{"id":"https://openalex.org/T12829","display_name":"Advanced Breast Cancer Therapies","description":"This cluster of papers focuses on the use of cyclin-dependent kinase 4/6 (CDK4/6) inhibitors, such as palbociclib, letrozole, ribociclib, and abemaciclib, in the treatment of hormone receptor-positive metastatic breast cancer. The papers cover various aspects including clinical trials, mechanisms of action, therapeutic resistance, combination strategies, and potential biomarkers.","keywords":[{"id":"https://openalex.org/keywords/cdk4-6-inhibitors","display_name":"CDK4/6 inhibitors","score":0.6031},{"id":"https://openalex.org/keywords/palbociclib","display_name":"palbociclib","score":0.5724},{"id":"https://openalex.org/keywords/hormone-receptor-positive-breast-cancer","display_name":"hormone receptor-positive breast cancer","score":0.215},{"id":"https://openalex.org/keywords/fulvestrant","display_name":"fulvestrant","score":0.3364},{"id":"https://openalex.org/keywords/her2-negative-breast-cancer","display_name":"HER2-negative breast cancer","score":0.2269},{"id":"https://openalex.org/keywords/ribociclib","display_name":"ribociclib","score":0.6608},{"id":"https://openalex.org/keywords/abemaciclib","display_name":"abemaciclib","score":0.5819},{"id":"https://openalex.org/keywords/endocrine-resistance","display_name":"endocrine therapy resistance","score":0.2373},{"id":"https://openalex.org/keywords/hr-her2-breast-cancer","display_name":"hormone receptor-positive HER2-negative breast cancer","score":0.464},{"id":"https://openalex.org/keywords/esr1-mutations","display_name":"ESR1 mutations","score":0.4686},{"id":"https://openalex.org/keywords/cdk4-6-inhibitor-resistance","display_name":"CDK4/6 inhibitor resistance","score":0.7946},{"id":"https://openalex.org/keywords/exemestane","display_name":"exemestane","score":0.2288},{"id":"https://openalex.org/keywords/alpelisib","display_name":"alpelisib","score":0.2851},{"id":"https://openalex.org/keywords/selective-estrogen-receptor-degrader","display_name":"selective estrogen receptor degrader","score":0.5277},{"id":"https://openalex.org/keywords/hr-her2-metastatic-breast-cancer","display_name":"HR+/HER2- metastatic breast cancer","score":0.7864},{"id":"https://openalex.org/keywords/aromatase-inhibitor-resistance","display_name":"aromatase inhibitor resistance","score":0.3511},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-4-6-inhibitors","display_name":"cyclin-dependent kinase 4/6 inhibitors","score":0.6758},{"id":"https://openalex.org/keywords/hr-her2-advanced-breast-cancer","display_name":"HR+/HER2- advanced breast cancer","score":0.8247},{"id":"https://openalex.org/keywords/clinical-benefit-rate","display_name":"clinical benefit rate","score":0.2313},{"id":"https://openalex.org/keywords/er-positive-her2-negative-breast-cancer","display_name":"ER-positive HER2-negative breast cancer","score":0.2807},{"id":"https://openalex.org/keywords/elacestrant","display_name":"elacestrant","score":0.6975},{"id":"https://openalex.org/keywords/her2-negative-metastatic-breast-cancer","display_name":"HER2-negative metastatic breast cancer","score":0.343},{"id":"https://openalex.org/keywords/first-line-endocrine-therapy","display_name":"first-line endocrine therapy","score":0.6858},{"id":"https://openalex.org/keywords/capivasertib","display_name":"capivasertib","score":0.282},{"id":"https://openalex.org/keywords/nonsteroidal-aromatase-inhibitors","display_name":"nonsteroidal aromatase inhibitors","score":0.3582}],"legacy_keywords":"CDK4/6 Inhibitors; Breast Cancer; Palbociclib; Letrozole; Ribociclib; Abemaciclib; Hormone Receptor-Positive; Metastatic Breast Cancer; Cell Cycle Control; Therapeutic Resistance","ids":{"openalex":"https://openalex.org/T12829","wikipedia":"https://en.wikipedia.org/wiki/Palbociclib#Breast_cancer_therapy"},"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"},"siblings":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment"},{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research"},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment"},{"id":"https://openalex.org/T10253","display_name":"Sarcoma Diagnosis and Treatment"},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms"},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations"},{"id":"https://openalex.org/T10449","display_name":"Renal cell carcinoma treatment"},{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders"},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research"},{"id":"https://openalex.org/T10549","display_name":"Neonatal Respiratory Health Research"},{"id":"https://openalex.org/T10606","display_name":"Kidney Stones and Urolithiasis Treatments"},{"id":"https://openalex.org/T10618","display_name":"Aortic Disease and Treatment Approaches"},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances"},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes"},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions"},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments"},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases"},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis"},{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies"},{"id":"https://openalex.org/T10983","display_name":"Aortic aneurysm repair treatments"},{"id":"https://openalex.org/T10990","display_name":"Infection Control and Ventilation"},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases"},{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research"},{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry"},{"id":"https://openalex.org/T11260","display_name":"Tracheal and airway disorders"},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis"},{"id":"https://openalex.org/T11356","display_name":"Pleural and Pulmonary Diseases"},{"id":"https://openalex.org/T11361","display_name":"Digital Radiography and Breast Imaging"},{"id":"https://openalex.org/T11487","display_name":"Automotive and Human Injury Biomechanics"},{"id":"https://openalex.org/T11554","display_name":"Vascular Procedures and Complications"},{"id":"https://openalex.org/T11579","display_name":"Cardiovascular and Diving-Related Complications"},{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment"},{"id":"https://openalex.org/T11651","display_name":"Inhalation and Respiratory Drug Delivery"},{"id":"https://openalex.org/T11721","display_name":"Blood properties and coagulation"},{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders"},{"id":"https://openalex.org/T12018","display_name":"Coronary Artery Anomalies"},{"id":"https://openalex.org/T12067","display_name":"Renal and Vascular Pathologies"},{"id":"https://openalex.org/T12198","display_name":"Oral health in cancer treatment"},{"id":"https://openalex.org/T12333","display_name":"Abdominal Surgery and Complications"},{"id":"https://openalex.org/T12418","display_name":"Respiratory and Cough-Related Research"},{"id":"https://openalex.org/T12419","display_name":"Phonocardiography and Auscultation Techniques"},{"id":"https://openalex.org/T12689","display_name":"Silymarin and Mushroom Poisoning"},{"id":"https://openalex.org/T12818","display_name":"Pneumothorax, Barotrauma, Emphysema"},{"id":"https://openalex.org/T12845","display_name":"Methemoglobinemia and Tumor Lysis Syndrome"},{"id":"https://openalex.org/T12876","display_name":"Potassium and Related Disorders"},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies"},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies"},{"id":"https://openalex.org/T13176","display_name":"Winter Sports Injuries and Performance"},{"id":"https://openalex.org/T13657","display_name":"Aortic Thrombus and Embolism"},{"id":"https://openalex.org/T13697","display_name":"Biliary and Gastrointestinal Fistulas"},{"id":"https://openalex.org/T13759","display_name":"Medical Imaging and Pathology Studies"}],"works_count":16078,"cited_by_count":195530,"works_api_url":"https://api.openalex.org/works?filter=topics.id:T12829","updated_date":"2026-10-21T03:01:35","created_date":"2024-01-23T15:27:15"}
