{"id":"https://openalex.org/T12840","display_name":"Renal function and acid-base balance","description":"This cluster of papers focuses on the diagnosis, management, and effects of metabolic acidosis, particularly in the context of chronic kidney disease. It explores the impact of bicarbonate therapy, dietary acid load, and renal function on acid-base balance, bone health, endothelin activity, and cardiovascular risk. The papers also discuss the potential benefits of nutritional interventions in addressing metabolic acidosis.","keywords":[{"id":"https://openalex.org/keywords/acid-base-balance","display_name":"acid-base balance","score":0.2666},{"id":"https://openalex.org/keywords/metabolic-acidosis","display_name":"metabolic acidosis","score":0.2089},{"id":"https://openalex.org/keywords/acid-base-disorders","display_name":"acid-base disorders","score":0.5221},{"id":"https://openalex.org/keywords/alkalosis","display_name":"alkalosis","score":0.4283},{"id":"https://openalex.org/keywords/metabolic-alkalosis","display_name":"metabolic alkalosis","score":0.2833},{"id":"https://openalex.org/keywords/renal-tubular-acidosis","display_name":"renal tubular acidosis","score":0.3865},{"id":"https://openalex.org/keywords/distal-renal-tubular-acidosis","display_name":"distal renal tubular acidosis","score":0.4368},{"id":"https://openalex.org/keywords/anion-gap","display_name":"anion gap","score":0.3048},{"id":"https://openalex.org/keywords/respiratory-alkalosis","display_name":"respiratory alkalosis","score":0.2301},{"id":"https://openalex.org/keywords/serum-bicarbonate","display_name":"serum bicarbonate","score":0.2994},{"id":"https://openalex.org/keywords/hyperchloremic-metabolic-acidosis","display_name":"hyperchloremic metabolic acidosis","score":0.3488},{"id":"https://openalex.org/keywords/bicarbonate-reabsorption","display_name":"bicarbonate reabsorption","score":0.5251},{"id":"https://openalex.org/keywords/strong-ion-difference","display_name":"strong ion difference","score":0.5075},{"id":"https://openalex.org/keywords/plasma-bicarbonate","display_name":"plasma bicarbonate","score":0.4019},{"id":"https://openalex.org/keywords/dietary-acid-load","display_name":"dietary acid load","score":0.4184},{"id":"https://openalex.org/keywords/acid-base-regulation","display_name":"acid-base regulation","score":0.2015},{"id":"https://openalex.org/keywords/respiratory-compensation","display_name":"respiratory compensation","score":0.3154},{"id":"https://openalex.org/keywords/henderson-hasselbalch-equation","display_name":"Henderson-Hasselbalch equation","score":0.3727},{"id":"https://openalex.org/keywords/sodium-bicarbonate-therapy","display_name":"bicarbonate therapy","score":0.2633},{"id":"https://openalex.org/keywords/renal-acid-excretion","display_name":"renal acid excretion","score":0.7419},{"id":"https://openalex.org/keywords/urinary-acidification","display_name":"urinary acidification","score":0.2316},{"id":"https://openalex.org/keywords/acid-base-physiology","display_name":"acid-base physiology","score":0.6725},{"id":"https://openalex.org/keywords/alkali-therapy","display_name":"alkali therapy","score":0.3284},{"id":"https://openalex.org/keywords/renal-acid-base-balance","display_name":"renal acid-base balance","score":0.5237},{"id":"https://openalex.org/keywords/renal-acid-base-regulation","display_name":"renal acid-base regulation","score":0.7261}],"legacy_keywords":"Metabolic Acidosis; Chronic Kidney Disease; Bicarbonate Therapy; Dietary Acid Load; Renal Function; Acid-Base Balance; Bone Health; Endothelin Activity; Cardiovascular Risk; Nutritional Intervention","ids":{"openalex":"https://openalex.org/T12840","wikipedia":"https://en.wikipedia.org/wiki/Metabolic_acidosis"},"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"},"siblings":[{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management"},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes"},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments"},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research"},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies"},{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid"}],"works_count":25489,"cited_by_count":273062,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T12840","updated_date":"2026-10-16T03:01:39","created_date":"2024-01-23T15:27:15"}