://openalex.org/T11374","display_name":"Cleft Lip and Palate Research"},{"id":"https://openalex.org/T11412","display_name":"Genetic and Kidney Cyst Diseases"},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals"},{"id":"https://openalex.org/T11642","display_name":"Genomics and Rare Diseases"},{"id":"https://openalex.org/T11679","display_name":"Craniofacial Disorders and Treatments"},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics"},{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders"},{"id":"https://openalex.org/T11928","display_name":"Genetic Syndromes and Imprinting"},{"id":"https://openalex.org/T11968","display_name":"High Altitude and Hypoxia"},{"id":"https://openalex.org/T11974","display_name":"Lepidoptera: Biology and Taxonomy"},{"id":"https://openalex.org/T12232","display_name":"Yersinia bacterium, plague, ectoparasites research"},{"id":"https://openalex.org/T12355","display_name":"Genetic and rare skin diseases."},{"id":"https://openalex.org/T12370","display_name":"Advances in Cucurbitaceae Research"},{"id":"https://openalex.org/T12447","display_name":"Spider Taxonomy and Behavior Studies"},{"id":"https://openalex.org/T12749","display_name":"Race, Genetics, and Society"},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments"},{"id":"https://openalex.org/T12924","display_name":"Dermatological and Skeletal Disorders"},{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction"},{"id":"https://openalex.org/T13199","display_name":"Digestive system and related health"},{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance"},{"id":"https://openalex.org/T13664","display_name":"Genome Rearrangement Algorithms"},{"id":"https://openalex.org/T13984","display_name":"Nutrition, Genetics, and Disease"},{"id":"https://openalex.org/T14333","display_name":"Dermatoglyphics and Human Traits"}],"works_count":35974,"cited_by_count":301263,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T12989","updated_date":"2026-10-20T03:01:21","created_date":"2024-01-23T15:27:16"}